ES383712A1 - Procedure to prepare new steres of polyhydric alcohols of the lysergic and dihydrolysergic acids. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Procedure for preparing new polyhydric alcohol esters of lysergic and dihydrolysergic acids of formula: **(See formula)** wherein R1 is hydrogen, C1-C3 lower alkyl, allyl, or benzyl, and R2 corresponds to C2-C8 monohydroxyalkyl, C2-C8 dihydroxyalkyl, or C5-C11 monohydroxycycloalkyl formed of 5 to 8 ring carbon atoms; characterized by the fact that, in any order, the following steps are carried out: (a) styrification of the carboxylic group at position 9 of lysergic acid, dihydrolysergic acid or a derivative of either acid having a C1-C3 lower alkyl or an allyl or benzyl group at position 4, with an alcohol polyhydric containing the radical R2 as defined above; and (b) when R1 represents another group other than hydrogen in the product, the alkylation of the 4-position of the lysergic acid, of the dihydrolysergic acid or of an ester of any of the two acids in which the ester portion contains the radical R2 according to previously defined; lysergic acid as starting material or derivative of alkylated and/or esterified lysergic acid is optionally reduced relative to the corresponding dihydrolysergic acid or its derivatives before alkylation and esterification or after alkylation and/or esterification when the substituents are saturated in positions 4 and/or 9. (Machine-translation by Google Translate, not legally binding)