ES2914516A1 - Self -expandable pediatric stent (Machine-translation by Google Translate, not legally binding) - Google Patents
Self -expandable pediatric stent (Machine-translation by Google Translate, not legally binding) Download PDFInfo
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- ES2914516A1 ES2914516A1 ES202230011A ES202230011A ES2914516A1 ES 2914516 A1 ES2914516 A1 ES 2914516A1 ES 202230011 A ES202230011 A ES 202230011A ES 202230011 A ES202230011 A ES 202230011A ES 2914516 A1 ES2914516 A1 ES 2914516A1
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- stent
- expandable
- self
- pediatric
- internal
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- HLXZNVUGXRDIFK-UHFFFAOYSA-N nickel titanium Chemical compound [Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni] HLXZNVUGXRDIFK-UHFFFAOYSA-N 0.000 claims abstract description 11
- 229910001000 nickel titanium Inorganic materials 0.000 claims abstract description 10
- 229920000728 polyester Polymers 0.000 claims abstract description 4
- 210000001367 artery Anatomy 0.000 abstract description 16
- 229910052751 metal Inorganic materials 0.000 abstract description 8
- 239000002184 metal Substances 0.000 abstract description 8
- 229920006267 polyester film Polymers 0.000 abstract description 3
- 238000001356 surgical procedure Methods 0.000 abstract description 3
- 210000001147 pulmonary artery Anatomy 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 229910000684 Cobalt-chrome Inorganic materials 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2/07—Stent-grafts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/92—Stents in the form of a rolled-up sheet expanding after insertion into the vessel, e.g. with a spiral shape in cross-section
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0077—Special surfaces of prostheses, e.g. for improving ingrowth
- A61F2002/009—Special surfaces of prostheses, e.g. for improving ingrowth for hindering or preventing attachment of biological tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2/07—Stent-grafts
- A61F2002/072—Encapsulated stents, e.g. wire or whole stent embedded in lining
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Abstract
Description
DESCRIPCIÓNDESCRIPTION
STENT PEDIÁTRICO AUTOEXPANDIBLESELF-EXPANDING PEDIATRIC STENT
OBJETO DE LA INVENCIÓNOBJECT OF THE INVENTION
Es objeto de la presente invención, tal y como el título de la invención establece, un stent pediátrico autoexpandible de uso en recién nacidos que presentan un estrechamiento de las arterias pulmonares.The object of the present invention, as the title of the invention establishes, is a self-expandable pediatric stent for use in newborns with narrowing of the pulmonary arteries.
Caracteriza a la presente invención la especial configuración, diseño y materiales empleados en la fabricación del stent objeto de la invención de manera que se consigue que el stent crezca con el crecimiento del paciente.The present invention is characterized by the special configuration, design and materials used in the manufacture of the stent object of the invention in such a way that the stent grows with the growth of the patient.
Por lo tanto, la presente invención se circunscribe dentro del ámbito de los stents y de modo particular de entre los stents pediátricos.Therefore, the present invention is circumscribed within the field of stents and particularly among pediatric stents.
ANTECEDENTES DE LA INVENCIÓNBACKGROUND OF THE INVENTION
Los Stents son unas prótesis metálicas (cromo-cobalto, platino) que tienen forma de malla metálica cilíndrica y van montados sobre un balón que, al hincharlo a nivel de la obstrucción coronaria, hace recuperar el diámetro de la arteria y normalizar la circulación de la sangre.Stents are metal prostheses (chrome-cobalt, platinum) that are shaped like a cylindrical metal mesh and are mounted on a balloon that, when inflated at the level of the coronary obstruction, recovers the diameter of the artery and normalizes the circulation of the artery. blood.
Ocurre con frecuencia que los recién nacidos presentan un estrechamiento de las arterias pulmonares lo que redunda en una insuficiencia cardiaca, que incluso les puede llevar a la muerte.It often happens that newborns have a narrowing of the pulmonary arteries which results in heart failure, which can even lead to death.
Actualmente se desconoce la existencia de stents para bebés o incluso recién nacidos. Aún en el caso de que se implantara algún tipo de dispositivo que ensanche el diámetro libre de las arterias pulmonares, éstos tendrían que ser reemplazados regularmente con el crecimiento del paciente, teniendo que ser sometidos a continuas cirugías.The existence of stents for infants or even newborns is currently unknown. Even in the event that some type of device was implanted that widens the free diameter of the pulmonary arteries, these would have to be replaced regularly with the growth of the patient, having to undergo continuous surgeries.
Además, sucede que los stents una vez colocados el propio tejido de las arterias hace suyo, integra al stent absorbiéndolo, lo que complica una posterior retirada.In addition, it happens that once the stents are placed, the artery tissue itself becomes its own, integrates the stent by absorbing it, which complicates subsequent removal.
Por lo tanto, es objeto de la presente invención superar los inconvenientes apuntados de necesitar reemplazar los stents regularmente según el crecimiento del paciente, y de absorción de los stents por los propios tejidos donde se implanta, desarrollando un stent pediátrico como el que a continuación se describe y queda recogido en su esencialidad en la reivindicación primera.Therefore, the object of the present invention is to overcome the aforementioned drawbacks of needing to replace the stents regularly according to the growth of the patient, and of absorption of the stents by the very tissues where they are implanted, developing a pediatric stent such as the one described below. describes and is collected in its essentials in the first claim.
DESCRIPCIÓN DE LA INVENCIÓNDESCRIPTION OF THE INVENTION
Es objeto de la presente invención un stent pediátrico autoexpandible que se implanta en un primer momento por ejemplo en una arteria de unos 3 mm de diámetro, a un paciente con unos días de vida y a medida que el paciente crece, el stent incrementa de diámetro con el crecimiento de paciente hasta que las arterias tienen un diámetro de unos 14-16 mm sin necesidad de tener que ser reemplazado o llevar a cabo cirugías para su reemplazo.The object of the present invention is a self-expandable pediatric stent that is initially implanted, for example, in an artery of about 3 mm in diameter, to a patient with a few days of life and as the patient grows, the stent increases in diameter with the patient's growth until the arteries have a diameter of about 14-16 mm without the need to have them replaced or to carry out surgeries for their replacement.
El stent pediátrico autoexpandible comprende:The pediatric self-expanding stent comprises:
- Una estructura interna metálica realizada en Nitinol- An internal metal structure made of Nitinol
- Una película interna de poliéster expandible que recubre la estructura interna metálica- An internal expandable polyester film that covers the internal metal structure
- Una película externa de poliéster expandible que recubre la estructura interna metálica.- An external expandable polyester film that covers the internal metallic structure.
Donde la estructura interna metálica además de estar realizada en Nitinol presenta unas angulaciones de al menos 45° lo que dota al stent de una fuerza radial latente y que permite la autoexpansión con el crecimiento de la arteria y ayudar al propio crecimiento del diámetro libre de la arteria.Where the internal metallic structure, in addition to being made of Nitinol, presents angles of at least 45°, which gives the stent a strength latent radial and that allows self-expansion with the growth of the artery and help the growth of the free diameter of the artery.
La película que recubre la estructura interna metálica de Nitinol, también es expandible con objeto de poder crecer a medida que el stent crece por efecto de la fuerza radial de los alambres de Nitinol.The film that covers the internal metallic Nitinol structure is also expandable in order to grow as the stent grows due to the radial force of the Nitinol wires.
También dicha película que recubre la estructura interna metálica, evita la absorción o integración de la estructura interna con el propio tejido de la arteria facilitando al final la retirada del stent pediátrico autoexplandible.Said film, which covers the internal metallic structure, also prevents the absorption or integration of the internal structure with the artery tissue itself, ultimately facilitating the removal of the self-expanding pediatric stent.
Gracias a las características descritas se consigue un stent autoexplandible que ayuda al crecimiento de las arterias donde se coloca, que sirve para arterias que presentan un diámetro de 3 mm hasta arterias que tienen un diámetro de entre 14 a 16 mm.Thanks to the characteristics described, a self-expanding stent is achieved that helps the growth of the arteries where it is placed, which is used for arteries with a diameter of 3 mm up to arteries with a diameter of between 14 and 16 mm.
Salvo que se indique lo contrario, todos los elementos técnicos y científicos usados en la presente memoria poseen el significado que habitualmente entiende un experto normal en la técnica a la que pertenece esta invención. En la práctica de la presente invención se pueden usar procedimientos y materiales similares o equivalentes a los descritos en la memoria.Unless otherwise indicated, all technical and scientific elements used herein have the meaning ordinarily understood by one of ordinary skill in the art to which this invention pertains. Methods and materials similar or equivalent to those described herein may be used in the practice of the present invention.
A lo largo de la descripción y de las reivindicaciones la palabra "comprende” y sus variantes no pretenden excluir otras características técnicas, aditivos, componentes o pasos. Para los expertos en la materia, otros objetos, ventajas y características de la invención se desprenderán en parte de la descripción y en parte de la práctica de la invención.Throughout the description and claims, the word "comprises" and its variants are not intended to exclude other technical characteristics, additives, components or steps. For those skilled in the art, other objects, advantages and characteristics of the invention will emerge in part of the description and part of the practice of the invention.
EXPLICACION DE LAS FIGURASEXPLANATION OF THE FIGURES
Para complementar la descripción que se está realizando y con objeto de ayudar a una mejor comprensión de las características de la invención, de acuerdo con un ejemplo preferente de realización práctica de la misma, se acompaña como parte integrante de dicha descripción, un juego de dibujos en donde con carácter ilustrativo y no limitativo, se ha representado lo siguiente.To complement the description that is being made and in order to help a better understanding of the characteristics of the invention, According to a preferred example of a practical embodiment of the same, a set of drawings is attached as an integral part of said description, where the following has been represented for illustrative and non-limiting purposes.
En la figura 1, podemos observar una representación del stent pediátrico autoexpandible objeto de la invención.Figure 1 shows a representation of the self-expandable pediatric stent object of the invention.
En la figura 2, podemos observar la estructura interna metálica de Nitinol.In figure 2, we can observe the internal metallic structure of Nitinol.
REALIZACIÓN PREFERENTE DE LA INVENCIÓNPREFERRED EMBODIMENT OF THE INVENTION
A la vista de las figuras se describe seguidamente un modo de realización preferente de la invención propuesta.In view of the figures, a preferred embodiment of the proposed invention is described below.
En la figura 1 podemos observar que el stent pediátrico autoexpandible comprende una estructura interna metálica (1) realizada en Nitinol y un recubrimiento interior y exterior, formado por una película interior expandible (2) y una película exterior expandible (3) ambas realizadas en poliéster expandible y que alojan en su interior la estructura interna metálica (1).In Figure 1 we can see that the self-expanding pediatric stent comprises an internal metallic structure (1) made of Nitinol and an internal and external coating, formed by an internal expandable film (2) and an external expandable film (3), both made of polyester. expandable and that house the internal metallic structure (1).
En la figura 2 se observa una característica constructiva de la estructura interna metálica (1) que además estar realizada en Nitinol, presenta un mallado con unas angulaciones (4) de al menos 45°, que aseguran una fuerza radial continua que ayuda a la arteria en su crecimiento y hace que el stent vaya autoexpandiéndose de manera acompasada con el crecimiento de la arteria, evitando tener que ser retirado e implantado cuando las arterías crecían de diámetro.Figure 2 shows a constructive characteristic of the internal metal structure (1) which, in addition to being made of Nitinol, has a mesh with angles (4) of at least 45°, which ensure a continuous radial force that helps the artery in its growth and makes the stent self-expand in rhythm with the growth of the artery, avoiding having to be removed and implanted when the arteries grew in diameter.
Descrita suficientemente la naturaleza de la presente invención, así como la manera de ponerla en práctica, se hace constar que, dentro de su esencialidad, podrá ser llevada a la práctica en otras formas de realización que difieran en detalle de la indicada a título de ejemplo, y a las cuales alcanzará igualmente la protección que se recaba, siempre que no altere, cambie o modifique su principio fundamental. Having sufficiently described the nature of the present invention, as well as the way of putting it into practice, it is stated that, within its essentiality, it may be put into practice in other embodiments that differ in detail from the one indicated by way of example. , and which will also reach the protection that is sought, provided that it does not alter, change or modify its fundamental principle.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES202230011A ES2914516A1 (en) | 2022-01-07 | 2022-01-07 | Self -expandable pediatric stent (Machine-translation by Google Translate, not legally binding) |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES202230011A ES2914516A1 (en) | 2022-01-07 | 2022-01-07 | Self -expandable pediatric stent (Machine-translation by Google Translate, not legally binding) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2914516A1 true ES2914516A1 (en) | 2022-06-13 |
Family
ID=81940188
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES202230011A Pending ES2914516A1 (en) | 2022-01-07 | 2022-01-07 | Self -expandable pediatric stent (Machine-translation by Google Translate, not legally binding) |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2914516A1 (en) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2251973T3 (en) * | 1999-02-01 | 2006-05-16 | Board Of Regents, The University Of Texas System | WOVEN INTRAVASCULAR DEVICES AND MANUFACTURING AND APPLIANCE PROCEDURE TO PLACE THE SAME. |
| ES2541465T3 (en) * | 2009-09-16 | 2015-07-20 | Bentley Innomed Gmbh | Stent with expandable elements |
| US20180140444A1 (en) * | 2015-06-03 | 2018-05-24 | Andratec Gmbh | Stent |
| WO2019033026A1 (en) * | 2017-08-11 | 2019-02-14 | The Charles Stark Draper Laboratory, Inc. | Growth adaptive expandable stent |
| WO2020176122A1 (en) * | 2019-02-28 | 2020-09-03 | Renata Medical, Inc. | Growth stent for congenital narrowings |
| WO2020197869A1 (en) * | 2019-03-26 | 2020-10-01 | Edwards Lifesciences Corporation | Self growing heart valves |
| US20200306067A1 (en) * | 2019-03-26 | 2020-10-01 | Edwards Lifesciences Corporation | Radially self-expanding stents |
-
2022
- 2022-01-07 ES ES202230011A patent/ES2914516A1/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2251973T3 (en) * | 1999-02-01 | 2006-05-16 | Board Of Regents, The University Of Texas System | WOVEN INTRAVASCULAR DEVICES AND MANUFACTURING AND APPLIANCE PROCEDURE TO PLACE THE SAME. |
| ES2541465T3 (en) * | 2009-09-16 | 2015-07-20 | Bentley Innomed Gmbh | Stent with expandable elements |
| US20180140444A1 (en) * | 2015-06-03 | 2018-05-24 | Andratec Gmbh | Stent |
| WO2019033026A1 (en) * | 2017-08-11 | 2019-02-14 | The Charles Stark Draper Laboratory, Inc. | Growth adaptive expandable stent |
| WO2020176122A1 (en) * | 2019-02-28 | 2020-09-03 | Renata Medical, Inc. | Growth stent for congenital narrowings |
| WO2020197869A1 (en) * | 2019-03-26 | 2020-10-01 | Edwards Lifesciences Corporation | Self growing heart valves |
| US20200306067A1 (en) * | 2019-03-26 | 2020-10-01 | Edwards Lifesciences Corporation | Radially self-expanding stents |
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| FC2A | Grant refused |
Effective date: 20221020 |