ES2514165B1 - Anticuerpo anti-factor b, composición farmacéutica útil para el tratamiento de enfermedades del complemento y sus aplicaciones - Google Patents
Anticuerpo anti-factor b, composición farmacéutica útil para el tratamiento de enfermedades del complemento y sus aplicaciones Download PDFInfo
- Publication number
- ES2514165B1 ES2514165B1 ES201330452A ES201330452A ES2514165B1 ES 2514165 B1 ES2514165 B1 ES 2514165B1 ES 201330452 A ES201330452 A ES 201330452A ES 201330452 A ES201330452 A ES 201330452A ES 2514165 B1 ES2514165 B1 ES 2514165B1
- Authority
- ES
- Spain
- Prior art keywords
- antibody
- factor
- complement
- treatment
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn - After Issue
Links
- 230000000295 complement effect Effects 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 4
- 201000010099 disease Diseases 0.000 title abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 3
- 208000000733 Paroxysmal Hemoglobinuria Diseases 0.000 abstract 2
- 102100036050 Phosphatidylinositol N-acetylglucosaminyltransferase subunit A Human genes 0.000 abstract 2
- 201000003045 paroxysmal nocturnal hemoglobinuria Diseases 0.000 abstract 2
- 208000035913 Atypical hemolytic uremic syndrome Diseases 0.000 abstract 1
- 102000016574 Complement C3-C5 Convertases Human genes 0.000 abstract 1
- 108010067641 Complement C3-C5 Convertases Proteins 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 230000003321 amplification Effects 0.000 abstract 1
- 230000024203 complement activation Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000002949 hemolytic effect Effects 0.000 abstract 1
- 210000004408 hybridoma Anatomy 0.000 abstract 1
- 238000003199 nucleic acid amplification method Methods 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
Anticuerpo anti-factor B, composición farmacéutica útil para el tratamiento de enfermedades del complemento y sus aplicaciones.#La presente invención describe un anticuerpo anti-factor B que bloquea la generación de la convertasa del C3 de la vía alternativa útil para prevenir o modular la activación o amplificación de la activación del complemento. Una forma concreta de este anticuerpo es el anticuerpo monoclonal anti-factor B producido por el hibridoma FB-28.4.2 depositado en ACECC el 13 de noviembre de 2012 con la referencia 12111301. Además, proporciona una composición farmacéutica útil para el tratamiento de enfermedades asociadas del complemento como por ejemplo, el síndrome hemolítico urémico atípico (aHUS) o la hemoglobinuria paroxística nocturna (HPN). Igualmente, se proporciona un complejo biotecnológico útil para la realización de ensayos para la identificación y diseño de medicamentos o composiciones farmacéuticas inhibidoras del complemento.
Description
Claims (1)
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imagen1 imagen2 imagen3 imagen4 imagen5 imagen6
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES201330452A ES2514165B1 (es) | 2013-03-27 | 2013-03-27 | Anticuerpo anti-factor b, composición farmacéutica útil para el tratamiento de enfermedades del complemento y sus aplicaciones |
| PCT/ES2014/070236 WO2014154930A1 (es) | 2013-03-27 | 2014-03-27 | Anticuerpo anti-factor b, composición farmacéutica útil para el tratamiento de enfermedades del complemento y sus aplicaciones |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES201330452A ES2514165B1 (es) | 2013-03-27 | 2013-03-27 | Anticuerpo anti-factor b, composición farmacéutica útil para el tratamiento de enfermedades del complemento y sus aplicaciones |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2514165A1 ES2514165A1 (es) | 2014-10-27 |
| ES2514165B1 true ES2514165B1 (es) | 2015-09-09 |
Family
ID=51622475
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES201330452A Withdrawn - After Issue ES2514165B1 (es) | 2013-03-27 | 2013-03-27 | Anticuerpo anti-factor b, composición farmacéutica útil para el tratamiento de enfermedades del complemento y sus aplicaciones |
Country Status (2)
| Country | Link |
|---|---|
| ES (1) | ES2514165B1 (es) |
| WO (1) | WO2014154930A1 (es) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6333034B1 (en) * | 1997-08-26 | 2001-12-25 | Gliatech, Inc. | Process for inhibiting complement activation via the alternative pathway |
| CA2321140C (en) * | 1998-02-20 | 2015-04-07 | Tanox, Inc. | Inhibitors of complement activation |
| ITMI20021527A1 (it) * | 2002-07-11 | 2004-01-12 | Consiglio Nazionale Ricerche | Anticorpi anti componente c5 del complemento e loro uso |
| EP2340850A1 (en) * | 2004-02-10 | 2011-07-06 | The Regents of the University of Colorado, a Body Corporate | Inhibition of factor B, the alternative complement pathway and methods related thereto |
-
2013
- 2013-03-27 ES ES201330452A patent/ES2514165B1/es not_active Withdrawn - After Issue
-
2014
- 2014-03-27 WO PCT/ES2014/070236 patent/WO2014154930A1/es active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| ES2514165A1 (es) | 2014-10-27 |
| WO2014154930A1 (es) | 2014-10-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
Ref document number: 2514165 Country of ref document: ES Kind code of ref document: B1 Effective date: 20150909 |
|
| FA2A | Application withdrawn |
Effective date: 20160210 |