ES447917A1 - Process for the synthesis of prostaglandins - Google Patents
Process for the synthesis of prostaglandinsInfo
- Publication number
- ES447917A1 ES447917A1 ES447917A ES447917A ES447917A1 ES 447917 A1 ES447917 A1 ES 447917A1 ES 447917 A ES447917 A ES 447917A ES 447917 A ES447917 A ES 447917A ES 447917 A1 ES447917 A1 ES 447917A1
- Authority
- ES
- Spain
- Prior art keywords
- radical
- substituted
- represent
- alkenylene
- free
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- 150000003180 prostaglandins Chemical class 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- -1 aliphatic radical Chemical class 0.000 abstract 9
- 150000003254 radicals Chemical class 0.000 abstract 4
- 125000002947 alkylene group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000004419 alkynylene group Chemical group 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- JEVCWSUVFOYBFI-UHFFFAOYSA-N cyanyl Chemical compound N#[C] JEVCWSUVFOYBFI-UHFFFAOYSA-N 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000002184 metal Chemical class 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical compound [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
- 235000007586 terpenes Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Procedure for the preparation of prostaglandin intermediates, particularly of a compound of formula I; **(See formula)** characterized by treating a compound of formula II: **(See formula)** in acidic medium, in these formulas R10, R'10, R11, R'11, R12, R4 and R8 separately represent a hydrogen, halogen atom, an aliphatic radical, a free or protected methyl radical or a cyano radical; R'11 can also be an aryl, cycloaliphatic radical or a free or protected hydroxy radical; R'10 and R'11 taken together may represent a double bond or a substituted or unsubstituted alkylene or alkenylene radical; R5 and R6 represent separately an aliphatic radical, or taken together an unsubstituted or substituted alkylene or alkenylene radical; represents a hydrogen, a halogen atom, an aliphatic radical, a substituted or unsubstituted aryl, cycloaliphatic radical, a terpene radical, a silyl substituted radical or a metal cation; R9 represents a free or protected hydroxy radical; R'9 represents a hydrogen atom or an alkyl radical, or Rg and R'g taken together represent an oxo radical; and -A- represents an alkylene, alkenylene, alkynylene, cyclopropanylene radical, halogenated or not, cyclopropanylene-ylidene halogenated or not, a 5-membered cyclic radical containing 1 or 2 heteroatoms or represents such a simple bond; m and n are integers between 0 and 3 inclusive. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7514120A FR2310339A1 (en) | 1975-05-06 | 1975-05-06 | NEW PROCESSES FOR THE SYNTHESIS OF PROSTAGLANDIN DERIVATIVES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES447917A1 true ES447917A1 (en) | 1977-09-16 |
Family
ID=9154905
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES447917A Expired ES447917A1 (en) | 1975-05-06 | 1976-05-06 | Process for the synthesis of prostaglandins |
Country Status (15)
| Country | Link |
|---|---|
| JP (1) | JPS51136652A (en) |
| AU (1) | AU511756B2 (en) |
| BE (1) | BE841138A (en) |
| CA (1) | CA1078860A (en) |
| CH (1) | CH615909A5 (en) |
| DE (1) | DE2620125A1 (en) |
| DK (1) | DK201076A (en) |
| ES (1) | ES447917A1 (en) |
| FI (1) | FI761271A (en) |
| FR (1) | FR2310339A1 (en) |
| GB (1) | GB1552140A (en) |
| IL (1) | IL49527A0 (en) |
| NL (1) | NL7604851A (en) |
| SE (1) | SE7604754L (en) |
| ZA (1) | ZA762625B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA814307B (en) * | 1980-07-01 | 1983-02-23 | Nat Res Dev | Prostaglandins |
| JPS58502148A (en) * | 1981-12-23 | 1983-12-15 | ナシヨナル リサ−チ デイベロツプメント コ−ポレイシヨン | prostaglandin |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773795A (en) * | 1971-06-28 | 1973-11-20 | Ayerst Mckenna & Harrison | 11-deoxy prostaglandin intermediates |
| GB1432950A (en) * | 1972-11-10 | 1976-04-22 | Ici Ltd | Cyclopentane aldehydes as chemical intermediates |
-
1975
- 1975-05-06 FR FR7514120A patent/FR2310339A1/en active Granted
-
1976
- 1976-04-26 SE SE7604754A patent/SE7604754L/en unknown
- 1976-04-26 BE BE166474A patent/BE841138A/en unknown
- 1976-04-27 CH CH525776A patent/CH615909A5/en not_active IP Right Cessation
- 1976-04-28 CA CA251,341A patent/CA1078860A/en not_active Expired
- 1976-05-03 ZA ZA762625A patent/ZA762625B/en unknown
- 1976-05-04 IL IL49527A patent/IL49527A0/en unknown
- 1976-05-05 DK DK201076A patent/DK201076A/en unknown
- 1976-05-05 GB GB18401/76A patent/GB1552140A/en not_active Expired
- 1976-05-06 JP JP51051614A patent/JPS51136652A/en active Pending
- 1976-05-06 NL NL7604851A patent/NL7604851A/en active Search and Examination
- 1976-05-06 ES ES447917A patent/ES447917A1/en not_active Expired
- 1976-05-06 DE DE19762620125 patent/DE2620125A1/en not_active Withdrawn
- 1976-05-06 FI FI761271A patent/FI761271A/fi not_active Application Discontinuation
- 1976-05-06 AU AU13681/76A patent/AU511756B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR2310339A1 (en) | 1976-12-03 |
| FR2310339B1 (en) | 1977-12-09 |
| DE2620125A1 (en) | 1976-11-25 |
| AU511756B2 (en) | 1980-09-04 |
| ZA762625B (en) | 1977-04-27 |
| JPS51136652A (en) | 1976-11-26 |
| DK201076A (en) | 1976-11-07 |
| BE841138A (en) | 1976-10-26 |
| CH615909A5 (en) | 1980-02-29 |
| NL7604851A (en) | 1976-11-09 |
| FI761271A (en) | 1976-11-07 |
| CA1078860A (en) | 1980-06-03 |
| AU1368176A (en) | 1977-11-10 |
| SE7604754L (en) | 1976-11-07 |
| IL49527A0 (en) | 1976-07-30 |
| GB1552140A (en) | 1979-09-12 |
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