ES250491A1 - New substituted 3,5-dioxo-isoxazolidines and process for the manufacture thereof - Google Patents
New substituted 3,5-dioxo-isoxazolidines and process for the manufacture thereofInfo
- Publication number
- ES250491A1 ES250491A1 ES0250491A ES250491A ES250491A1 ES 250491 A1 ES250491 A1 ES 250491A1 ES 0250491 A ES0250491 A ES 0250491A ES 250491 A ES250491 A ES 250491A ES 250491 A1 ES250491 A1 ES 250491A1
- Authority
- ES
- Spain
- Prior art keywords
- malonylating
- hydrogen atom
- prepared
- hydrocarbon radical
- product
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/12—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
The invention comprises compounds having, in one tautomeric form, the general formula <FORM:0914716/IV (b)/1> (wherein R, R1 and R2 each represent a hydrogen atom or a hydrocarbon radical free from aliphatic unsaturated bonds, at least one but not more than two of them representing a hydrogen atom), and their salts with inorganic or organic bases (e.g. alkali and alkalineearth metals, ammonium, methylamine, monoand di-ethanolamine, triethylamine, diethylaminoethanol and morpholine), and the preparation thereof by condensing a compound RNH.OH with a malonylating agent capable of supplying a malonyl group of the formula <FORM:0914716/IV (b)/2> and, if desired, when a product is obtained in which R1 = R2 = H, substituting it with a hydrocarbon radical free from aliphatic unsubstitution, and further, if desired, reacting the product with a base to form a salt. Substituted malonyl chlorides for use as malonylating agents are prepared by treating the corresponding acid with thionyl chloride. n-Nonylmalonic acid is prepared by saponifying its diethyl ester with aqueous ethanolic caustic potash, distilling off the ethanol and acidifying the residual aqueous solution. Pharmaceutical compositions.-The products are useful for the treatment of inflammatory phenomena, for which purpose they may be administered orally (e.g. in tablets, sugarcoated pills or capsules) or parenterally (e.g. dissolved in water, propylene glycol or polyethylene glycol).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH6134458A CH368175A (en) | 1958-07-03 | 1958-07-03 | Process for the preparation of 3,5-dioxo-isoxazolidines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES250491A1 true ES250491A1 (en) | 1960-01-16 |
Family
ID=4523565
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0250491A Expired ES250491A1 (en) | 1958-07-03 | 1959-07-02 | New substituted 3,5-dioxo-isoxazolidines and process for the manufacture thereof |
Country Status (4)
| Country | Link |
|---|---|
| BE (1) | BE580263A (en) |
| CH (1) | CH368175A (en) |
| ES (1) | ES250491A1 (en) |
| GB (1) | GB914716A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4946963A (en) * | 1987-11-13 | 1990-08-07 | The University Of North Carolina At Chapel Hill | Compounds for the control of hyperlipidemia using N-substituted isoxazolidine-3,5-diones |
-
1958
- 1958-07-03 CH CH6134458A patent/CH368175A/en unknown
-
1959
- 1959-06-30 GB GB2235359A patent/GB914716A/en not_active Expired
- 1959-07-01 BE BE580263A patent/BE580263A/en unknown
- 1959-07-02 ES ES0250491A patent/ES250491A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CH368175A (en) | 1963-03-31 |
| BE580263A (en) | 1959-11-03 |
| GB914716A (en) | 1963-01-02 |
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