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Novartis AG
BASF Schweiz AG
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Ciba Geigy AG
Ciba AG
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Publication date
Priority claimed from CH970768Aexternal-prioritypatent/CH538464A/en
Priority claimed from CH865469Aexternal-prioritypatent/CH547790A/en
Application filed by Ciba Geigy AG, Ciba AGfiledCriticalCiba Geigy AG
Publication of ES368835A1publicationCriticalpatent/ES368835A1/en
Procedure for obtaining halogenopregnadienes, of formula **(See formula)** where R1 signifies hydrogen, a methyl group or a halogen atom, R2 signifies hydrogen or a methyl group in the α or β position, R3 signifies a free or esterized hydroxyl group, especially a hydroxyl group esterified with an alkane acid. lower carboxylic and R4 signifies a free, esterified or etherized hydroxyl group, X and Y each signify a halogen atom, characterized in that a compound of formula **(See formula)** in which R1, R2, R3 and R4 have the above-mentioned meanings, in a manner known per se, are reacted in the presence of halogen anions with a positively charged halogen-releasing compound, or in a compound of the general formula **(See formula)** in which R1, R2, R3 R4, X and Y have the meanings indicated above, chlorine is added to the 1,2-double bond and of the 1,2-dichloro compound obtained, hydrochloric acid is dissociated and, if desired, in the compounds obtained, an existing free hydroxy group is sterilized and/or the 21-hydroxy group is etherized and/or the esterified or etherized hydroxy groups are transformed into free hydroxy groups. (Machine-translation by Google Translate, not legally binding)
ES368835A1968-06-281969-06-26Procedure for the obtaining of halogenopregnadienos. (Machine-translation by Google Translate, not legally binding)
ExpiredES368835A1
(en)
Anti-inflammatory 2-chloro-substd. 3,20-dioxo-pregna-1,4-dienes - obtd from corresp. unsubstd cpds, by 1,4-chlorine addn in the dark and hydro-chloric acid elimination with tert bases
Procedure for the manufacture of 1-aril-2,3,4,5 -tetrahydro-1H-1,5-benzodiacepin-2-ones. (Machine-translation by Google Translate, not legally binding)
Procedure for the preparation of acids 6,7-dihydro-17-hydroxy-3-oxo-3 'h-ciclopropa (6,7) -17 x-pregn-4-eno-21-carboxylics. (Machine-translation by Google Translate, not legally binding)