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ES2539843B2 - Dispositivo microfluídico para la separación de líquido del mismo líquido conteniendo partículas deformables sin fuentes de energía externas - Google Patents

Dispositivo microfluídico para la separación de líquido del mismo líquido conteniendo partículas deformables sin fuentes de energía externas Download PDF

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Publication number
ES2539843B2
ES2539843B2 ES201331666A ES201331666A ES2539843B2 ES 2539843 B2 ES2539843 B2 ES 2539843B2 ES 201331666 A ES201331666 A ES 201331666A ES 201331666 A ES201331666 A ES 201331666A ES 2539843 B2 ES2539843 B2 ES 2539843B2
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Prior art keywords
separation
fluid
energy sources
liquid
microfluidic device
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Active
Application number
ES201331666A
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English (en)
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ES2539843A1 (es
Inventor
Jasmina CASALS-TERRE
Hojjat MADADI
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Universitat Politecnica de Catalunya UPC
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Universitat Politecnica de Catalunya UPC
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Priority to ES201331666A priority Critical patent/ES2539843B2/es
Priority to EP14861638.6A priority patent/EP3070471A4/en
Priority to PCT/ES2014/070833 priority patent/WO2015071515A1/es
Publication of ES2539843A1 publication Critical patent/ES2539843A1/es
Application granted granted Critical
Publication of ES2539843B2 publication Critical patent/ES2539843B2/es
Priority to US15/154,937 priority patent/US10041931B2/en
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/491—Blood by separating the blood components
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C5/00—Separating dispersed particles from liquids by electrostatic effect
    • B03C5/02—Separators
    • B03C5/022—Non-uniform field separators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44791—Microapparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D17/00—Separation of liquids, not provided for elsewhere, e.g. by thermal diffusion
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0652—Sorting or classification of particles or molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0663—Stretching or orienting elongated molecules or particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B01L2300/0851—Bottom walls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B01L2300/165—Specific details about hydrophobic, oleophobic surfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/088—Passive control of flow resistance by specific surface properties

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Ecology (AREA)
  • Fluid Mechanics (AREA)
  • Electrochemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • External Artificial Organs (AREA)

Abstract

Dispositivo microfluídico para la separación de líquido del mismo líquido conteniendo partículas deformables sin fuentes de energía externas. El dispositivo comprende al menos un canal de transporte (1) que utiliza varios principios fluido-hidrodinámicos para incrementar la cantidad de fluido separado/obtenido; al menos un área de separación (2) que divide parte del fluido que circula por el canal de transporte hacia un como mínimo un canal de recogida (3) o cámara de reacción. El área de separación (2) puede incluir al menos una agrupación de pilares, la configuración de los cuales maximiza la cantidad extraída de fluido en el mismo tiempo. El canal de recogida (3) tiene una profundidad y un ancho adaptables según la necesidad del test que se vaya a implementar. En particular, la invención proporcionar un filtro para separar plasma de una gota de sangre con gran eficiencia, que puede ser utilizado en sistemas portátiles de análisis sanguíneo.

Description

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Claims (1)

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ES201331666A 2013-11-15 2013-11-15 Dispositivo microfluídico para la separación de líquido del mismo líquido conteniendo partículas deformables sin fuentes de energía externas Active ES2539843B2 (es)

Priority Applications (4)

Application Number Priority Date Filing Date Title
ES201331666A ES2539843B2 (es) 2013-11-15 2013-11-15 Dispositivo microfluídico para la separación de líquido del mismo líquido conteniendo partículas deformables sin fuentes de energía externas
EP14861638.6A EP3070471A4 (en) 2013-11-15 2014-11-11 Microfluidic device for separating liquid from the same liquid containing deformable particles without external sources of energy
PCT/ES2014/070833 WO2015071515A1 (es) 2013-11-15 2014-11-11 Dispositivo microfluídico para la separación de líquido del mismo líquido conteniendo partículas deformables sin fuentes de energía externas
US15/154,937 US10041931B2 (en) 2013-11-15 2016-05-13 Microfluidic device for separating liquid from the same liquid containing deformable particles without external sources of energy

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES201331666A ES2539843B2 (es) 2013-11-15 2013-11-15 Dispositivo microfluídico para la separación de líquido del mismo líquido conteniendo partículas deformables sin fuentes de energía externas

Publications (2)

Publication Number Publication Date
ES2539843A1 ES2539843A1 (es) 2015-07-06
ES2539843B2 true ES2539843B2 (es) 2015-11-16

Family

ID=53056824

Family Applications (1)

Application Number Title Priority Date Filing Date
ES201331666A Active ES2539843B2 (es) 2013-11-15 2013-11-15 Dispositivo microfluídico para la separación de líquido del mismo líquido conteniendo partículas deformables sin fuentes de energía externas

Country Status (4)

Country Link
US (1) US10041931B2 (es)
EP (1) EP3070471A4 (es)
ES (1) ES2539843B2 (es)
WO (1) WO2015071515A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2539843B2 (es) 2013-11-15 2015-11-16 Universitat Politècnica De Catalunya Dispositivo microfluídico para la separación de líquido del mismo líquido conteniendo partículas deformables sin fuentes de energía externas
US11253835B2 (en) * 2015-12-11 2022-02-22 Paris Sciences Et Lettres Diphasic gas/liquid plasma reactor

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0871539B1 (en) * 1995-06-16 2002-02-20 University of Washington Tangential flow planar microfabricated fluid filter
WO2004084263A2 (en) * 2002-09-07 2004-09-30 Arizona Board Of Regents Integrated apparatus and methods for treating liquids
DE10313201A1 (de) 2003-03-21 2004-10-07 Steag Microparts Gmbh Mikrostrukturierte Trennvorrichtung und mikrofluidisches Verfahren zum Abtrennen von flüssigen Bestandteilen aus einer Flüssigkeit, die Partikel enthält
KR20050096489A (ko) 2004-03-31 2005-10-06 주식회사 올메디쿠스 혈액 내 혈구를 평면상의 기판에서 특별한 전기, 자기적인장치없이 분리 및 이송할 수 있는 필터
GB0525997D0 (en) * 2005-12-21 2006-02-01 Oxford Biosensors Ltd Micro-fluidic structures
US9539572B2 (en) * 2008-02-27 2017-01-10 Boehringer Ingelheim Microparts Gmbh Apparatus for the separation of plasma
ES2968853T3 (es) * 2008-03-24 2024-05-14 Univ Louisiana State Aislamiento microfluídico de células tumorales u otras células raras a partir de sangre total u otros líquidos
WO2012125723A2 (en) * 2011-03-14 2012-09-20 The University Of North Carolina At Chapel Hill Microfluidic nitric oxide sensor
ES2539843B2 (es) 2013-11-15 2015-11-16 Universitat Politècnica De Catalunya Dispositivo microfluídico para la separación de líquido del mismo líquido conteniendo partículas deformables sin fuentes de energía externas

Also Published As

Publication number Publication date
EP3070471A4 (en) 2017-07-12
US20160258928A1 (en) 2016-09-08
WO2015071515A1 (es) 2015-05-21
US10041931B2 (en) 2018-08-07
EP3070471A1 (en) 2016-09-21
ES2539843A1 (es) 2015-07-06

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