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ES428442A1 - 1,2,3,4-tetrahydroisoquinoline derivatives and the preparation thereof - Google Patents

1,2,3,4-tetrahydroisoquinoline derivatives and the preparation thereof

Info

Publication number
ES428442A1
ES428442A1 ES74428442A ES428442A ES428442A1 ES 428442 A1 ES428442 A1 ES 428442A1 ES 74428442 A ES74428442 A ES 74428442A ES 428442 A ES428442 A ES 428442A ES 428442 A1 ES428442 A1 ES 428442A1
Authority
ES
Spain
Prior art keywords
hydroxy
general formula
preparation
compound
sulfamoyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES74428442A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP8200473A external-priority patent/JPS5637983B2/ja
Priority claimed from JP8200373A external-priority patent/JPS572707B2/ja
Priority claimed from JP8598773A external-priority patent/JPS5734275B2/ja
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of ES428442A1 publication Critical patent/ES428442A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A procedure for the preparation of 1,2,3,4-tetrahydroisoquinoline derivatives of the general formula: **(See formula)** where R1 and R2 are each hydrogen or lower alkyl, R3 is phenyl having substituent (s) selected from the group consisting of lower alkenyloxy, mercapto, lower alkylthio, sulfamoyl, and disubstituted mono or sulfamoyl, or a heterocyclic group, R'4 and R'5 are each hydroxy or a protected hydroxy and X is -0- or -S- and a pharmaceutically acceptable salt thereof comprising reacting a compound of the general formula: **(See formula)** where R1 and R2 are each as defined above, R4 and R5 are each hydroxy or a protected hydroxy, or a salt thereof, with an aldehyde compound of the general formula: R3-X-CH2CHO where R3 and X are each as defined above, or a reactive derivative thereof, and optionally subjecting the resulting compound to a removal reaction of the hydroxy protecting group. (Machine-translation by Google Translate, not legally binding)
ES74428442A 1973-07-20 1974-07-19 1,2,3,4-tetrahydroisoquinoline derivatives and the preparation thereof Expired ES428442A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP8200473A JPS5637983B2 (en) 1973-07-20 1973-07-20
JP8200373A JPS572707B2 (en) 1973-07-20 1973-07-20
JP8598773A JPS5734275B2 (en) 1973-07-30 1973-07-30

Publications (1)

Publication Number Publication Date
ES428442A1 true ES428442A1 (en) 1977-01-01

Family

ID=27303776

Family Applications (1)

Application Number Title Priority Date Filing Date
ES74428442A Expired ES428442A1 (en) 1973-07-20 1974-07-19 1,2,3,4-tetrahydroisoquinoline derivatives and the preparation thereof

Country Status (11)

Country Link
AR (1) AR204327A1 (en)
CA (1) CA1035359A (en)
CH (1) CH605775A5 (en)
DE (1) DE2434310A1 (en)
DK (1) DK389874A (en)
ES (1) ES428442A1 (en)
FR (1) FR2237634B1 (en)
GB (1) GB1470675A (en)
IE (1) IE39724B1 (en)
NL (1) NL7409805A (en)
SE (1) SE420600B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5734275B2 (en) * 1973-07-30 1982-07-22
GB8807922D0 (en) * 1988-04-05 1988-05-05 Fujisawa Pharmaceutical Co Isoquinoline compound & process for preparation thereof
GB8921304D0 (en) * 1989-09-20 1989-11-08 Wyeth John & Brother Ltd New method of treatment and heterocyclic compounds used therein

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1145254A (en) * 1965-03-18 1969-03-12 Bristol Myers Co Novel tetrahydroisoquinoline derivatives and a process for the preparation thereof
US3389141A (en) * 1966-05-16 1968-06-18 Bristol Myers Co 1-beta-aryloxyethyltetrahydro-isoquinolines
FR2119989B1 (en) * 1970-12-29 1975-10-10 Fujisawa Pharmaceutical Co

Also Published As

Publication number Publication date
DE2434310A1 (en) 1975-02-06
IE39724L (en) 1975-01-20
CA1035359A (en) 1978-07-25
AR204327A1 (en) 1975-12-22
AU7145674A (en) 1976-01-22
FR2237634B1 (en) 1978-06-30
NL7409805A (en) 1975-01-22
IE39724B1 (en) 1978-12-20
DK389874A (en) 1975-03-17
SE420600B (en) 1981-10-19
CH605775A5 (en) 1978-10-13
SE7409470L (en) 1975-01-21
FR2237634A1 (en) 1975-02-14
GB1470675A (en) 1977-04-21

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