ES2453715A1 - Topical composition for veterinary use and use thereof for the treatment of horse piqui¿a (Machine-translation by Google Translate, not legally binding) - Google Patents
Topical composition for veterinary use and use thereof for the treatment of horse piqui¿a (Machine-translation by Google Translate, not legally binding) Download PDFInfo
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- ES2453715A1 ES2453715A1 ES201101318A ES201101318A ES2453715A1 ES 2453715 A1 ES2453715 A1 ES 2453715A1 ES 201101318 A ES201101318 A ES 201101318A ES 201101318 A ES201101318 A ES 201101318A ES 2453715 A1 ES2453715 A1 ES 2453715A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
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- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
COMPOSICiÓN TÓPICA DE USO VETERINARIO Y USO DE LA MISMA PARA EL TRATAMIENTO DE LA PIQUIÑA DEL CABALLO
TOPICAL COMPOSITION OF VETERINARY USE AND USE OF THE SAME FOR THE TREATMENT OF THE HORSE PIQUIÑA
5 La presente invención se refiere a una composición tópica de uso veterinario que incluye antiinflamatorios, antiparásitos y repelente de insectos para el tratamiento de la piquiña del caballo, también llamada "picazón dulce del caballo" o bien "dermatitis periódica de verano", que en unas proporciones especificas es capaz de curar la enfermedad, ya que The present invention relates to a topical composition for veterinary use that includes anti-inflammatory, antiparasitic and insect repellent for the treatment of horse piquiña, also called "sweet horse itching" or "periodic summer dermatitis", which in specific proportions is able to cure the disease, since
10 actúa directamente sobre su mecanismo etipatogenico. Aporta además una alta seguridad, sin producir efectos
secundarios sistémicos, ya que no contiene sustancias químicas que tengan absorción percutánea, en particular antiinflamatorios esteroideos. La "piquiña del caballo" afecta a miles de caballos y burros en 10 acts directly on its etipatogenic mechanism. It also provides high security, without producing effects
systemic side effects, since it does not contain chemicals that have percutaneous absorption, in particular steroidal anti-inflammatory drugs. The "horse piquiña" affects thousands of horses and donkeys in
15 muchos países del mundo. Casi todas las razas pueden estar afectadas y en España creemos que hasta el 65% de la raza equina padece algún grado de picazón dulce. 15 many countries of the world. Almost all races can be affected and in Spain we believe that up to 65% of the equine race suffers from some degree of sweet itching.
Los síntomas incluyen picazón intenso, pérdida de pelo, gordura de la piel, y lo que parece ser caspas en laminillas. Srntomas más serios 20 incluyen mataduras y heridas abiertas que pueden presentar infecciones secundarias, y cortes y abrasiones causados por el propio caballo intentando aliviar el picazón intenso. El animal puede friccionarse contra Symptoms include severe itching, hair loss, skin fatness, and what appears to be lamellae dandruff. More serious symptoms 20 include open killings and wounds that can present secondary infections, and cuts and abrasions caused by the horse itself trying to relieve severe itching. The animal can rub against
las paredes, agitar vigorosamente la cola e intentar rascarse para aliviar the walls, vigorously shake the tail and try to scratch to relieve
la irritación. También pueden intentar arrastrarse por el suelo o sentarse a la manera de un perro moviéndose para intentar rascarse la parte superior irritation They can also try to crawl on the ground or sit in the manner of a dog moving to try to scratch the top
5 de la cola. Las zonas más afectadas son las crines y la parte superior de la cola. Otras zonas afectadas son el cuello, la cadera, las orejas y la frente, y, en casos severos, la parte mediana del abdomen, la zona de la silla de montar, las partes laterales de la cabeza, la vaina o las mamas y las patas. El animal también puede presentar cambio de temperamento 5 of the tail. The most affected areas are the mane and the top of the tail. Other affected areas are the neck, the hip, the ears and the forehead, and, in severe cases, the middle part of the abdomen, the saddle area, the side parts of the head, the sheath or the breasts and the legs. The animal may also show a change in temperament.
10 llegando a ser letárgico y sin brillo o agitado o impaciente especialmente en presencia de insectos voladores. Algunos caballos pueden llegar a fallecer por sus complicaciones infecciosas. Actualmente, existen datos que indican se debe el proceso a picaduras de insectos, en particular mosquitos o moscas de agua 10 becoming lethargic and dull or agitated or impatient especially in the presence of flying insects. Some horses may die due to their infectious complications. Currently, there are data that indicate the process is due to insect bites, in particular mosquitoes or water flies
15 (Culicoides) y ciertas especies de moscas negras que se alimenten de sangre (Simulium Equinum). La enfermedad estaría inducida por el sistema inmunitario del propio animal atacando sus células cutáneas" por error" al intentar rechazar las proteínas inofensivas dejadas en la saliva de los insectos picadores. 15 (Culicoides) and certain species of black flies that feed on blood (Simulium Equinum). The disease would be induced by the animal's own immune system by attacking its skin cells "by mistake" by trying to reject the harmless proteins left in the saliva of the biting insects.
20 Su aplicación industrial se encuadra dentro del campo técnico de la elaboración de compuestos tópicos de uso veterinario y más particularmente, en la industria elaboradora de productos contra la piquiña del caballo. 20 Its industrial application falls within the technical field of the elaboration of topical compounds for veterinary use and more particularly, in the manufacturing industry of products against horse piquiña.
ANTECEDENTES DE LA INVENCiÓN BACKGROUND OF THE INVENTION
Aunque no se ha encontrado ningún documento anterior igual o parecido, que plantee un producto farmacéutico que asocie antiinflamatorios tópicos no esteroideos, antiparasitarios y repelente de Although no previous document has been found the same or similar, that proposes a pharmaceutical product that associates topical non-steroidal anti-inflammatory, antiparasitic and anti-parasite
5 insectos citamos los siguientes documentos encontrados como reflejo del estado de la técnica al respecto: 5 insects we cite the following documents found as a reflection of the state of the art in this regard:
Así, el documento ES 2 263 182 T3 se refiere a una composición tópica apropiada para el tratamiento de laminitis equina que comprende un donador de óxido nítrico (NO) de acción rápida capaz de aumentar a Thus, ES 2 263 182 T3 refers to a topical composition suitable for the treatment of equine laminitis comprising a fast-acting nitric oxide (NO) donor capable of increasing to
10 niveles detectables el NO en el plasma o tejido en uno o diez minutos de exposición, y L-arginina (L-Arg) dispersado en un transportador de base lipídica el cual comprende por lo menos un Hpido formador de membrana, por lo menos un solvente orgánico alifático biocompatible compuesto de esteres y ácidos grasos que contienen grupos alifáticos de cadena larga 10 levels detectable NO in the plasma or tissue in one or ten minutes of exposure, and L-arginine (L-Arg) dispersed in a lipid-based transporter which comprises at least one membrane-forming lipid, at least one biocompatible aliphatic organic solvent composed of esters and fatty acids containing long chain aliphatic groups
15 saturados o insaturados que tienen desde 8 a 50 átomos de carbono, por lo menos un grupo hidroxilo que contiene solvente orgánico alifático que tiene desde 1 a 8 átomos de carbono y por lo menos un tensioactivo. Saturated or unsaturated having from 8 to 50 carbon atoms, at least one hydroxyl group containing aliphatic organic solvent having from 1 to 8 carbon atoms and at least one surfactant.
La patente europea ES 2 276 604 A 1 describe una composición para uso veterinario que comprende: 20 European patent ES 2 276 604 A 1 describes a composition for veterinary use comprising:
a) Oxido de zinc, una sal de zinc o una mezcla en una cantidad entre el 15 y el 30 por ciento del peso total de la composición. b) Un antiséptico en una cantidad entre el 0,001 y el 5 por ciento del a) Zinc oxide, a zinc salt or a mixture in an amount between 15 and 30 percent of the total weight of the composition. b) An antiseptic in an amount between 0.001 and 5 percent of the
peso total de la composición. total weight of the composition.
c) Un cicatrizante en una cantidad entre el 0,001 y el 5 por ciento del c) A healing agent in an amount between 0.001 and 5 percent of the
peso total de la composición. d) Un rubefaciente y antipruriginoso en una cantidad entre 0,001 y 10 por ciento del peso total de la composición. 5 e) Un agente espesante en una cantidad entre el 1 y el 30 por ciento del peso total de la composición. f) Una base emoliente en una cantidad entre el 30 y el 80 por ciento del peso total de la composición. g) Agua en una cantidad inferior al 10 por ciento del peso total de la 10 composición. total weight of the composition. d) A rubefacient and antipruritic in an amount between 0.001 and 10 percent of the total weight of the composition. 5 e) A thickening agent in an amount between 1 and 30 percent of the total weight of the composition. f) An emollient base in an amount between 30 and 80 percent of the total weight of the composition. g) Water in an amount less than 10 percent of the total weight of the composition.
Dicha composición se aplica sobre las heridas de animales pertenecientes al grupo bovino, equino, porcino, ovino, aves, roedores, vacas, terneros, cerdos, caballos, ovejas, cabras, burros, mulas, cebras, gatos, perros, aves ornamentales, aves exóticas, aves de corral, reptiles, This composition is applied to the wounds of animals belonging to the bovine, equine, pig, sheep, birds, rodents, cows, calves, pigs, horses, sheep, goats, donkeys, mules, zebras, cats, dogs, ornamental birds, birds exotic, poultry, reptiles,
15 animales exóticos, pollos, canarios, periquitos, patos, loros, cacatúas y conejos, siendo su uso para la profilaxis y tratamiento de heridas de la piel de animales que comprende el paso de la aplicación de una cantidad efectiva de la composición sobre la zona a tratar. 15 exotic animals, chickens, canaries, parakeets, ducks, parrots, cockatoos and rabbits, being its use for the prophylaxis and treatment of skin wounds of animals that includes the passage of the application of an effective amount of the composition on the area to treat
ES 2 275 846 T3 describe un uso cosmético de un compuesto activo ES 2 275 846 T3 describes a cosmetic use of an active compound
20 seleccionado del grupo que comprende una base esfingoide, un derivado de base esfingoide o una mezcla de dos o más de dichos compuestos, para su aplicación tópica en animales cuya piel está al menos parcialmente cubierta de pelo, para mantener y/o mejorar el estado 20 selected from the group comprising a sphingoid base, a sphingoid base derivative or a mixture of two or more of said compounds, for topical application in animals whose skin is at least partially covered with hair, to maintain and / or improve the condition
queratoseborreico de la piel y del pelaje. El compuesto activo se keratoseborrheic skin and fur. The active compound is
selecciona del grupo de esfingosina, esfinganina, fitoesfingosina o una mezcla de dos o más de dichos compuestos. Como derivado de base esfingoide, se usa sal de fitoesfingosina seleccionada del grupo de sal de 5 ácido _-hidroxi-alcanoico, sal de ácido _-hidroxi-alcanoico, sal de ácido_, _ -hidroxi-alcanoico, sal de ácido alcanodioico, sal de ácido mineral o sal de ácido orgánico lipofílico. También como derivado de base esfingoide, se usa ácido láctico, ácido glicólico, ácido málico, ácido pirúvico, ácido succínico, ácido fumárico, ácido ascórbico, ácido glucónico, ácido 10 piroglutámico, un ácido hidroclórico, ácido nítrico y/o sal de ácido fosfórico de fitoesfingosina. La composición contiene el 0,001-20% en peso del compuesto activo, preferiblemente el 0,005-10% en peso, más preferiblemente el 0,01-5% en peso. 9. El uso según se reivindica en cualquiera de las reivindicaciones 1 a 8, caracterizado por el hecho de 15 que en su composición se incluye un aditivo capaz de exhibir una actividad complementaria, seleccionándose dicho aditivo del grupo de ácidos alfa-hidróxidos, ácido láctico, ácido cítrico, ácido glicólico, ácidos beta-hidróxidos, ácido salicílico y derivados de los mencionados ácidos hidróxidos, citoquinas, esteroideos antiinflamatorios y no estereoideos, 20 vitamina A, C, D, E, PP, biotina y vitaminas del tipo B, hormonas, peróxido de benzoilo, diversos emolientes, urea, reductores, agentes antipolilla, antibióticos, agentes antifúngicos, desinfectantes. La composición se usa para fabricar un medicamento veterinario adecuado para su aplicación select from the group of sphingosine, sphinganine, phytosphingosine or a mixture of two or more of said compounds. As the sphingoid base derivative, phytosphingosine salt selected from the salt group of 5-hydroxy-alkanoic acid, salt of _-hydroxy-alkanoic acid, salt of _, _-hydroxy-alkanoic acid, alkanedioic acid salt, salt is used of mineral acid or salt of lipophilic organic acid. Also as a sphingoid base derivative, lactic acid, glycolic acid, malic acid, pyruvic acid, succinic acid, fumaric acid, ascorbic acid, gluconic acid, pyroglutamic acid, a hydrochloric acid, nitric acid and / or phosphoric acid salt are used. of phytosphingosine. The composition contains 0.001-20% by weight of the active compound, preferably 0.005-10% by weight, more preferably 0.01-5% by weight. 9. The use as claimed in any of claims 1 to 8, characterized in that its composition includes an additive capable of exhibiting a complementary activity, said additive being selected from the group of alpha-hydroxides, lactic acid , citric acid, glycolic acid, beta-hydroxides, salicylic acid and derivatives of the aforementioned hydroxides, cytokines, anti-inflammatory and non-steroidal steroids, 20 vitamins A, C, D, E, PP, biotin and type B vitamins, hormones , benzoyl peroxide, various emollients, urea, reducers, anti-moth agents, antibiotics, antifungal agents, disinfectants. The composition is used to make a veterinary medicinal product suitable for its application.
tópica en animales cuya piel está al menos parcialmente cubierta de pelo para tratar afecciones asociadas a la presencia de Staphylococcus Intermedius y/o Malassezia Pachyadermatis y para su aplicación tópica en animales cuya piel está al menos parcialmente cubierta de pelo para topical in animals whose skin is at least partially covered with hair to treat conditions associated with the presence of Staphylococcus Intermedius and / or Malassezia Pachyadermatis and for topical application in animals whose skin is at least partially covered with hair for
5 prevenir y/o corregir las afecciones cutáneas asociadas a problemas de la microflora de la piel animal, en animales cuya piel está al menos parcialmente cubierta de pelo. 5 prevent and / or correct skin conditions associated with microflora problems of animal skin, in animals whose skin is at least partially covered with hair.
Como se desprende de la investigación realizada, los documentos encontrados se refieren a patologías y composiciones muy diferentes a la 10 composición objeto de invención. DESCRIPCiÓN DE LA INVENCiÓN As can be seen from the research carried out, the documents found refer to pathologies and compositions very different from the composition object of the invention. DESCRIPTION OF THE INVENTION
La composición tópica de uso veterinario para el tratamiento de la piquiña del caballo objeto de la presente invención se obtiene a partir de la mezcla en un reactor de la siguiente formulación química dada en The topical veterinary composition for the treatment of horse piquiña object of the present invention is obtained from the mixing in a reactor of the following chemical formulation given in
15 porcentajes en relación al peso y dentro de los siguientes rangos: 15 percentages in relation to weight and within the following ranges:
Dietil toluamida Diethyl toluamide
Urea Urea
Acido salicílico Salicylic acid
Permetrina Permethrin
20 Alfa bisabolol Mentol Dexpantenol Glicerina 20 Alpha bisabolol Menthol Dexpanthenol Glycerin
5-16% 2-6% 2-4% 3-6% 0,2-0,6% 5-16% 2-6% 2-4% 3-6% 0.2-0.6%
2% 2-6% 6% 2% 2-6% 6%
Alcohol de 96 54-82% Alcohol 96 54-82%
La composición obtenida se envasa en aerosol para su mejor aplicación. The composition obtained is aerosolized for best application.
DESCRIPCiÓN DE UNA REALIZACiÓN PREFERENTE DESCRIPTION OF A PREFERRED EMBODIMENT
La presente invención se ilustra con el siguiente ejemplo o modo de realización preferente, el cual no debe considerarse limitativo de su alcance. The present invention is illustrated by the following example or preferred embodiment, which should not be considered as limiting its scope.
Una realización preferente de la presente invención se obtiene a 10 partir de la mezcla en un reactor de la siguiente formulación qurmica dada en porcentajes en relación al peso y dentro de los siguientes rangos: A preferred embodiment of the present invention is obtained from the mixture in a reactor of the following chemical formulation given in percentages in relation to weight and within the following ranges:
- Dietil toluamida Diethyl toluamide
- Urea Urea
- Acido salicílico Salicylic acid
- 15 fifteen
- Permetrina Permethrin
- Alfa bisabolol Bisabolol Alpha
- Mentol Menthol
- Dexpantenol Dexpanthenol
- Glicerina Glycerin
- 20 twenty
- Alcohol de 96 96 alcohol
5-16% 2-6% 2-4% 3-6% 0,2-0,6% 5-16% 2-6% 2-4% 3-6% 0.2-0.6%
2% 2-6% 6% 2% 2-6% 6%
54-82% 54-82%
Claims (1)
Alcohol de 96 54-82% 10 Alpha bisabolol 0.2-0.6% Menthol 2% Dexpanthenol 2-6% Glycerin 6%
Alcohol 96 54-82%
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES201101318A ES2453715B1 (en) | 2012-10-08 | 2012-10-08 | Topical composition for veterinary use and its use for the treatment of horse piquiña |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES201101318A ES2453715B1 (en) | 2012-10-08 | 2012-10-08 | Topical composition for veterinary use and its use for the treatment of horse piquiña |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2453715A1 true ES2453715A1 (en) | 2014-04-08 |
| ES2453715B1 ES2453715B1 (en) | 2015-01-16 |
Family
ID=50397400
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES201101318A Expired - Fee Related ES2453715B1 (en) | 2012-10-08 | 2012-10-08 | Topical composition for veterinary use and its use for the treatment of horse piquiña |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2453715B1 (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999056548A1 (en) * | 1998-04-21 | 1999-11-11 | Gunnar Volden | Insecticide |
| WO2002036130A1 (en) * | 2000-11-03 | 2002-05-10 | H-10 Limited | Veterinary composition for the topical treatment of traumatized or inflamed skin |
| WO2005011567A2 (en) * | 2003-08-04 | 2005-02-10 | Foamix Ltd. | Foam carrier containing amphiphilic copolymeric gelling agent |
| US20070275064A1 (en) * | 2006-05-29 | 2007-11-29 | Mumoli Jose A | Solid Tablets Composition Rapidly Dissolvable in Water or Watery Liquids and Used for Body, Skin, Hair and Oral Hygiene and Desinfection |
-
2012
- 2012-10-08 ES ES201101318A patent/ES2453715B1/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999056548A1 (en) * | 1998-04-21 | 1999-11-11 | Gunnar Volden | Insecticide |
| WO2002036130A1 (en) * | 2000-11-03 | 2002-05-10 | H-10 Limited | Veterinary composition for the topical treatment of traumatized or inflamed skin |
| WO2005011567A2 (en) * | 2003-08-04 | 2005-02-10 | Foamix Ltd. | Foam carrier containing amphiphilic copolymeric gelling agent |
| US20070275064A1 (en) * | 2006-05-29 | 2007-11-29 | Mumoli Jose A | Solid Tablets Composition Rapidly Dissolvable in Water or Watery Liquids and Used for Body, Skin, Hair and Oral Hygiene and Desinfection |
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| Publication number | Publication date |
|---|---|
| ES2453715B1 (en) | 2015-01-16 |
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