ES428011A1 - PROCEDURE FOR THE PREPARATION OF 2-AMINO-3,5-DIBROMO-BENZYLAMINE. - Google Patents
PROCEDURE FOR THE PREPARATION OF 2-AMINO-3,5-DIBROMO-BENZYLAMINE.Info
- Publication number
- ES428011A1 ES428011A1 ES428011A ES428011A ES428011A1 ES 428011 A1 ES428011 A1 ES 428011A1 ES 428011 A ES428011 A ES 428011A ES 428011 A ES428011 A ES 428011A ES 428011 A1 ES428011 A1 ES 428011A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- benzylamine
- dibromo
- amino
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- NAIJZCXBMHHHDM-UHFFFAOYSA-N 2-(aminomethyl)-4,6-dibromoaniline Chemical compound NCC1=CC(Br)=CC(Br)=C1N NAIJZCXBMHHHDM-UHFFFAOYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000007522 mineralic acids Chemical class 0.000 abstract 2
- 150000007524 organic acids Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- XTUVJUMINZSXGF-UHFFFAOYSA-N N-methylcyclohexylamine Chemical compound CNC1CCCCC1 XTUVJUMINZSXGF-UHFFFAOYSA-N 0.000 abstract 1
- PAMIQIKDUOTOBW-UHFFFAOYSA-N N-methylcyclohexylamine Natural products CN1CCCCC1 PAMIQIKDUOTOBW-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Process for the preparation of 2-amino-3,5-dibromo-benzylamine of the formula i, ** (see formula) ** As well as their acid addition salts physiologically compatible with organic or inorganic acids, characterized in that a compound of the general formula ii is reacted, ** (see formula) ** Wherein r represents a hydrogen atom or an aliphatic acyl radical, with N-methylcyclohexylamine in the presence of a base and the compound of the formula i obtained is converted, if desired, into its physiologically compatible salts with organic or inorganic acids. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19732337455 DE2337455A1 (en) | 1973-07-24 | 1973-07-24 | Pure 2-amino-3,5-dibromo-benzylamine prepn - by reacting 2-acylamino-3,5-dibromobenzylalcohol with N-methyl cyclohexylamine in presence of base |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES428011A1 true ES428011A1 (en) | 1976-07-16 |
Family
ID=5887783
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES428011A Expired ES428011A1 (en) | 1973-07-24 | 1974-07-05 | PROCEDURE FOR THE PREPARATION OF 2-AMINO-3,5-DIBROMO-BENZYLAMINE. |
Country Status (12)
| Country | Link |
|---|---|
| JP (1) | JPS5047944A (en) |
| AT (1) | AT330146B (en) |
| BG (1) | BG22384A3 (en) |
| CA (1) | CA1022572A (en) |
| CS (1) | CS177181B2 (en) |
| DE (1) | DE2337455A1 (en) |
| DK (1) | DK135499C (en) |
| ES (1) | ES428011A1 (en) |
| FI (1) | FI177474A (en) |
| HU (1) | HU169285B (en) |
| NL (1) | NL7409045A (en) |
| SE (1) | SE7409584L (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102924295B (en) * | 2012-10-09 | 2014-10-29 | 石家庄东方药业有限公司 | Bromhexine hydrochloride crystal as well as preparation method and application of crystal |
| CN103145564B (en) * | 2013-03-15 | 2014-06-18 | 湖北美林药业有限公司 | Bromhexine hydrochloride compound and pharmaceutical composition thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5031141B2 (en) * | 1972-03-30 | 1975-10-07 |
-
1973
- 1973-07-24 DE DE19732337455 patent/DE2337455A1/en active Pending
-
1974
- 1974-06-11 FI FI177474A patent/FI177474A/fi unknown
- 1974-06-20 AT AT510574A patent/AT330146B/en not_active IP Right Cessation
- 1974-06-25 CS CS446674A patent/CS177181B2/cs unknown
- 1974-06-27 BG BG027098A patent/BG22384A3/en unknown
- 1974-07-04 NL NL7409045A patent/NL7409045A/en not_active Application Discontinuation
- 1974-07-05 ES ES428011A patent/ES428011A1/en not_active Expired
- 1974-07-22 HU HUTO000971 patent/HU169285B/hu unknown
- 1974-07-23 SE SE7409584A patent/SE7409584L/ not_active Application Discontinuation
- 1974-07-23 DK DK397174A patent/DK135499C/en active
- 1974-07-23 CA CA205,453A patent/CA1022572A/en not_active Expired
- 1974-07-23 JP JP8454074A patent/JPS5047944A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DK397174A (en) | 1975-03-10 |
| NL7409045A (en) | 1975-01-28 |
| DK135499B (en) | 1977-05-09 |
| FI177474A (en) | 1975-01-25 |
| CS177181B2 (en) | 1977-07-29 |
| ATA510574A (en) | 1975-09-15 |
| CA1022572A (en) | 1977-12-13 |
| HU169285B (en) | 1976-10-28 |
| DE2337455A1 (en) | 1975-02-13 |
| JPS5047944A (en) | 1975-04-28 |
| SE7409584L (en) | 1975-01-27 |
| BG22384A3 (en) | 1977-02-20 |
| AT330146B (en) | 1976-06-10 |
| DK135499C (en) | 1977-10-24 |
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