ES254144A1 - Un procedimiento de preparaciën de corticosteroides sustituidos - Google Patents

Un procedimiento de preparaciën de corticosteroides sustituidos

Info

Publication number: ES254144A1
Authority: ES; Spain
Prior art keywords: hydroxy; methylpregna; dione; group; trione
Prior art date: 1958-12-16
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

ES0254144A

Other languages

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Laboratoires Francais de Chimiotherapie SA

Laboratoires Francaise de Chimiotherapie

Original Assignee

Laboratoires Francais de Chimiotherapie SA

Laboratoires Francaise de Chimiotherapie

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1958-12-16

Filing date

1959-12-12

Publication date

1960-02-16

1959-12-12 Application filed by Laboratoires Francais de Chimiotherapie SA, Laboratoires Francaise de Chimiotherapie filed Critical Laboratoires Francais de Chimiotherapie SA

1960-02-16 Publication of ES254144A1 publication Critical patent/ES254144A1/es

Status Expired legal-status Critical Current

Links

238000000034 method Methods 0.000 title abstract 2
239000003246 corticosteroid Substances 0.000 title 1
229960001334 corticosteroids Drugs 0.000 title 1
PCLIMKBDDGJMGD-UHFFFAOYSA-N N-bromosuccinimide Chemical compound BrN1C(=O)CCC1=O PCLIMKBDDGJMGD-UHFFFAOYSA-N 0.000 abstract 2
KRVSOGSZCMJSLX-UHFFFAOYSA-L chromic acid Substances O[Cr](O)(=O)=O KRVSOGSZCMJSLX-UHFFFAOYSA-L 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
AWJWCTOOIBYHON-UHFFFAOYSA-N furo[3,4-b]pyrazine-5,7-dione Chemical compound C1=CN=C2C(=O)OC(=O)C2=N1 AWJWCTOOIBYHON-UHFFFAOYSA-N 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
229910052744 lithium Inorganic materials 0.000 abstract 2
230000003647 oxidation Effects 0.000 abstract 2
238000007254 oxidation reaction Methods 0.000 abstract 2
238000002360 preparation method Methods 0.000 abstract 2
FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 2
QWIUIZIJMJZTMV-IPYFZPTRSA-N (8S,9R,10S,13S,14S,16R,17R)-17-acetyl-9-fluoro-17-hydroxy-10,13,16-trimethyl-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthrene-3,11-dione Chemical compound F[C@@]12[C@]3(C=CC(C=C3CC[C@H]1[C@@H]1C[C@H]([C@](C(C)=O)([C@]1(CC2=O)C)O)C)=O)C QWIUIZIJMJZTMV-IPYFZPTRSA-N 0.000 abstract 1
QQCBOIWDENXRLP-BYZMTCBYSA-N (8s,9s,10r,13r,14s,17s)-17-ethyl-10,13-dimethyl-6,7,8,9,11,12,14,15,16,17-decahydro-3h-cyclopenta[a]phenanthrene Chemical compound C1CC2=CCC=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](CC)[C@@]1(C)CC2 QQCBOIWDENXRLP-BYZMTCBYSA-N 0.000 abstract 1
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
241000222199 Colletotrichum Species 0.000 abstract 1
239000004593 Epoxy Substances 0.000 abstract 1
KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 abstract 1
YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 abstract 1
WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 abstract 1
JAZBMNIJZWDVQJ-UKQOWTAJSA-N [(3r,8s,9s,10s,13s,14s)-17-acetyl-10,13-dimethyl-11-oxo-1,2,3,4,5,6,7,8,9,12,14,15-dodecahydrocyclopenta[a]phenanthren-3-yl] acetate Chemical compound C1C(=O)[C@@H]2[C@@]3(C)CC[C@@H](OC(=O)C)CC3CC[C@H]2[C@@H]2CC=C(C(C)=O)[C@]21C JAZBMNIJZWDVQJ-UKQOWTAJSA-N 0.000 abstract 1
229910052783 alkali metal Inorganic materials 0.000 abstract 1
150000001340 alkali metals Chemical class 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
230000031709 bromination Effects 0.000 abstract 1
238000005893 bromination reaction Methods 0.000 abstract 1
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
238000007269 dehydrobromination reaction Methods 0.000 abstract 1
238000000855 fermentation Methods 0.000 abstract 1
230000004151 fermentation Effects 0.000 abstract 1
229910052731 fluorine Inorganic materials 0.000 abstract 1
239000011737 fluorine Substances 0.000 abstract 1
229910000040 hydrogen fluoride Inorganic materials 0.000 abstract 1
230000033444 hydroxylation Effects 0.000 abstract 1
238000005805 hydroxylation reaction Methods 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
125000000468 ketone group Chemical group 0.000 abstract 1
-1 lithium halide Chemical class 0.000 abstract 1
VXWPONVCMVLXBW-UHFFFAOYSA-M magnesium;carbanide;iodide Chemical compound [CH3-].[Mg+2].[I-] VXWPONVCMVLXBW-UHFFFAOYSA-M 0.000 abstract 1
230000002906 microbiologic effect Effects 0.000 abstract 1
230000001590 oxidative effect Effects 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
DUIOPKIIICUYRZ-UHFFFAOYSA-N semicarbazide Chemical compound NNC(N)=O DUIOPKIIICUYRZ-UHFFFAOYSA-N 0.000 abstract 1
239000007858 starting material Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
General Chemical & Material Sciences (AREA)
Microbiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

ES0254144A 1958-12-16 1959-12-12 Un procedimiento de preparaciën de corticosteroides sustituidos Expired ES254144A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR781777A FR1274397A (fr)	1958-12-16	1958-12-16	Procédé de préparation de dérivés 9alpha-fluoro 16alpha-méthyl delta1, 4-pregnadiènes

Publications (1)

Publication Number	Publication Date
ES254144A1 true ES254144A1 (es)	1960-02-16

Family

ID=8709309

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES0254144A Expired ES254144A1 (es)	1958-12-16	1959-12-12	Un procedimiento de preparaciën de corticosteroides sustituidos

Country Status (5)

Country	Link
BE (1)	BE585694A (fr)
CH (2)	CH415621A (fr)
ES (1)	ES254144A1 (fr)
FR (1)	FR1274397A (fr)
GB (3)	GB934711A (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2059050A1 (de) *	1969-12-13	1972-04-06	Ivan Villax	Verfahren zum Herstellen von 16ss-Methyl-9alpha-fluor-steroiden

1958
- 1958-12-16 FR FR781777A patent/FR1274397A/fr not_active Expired
1959
- 1959-12-01 CH CH1403265A patent/CH415621A/fr unknown
- 1959-12-01 CH CH8131659A patent/CH401962A/fr unknown
- 1959-12-08 GB GB1911461A patent/GB934711A/en not_active Expired
- 1959-12-08 GB GB4169059A patent/GB934701A/en not_active Expired
- 1959-12-08 GB GB1911361A patent/GB934710A/en not_active Expired
- 1959-12-12 ES ES0254144A patent/ES254144A1/es not_active Expired
- 1959-12-15 BE BE585694A patent/BE585694A/fr unknown

Also Published As

Publication number	Publication date
GB934710A (en)	1963-08-21
CH401962A (fr)	1965-11-15
GB934701A (en)	1963-08-21
FR1274397A (fr)	1961-10-27
CH415621A (fr)	1966-06-30
GB934711A (en)	1963-08-21
BE585694A (fr)	1960-06-15

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