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ES410731A1 - Alpha-aryl-4-substituted piperidinoalkanol derivatives - Google Patents

Alpha-aryl-4-substituted piperidinoalkanol derivatives

Info

Publication number
ES410731A1
ES410731A1 ES410731A ES410731A ES410731A1 ES 410731 A1 ES410731 A1 ES 410731A1 ES 410731 A ES410731 A ES 410731A ES 410731 A ES410731 A ES 410731A ES 410731 A1 ES410731 A1 ES 410731A1
Authority
ES
Spain
Prior art keywords
group
substituted
aryl
formula
substituted phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES410731A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richardson Vicks Inc
Original Assignee
Richardson Merrell Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22829539&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES410731(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Richardson Merrell Inc filed Critical Richardson Merrell Inc
Publication of ES410731A1 publication Critical patent/ES410731A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Procedure for the preparation of substituted alpha-aryl-4-piperidino alkanol derivatives, especially of a compound selected from a base of the formula: **(See formula)** where R is selected from the group consisting of hydrogen or hydroxy; R1 is hydrogen, or R and R1 taken together form a second bond between the carbon atoms bearing R and R1 n is a positive integer from 1 to 3, and Z is selected from the group consisting of thienyl, phenyl, or substituted phenyl wherein the substituents on the substituted phenyl may be attached at the ortho, meta or para positions of the substituted phenyl ring and are selected from the group consisting of a halogen atom, a straight or branched lower alkyl chain of from 1 to 4 atoms carbon, a dialkylamino lower group or a saturated monocyclic, heterocyclic ring selected from the group consisting of pyrrolidino, piperidino, morpholino or N-lower alkylpiperazino, to the pharmaceutically acceptable acid addition salts thereof, characterized in that it comprises reacting in a suitable solvent a 4-substituted aryl piperidinoalkyl ketone of the formula: **(See formula)** where R, and R1, n and a have the meanings defined above with a ketone reducing agent for 0.5 to 8 hours at a temperature of from 0ºC. at the reflux temperature of the solvent. (Machine-translation by Google Translate, not legally binding)
ES410731A 1972-01-28 1973-01-18 Alpha-aryl-4-substituted piperidinoalkanol derivatives Expired ES410731A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22182172A 1972-01-28 1972-01-28

Publications (1)

Publication Number Publication Date
ES410731A1 true ES410731A1 (en) 1976-04-01

Family

ID=22829539

Family Applications (1)

Application Number Title Priority Date Filing Date
ES410731A Expired ES410731A1 (en) 1972-01-28 1973-01-18 Alpha-aryl-4-substituted piperidinoalkanol derivatives

Country Status (26)

Country Link
JP (1) JPS5115035B2 (en)
AR (1) AR195314A1 (en)
AT (2) AT321917B (en)
AU (1) AU467361B2 (en)
BE (1) BE794597A (en)
CA (1) CA978946A (en)
CH (2) CH593259A5 (en)
CS (1) CS177834B2 (en)
DD (1) DD103239A5 (en)
DE (1) DE2303306C3 (en)
DK (1) DK136713B (en)
ES (1) ES410731A1 (en)
FR (1) FR2181690B1 (en)
GB (1) GB1413138A (en)
HU (1) HU166477B (en)
IE (1) IE36983B1 (en)
IL (1) IL41060A (en)
LU (1) LU66916A1 (en)
NL (1) NL175410C (en)
NO (1) NO140057C (en)
PH (1) PH10264A (en)
PL (1) PL89095B1 (en)
SE (1) SE382058B (en)
SU (1) SU464997A3 (en)
YU (1) YU36013B (en)
ZA (1) ZA728544B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3941795A (en) 1974-02-08 1976-03-02 Richardson-Merrell Inc. α-ARYL-4-SUBSTITUTED PIPERIDINOALKANOL DERIVATIVES
US4254130A (en) * 1979-04-10 1981-03-03 Richardson-Merrell Inc. Piperidine derivatives
US4254129A (en) * 1979-04-10 1981-03-03 Richardson-Merrell Inc. Piperidine derivatives
IT1200123B (en) * 1985-09-27 1989-01-05 Ind Chimica Srl PROCESS FOR ALPHA PREPARATION
US4742175A (en) * 1986-05-07 1988-05-03 Merrell Dow Pharmaceuticals Inc. Preparation of polymorphically pure terfenadine
JPS63101760U (en) * 1986-12-19 1988-07-02
IT1205685B (en) * 1987-05-26 1989-03-31 Erregierre Spa PROCESS FOR THE PREPARATION OF ALPHA- (ALCHYLPHENYL) -4- (HYDROXY DIPHENYLMETHYL) -1-PIPERIDINE BUTANOL
IL93499A0 (en) * 1989-02-28 1990-11-29 Merrell Dow Pharma Preparation of the low melting polymorphic form of terfenadine
ZA903145B (en) * 1989-05-01 1991-02-27 Merrell Dow Pharma Process for the preparation of the high melting polymorphic form of terfenadine
DE3917241A1 (en) * 1989-05-26 1990-11-29 Schaper & Bruemmer Gmbh 4- (HYDROXYDIPHENYLMETHYL) -1-PIPERIDYL-PHENYLALKANE DERIVATIVES
US5466691A (en) * 1991-08-09 1995-11-14 Yoshitomi Pharmaceutical Industries, Ltd. Thiophene compound
WO1996035667A1 (en) * 1995-05-08 1996-11-14 Hoescht Marion Roussel, Inc. Alpha-(substituted alkylphenyl)-4-(hydroxydiphenylmethyl)-1-piperidine butanol derivatives, their preparation and their use as anti-histamines, anti-allergy agents and bronchodilators
PT864653E (en) * 1997-03-11 2004-08-31 Aventis Pharma Inc PROCESS FOR PREPARATION OF 4- (4- (4- (HYDROXIDIFENYL) -1-PIPERIDINYL) -1-HYDROXIBUTIL) -ALFA, ALPHA-DIMETHYLPHENYL ACETATE AND PHOSPHORYLED DERIVATIVES
US7498345B2 (en) * 2004-09-17 2009-03-03 Albany Molecular Research, Inc. Process for production of piperidine derivatives
WO2006043691A1 (en) * 2004-10-18 2006-04-27 Reverse Proteomics Research Institute Co., Ltd. Target protein and target gene in drug designing and screening method

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3081303A (en) * 1961-10-13 1963-03-12 Searle & Co 1-aminoalkyl-alpha, alpha-diphenylpiperidine-methanols
GB1242169A (en) * 1969-04-09 1971-08-11 Ucb Sa Piperidine derivatives

Also Published As

Publication number Publication date
DE2303306C3 (en) 1979-05-31
IE36983L (en) 1973-07-28
ZA728544B (en) 1974-02-27
PL89095B1 (en) 1976-10-30
IL41060A0 (en) 1973-02-28
PH10264A (en) 1976-10-20
CS177834B2 (en) 1977-08-31
CH587820A5 (en) 1977-05-13
IE36983B1 (en) 1977-04-13
NL175410B (en) 1984-06-01
LU66916A1 (en) 1973-07-27
GB1413138A (en) 1975-11-05
YU3473A (en) 1981-02-28
BE794597A (en) 1973-05-16
DK136713C (en) 1978-05-01
CA978946A (en) 1975-12-02
DD103239A5 (en) 1974-01-12
NL175410C (en) 1984-11-01
NO140057B (en) 1979-03-19
AT323742B (en) 1975-07-25
YU36013B (en) 1981-11-13
AU4989372A (en) 1974-06-13
IL41060A (en) 1975-06-25
DK136713B (en) 1977-11-14
FR2181690B1 (en) 1976-05-14
NL7300873A (en) 1973-07-31
CH593259A5 (en) 1977-11-30
DE2303306B2 (en) 1978-09-28
JPS5115035B2 (en) 1976-05-13
JPS4885578A (en) 1973-11-13
DE2303306A1 (en) 1973-08-02
SE382058B (en) 1976-01-12
SU464997A3 (en) 1975-03-25
NO140057C (en) 1979-07-04
AT321917B (en) 1975-04-25
AR195314A1 (en) 1973-09-28
HU166477B (en) 1975-03-28
FR2181690A1 (en) 1973-12-07
AU467361B2 (en) 1975-11-27

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