[go: up one dir, main page]

ES375013A1 - Un procedimiento para la preparacion de un nuevo compuesto pirrolobenzodiazepinona. - Google Patents

Un procedimiento para la preparacion de un nuevo compuesto pirrolobenzodiazepinona.

Info

Publication number
ES375013A1
ES375013A1 ES375013A ES375013A ES375013A1 ES 375013 A1 ES375013 A1 ES 375013A1 ES 375013 A ES375013 A ES 375013A ES 375013 A ES375013 A ES 375013A ES 375013 A1 ES375013 A1 ES 375013A1
Authority
ES
Spain
Prior art keywords
formula
pyrrolobenzodiazepinone
compound
derivatives
arylalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES375013A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP44050780A external-priority patent/JPS4843755B1/ja
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of ES375013A1 publication Critical patent/ES375013A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ES375013A 1968-12-30 1969-12-29 Un procedimiento para la preparacion de un nuevo compuesto pirrolobenzodiazepinona. Expired ES375013A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP8368 1968-12-30
JP44050780A JPS4843755B1 (es) 1969-06-26 1969-06-26

Publications (1)

Publication Number Publication Date
ES375013A1 true ES375013A1 (es) 1972-03-01

Family

ID=26332992

Family Applications (1)

Application Number Title Priority Date Filing Date
ES375013A Expired ES375013A1 (es) 1968-12-30 1969-12-29 Un procedimiento para la preparacion de un nuevo compuesto pirrolobenzodiazepinona.

Country Status (6)

Country Link
ES (1) ES375013A1 (es)
FI (1) FI46259C (es)
GB (1) GB1299198A (es)
IE (1) IE33906B1 (es)
IL (1) IL33558A (es)
RO (1) RO55813A (es)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4464467A (en) * 1982-07-26 1984-08-07 Bristol-Myers Company Antitumor antibiotics produced by new streptomyces
GB9818732D0 (en) 1998-08-27 1998-10-21 Univ Portsmouth Collection of compounds
GB9818730D0 (en) 1998-08-27 1998-10-21 Univ Portsmouth Collections of compounds
DE69907977T2 (de) * 1998-08-27 2004-07-22 Spirogen Ltd., Ryde Pyrrolobenzodiazepine
US6909006B1 (en) 1999-08-27 2005-06-21 Spirogen Limited Cyclopropylindole derivatives
GB0226593D0 (en) 2002-11-14 2002-12-24 Consultants Ltd Compounds
GB0321295D0 (en) 2003-09-11 2003-10-15 Spirogen Ltd Synthesis of protected pyrrolobenzodiazepines
GB0404577D0 (en) 2004-03-01 2004-04-07 Spirogen Ltd Pyrrolobenzodiazepines
CA2558195C (en) 2004-03-01 2012-11-06 Spirogen Limited 11-hydroxy-5h-pyrrolo[2,1-c][1,4]benzodiazepin-5-one derivatives as key intermediates for the preparation of c2 substituted pyrrolobenzodiazepines
WO2005085260A1 (en) 2004-03-09 2005-09-15 Spirogen Limited Pyrrolobenzodiazepines
GB0819095D0 (en) 2008-10-17 2008-11-26 Spirogen Ltd Pyrrolobenzodiazepines
JP5870400B2 (ja) 2010-04-15 2016-03-01 シアトル ジェネティクス，インコーポレーテッド 標的化ピロロベンゾジアゼピンコンジュゲート
MX368648B (es) 2010-04-15 2019-10-09 Seattle Genetics Inc Pirrolobenzodiazepinas usadas para tratar enfermedades proliferativas.
GB201006340D0 (en) 2010-04-15 2010-06-02 Spirogen Ltd Synthesis method and intermediates
BR112014006703A8 (pt) 2011-09-20 2018-01-09 Spirogen Sarl "pirrolobenzodiazepinas
EA027386B1 (ru) 2011-10-14 2017-07-31 Медимьюн Лимитед Пирролобензодиазепины
WO2013053872A1 (en) 2011-10-14 2013-04-18 Spirogen Sàrl Synthesis method and intermediates useful in the preparation of pyrrolobenzodiazepines
ES2945932T3 (es) 2011-10-14 2023-07-10 Seagen Inc Pirrolobenzodiazepinas y conjugados dirigidos
EP3309162A1 (en) 2011-10-14 2018-04-18 Seattle Genetics, Inc. Targeted conjugates of pyrrolobenzodiazepines
CA2850103C (en) 2011-10-14 2019-09-10 Spirogen Sarl Pyrrolobenzodiazepines
WO2014057120A1 (en) 2012-10-12 2014-04-17 Adc Therapeutics Sàrl Pyrrolobenzodiazepine-antibody conjugates
TR201910662T4 (tr) 2012-10-12 2019-08-21 Medimmune Ltd Pirrolobenzodiazepinler ve bunlara ait konjugatlar.
SMT201800010T1 (it) 2012-10-12 2018-03-08 Medimmune Ltd Coniugati pirrolobenzodiazepina-anticorpo anti-cd22
CA2887895C (en) 2012-10-12 2019-10-29 Adc Therapeutics Sarl Pyrrolobenzodiazepine-anti-cd19 antibody conjugates
WO2014057114A1 (en) 2012-10-12 2014-04-17 Adc Therapeutics Sàrl Pyrrolobenzodiazepine-anti-psma antibody conjugates
LT2906296T (lt) 2012-10-12 2018-06-11 Adc Therapeutics Sa Pirolobenzodiazepino-antikūno konjugatai
EP2906253B9 (en) 2012-10-12 2019-02-27 ADC Therapeutics SA Pyrrolobenzodiazepine - anti-psma antibody conjugates
TR201902494T4 (tr) 2012-10-12 2019-03-21 Medimmune Ltd Pirrolobenzodiazepinler ve onların konjugatları.
WO2014057072A1 (en) 2012-10-12 2014-04-17 Spirogen Sàrl Synthesis and intermediates of pyrrolobenzodiazepine derivatives for conjugation
WO2015052532A1 (en) 2013-10-11 2015-04-16 Spirogen Sàrl Pyrrolobenzodiazepine-antibody conjugates
GB201317981D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
WO2015052535A1 (en) 2013-10-11 2015-04-16 Spirogen Sàrl Pyrrolobenzodiazepine-antibody conjugates
EP3054985B1 (en) 2013-10-11 2018-12-26 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
GB201416112D0 (en) 2014-09-12 2014-10-29 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
BR112017011111A2 (pt) 2014-11-25 2017-12-26 Adc Therapeutics Sa conjugados de pirrolobenzodiazepina-anticorpo
GB201506402D0 (en) 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
GB201506411D0 (en) 2015-04-15 2015-05-27 Bergenbio As Humanized anti-axl antibodies
GB201601431D0 (en) 2016-01-26 2016-03-09 Medimmune Ltd Pyrrolobenzodiazepines
GB201602356D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201602359D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201607478D0 (en) 2016-04-29 2016-06-15 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201617466D0 (en) 2016-10-14 2016-11-30 Medimmune Ltd Pyrrolobenzodiazepine conjugates
GB201702031D0 (en) 2017-02-08 2017-03-22 Medlmmune Ltd Pyrrolobenzodiazepine-antibody conjugates
AU2018217926B2 (en) 2017-02-08 2019-10-03 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates
JP2020517609A (ja) 2017-04-18 2020-06-18 メディミューン リミテッド ピロロベンゾジアゼピン複合体
AU2018253948B2 (en) 2017-04-20 2024-08-01 Adc Therapeutics Sa Combination therapy with an anti-AXL Antibody-Drug Conjugate
AU2018285562B2 (en) 2017-06-14 2024-01-18 Adc Therapeutics Sa Dosage regimes for the administration of an anti-CD19 ADC
ES2906965T3 (es) 2017-08-18 2022-04-21 Medimmune Ltd Conjugados de pirrolobenzodiazepina
GB201803342D0 (en) 2018-03-01 2018-04-18 Medimmune Ltd Methods
GB201806022D0 (en) 2018-04-12 2018-05-30 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
KR20210139270A (ko) 2019-03-15 2021-11-22 메드임뮨 리미티드 암의 치료에 사용하기 위한 아제티도벤조디아제핀 이량체 및 이를 포함하는 컨쥬게이트

Also Published As

Publication number Publication date
IE33906B1 (en) 1974-12-11
IL33558A0 (en) 1970-04-20
IE33906L (en) 1970-06-30
GB1299198A (en) 1972-12-06
FI46259B (es) 1972-10-31
RO55813A (es) 1974-02-01
IL33558A (en) 1973-10-25
FI46259C (fi) 1973-02-12

Similar Documents

Publication Publication Date Title
ES375013A1 (es) Un procedimiento para la preparacion de un nuevo compuesto pirrolobenzodiazepinona.
ES310240A1 (es) Un procedimiento para preparar un indol polinuclear desacilado.
ES457993A1 (es) Un procedimiento para la preparacion de una isotiazolopiri- dina.
ES388614A1 (es) Procedimiento para la obtencion de 14 - desoxi - 14 - tosi-loxiacetoxi - mutilina.
ES405555A1 (es) Procedimiento para la preparacion de derivados de ftalazo- na.
FR2240731B1 (es)
ES401898A1 (es) Procedimiento para la preparacion de derivados de benzofu- rano.
ES380355A1 (es) Un procedimiento para la preparacion de 4-pirazolidinoles 1,2-disustituidos.
ES332657A1 (es) Metodo para preparar tiadiazoles.
GB1307646A (en) 5-hydroxycoumarin derivatives
GB1229993A (es)
GB1325944A (en) Bisoxalic acid diamides
ES442988A1 (es) Un procedimiento de preparacion de nuevos compuestos de sul-fenamida.
ES391118A1 (es) Un procedimiento para la preparacion de un nuevo derivado de acido fluoronico.
ES329067A1 (es) Procedimiento para la preparacion de compuestos heterociclicos.
ES381209A1 (es) Un procedimiento para preparar nuevas 1,2-difenil-3,5-dio- xo-pirazolidinas sustituidas en la posicion 4.
ES377775A1 (es) Procedimiento para la obtencion del ester bis-(n-meticarba-mico) del 2,6-piridindimetanol.
ES457708A1 (es) Un procedimiento para la preparacion de un compuesto de 3- hidroximetil-2-cefem.
ES461191A1 (es) Un procedimiento para la preparacion de nuevos derivados de arilcarboxamida.
GB1021530A (en) Derivatives of 2-oxo-2h-1,4-benzoxazine
ES293287A1 (es) Procedimiento de obtención de un nuevo compuesto para el control de la hipertensión
ES331239A3 (es) Un procedimiento para preparar compuestos de fenotiazina.
ES460287A1 (es) Un procedimiento para la obtencion de compuestos heterociclicos.
GB1062354A (en) Manufacture of naphthalene derivatives
ES323103A1 (es) Un procedimiento para la preparación de nuevas penicilinas.