ES335436A1 - Procedimiento para la obtencion de 5-a-pirazolo (3,4-b) pi-ridinas, insustituidas en la posicion 4. - Google Patents
Procedimiento para la obtencion de 5-a-pirazolo (3,4-b) pi-ridinas, insustituidas en la posicion 4.Info
- Publication number
- ES335436A1 ES335436A1 ES335436A ES335436A ES335436A1 ES 335436 A1 ES335436 A1 ES 335436A1 ES 335436 A ES335436 A ES 335436A ES 335436 A ES335436 A ES 335436A ES 335436 A1 ES335436 A1 ES 335436A1
- Authority
- ES
- Spain
- Prior art keywords
- prepared
- compound
- pyrazolopyridines
- phenyl
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 trimethoxybenzoyl Chemical group 0.000 abstract 3
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 230000005494 condensation Effects 0.000 abstract 2
- 238000009833 condensation Methods 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- JVVRJMXHNUAPHW-UHFFFAOYSA-N 1h-pyrazol-5-amine Chemical compound NC=1C=CNN=1 JVVRJMXHNUAPHW-UHFFFAOYSA-N 0.000 abstract 1
- PWSZRRFDVPMZGM-UHFFFAOYSA-N 5-phenyl-1h-pyrazol-3-amine Chemical compound N1N=C(N)C=C1C1=CC=CC=C1 PWSZRRFDVPMZGM-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- ZJRCIQAMTAINCB-UHFFFAOYSA-N benzoylacetonitrile Chemical compound N#CCC(=O)C1=CC=CC=C1 ZJRCIQAMTAINCB-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 150000001735 carboxylic acids Chemical class 0.000 abstract 1
- 239000000496 cardiotonic agent Substances 0.000 abstract 1
- 230000003177 cardiotonic effect Effects 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 238000005660 chlorination reaction Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000006298 dechlorination reaction Methods 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- LTMHNWPUDSTBKD-UHFFFAOYSA-N diethyl 2-(ethoxymethylidene)propanedioate Chemical compound CCOC=C(C(=O)OCC)C(=O)OCC LTMHNWPUDSTBKD-UHFFFAOYSA-N 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- HDZGCSFEDULWCS-UHFFFAOYSA-N monomethylhydrazine Chemical compound CNN HDZGCSFEDULWCS-UHFFFAOYSA-N 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 229940124531 pharmaceutical excipient Drugs 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
- 229940124549 vasodilator Drugs 0.000 abstract 1
- 239000003071 vasodilator agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH35966 | 1966-01-12 | ||
| CH1578666 | 1966-11-01 | ||
| CH1673866 | 1966-11-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES335436A1 true ES335436A1 (es) | 1968-03-16 |
Family
ID=27172034
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES335436A Expired ES335436A1 (es) | 1966-01-12 | 1967-01-10 | Procedimiento para la obtencion de 5-a-pirazolo (3,4-b) pi-ridinas, insustituidas en la posicion 4. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US3542793A (es) |
| AT (1) | AT265250B (es) |
| BE (1) | BE692453A (es) |
| ES (1) | ES335436A1 (es) |
| FR (3) | FR6121M (es) |
| GB (1) | GB1115254A (es) |
| GR (1) | GR35751B (es) |
| NL (1) | NL6700421A (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3855675A (en) * | 1971-05-25 | 1974-12-24 | Squibb & Sons Inc | 1-(2-furanylmethyl)-1h-pyrazolo(3,4-b)pyridine-5-methanones |
| US3879512A (en) * | 1971-10-19 | 1975-04-22 | Squibb & Sons Inc | Anti-anxiety combination and method of use |
| US3873556A (en) * | 1973-05-17 | 1975-03-25 | Squibb & Sons Inc | Amino derivatives of pyrazolopyridine ketones |
| US4115394A (en) * | 1974-05-06 | 1978-09-19 | E. R. Squibb & Sons, Inc. | Amino derivatives of 6-phenylpyrazolo[3,4-b]pyridines |
| US4020072A (en) * | 1976-05-04 | 1977-04-26 | E. R. Squibb & Sons, Inc. | 5-Aminomethyl-1H-pyrazolo[3,4-b]pyridines |
| WO2001098301A1 (fr) * | 2000-06-20 | 2001-12-27 | Japan Tobacco Inc. | Composes de pyrazolopyridine et utilisation de ces derniers en tant que medicaments |
| WO2004002531A1 (ja) * | 2002-06-26 | 2004-01-08 | Ono Pharmaceutical Co., Ltd. | 血管の収縮または拡張による疾患治療剤 |
| WO2009000832A2 (en) * | 2007-06-25 | 2008-12-31 | Boehringer Ingelheim International Gmbh | Chemical compounds |
| AR072657A1 (es) * | 2008-02-29 | 2010-09-15 | Genentech Inc | Compuestos inhibidores de raf y metodos para su uso |
| WO2011159864A1 (en) * | 2010-06-17 | 2011-12-22 | Bracco Imaging S.P.A. | Jte013 analogs and methods of making and using same |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3365459A (en) * | 1964-09-08 | 1968-01-23 | Ciba Geigy Corp | Certain tetrahydro pyrazolo-pyridine and pyrazolo-piperidine derivatives |
| US3423414A (en) * | 1966-01-13 | 1969-01-21 | Ciba Geigy Corp | Pyrazolopyridines |
-
1957
- 1957-02-28 FR FR96739A patent/FR6121M/fr not_active Expired
-
1966
- 1966-12-27 US US604628A patent/US3542793A/en not_active Expired - Lifetime
-
1967
- 1967-01-04 FR FR89892A patent/FR1509257A/fr not_active Expired
- 1967-01-09 GB GB1077/67A patent/GB1115254A/en not_active Expired
- 1967-01-09 GR GR670135751A patent/GR35751B/el unknown
- 1967-01-10 ES ES335436A patent/ES335436A1/es not_active Expired
- 1967-01-11 AT AT27867A patent/AT265250B/de active
- 1967-01-11 NL NL6700421A patent/NL6700421A/xx unknown
- 1967-01-11 BE BE692453D patent/BE692453A/xx unknown
- 1967-02-28 FR FR96738A patent/FR6120M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR6121M (es) | 1968-06-17 |
| FR6120M (es) | 1968-06-17 |
| BE692453A (es) | 1967-07-11 |
| AT265250B (de) | 1968-10-10 |
| US3542793A (en) | 1970-11-24 |
| FR1509257A (fr) | 1968-01-12 |
| GR35751B (el) | 1968-10-25 |
| NL6700421A (es) | 1967-07-13 |
| GB1115254A (en) | 1968-05-29 |
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