ES343428A1 - Procedure for obtaining azaciclo-aliphatic compounds. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Process for the preparation of azabicycloaliphatic compounds of the formula ar-c (= x) -alk-het, in which ar means a monocyclic aryl radical or a monocyclic monoheterocyclic radical of aromatic character, x an oxygen atom or a free hydroxy radical or substituted together with a hydrogen atom or a hydrocarbon radical, alk an alkylene radical that separates the radicals -c (= x) and het by at least 3 carbon atoms and het a bicycloalkylene amino radical, and the salts thereof, characterized by that A) an ester capable of reacting a compound of formula ar-c (= x) -alk-oh is reacted with a compound of formula h-het, or with a monocyclic amino compound that allows synthesis of the bicyclic radical het, or a compound of formula ar-c (= x) -alk-nh2 with an ester capable of reacting a monocyclic hydroxy compound which allows the synthesis of the bicyclic radical het together with the amino radical, or B) the compounds of formulas ar-y and z-alk-het0 are reacted with each other, in which het0 represents the het moiety or a radical transformable therein, and in which one of the radicals y and z represents an ion positive metal and the other a functionally modified carboxyl radical, which reacts with the organometallic reagent under the formation of a carbonyl radical, or C) a compound of formula ar-c (= x) -alk-het, in which at least one of the radicals directly adjacent to the nitrogen atom of the het radical represents a carbonyl or thiocarbonyl radical, this is converted into a radical methylene, and if necessary, in the obtained compound the bicycloalkylenamic residue het is synthesized, and, if desired, in a compound obtained with a carbonyl radical -c (= x) -, this is transformed into a carbinol radical -c ( = x) -, and/or, if desired, in a compound obtained with the carbinol radical -c (= x) -, this is transformed into a carbonyl radical -c (= x) - or a radical carbinol -c (= x) - O-substituted, and/or, if desired, a free compound obtained is transformed into a salt, or a salt obtained in the free compound or in another salt, and/or if desired, a mixture of isomers obtained is separated into the different isomers. (Machine-translation by Google Translate, not legally binding)