ES290275A2 - PROCEDURE FOR PREPARING NEW 6-METHYL AND 1,6-DIMETHYL-ER-GOLINE II COMPOUNDS - Google Patents
PROCEDURE FOR PREPARING NEW 6-METHYL AND 1,6-DIMETHYL-ER-GOLINE II COMPOUNDSInfo
- Publication number
- ES290275A2 ES290275A2 ES290275A ES290275A ES290275A2 ES 290275 A2 ES290275 A2 ES 290275A2 ES 290275 A ES290275 A ES 290275A ES 290275 A ES290275 A ES 290275A ES 290275 A2 ES290275 A2 ES 290275A2
- Authority
- ES
- Spain
- Prior art keywords
- methyl
- dimethyl
- procedure
- compounds
- goline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 3
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- UNELDXFWWQRODL-IUODEOHRSA-N (6ar,10ar)-4,7-dimethyl-6,6a,8,9,10,10a-hexahydroindolo[4,3-fg]quinoline Chemical compound C1=CC([C@H]2CCCN([C@@H]2C2)C)=C3C2=CN(C)C3=C1 UNELDXFWWQRODL-IUODEOHRSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- LDGAPBJMEXRZOX-PXFYRTPJSA-N [(6aR,10aR)-4,7-dimethyl-6,6a,8,9,10,10a-hexahydroindolo[4,3-fg]quinolin-9-yl]methanol Chemical compound CN1C=C2C[C@H]3N(CC(C[C@@H]3C=3C=CC=C1C32)CO)C LDGAPBJMEXRZOX-PXFYRTPJSA-N 0.000 abstract 1
- FLVJDDJJEGBXJI-DLTQXHKRSA-N [(6ar,9r)-4,7-dimethyl-5,5a,6,6a,8,9-hexahydroindolo[4,3-fg]quinoline-9-yl]methanol Chemical compound C([C@@H](CO)CN(C)[C@@H]1C2)=C1C1=CC=CC3=C1C2CN3C FLVJDDJJEGBXJI-DLTQXHKRSA-N 0.000 abstract 1
- UFKTZIXVYHGAES-WDBKCZKBSA-N [(6ar,9r,10ar)-7-methyl-6,6a,8,9,10,10a-hexahydro-4h-indolo[4,3-fg]quinoline-9-yl]methanol Chemical compound C1=CC([C@H]2C[C@@H](CO)CN([C@@H]2C2)C)=C3C2=CNC3=C1 UFKTZIXVYHGAES-WDBKCZKBSA-N 0.000 abstract 1
- 150000008064 anhydrides Chemical class 0.000 abstract 1
- -1 diethyloniline Chemical compound 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 150000003512 tertiary amines Chemical class 0.000 abstract 1
- UFKTZIXVYHGAES-UHFFFAOYSA-N trans-dihydrolysergol Natural products C1=CC(C2CC(CO)CN(C2C2)C)=C3C2=CNC3=C1 UFKTZIXVYHGAES-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Improvements in the object of the main patent No. 289,641, by "procedure for preparing new compounds of 6-methyl- and 1,6-dimethyl-ergoline II", and especially new compounds of 6-methyl- and 1 , 6-dimethyl-8-hydroxymethyl-ergoline I, of the following structural formula: ** (See formula) ** where R is hydrogen or methyl and R 'is the radical of an organic acid aliphatic, cycloaliphatic, aromatic or heterocyclic with 3 to 10 carbon atoms, characterized in that a compound taken in the group consisting of dihydro-lysergol I and 1-methyl-dihydro-lysergol I is esterified with the anhydride or the chloride of an organic acid aliphatic, cycloaliphatic, aromatic or heterocyclic with to 10 carbon atoms, in the presence or absence of tertiary amines, such as pyridine, diethyloniline, triethylamine and the like. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1506562 | 1962-07-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES290275A2 true ES290275A2 (en) | 1964-03-01 |
Family
ID=11146222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES290275A Expired ES290275A2 (en) | 1962-07-26 | 1963-07-05 | PROCEDURE FOR PREPARING NEW 6-METHYL AND 1,6-DIMETHYL-ER-GOLINE II COMPOUNDS |
Country Status (7)
| Country | Link |
|---|---|
| AT (1) | AT243993B (en) |
| BE (1) | BE635411A (en) |
| CH (1) | CH454890A (en) |
| DE (1) | DE1470248A1 (en) |
| DK (1) | DK104939C (en) |
| ES (1) | ES290275A2 (en) |
| GB (1) | GB1048555A (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1094965B (en) * | 1978-04-05 | 1985-08-10 | Corvi Mora E | LISERGOL DERIVATION PREPARATION PROCEDURE |
| DE3001752A1 (en) * | 1980-01-16 | 1981-07-30 | Schering Ag Berlin Und Bergkamen, 1000 Berlin | METHOD FOR PRODUCING 8 (ALPHA) SUBSTITUTED 6-METHYLERGOLINES |
-
1963
- 1963-07-05 ES ES290275A patent/ES290275A2/en not_active Expired
- 1963-07-22 GB GB28935/63A patent/GB1048555A/en not_active Expired
- 1963-07-23 AT AT587963A patent/AT243993B/en active
- 1963-07-24 DK DK352863AA patent/DK104939C/en active
- 1963-07-24 DE DE19631470248 patent/DE1470248A1/en active Pending
- 1963-07-25 CH CH924363A patent/CH454890A/en unknown
- 1963-07-25 BE BE635411A patent/BE635411A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CH454890A (en) | 1968-04-30 |
| DE1470248A1 (en) | 1969-10-09 |
| BE635411A (en) | 1963-11-18 |
| GB1048555A (en) | 1966-11-16 |
| DK104939C (en) | 1966-07-25 |
| AT243993B (en) | 1965-12-10 |
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