ES380127A1 - Pharmacodynamically effective 10-4-substituted piperazino-10,11- dihydrodibenzo-b,f thiepins and a method of preparing same - Google Patents

Abstract

A method for the preparation of pharmacodynamically active thiepins, such as 10- [piperazino-substituted] -10,11-dihydrodibenzo [b, f] thiepins of the general formula I **(See formula)** where: R1 signifies a hydrogen or halogen atom, an alcoholic radical R, a trifluoromethyl group, an alkoxy radical OR, an alcoholylthio group SR, an alkanesulfonyl group SO2R, a nitro group or a cyano group; R2 denotes an alcoholic, alkenyl, alkynyl, cycloalkyl, cycloalkoxy-alcohol, aralkoxy, hydroxyalkyl, acyloxyalkyl, dialkoxylaminoalkoxy or alkoxycarbonylalkyl group, where R represents a straight or branched alkenyl hydrocarbon radical with 1 to 4 carbon atoms, radical with 2 to 4 carbon atoms, cycloalkyl representing a cyolopropyl or cyclooctyl radical, acyl representing an aliphatic carboxylic acid radical with 2 to 5 carbon atoms and the aralkoxy radical being able to be substituted in the benzene nucleus with an alcoholic radical, alkoxy, alcoholylthio or trifluoromethyl or with a halogen atom and its salts, characterized in that secondary amines of the general formula II **(See formula)** where R1 means the same as in formula I, they are alcoholized with reactable alcohol esters of the general formula III R2-OH III where R2 also means the same as in formula I, preferably with corresponding halides, alkanesulfonates or arenesulfonates, after which the resulting basic products are transformed into the corresponding salts by neutralization with organic or inorganic acids. (Machine-translation by Google Translate, not legally binding)