ES330970A1 - Procedure for the obtaining of new i-4-oxo-4- (4-fluorfenil) -butil-piperidinas. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the obtaining of new i-4-oxo-4- (4-fluorfenil) -butil-piperidinas. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES330970A1 ES330970A1 ES0330970A ES330970A ES330970A1 ES 330970 A1 ES330970 A1 ES 330970A1 ES 0330970 A ES0330970 A ES 0330970A ES 330970 A ES330970 A ES 330970A ES 330970 A1 ES330970 A1 ES 330970A1
- Authority
- ES
- Spain
- Prior art keywords
- phenyl
- formula
- oxo
- translation
- machine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Process for obtaining new 1- [4-oxo-4- (4-fluoro-phenyl) -butyl] -piperidines of the general formula ** (See formula) ** - where R 1 represents hydrogen, methyl, hydroxy, methoxy, fluorine, chlorine or bromine, R 2 alkyl with 1 to 8 C atoms, cycloalkyl or phenyl, and R 3 hydrogen or methyl (alpha or beta) as well as their addition salts with acids, characterized by alkylating at the nitrogen atom a secondary piperidine derivative of the formula ** (See formula) ** - where R1, R2 and R3 have the meanings indicated above with 4-chloro-1- (4-fluoro-phenyl) -butanone- (1), preferably in the presence of an organic solvent and a weak base, optionally a group is methylated hydroxy which is in the phenyl ring of a compound of the formula I or a methoxy group is demethylated, and the compounds thus obtained are optionally converted, by methods known per se, into their addition salts with physiologically tolerable acids. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEB0083682 | 1965-09-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES330970A1 true ES330970A1 (en) | 1967-10-01 |
Family
ID=6982085
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0330970A Expired ES330970A1 (en) | 1965-09-10 | 1966-09-07 | Procedure for the obtaining of new i-4-oxo-4- (4-fluorfenil) -butil-piperidinas. (Machine-translation by Google Translate, not legally binding) |
Country Status (8)
| Country | Link |
|---|---|
| BE (1) | BE686678A (en) |
| CH (1) | CH467780A (en) |
| DK (1) | DK115843B (en) |
| ES (1) | ES330970A1 (en) |
| FR (1) | FR6047M (en) |
| GB (1) | GB1085429A (en) |
| NL (2) | NL6612730A (en) |
| SE (1) | SE326958B (en) |
-
0
- NL NL128588D patent/NL128588C/xx active
-
1966
- 1966-09-02 CH CH1273466A patent/CH467780A/en unknown
- 1966-09-06 GB GB39852/66A patent/GB1085429A/en not_active Expired
- 1966-09-07 ES ES0330970A patent/ES330970A1/en not_active Expired
- 1966-09-09 BE BE686678D patent/BE686678A/xx unknown
- 1966-09-09 DK DK466666AA patent/DK115843B/en unknown
- 1966-09-09 NL NL6612730A patent/NL6612730A/xx unknown
- 1966-09-09 SE SE12181/66A patent/SE326958B/xx unknown
- 1966-12-06 FR FR86289A patent/FR6047M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| BE686678A (en) | 1967-03-09 |
| SE326958B (en) | 1970-08-10 |
| DK115843B (en) | 1969-11-17 |
| CH467780A (en) | 1969-01-31 |
| NL128588C (en) | |
| FR6047M (en) | 1968-05-20 |
| NL6612730A (en) | 1967-03-13 |
| GB1085429A (en) | 1967-10-04 |
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