ES401124A1 - 1,2-biguanides - Google Patents
1,2-biguanidesInfo
- Publication number
- ES401124A1 ES401124A1 ES401124A ES401124A ES401124A1 ES 401124 A1 ES401124 A1 ES 401124A1 ES 401124 A ES401124 A ES 401124A ES 401124 A ES401124 A ES 401124A ES 401124 A1 ES401124 A1 ES 401124A1
- Authority
- ES
- Spain
- Prior art keywords
- general formula
- carbon atoms
- above meanings
- formula
- see formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/24—Y being a hetero atom
- C07C279/26—X and Y being nitrogen atoms, i.e. biguanides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C1/00—Dental machines for boring or cutting ; General features of dental machines or apparatus, e.g. hand-piece design
- A61C1/02—Dental machines for boring or cutting ; General features of dental machines or apparatus, e.g. hand-piece design characterised by the drive of the dental tools
- A61C1/05—Dental machines for boring or cutting ; General features of dental machines or apparatus, e.g. hand-piece design characterised by the drive of the dental tools with turbine drive
- A61C1/057—Dental machines for boring or cutting ; General features of dental machines or apparatus, e.g. hand-piece design characterised by the drive of the dental tools with turbine drive with means for preventing suction effect in turbine after deactivation of the drive air
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dentistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Procedure for the preparation of substituted biguanides of the general formula I **(See formula)** in which R1 means a saturated or unsaturated straight or branched chain hydrocarbon group with 1 to 12 carbon atoms, which may be substituted by one or more fluorine atoms, a cycloalkyl group with 3 to 6 carbon atoms or an aryl or aralcohyl radical of the type **(See formula)** in which n = 0, 1 or 2, and X signifies hydrogen or halogen; R1'means a hydrogen atom or a hydrocarbon group with 1 to 12 straight or branched, saturated or unsaturated carbon atoms; or R1 and R1', together with the nitrogen atom, signify a heterocyclic ring, which may be interrupted by one or more other heteroatoms; and R2 means a saturated or unsaturated, straight or branched, straight or branched, hydrocarbon group with 1 to 12 carbon atoms, which may be substituted by one to several fluorine atoms, or a cycloalkoxy group with 3 to 6 carbon atoms, an alkoxyalcoyl group with 2 to 12 carbon atoms in total, or an alkoxy group with 1 to 6 carbon atoms; and its acid addition salts with organic or inorganic acids, characterized in that a) a thiourea of the general formula II is reacted **(See formula)** in which R1, R1'and R2 have the above meanings, in the presence of a metal or metal oxide, or an isothiourea of the general formula III **(See formula)** in which R, R1'and R2 have the above meanings, in the presence of a tertiary amine, or a carbodiimide of the general formula IV R1-N = C = N-R2 IV, in which R1 and R2 have the above meanings, with guanidine or a guanidine salt; or b) a guanylthiourea of the general formula V is reacted **(See formula)** in which R2 has the above meanings, or one of its salts, in the presence of a heavy metal salt as well as desired in the presence of a tertiary amine, or a guanylyisothiourea of the general formula VI **(See formula)** in which R2 has the above meanings, or one of its salts, with an amine of the general formula VII R-NH-R1'VII, in which R1 and R1'have the above meanings; or c) a cyanguanidine of the general formula VIII is reacted **(See formula)** in which R1, R1'and R2 have the above meanings, with an ammonium salt in a high boiling point solvent at elevated temperature; and optionally, from the acid addition salts obtained according to modes a) to c), the free base of formula I is liberated by means of a strong base and/or optionally the free base is transformed into salts by addition of acid by means of organic or inorganic acids. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19712117015 DE2117015A1 (en) | 1971-04-02 | 1971-04-02 | 1,2-biguanides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES401124A1 true ES401124A1 (en) | 1975-02-16 |
Family
ID=5804148
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES401124A Expired ES401124A1 (en) | 1971-04-02 | 1972-03-23 | 1,2-biguanides |
Country Status (19)
| Country | Link |
|---|---|
| AR (3) | AR194360A1 (en) |
| AT (4) | AT317240B (en) |
| AU (1) | AU468307B2 (en) |
| BE (1) | BE781590A (en) |
| CA (1) | CA988084A (en) |
| CH (1) | CH579534A5 (en) |
| CS (3) | CS161935B2 (en) |
| DD (1) | DD95228A5 (en) |
| DE (1) | DE2117015A1 (en) |
| DK (1) | DK129651B (en) |
| ES (1) | ES401124A1 (en) |
| FR (1) | FR2132396B1 (en) |
| GB (1) | GB1386130A (en) |
| HU (1) | HU162902B (en) |
| NL (1) | NL7204493A (en) |
| NO (1) | NO135418C (en) |
| SE (1) | SE377332B (en) |
| SU (4) | SU465784A3 (en) |
| ZA (1) | ZA722183B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102008007314A1 (en) | 2008-02-02 | 2009-08-06 | Merck Patent Gmbh | Process for the preparation of 3,6-dihydro-1,3,5-triazine derivatives |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR940304A (en) * | 1946-01-07 | 1948-12-09 | Ici Ltd | Manufacturing process for biguanide derivatives |
-
1971
- 1971-04-02 DE DE19712117015 patent/DE2117015A1/en not_active Withdrawn
-
1972
- 1972-03-15 CS CS1724A patent/CS161935B2/cs unknown
- 1972-03-15 CS CS6963*A patent/CS161936B2/cs unknown
- 1972-03-15 CS CS6964*A patent/CS161937B2/cs unknown
- 1972-03-22 DK DK134572AA patent/DK129651B/en unknown
- 1972-03-23 ES ES401124A patent/ES401124A1/en not_active Expired
- 1972-03-27 CH CH454672A patent/CH579534A5/xx not_active IP Right Cessation
- 1972-03-27 GB GB1416272A patent/GB1386130A/en not_active Expired
- 1972-03-29 SE SE7204127A patent/SE377332B/xx unknown
- 1972-03-29 AR AR241248A patent/AR194360A1/en active
- 1972-03-29 NO NO1084/72A patent/NO135418C/no unknown
- 1972-03-30 ZA ZA722183A patent/ZA722183B/en unknown
- 1972-03-30 AT AT00785/73A patent/AT317240B/en not_active IP Right Cessation
- 1972-03-30 DD DD161938A patent/DD95228A5/xx unknown
- 1972-03-30 AU AU40661/72A patent/AU468307B2/en not_active Expired
- 1972-03-30 AT AT279272A patent/AT313301B/en not_active IP Right Cessation
- 1972-03-30 AT AT00786/73A patent/AT321318B/en not_active IP Right Cessation
- 1972-03-30 AT AT00784/73A patent/AT317239B/en not_active IP Right Cessation
- 1972-03-30 HU HUSC383A patent/HU162902B/hu unknown
- 1972-03-31 SU SU1907665A patent/SU465784A3/en active
- 1972-03-31 SU SU1907667A patent/SU472501A3/en active
- 1972-03-31 SU SU1767915A patent/SU535903A3/en active
- 1972-03-31 BE BE781590A patent/BE781590A/en unknown
- 1972-03-31 SU SU1907668A patent/SU493959A3/en active
- 1972-04-04 CA CA138,838A patent/CA988084A/en not_active Expired
- 1972-04-04 FR FR7211727A patent/FR2132396B1/fr not_active Expired
- 1972-04-04 NL NL7204493A patent/NL7204493A/xx not_active Application Discontinuation
- 1972-11-13 AR AR245079A patent/AR194285A1/en active
- 1972-11-13 AR AR245080A patent/AR192485A1/en active
Also Published As
| Publication number | Publication date |
|---|---|
| CS161937B2 (en) | 1975-06-10 |
| SU535903A3 (en) | 1976-11-15 |
| FR2132396A1 (en) | 1972-11-17 |
| NO135418B (en) | 1976-12-27 |
| AU4066172A (en) | 1973-10-04 |
| DD95228A5 (en) | 1973-01-20 |
| DK129651B (en) | 1974-11-04 |
| SE377332B (en) | 1975-06-30 |
| CS161935B2 (en) | 1975-06-10 |
| CA988084A (en) | 1976-04-27 |
| AT317240B (en) | 1974-08-26 |
| AR194360A1 (en) | 1973-07-13 |
| SU472501A3 (en) | 1975-05-30 |
| AR192485A1 (en) | 1973-02-21 |
| AU468307B2 (en) | 1973-10-04 |
| AR194285A1 (en) | 1973-06-29 |
| AT313301B (en) | 1974-02-11 |
| FR2132396B1 (en) | 1975-10-10 |
| CS161936B2 (en) | 1975-06-10 |
| GB1386130A (en) | 1975-03-05 |
| CH579534A5 (en) | 1976-09-15 |
| AT317239B (en) | 1974-08-26 |
| SU465784A3 (en) | 1975-03-30 |
| HU162902B (en) | 1973-04-28 |
| DK129651C (en) | 1975-04-07 |
| BE781590A (en) | 1972-10-02 |
| ZA722183B (en) | 1972-12-27 |
| DE2117015A1 (en) | 1972-10-26 |
| SU493959A3 (en) | 1975-11-28 |
| AT321318B (en) | 1975-03-25 |
| NL7204493A (en) | 1972-10-04 |
| NO135418C (en) | 1977-04-05 |
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