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ES406528A1 - PROCEDURE FOR THE PREPARATION OF NEW 4- (4-BI-FENYLIL) -4-OXOBUTIRIC ACIDS AND THEIR ESTERS. - Google Patents

PROCEDURE FOR THE PREPARATION OF NEW 4- (4-BI-FENYLIL) -4-OXOBUTIRIC ACIDS AND THEIR ESTERS.

Info

Publication number
ES406528A1
ES406528A1 ES406528A ES406528A ES406528A1 ES 406528 A1 ES406528 A1 ES 406528A1 ES 406528 A ES406528 A ES 406528A ES 406528 A ES406528 A ES 406528A ES 406528 A1 ES406528 A1 ES 406528A1
Authority
ES
Spain
Prior art keywords
esters
oxobutiric
fenylil
acids
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES406528A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES406528A1 publication Critical patent/ES406528A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/88—Unsaturated compounds containing keto groups containing halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Title cpds. of formula (I): where A = CH2, CHOH or CO R1 = H or hal, or (if R2 and R3 = H) ME R3 = H) Me R2 = H, hal, CN, NO2, NH2, or (1-4C) NH acyl R3 = H or hal R4 = (1-4C) alkyl and at least one of R1-R3 = H, including salts, esters, and lactones of (I), are of use as anti-phlogistics. (I) are prepd. e.g., A = CO, by condensing a biphenyl with a succinic halide or anhydride and a Lewis acid A = CH2 by reducing I (A = CO or CHOH) and other unsatd. analogues A = CHOH by selective, partial redn. of I(A = CO).
ES406528A 1971-03-17 1972-09-05 PROCEDURE FOR THE PREPARATION OF NEW 4- (4-BI-FENYLIL) -4-OXOBUTIRIC ACIDS AND THEIR ESTERS. Expired ES406528A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19712112716 DE2112716A1 (en) 1971-03-17 1971-03-17 Biphenylyl-butyric acid derivs. - anti phlogistics

Publications (1)

Publication Number Publication Date
ES406528A1 true ES406528A1 (en) 1975-08-01

Family

ID=5801760

Family Applications (15)

Application Number Title Priority Date Filing Date
ES400791A Expired ES400791A1 (en) 1971-03-17 1972-03-15 PROCEDURE FOR THE PREPARATION OF NEW 4- (4-BI-FENYLIL) -4-OXOBUTIRIC ACIDS AND THEIR ESTERS.
ES406528A Expired ES406528A1 (en) 1971-03-17 1972-09-05 PROCEDURE FOR THE PREPARATION OF NEW 4- (4-BI-FENYLIL) -4-OXOBUTIRIC ACIDS AND THEIR ESTERS.
ES406537A Expired ES406537A1 (en) 1971-03-17 1972-09-09 Biphenylyl-butyric acid derivs. - anti phlogistics
ES406530A Expired ES406530A1 (en) 1971-03-17 1972-09-09 Biphenylyl-butyric acid derivs. - anti phlogistics
ES406526A Expired ES406526A1 (en) 1971-03-17 1972-09-09 PROCEDURE FOR THE PREPARATION OF NEW 4- (4-BI-FENYLIL) -4-OXOBUTIRIC ACIDS AND THEIR ESTERS.
ES406532A Expired ES406532A1 (en) 1971-03-17 1972-09-09 PROCEDURE FOR THE PREPARATION OF NEW ACIDS 4- (4-BI-FENYLIL) - 4-OXOBUTIRICOS AND ITS ESTERS.
ES406535A Expired ES406535A1 (en) 1971-03-17 1972-09-09 Biphenylyl-butyric acid derivs. - anti phlogistics
ES406531A Expired ES406531A1 (en) 1971-03-17 1972-09-09 Biphenylyl-butyric acid derivs. - anti phlogistics
ES406529A Expired ES406529A1 (en) 1971-03-17 1972-09-09 Biphenylyl-butyric acid derivs. - anti phlogistics
ES406538A Expired ES406538A1 (en) 1971-03-17 1972-09-09 Biphenylyl-butyric acid derivs. - anti phlogistics
ES406536A Expired ES406536A1 (en) 1971-03-17 1972-09-09 PROCEDURE FOR THE PREPARATION OF NEW ACIDS 4- (4-BI-FENYLIL) - 4-OXOBUTIRICOS AND ITS ESTERS.
ES406533A Expired ES406533A1 (en) 1971-03-17 1972-09-09 PROCEDURE FOR THE PREPARATION OF NEW ACIDS 4- (4-BI-FENYLIL) - 4-OXOBUTIRICOS AND ITS ESTERS.
ES406527A Expired ES406527A1 (en) 1971-03-17 1972-09-09 Biphenylyl-butyric acid derivs. - anti phlogistics
ES406534A Expired ES406534A1 (en) 1971-03-17 1972-09-09 PROCEDURE FOR THE PREPARATION OF NEW 4- (4-BI-FENYLIL) -4-OXOBUTIRIC ACIDS AND THEIR ESTERS.
ES406539A Expired ES406539A1 (en) 1971-03-17 1972-09-09 Biphenylyl-butyric acid derivs. - anti phlogistics

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES400791A Expired ES400791A1 (en) 1971-03-17 1972-03-15 PROCEDURE FOR THE PREPARATION OF NEW 4- (4-BI-FENYLIL) -4-OXOBUTIRIC ACIDS AND THEIR ESTERS.

Family Applications After (13)

Application Number Title Priority Date Filing Date
ES406537A Expired ES406537A1 (en) 1971-03-17 1972-09-09 Biphenylyl-butyric acid derivs. - anti phlogistics
ES406530A Expired ES406530A1 (en) 1971-03-17 1972-09-09 Biphenylyl-butyric acid derivs. - anti phlogistics
ES406526A Expired ES406526A1 (en) 1971-03-17 1972-09-09 PROCEDURE FOR THE PREPARATION OF NEW 4- (4-BI-FENYLIL) -4-OXOBUTIRIC ACIDS AND THEIR ESTERS.
ES406532A Expired ES406532A1 (en) 1971-03-17 1972-09-09 PROCEDURE FOR THE PREPARATION OF NEW ACIDS 4- (4-BI-FENYLIL) - 4-OXOBUTIRICOS AND ITS ESTERS.
ES406535A Expired ES406535A1 (en) 1971-03-17 1972-09-09 Biphenylyl-butyric acid derivs. - anti phlogistics
ES406531A Expired ES406531A1 (en) 1971-03-17 1972-09-09 Biphenylyl-butyric acid derivs. - anti phlogistics
ES406529A Expired ES406529A1 (en) 1971-03-17 1972-09-09 Biphenylyl-butyric acid derivs. - anti phlogistics
ES406538A Expired ES406538A1 (en) 1971-03-17 1972-09-09 Biphenylyl-butyric acid derivs. - anti phlogistics
ES406536A Expired ES406536A1 (en) 1971-03-17 1972-09-09 PROCEDURE FOR THE PREPARATION OF NEW ACIDS 4- (4-BI-FENYLIL) - 4-OXOBUTIRICOS AND ITS ESTERS.
ES406533A Expired ES406533A1 (en) 1971-03-17 1972-09-09 PROCEDURE FOR THE PREPARATION OF NEW ACIDS 4- (4-BI-FENYLIL) - 4-OXOBUTIRICOS AND ITS ESTERS.
ES406527A Expired ES406527A1 (en) 1971-03-17 1972-09-09 Biphenylyl-butyric acid derivs. - anti phlogistics
ES406534A Expired ES406534A1 (en) 1971-03-17 1972-09-09 PROCEDURE FOR THE PREPARATION OF NEW 4- (4-BI-FENYLIL) -4-OXOBUTIRIC ACIDS AND THEIR ESTERS.
ES406539A Expired ES406539A1 (en) 1971-03-17 1972-09-09 Biphenylyl-butyric acid derivs. - anti phlogistics

Country Status (7)

Country Link
AT (19) AT311949B (en)
CH (2) CH573387A5 (en)
DE (1) DE2112716A1 (en)
DK (1) DK132944C (en)
ES (15) ES400791A1 (en)
SE (1) SE393102B (en)
ZA (1) ZA721798B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1171605B (en) * 1981-10-22 1987-06-10 Roussel Maestretti Spa PHARMACOLOGICALLY ACTIVE 4-FENYL-4-OSSOBUTEN-2-OIC ACID DERIVATIVES AND PROCEDURE FOR THEIR PREPARATION
CS243570B1 (en) * 1984-08-31 1986-06-12 Miroslav Kuchar Omega-aryloxoalkane acids
US5968795A (en) * 1996-05-15 1999-10-19 Bayer Corporation Biaryl acetylenes as inhibitors of matrix metalloproteases
HRP970243B1 (en) * 1996-05-15 2002-06-30 Bayer Ag Inhibition of matrix metalloproteases by substituted phenethyl compounds
TNSN97084A1 (en) * 1996-05-15 2005-03-15 Bayer Corp BIARYL ACETYLENES AS INHIBITORS OF METALLOPROTEINASE MATRICES
US6706917B1 (en) * 2000-01-04 2004-03-16 Korea Research Institute Of Chemical Technology Preparing method of 2-phenylalkanoic acid derivatives
FR2817256B1 (en) * 2000-11-27 2005-07-15 Univ Pasteur DERIVATIVES OF 4-HYDROXYBUTANOIC ACID AND ITS SUPERIOR APPROACHES AS GAMMA-HYDROXYBUTYRATE (GHB) RECEPTOR LIGANDS, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND PHARMACEUTICAL USES
AR044152A1 (en) 2003-05-09 2005-08-24 Bayer Corp RENTAL DERIVATIVES, METHOD OF PREPARATION AND USE FOR THE TREATMENT OF OBESITY
DE102006031813B4 (en) * 2006-07-07 2011-04-28 Christian-Albrechts-Universität Zu Kiel Use of basic acetophenones as inhibitors of NO synthases
TN2022000350A1 (en) * 2020-06-26 2024-07-04 Ltd “Valenta Intellekt” Use of a glutarimide derivative for treating diseases associated with aberrant interleukin-6 activity

Also Published As

Publication number Publication date
AT311949B (en) 1973-12-10
ES406539A1 (en) 1975-09-01
AT319924B (en) 1975-01-10
ES406537A1 (en) 1975-09-01
SE393102B (en) 1977-05-02
AT318590B (en) 1974-10-25
ES406527A1 (en) 1975-09-01
ES406533A1 (en) 1975-09-01
DK132944B (en) 1976-03-01
AT319925B (en) 1975-01-10
ES406529A1 (en) 1975-09-16
AT319922B (en) 1975-01-10
AT318591B (en) 1974-10-25
AT318589B (en) 1974-10-25
ES406526A1 (en) 1975-09-01
AT319923B (en) 1975-01-10
DK132944C (en) 1976-08-02
ES406538A1 (en) 1975-09-16
DE2112716A1 (en) 1972-10-05
AT318593B (en) 1974-10-25
ZA721798B (en) 1973-11-28
ES406536A1 (en) 1975-09-01
AT320623B (en) 1975-02-25
AT318588B (en) 1974-10-25
ES406532A1 (en) 1975-09-01
CH572015A5 (en) 1976-01-30
AT320625B (en) 1975-02-25
AT318592B (en) 1974-10-25
AT320624B (en) 1975-02-25
AT318594B (en) 1974-10-25
AT318587B (en) 1974-10-25
ES406535A1 (en) 1975-09-01
ES406534A1 (en) 1975-09-16
AT317879B (en) 1974-09-25
AT318595B (en) 1974-10-25
CH573387A5 (en) 1976-03-15
AT317880B (en) 1974-09-25
ES400791A1 (en) 1975-01-16
ES406530A1 (en) 1975-09-01
ES406531A1 (en) 1975-09-01

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