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Abbott Laboratories
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Abbott Laboratories
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Publication of ES278067A1publicationCriticalpatent/ES278067A1/en
C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
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Chemical & Material Sciences
(AREA)
Organic Chemistry
(AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Abstract
Method of preparation of compounds of formula ** (See formula) ** wherein Ph is phenyl, n is an integer selected from 1, 2 and 3, and R 'is lower alkyl, which comprises the reaction of equimolar proportions of an alkali metal 3-phenyl-2-benzofuranone and a dihaloalkane of formula X- (CH2) nX, in which each X is halogen consisting of chlorine and bromine, and n is an integer as defined, in an inert organic solvent, at a temperature between 0ยบ C and the reflux temperature of the reaction mixture, to obtain the intermediate 3-haloalkyl-3-phenyl-2-benzofuranone, which is then put into reaction with an equivalent amount of an alkali metal alkoxide, at a temperature between the ambient and the reflux temperature of the reaction mixture, and isolation of the resulting product. (Machine-translation by Google Translate, not legally binding)
ES278067A1961-06-081962-06-07Method of preparation of formula compounds (Machine-translation by Google Translate, not legally binding)
ExpiredES278067A1
(en)
Procedure for the preparation of new products of sulfonilarilurea and its employment as agents to combat the bad herbs. (Machine-translation by Google Translate, not legally binding)