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ES439073A1 - Manufacture of novel phenothiazine derivative - Google Patents

Manufacture of novel phenothiazine derivative

Info

Publication number
ES439073A1
ES439073A1 ES439073A ES439073A ES439073A1 ES 439073 A1 ES439073 A1 ES 439073A1 ES 439073 A ES439073 A ES 439073A ES 439073 A ES439073 A ES 439073A ES 439073 A1 ES439073 A1 ES 439073A1
Authority
ES
Spain
Prior art keywords
carbon atoms
radical
part contains
general formula
manufacture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES439073A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Industries SA
Original Assignee
Rhone Poulenc Industries SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Industries SA filed Critical Rhone Poulenc Industries SA
Publication of ES439073A1 publication Critical patent/ES439073A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings
    • C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
    • C07D279/24—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom
    • C07D279/28—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom with other substituents attached to the ring system

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Otolaryngology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Procedure for preparing phenothiazine derivatives, of general formula: **(See formula)** in which X represents a methylthio, methylsulfonyl or dimethylsulfamoyl radical, A represents a radical - (CH2) 3- or -CH- (CH3) -CH2-, R1 represents a hydrogen atom or an alkanoyl radical whose alkyl part contains 1 to 16 carbon atoms, alkenoyl whose alkenyl part contains 2 to 16 carbon atoms; as well as its addition salts with acids; characterized in that a product of general formula is treated in an acid medium: **(See formula)** in which X, A and R1 are defined as above and R represents an alkyl radical containing 1 to 10 carbon atoms or phenylalkyl whose alkyl part contains 1 to 4 carbon atoms or tetrahydropyranyl, and then the product obtained is eventually transformed into an addition salt with an acid. (Machine-translation by Google Translate, not legally binding)
ES439073A 1974-11-12 1975-07-02 Manufacture of novel phenothiazine derivative Expired ES439073A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7437295A FR2290907A2 (en) 1974-11-12 1974-11-12 10-((4-hydroxyethylpiperidino)alkyl)-phenothiazines - with antiemetic activity

Publications (1)

Publication Number Publication Date
ES439073A1 true ES439073A1 (en) 1977-03-01

Family

ID=9144859

Family Applications (1)

Application Number Title Priority Date Filing Date
ES439073A Expired ES439073A1 (en) 1974-11-12 1975-07-02 Manufacture of novel phenothiazine derivative

Country Status (5)

Country Link
JP (1) JPS54109988A (en)
AR (1) AR206441A1 (en)
CH (1) CH599955A5 (en)
ES (1) ES439073A1 (en)
FR (1) FR2290907A2 (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1212031A (en) * 1957-10-21 1960-03-21 Rhone Poulenc Sa Phenothiazine derivatives substituted on nitrogen with a basic chain comprising a heterocycle and their preparation

Also Published As

Publication number Publication date
JPS54109988A (en) 1979-08-29
FR2290907A2 (en) 1976-06-11
AR206441A1 (en) 1976-07-23
CH599955A5 (en) 1978-06-15
FR2290907B2 (en) 1978-08-18

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