ES352964A1 - Procedure for the preparation of heterociclic compounds. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Process for the preparation of heterocyclic compounds containing at least one ethylenic double bond in conjugation with a carbocyclic aromatic hexagonal ring, characterized in that a compound of the formula is reacted ** (see formula) ** Where A1 represents a heterocyclic cyclic system which: A) contains at least one 5 or 6 membered heterocyclic ring, provided with at least one cyclic oxygen atom and/or a cyclic sulfur atom, B) it lacks cyclic nitrogen atoms and hydrogen atoms that are replaceable by alkali metal, C) is linked by a cyclic carbon atom to a cyclic carbon atom of b1 or has two neighboring cyclic carbon atoms with two neighboring cyclic carbon atoms of b1, And where also A) b1 means a benzene ring or a heterocyclic ring of aromatic character containing 5 or 6 cyclic members, rings which may still contain, juxtacondensates, other rings (but preferably only one) aromatic, heterocyclic or hydroaromatic of 5 to 6 members, B) v means an integer value of 1 to 2 and C) m means, in the case of a simple link between a1 and b1, an integer value from 1 to 4: and in the case of rings a1 and b1 condensed with each other, the numbers 1 or 2, in the presence of a strongly basic alkaline compound with a schiff base, for which a strongly polar, neutral to basic organic solvent must be used as the reaction medium, which: i) lacks atoms (in particular, hydrogen atoms) that are replaceable by alkali metal; and ii) is practically anhydrous; and if alkali metal hydroxides are used as a strongly basic alkaline compound, these alkali hydroxides can have a water content of up to 25%. (Machine-translation by Google Translate, not legally binding)