ES409669A1 - A procedure for the preparation of new derivatives of 2-nitroindan-1,3-diona. (Machine-translation by Google Translate, not legally binding)
- Google Patents
A procedure for the preparation of new derivatives of 2-nitroindan-1,3-diona. (Machine-translation by Google Translate, not legally binding)
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Beecham Group PLC
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Beecham Group PLC
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Publication of ES409669A1publicationCriticalpatent/ES409669A1/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions
(AREA)
Abstract
A procedure for the preparation of new derivatives of 2-nitroindan-l, 3-dione. or a pharmaceutically acceptable salt thereof, whose compound or salt possess antiallergic properties of the formula: **(See formula)** where R1 R2, R3 and R4 are each hydrogen or alkyl, alkoxy, aryl, aralkyl, a heterocyclic or halogen group and any two adjacent groups R1 and R2, R2 and R3 or R3 and R4, may be linked forming a system of carbocyclic or heterocyclic ring, except for the following compounds and their salts: 2-nitroindan-1,3-dione 4,5-dimethoxy-2-nitroindan-1,3-dione 5-methoxy-2-nitroindan-1,3-dione 4-chloro-2-nitroindan-1,3-dione 3-chloro-2-nitroindan-1,3-dione 4-bromo-2-nitroindan-1,3-dione 5-bromo-2 -nitroindan-1,3-dione 4-methyl-2-nitroindan-1,3-dione 5-iodine-2-nitroindan-1,3-dione whose procedure includes the nitration of the initial indan-1,3-dione of formula (III): **(See formula)** where R1, R2, R3 and R4 are as defined above and, if desired, reaction of the resulting 2-nitroindan-1,3-dione with a base to produce a pharmaceutically acceptable salt of 2-nitroindan-1,3- diona. (Machine-translation by Google Translate, not legally binding)
ES409669A1972-01-251972-12-15A procedure for the preparation of new derivatives of 2-nitroindan-1,3-diona. (Machine-translation by Google Translate, not legally binding)
ExpiredES409669A1
(en)
Procedure for the preparation of amino-derivatives of pirazolo (3,4-b) pyridine-5-carboxylic acids. (Machine-translation by Google Translate, not legally binding)
Analgesic drugs based on N- (aroilalkil) n '- (alfanols) piperacinas and their derivatives, and procedure for their obtaination. (Machine-translation by Google Translate, not legally binding)