ES2323972T3 - Metodos y reactivos para la deteccion de melanoma. - Google Patents
Metodos y reactivos para la deteccion de melanoma. Download PDFInfo
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Abstract
Un método para identificar un melanoma que comprende las etapas de (a) obtener una muestra tisular; y (b) medir los niveles de expresión en la muestra de genes que codifican ARNm correspondiente a PLAB (SEC ID Nº: 1) y L1CAM (SEC ID Nº: 2); o PLAB, L1CAM y NTRK3 (SEC ID Nº: 3) en el que los niveles de expresión génica por encima de niveles límite predeterminados son indicativos de la presencia de un melanoma en la muestra y en el que dichos niveles límite predeterminados tienen la mayor puntuación en: muestras normales primarias; y/o muestras de nevos benignos.
Description
Métodos y reactivos para la detección de
melanoma.
El melanoma maligno cutáneo es un cáncer
agresivo, común, con incidencia creciente. Es un grave problema
sanitario con más de 55.100 nuevos casos previstos en 2004 en
Estados Unidos y una tasa de mortalidad de aproximadamente el
14,5%. Cancer Facts and Figures 2003. American Cancer Society, 2003.
La incidencia de melanoma continúa creciendo más rápidamente que la
de cualquier otra neoplasia. De Braud et al., (2003).
Mientras que el pronóstico de melanoma local temprano es favorable
con una supervivencia global a los 5 años de más del 90%, la
implicación de ganglio linfático regional disminuye la tasa de
supervivencia global hasta el 10-46%. Balch et
al. (2001). Por lo tanto, el estado de ganglios linfáticos (GL)
regionales se convierte en el factor de pronóstico más
significativo en la supervivencia de un paciente con melanoma. La
introducción de la técnica de ganglios linfáticos centinelas (GLC)
(Morton (1992)) ha aumentado la sensibilidad de la detección de
micrometástasis de melanoma en comparación con solamente tinción con
H&E. Yu et al. (1999); y Messina et al. (1999).
Sin embargo, incluso aunque mejorado por IHC, el análisis
histológico está limitado por la capacidad de la microscopia óptica
de reconocer las células tumorales. Recientemente se ha propuesto
el análisis por reacción en cadena de la polimerasa de transcripción
inversa (RT-PCR) para una detección más sensible de
células de melanoma en GL. Muchos estudios, cuando usan marcadores
específicos de melanocitos bien caracterizados, tales como
tirosinasa y MART-1, han demostrado la presencia de
estos transcritos génicos en GL que, por lo demás, se observa que
son negativos por histología rutinaria e IHC. Shivers et al.
(1998); y Kuo et al. (2003). Sin embargo, estos genes no son
específicos de células tumorales y no se pueden usar para
distinguir entre tejido benigno y maligno. De hecho, han provocado
resultados de falsos positivos en presencia de nevos capsulares
benignos. Takeuchi et al. (2004); Stara et al.
(2003); y Gutzmer et al. (2002). Considerando que los nevos
benignos no son acontecimientos raros en el GLC de melanoma, los
ensayos actuales de RT-PCR no son útiles
clínicamente para el diagnóstico de micrometástasis de melanoma. Un
estudio reciente ha propuesto un panel de
multi-marcadores, incluyendo marcadores específicos
de cáncer para ensayo por RT-PCR para aumentar la
especificidad de ensayo. Hoon et al. (2004). La
identificación de marcadores específicos de melanoma novedosos sigue
siendo una de las cuestiones clave en la investigación del
melanoma.
Se ha demostrado que ciertas proteínas están
asociadas con melanoma y sus metástasis. Estas proteínas o sus
actividades se han usado en IHC para identificar metástasis e
incluyen L1CAM (Thies et al. (2002); Fogel et al.
(2003); y S-100 (Diego et al. (2003)).
Se han propuesto ensayos con ácido nucleico para
aumentar la sensibilidad de detección de melanoma metastático.
Publicaciones de Patente de Estados Unidos Nº 2002/0110820; y
2003/0232356. Los estudios han usado marcadores que incluyen genes
de MAGE3, tirosinasa, MART-1, MITF-M
o IL-1, R1, endotelina-2,
efrina-A5, proteína de unión a IGF 7, cadena pesada
de HLA-A0202, Activina A (subunidad \betaA), TNF
RII, SPC4, CNTF R\alpha o gp100 (HMB45). Bostick et al.
(1999); Hoon et al. (2001); Palmieri et al. (2001);
Wrightson et al. (2001); Gutzmer et al. (2002);
Davids et al. (2003); Starz et al. (2003); Rimboldi
et al. (2003); Cook et al (2003); Reintgen et
al. (2004); Publicaciones de Patente de Estados Unidos Nº
2002/0098535; 2003/0049701; Patentes de Estados Unidos Nº 5.512.437;
5.512.444; 5.612.201; 5.759.783; 5.844.075; 6.025.474; 6.057.105;
6.235.525; 6.291.430; 6.338.947; 6.369.211; 6.426.217; 6.475.727;
6.500.919; 6.527.560; 6.599.699; documento WO 96/29430. Cuando se
determinaron, estos marcadores no se han considerado adecuados para
uso único en el diagnostico de melanoma. Riccioni et al.
(2002); Gutzmer et al. (2002); Davids et al. (2003);
Goydos et al. (2003); y Prichard et al. (2003).
También se ha demostrado que varios de estos
marcadores son indicativos de otras neoplasias tales como ME20M (GP
100) para sarcoma de células claras, carcinoma de conducto biliar y
carcinoma gástrico. Hiraga et al. (1997); Okada et al.
(2001); Okami et al. (2001); Antonescu et al. (2002);
Segal et al. (2003). MAGE3 también es indicativo de varias
neoplasias incluyendo de mama, hepatocelular, renal, neural, de
pulmón y esofágica. Yamanaka et al. (1999); Ooka et
al. (2000); Suzuki et al. (2000); Cheung et al.
(2001); y Weiser et al. (2001). Varios genes que codifican
antígeno de melanoma también se expresan en cáncer de pulmón.
Yoshimatsu et al. (1998).
Se ha demostrado que estos marcadores son
sensibles pero no específicos ya que mostraron expresión positiva
en otros cánceres y melanocitos benignos. Adicionalmente, la
tirosinasa se expresa en células de Schwann que están presentes en
ganglios linfáticos normales. La ausencia de especificidad sola
demanda el desarrollo de ensayos con marcadores nuevos o
adicionales. La histología de H&E e IHC siguen siendo el
"patrón de oro para la identificación de melanoma y células de
nevos en GLC". Starz et al. (2003). Los aspectos de
detección en el entorno intra-operativo hacen que
esta necesidad sea incluso más aguda.
La implicación de ganglio linfático es el factor
de pronóstico más fuerte en muchos tumores sólidos y la detección
de micrometástasis en ganglios linfáticos es de gran interés para
anatomopatólogos y cirujanos. La evaluación de ganglio linfático
actual implica examen microscópico de secciones tisulares teñidas
con H&E e IHC y padece tres limitaciones principales: (a)
pequeños focos de células, se omiten de forma sencilla; (b) el
resultado no está disponible rápidamente, significando que
cualquier resultado positivo en un procedimiento de GLC requiere
una segunda cirugía para la retirada de ganglios linfáticos
axilares; y (c) solamente se estudian una o dos secciones tisulares
y, por tanto, la gran mayoría de cada ganglio se deja sin examinar.
El corte en serie puede ayudar a superar el error de muestreo y la
IHC puede ayudar a identificar pequeños focos de células; sin
embargo, esta combinación es costosa y requiere tiempo para análisis
rutinario.
Las decisiones quirúrgicas sobre la disección de
ganglio linfático regional pueden basarse en análisis de corte
congelado intra-operativo de ganglios linfáticos;
sin embargo, la sensibilidad de estos métodos es relativamente
mala, variando entre el 50-70% con respecto a la
anatomopatología de H&E convencional, conduciendo a una alta
tasa de segundas cirugías. Por tanto, los anatomopatólogos no están
realizando de forma rutinaria análisis de sección congelada
intra-operativo o análisis de citología de impronta
para pacientes con melanoma. Las mejoras en la sensibilidad y
especificidad de ensayos intra-operativos para
melanoma serían significativamente beneficiosas para la
oncología.
Se han aplicado micromatrices de alta densidad
para controlar simultáneamente la expresión, en muestras biológicas,
de miles de genes. Los estudios han dado como resultado la
identificación de genes expresados de forma diferencial en lesiones
benignas y malignas, así como genes que pueden ser de valor
pronóstico. Luo et al. (2001); y Wang et al. (2004).
Se ha conseguido el perfil de expresión génica de melanoma maligno
usando una micromatriz que contenía sondas para 8.150 ADNc. Bittner
et al. (2000). Estos investigadores identificaron varios
genes que pueden estar asociados con comportamiento agresivo de
tumor. En un trabajo reciente, la comparación de perfiles de
expresión génica de unas pocas líneas celulares de melanoma y
melanocitos normales ha conducido a la identificación de genes
expresados de forma diferencial y rutas moduladas en melanoma.
Takeuchi et al. (2004).
En la presente invención se proporciona el
perfil de expresión génica de un conjunto extenso de muestras
tisulares clínicamente pertinentes. El ARN total de cuarenta y
cinco melanomas malignos primarios, 18 nevos de piel benignos y 7
tejidos de piel normal se hibridaron en una micromatriz Affymetrix
Hu133A que contenía 22.000 conjuntos de sondas. Se identificaron
genes expresados de forma diferencial en melanoma maligno en
comparación con tejido benigno. El análisis de la ruta de los genes
expresados diferencialmente mostró una
sobre-representación de genes asociados con el
desarrollo de tejido neural y activación de ruta de señalización de
procesamiento de amiloide. Se usó un ensayo de
RT-PCR cuantitativa de una etapa para ensayar una
combinación de dos genes específicos de melanoma, PLAB y L1CAM en
un panel de muestras clínicamente pertinentes que incluía melanoma
maligno primario, nevos benignos, metástasis de GL de melanoma y
muestras de ganglios linfáticos sin melanoma.
La presente invención proporciona un método para
identificar un melanoma obteniendo una muestra tisular; y ensayando
y midiendo los niveles de expresión en la muestra de genes que
codifican ARNm correspondientes al factor de diferenciación de
próstata (PLAB, MIC1) (SEC ID Nº: 1) y molécula de adhesión a
células L1 (L1CAM) (SEC ID Nº: 2); o PLAB, L1CAM y receptor de
tirosina quinasa neurotrófica, tipo 3 (NTRK3) (SEC ID Nº: 3) donde
los niveles de expresión génica por encima de niveles límite
predeterminados son indicativos de la presencia de un melanoma en
la muestra y donde dichos niveles límite predeterminados tienen la
mayor puntuación en: muestras normales primarias; y/o muestras de
nevos benignos. La invención proporciona adicionalmente un método
para identificar un melanoma obteniendo una muestra tisular; y
ensayando y midiendo los niveles de expresión en la muestra de
genes que codifican ARNm reconocido por los conjuntos de
cebador/sonda SEC ID Nº: 4-6 o SEC ID Nº:
7-9 y SEC ID Nº: 10-12 o SEC ID Nº:
13-15; o SEC ID Nº: 4-6 o SEC ID Nº:
7-9 y SEC ID Nº: 10-12 o SEC ID Nº:
13-15 y SEC ID Nº: 16-18 donde los
niveles de expresión génica por encima de los niveles límite
predeterminados son indicativos de la presencia de un melanoma en
la muestra.
La solicitud también proporciona un método para
distinguir un melanocito maligno de un melanocito benigno
obteniendo una muestra tisular; y ensayando y midiendo los niveles
de expresión en la muestra de genes que codifican PLAB y L1CAM; o
PLAB, L1CAM y NTRK3, donde los niveles de expresión génica por
encima de niveles límite predeterminados son indicativos de la
presencia de un melanoma en la muestra.
La solicitud también proporciona un método para
distinguir un melanocito maligno de un melanocito benigno
obteniendo una muestra tisular; y ensayando y midiendo los niveles
de expresión en la muestra de genes reconocidos por los conjuntos
de cebador/sonda SEC ID Nº: 4-6 o SEC ID Nº:
7-9 y SEC ID Nº: 10-12 o SEC ID Nº:
13-15; o SEC ID Nº: 4-6 o SEC ID
Nº: 7-9 y SEC ID Nº: 10-12 o SEC ID
Nº: 13-15 y SEC ID Nº: 16-18, donde
los niveles de expresión génica por encima de niveles límite
predeterminados son indicativos de la presencia de un melanoma en
la muestra.
La solicitud proporciona adicionalmente un
método para determinar el protocolo de tratamiento del paciente
obteniendo una muestra tisular del paciente; y ensayando y midiendo
los niveles de expresión en la muestra de genes que codifican PLAB
y L1CAM; o PLAB, L1 CAM y NTRK3, donde los niveles de expresión
génica por encima de niveles límite predeterminados son indicativos
de la presencia de un melanoma en la muestra.
La solicitud proporciona adicionalmente un
método para determinar el protocolo de tratamiento de un paciente
obteniendo una muestra tisular del paciente; y ensayando y midiendo
los niveles de expresión en la muestra de genes reconocidos por los
conjuntos de cebador/sonda SEC ID Nº: 4-6 o SEC ID
Nº: 7-9 y SEC ID Nº: 10-12 o SEC ID
Nº: 13-15; o SEC ID Nº: 4-6 o SEC ID
Nº: 7-9 y SEC ID Nº: 10-12 o SEC ID
Nº: 13-15 y SEC ID Nº: 16-18, donde
los niveles de expresión génica por encima de niveles límite
predeterminados son indicativos de la presencia de un melanoma en
la muestra.
La solicitud proporciona además genes marcadores
y de control adicionales, cuya expresión ayuda a los métodos
reivindicados. Estos genes adicionales incluyen las SEC ID Nº:
29-467 reguladas positivamente y las SEC ID Nº:
468-978 reguladas negativamente.
El Marcador primario puede ser PLAB y se define
en este documento como el gen que codifica cualquier variante,
alelo, etc., incluyendo la SEC ID Nº: 1. PLAB también se describe
por Paralkar et al. (1998) y se representa por el Acceso Nº
AF003934. PLAB también se define como el gen que codifica ARNm
reconocido por los conjuntos de cebador/sonda SEC ID Nº:
4-9.
El Marcador secundario puede ser L1CAM y se
define en este documento como el gen que codifica cualquier
variante, alelo, etc. incluyendo la SEC ID Nº: 2. L1CAM también se
describe por Haspel et al (2003); y la Patente de Estados
Unidos Nº 6.107.476 y se representa por el Acceso Nº NM_000425.
L1CAM también se define como el gen que codifica ARNm reconocido
por los conjuntos de cebador/sonda SEC ID Nº:
10-15.
La solicitud proporciona adicionalmente un kit
para realizar un ensayo para determinar la presencia de melanoma en
una muestra celular que comprende: reactivos de amplificación y
detección de ácido nucleico.
La solicitud proporciona adicionalmente
conjuntos de cebador/sonda para la amplificación y detección de
productos de PCR obtenidos en los métodos inventivos. Estos
conjuntos incluyen lo siguiente:
- SEC ID Nº: 4
- (cebador directo de PLAB) ggcagaatcttcgtccgca
- SEC ID Nº: 5
- (cebador inverso de PLAB) ggacagtggtccccgttg
- SEC ID Nº: 6
- (sonda de PLAB) cccagctggagttgcacttgcggcc
- SEC ID Nº: 7
- (cebador superior de PLAB) gaacaccgacctcgtccc
- SEC ID Nº: 8
- (cebador inferior de PLAB) ggcggcccgagagata
- SEC ID Nº: 9
- (sonda de PLAB) cgccagaagtgcggctgggattt
- SEC ID Nº: 10
- (directo de L1CAM) gctgggactgggaacagaact
- SEC ID Nº: 11
- (Inverso de L1CAM) ggagcagagatggcaaagaaa
- SEC ID Nº: 12
- (sonda de L1CAM) ttccccaccatctgctgt
- SEC ID Nº: 13
- (superior de L1CAM) ccacagatgacatcagcctcaa
- SEC ID Nº: 14
- (inferior de L1CAM) ggtcacacccagctcttcctt
- SEC ID Nº: 15
- (sonda de L1CAM) tggcaagcccgaagtgcagttcctt
- SEC ID Nº: 16
- (cebador de NTRK3) gccccggcacccttta
- SEC ID Nº: 17
- (cebador de NTRK3) aaccctgccagtggtggat
- SEC ID Nº: 18
- (sonda de NTRK3) cagatgggtgttttc
- SEC ID Nº: 19
- (superior de Tyr) actcagcccagcatcattcttc
- SEC ID Nº: 20
- (inferior de Tyr) atggctgttgtactcctccaatc
- SEC ID Nº: 21
- (sonda de Tyr) cttctcctcttggcagattgtctgtagctt
- SEC ID Nº: 22
- (superior de PBGD) ccacacacagcctactttccaa
- SEC ID Nº: 23
- (inferior de PBGD) tacccacgcgaatcactctca
- SEC ID Nº: 24
- (sonda de PBGD) aacggcaatgcggctgcaacggcggaatt
\newpage
La solicitud proporciona adicionalmente
amplicones obtenidos por métodos de PCR utilizados en los métodos.
Estos amplicones incluyen los siguientes:
Otros genes descritos en este documento incluyen
Marcadores regulados positivamente (SEC ID Nº:
29-467), Marcadores regulados negativamente (SEC ID
Nº: 468-978), PBGD (SEC ID Nº: 979), MART1 (SEC ID
Nº: 980), ME20M (GP100; SEC ID Nº: 981) y MAGE-3
(SEC ID Nº: 982) y diversos cebadores y sondas (SEC ID Nº:
983-1011) usados para detectar su expresión.
Figura 1. Organigrama de análisis de datos.
Figura 2. Agrupamiento jerárquico de los 15.795
genes que tienen al menos dos lecturas "presentes" en todas
las muestras. Cada columna es una muestra y cada fila es un gen.
Rojo es regulación positiva y verde es regulación negativa.
Violeta: Muestras de melanoma; amarillo: nevos benignos; y azul:
piel normal.
Figura 3. Expresión en micromatriz (A) y datos
de validación de RT-PCR en tiempo real (B) de los
genes seleccionados. Las primeras catorce muestras de la izquierda
son las muestras tisulares de melanoma (rojo); las siguientes siete
son muestras de nevos benignos (amarillo) y las últimas cinco son
piel normal (azul). Para representaciones de micromatriz, el eje x
muestra los valores de intensidad; para representaciones de PCR, el
eje x es 2^{\Delta CT}, donde \DeltaCT es Ct (Gen Diana) - Ct
PBGD.
Figura 4. Ruta de procesamiento de amiloide.
Adoptado de la Aplicación de Software de Análisis de Ruta
Ingenuity^{TM}. Los genes regulados positivamente en melanoma son rojos y los regulados negativamente en melanoma son verdes. Cada símbolo de gen viene seguido del factor de cambio del nivel de expresión entre muestras de melanoma y benignas/normales.
Ingenuity^{TM}. Los genes regulados positivamente en melanoma son rojos y los regulados negativamente en melanoma son verdes. Cada símbolo de gen viene seguido del factor de cambio del nivel de expresión entre muestras de melanoma y benignas/normales.
Figura 5. Ensayo de RT-PCR
cuantitativa de una etapa de PLAB y L1CAM (A) y marcadores de
melanoma convencionales, gp100, tirosinasa (SEC ID Nº: 999) y MART1
(B). Para cada representación, el eje x representa la puntuación
para los nuevos marcadores o los marcadores convencionales. Las
puntuaciones medias para cada categoría de muestra están marcadas.
En cada representación se marcan dos niveles límite basados en
muestras normales (verde) y benignas (rojo).
La presente solicitud proporciona métodos para
identificar cualitativamente y cuantitativamente un melanoma;
distinguir un melanocito maligno de un melanocito benigno;
diagnosticar lesiones melanocíticas con características
anatomopatológicas inciertas; y determinar el protocolo de
tratamiento de un paciente con melanoma. Los métodos proporcionan
adicionalmente ayudas al pronóstico del paciente, control del
paciente y desarrollo de fármacos. Los métodos dependen de ensayar
y medir niveles de expresión de diversos genes Marcadores que
codifican ARNm proporcionados en este documento donde la expresión
génica por encima de un nivel límite predeterminado es indicativa
de la presencia de un melanocito maligno en la muestra ensayada.
El melanoma cutáneo es un cáncer agresivo, común
con incidencia creciente. La identificación de genes no regulados
específicos de melanoma podría proporcionar marcadores moleculares
para ensayos de estadificación de GL y una comprensión adicional de
oncogénesis de melanoma. Se analizó ARN total aislado de 45
melanomas primarios, 18 nevos de piel benignos y 7 muestras de
tejido de piel normal en una micromatriz Affymetrix U133A que
contenía 22.000 conjuntos de sondas. El agrupamiento jerárquico
mostró una separación distinta de las muestras de melanoma de
espécimenes benignos y normales. Se identificaron genes novedosos
asociados con melanoma maligno. La expresión génica diferencial de
dos genes específicos de melanoma, PLAB y L1CAM, se ensayó por un
ensayo de RT-PCR cuantitativa de una etapa en
melanoma maligno primario, nevos benignos y muestras de piel normal
y también en metástasis de GL de melanoma maligno y ganglios
linfáticos sin melanoma. El rendimiento de los marcadores se comparó
con marcadores de melanoma convencionales tales como tirosinasa,
gp100 y MART1. Los resultados demostraron la capacidad, mediante el
uso de una combinación de PLAB y L1CAM en un ensayo de
RT-PCR, de diferenciar muestras de tejido
clínicamente pertinentes que contiene melanocitos benignos o
malignos.
Las micromatrices de ADNc de alta densidad y de
oligonucleótidos también permiten el control simultáneo de la
expresión de miles de genes. La tecnología de micromatriz
proporciona una medición cuantitativa de la abundancia de ARNm y ha
conseguido aceptación como una herramienta para el descubrimiento de
marcador basado en expresión génica. En el contexto de
investigación de cáncer, el análisis de micromatriz ha identificado
genes expresados diferencialmente en lesiones benignas y malignas,
diferentes tipos de cáncer o que tienen importancia pronóstica. Luo
et al. (2001); Su et al. (2001); Henshall et
al. (2003); y Wang et al. (2004). La primera formación
de perfil de expresión génica de melanoma maligno usó una
micromatriz que contenía sondas para 8.150 ADNc e identificó genes
que pueden estar asociados con comportamiento agresivo de tumor.
Bittner et al. (2000). Ya que las muestras analizadas en su
estudio no incluyeron muestras que contenían melanocitos normales o
benignos, los genes expresados diferencialmente en melanoma maligno
no se identificaron. Por el contrario a piel normal, el contenido
de melanocitos en nevos benignos es próximo al de en melanoma.
En otro estudio, dos muestras combinadas
obtenidas de melanoma o tejidos de nevos benignos se hibridaron con
una matriz de ADNc y se encontraron genes expresados de forma
preferente en muestras obtenidas de melanoma o nevos. Seykora et
al. (2003). Otros investigadores usaron hibridación sustractiva
o análisis de genotecas de SAGE generadas en líneas celulares de
melanoma para controlar la expresión génica en melanoma. Hipfel
et al. (2000); y Weeraratna (2004). Recientemente, la
comparación de perfiles de expresión génica de unas pocas líneas
celulares de melanoma y melanocitos condujo a la identificación de
genes expresados diferencialmente y rutas moduladas en melanoma.
Hoek et al. (2004). Aunque estos estudios proporcionan una
base sólida para la genética del melanoma, no existe ningún marcador
que pueda diferenciar claramente el melanoma de tejido benigno.
Varios marcadores usados actualmente tales como tirosinasa y
Mart-1 no pueden diferenciar entre tejido benigno y
maligno. Takeuchi et al. (2004). En consecuencia, estos
marcadores tienen un uso limitado en aplicaciones tales como la
estadificación basada en ganglios linfáticos
intra-operativa de la enfermedad.
Las dificultades en la obtención de suficientes
muestras de ARN de lesiones de melanoma maligno y lesiones
melanocíticas benignas, heterogeneidad tisular y la presencia de
melanina en ARN purificado siguen siendo los principales problemas
en estos estudios. En el estudio presentado en este documento, el
ARN total aislado de 45 melanomas malignos primarios, 18 nevos de
piel benignos y 7 tejidos de piel normal se hibridaron en una
micromatriz Affymetrix Hu133A que contenía 22.000 conjuntos de
sondas. Se desarrolló un método de extracción de ARN modificado
para producir muestras de ARN sin melanina que aumentó las señales
de hibridación de micromatriz. El agrupamiento jerárquico mostró
una separación distinta de las muestras de melanoma de espécimenes
benignos y normales. El método de Análisis de Significación de
Micromatriz (SAM), el ensayo t y el análisis de percentiles
identificó 439 genes regulados positivamente (SEC ID Nº:
29-467) y 511 regulados negativamente (SEC ID Nº:
468-978) en las muestras de melanoma. Además de
genes bien caracterizados tales como me20m (gp100), receptor 1 de
melanocortina y L1CAM, se identificaron muchos genes novedosos
previamente no asociados con melanoma que incluían NTKR3 y PLAB. El
análisis de ruta de los genes expresados diferencialmente mostró una
sobre-representación de genes asociados con el
desarrollo y la función de tejido neural, activación de rutas de
señalización de procesamiento de amiloide e integrina. Se realizaron
ensayos de RT-PCR para confirmar la expresión
diferencial de los genes seleccionados.
Los métodos proporcionados tienen suficiente
especificidad y sensibilidad para detectar metástasis de melanoma.
Una comparación de los métodos disponibles actuales indica que los
métodos tradicionales de H&E e IHC son clínicamente aceptables,
mientras que, antes de la presente invención, los métodos de PCR
eran inaceptables. La Tabla 1 muestra las desventajas y ventajas de
los métodos actuales antes de la invención reivindicada en este
documento.
En la presente invención, la especificidad es
preferiblemente al menos el 95%, más preferiblemente, la
especificidad es al menos el 97% y mucho más preferiblemente, la
especificidad es al menos el 99% basándose en una comparación de
ganglios negativos en H&E e IHC. Preferiblemente, la
sensibilidad es al menos el 80%, más preferiblemente, la
sensibilidad es al menos el 85% y mucho más preferiblemente, la
sensibilidad es al menos el 90% basándose en una comparación de
ganglios positivos en H&E e IHC. Preferiblemente, la
especificidad y sensibilidad son al menos el 97% basándose en una
comparación de ganglios negativos en H&E e IHC y al menos el 85%
basándose en una comparación de ganglios positivos en H&E e
IHC, respectivamente.
Preferiblemente, los niveles límite
predeterminados tienen una sobre-expresión de al
menos dos veces en tejido que tiene melanoma metastásico con
respecto a melanocito benigno o tejido normal.
Los métodos preferidos de la solicitud emplean
una técnica rápida para extraer ácidos nucleicos de una muestra
tisular y un método para amplificar y detectar fragmentos de ácido
nucleico indicativos de metástasis. Los fragmentos de ácido
nucleico miden cualitativamente y cuantitativamente el ARNm
codificado por los genes Marcadores. Las muestras tisulares
incluyen ganglio linfático, tanto regional como centinela, lesiones
de piel y otro material de biopsia.
Los métodos proporcionados en este documento
permiten la detección intra-operativa de
micrometástasis permitiendo que un médico determine si debe
extirpar ganglios linfáticos adicionales e implementar
inmediatamente un protocolo de tratamiento apropiado. Como se
muestra en la Tabla 2, si se observa que un GL es positivo para
melanoma, los GL regionales se extirpan y se podría sugerir la
terapia con interferón. Los métodos de biopsia convencionales
pueden requerir más de una semana y un resultado positivo requiere
cirugía adicional para eliminar los GL y existe un retraso
concomitante en la terapia con interferón.
Es importante muestrear adecuadamente el tejido
usado para realizar el ensayo. Esto incluye la extirpación
apropiada y el procesamiento de la muestra tisular así como la
extracción de ARN. Una vez obtenidas, es importante procesar las
muestras tisulares de forma apropiada de tal forma que se detecte
cualquier célula cancerosa presente.
En la realización más preferida, al muestreo de
ganglios también se presta atención tanto intra- como
extra-operativamente. Ya que la distribución de
células cancerosas en ganglios no es uniforme, es preferible que se
muestreen múltiples secciones del ganglio. Cada GLC identificado se
debe remitir para evaluación anatomopatológica. El material de GLC
normalmente se fija en formalina y se examina como muestra tisular
fijada con formalina, incluida en parafina. Las partes
representativas de forma equitativa de GLC se procesan para análisis
molecular (tejido fresco) e histología (tejido fijado). Los
procedimientos de muestreo de GL generales se describen en Cochran
et al. (2001); y Cochran et al. (2004). Un método para
conseguir tanto un ensayo basado en aspectos moleculares como un
examen de la misma muestra de ganglio por anatomopatología es
bisecar el ganglio por el diámetro más largo. Después, cada mitad
se divide en al menos cuatro secciones de cara completa con al
menos una sección externa e interna para anatomopatología como
material fijado y al menos una sección externa e interna para
ensayo molecular. Ya que la distribución de metástasis y
micrometástasis no es uniforme en ganglios u otros tejidos, se debe
obtener una muestra lo suficientemente grande de tal forma que no se
omitan las metástasis. Una estrategia para este aspecto de muestreo
en el presente método es homogeneizar una gran muestra tisular y
realizar posteriormente una dilución de la muestra homogeneizada
bien mezclada a usar en el ensayo molecular posterior.
En el caso de muestras tisulares de GL, es
preferible eliminar cualquier tejido adiposo antes de la ruptura
celular. La ruptura manual de celdas y tejidos puede ser mediante
cualquier medio conocido en la técnica tal como una picadora de
tejido desechable descrita en la Patente de Estados Unidos Nº
4.715.545 o un homogeneizador comercial tal como Omni GLH115 con
sondas desechables (Ovni International, Warrenton, VA). El tiempo de
homogeneización es de 1 a 2 minutos y es más preferiblemente
30-45 s. Después, la muestra se puede procesar para
purificar el ARN antes de ensayar y medir los niveles de expresión
de Marcador. Los métodos de purificación de ARN adecuados incluyen
columnas tales como (por ejemplo, mini columna RNeasy, QIAshredder,
QIAGEN Inc., Valencia, CA o un sustituto adecuado).
Está disponible una diversidad de técnicas para
extraer ácidos nucleicos de muestras tisulares. Los kits de
extracción de ácido nucleico disponibles en el mercado típicos
requieren al menos 15 minutos para extraer el ácido nucleico. En
los métodos intra-operativos preferidos, el ácido
nucleico se extrae en menos de 8 minutos y preferiblemente menos de
6 minutos.
El aislamiento exitoso de ARN intacto implica
generalmente cuatro etapas: ruptura eficaz de células o tejido,
desnaturalización de complejos de nucleoproteína, inactivación de
ribonucleasa endógena (RNasa) y retirada de ADN y proteína
contaminantes. Las propiedades de ruptura y protectoras de
isotiocianato de guanidinio (GITC) y
\beta-mercaptoetanol (\beta-me)
para inactivar las ribonucleasas presentes en extractos celulares
hace que los mismos sean reactivos preferidos para la primera
etapa. Cuando se usan junto con un tensioactivo tal como
dodecilsulfato sódico (SDS), la ruptura de complejos de
nucleoproteínas se consigue dejando que el ARN se libere a la
solución y se aísle sin proteína. Los tejidos se homogeneizan en el
tampón de lisis que contiene GITC, la adición de etanol crea las
condiciones apropiadas para que el ARN se una a la membrana de
sílice. La centrifugación puede aclarar el lisado de proteínas
precipitadas y ADN celular y se realiza preferiblemente por una
columna. La purificación de ARN se realiza preferiblemente en una
columna spin que contiene sílice u otro material.
El ARN se precipitaba por la columna spin como
se ha descrito anteriormente y los tiempos de centrifugación
preferiblemente no son superiores a 30 s. Típicamente, la muestra se
diluye con un volumen igual de etanol al 70% y se mezcla
minuciosamente antes de la aplicación a la columna. Después del
lavado, la columna se seca por centrifugación y el ARN se eluye en
agua sin RNAsa y se recoge por centrifugación. El tiempo total de
este protocolo rápido es inferior a 8 minutos y preferiblemente
inferior a 6 min.
En resumen, el método de extracción de ARN
rápido implica las siguientes etapas:
- obtener una muestra tisular;
- homogeneizar el tejido para producir un homogeneizado;
- poner en contacto el homogeneizado con un sustrato que contiene, o al que se fija, un material de unión a ARN;
- permitir que el ARN se una al material de unión a ARN;
- lavar el sustrato en condiciones suficientes para retirar cualquier contaminante, interferentes y ARN no unido; y
- eluir el ARN unido del sustrato.
Los reactivos implicados en este proceso de
extracción rápida pueden ser los proporcionados por el fabricante o
pueden ser, por ejemplo:
- Tampón de Lisis-Unión (preferiblemente, GITC 4,5 M, NaPO_{4}100 mM),
- Tampón de lavado I (preferiblemente, etanol al 37% en GITC 5 M, Tris-HCl 20 mM),
- Tampón de lavado II (preferiblemente, etanol al 80% en NaCl 20 mM, Tris-HCl 2 mM), y
- Agua doblemente destilada estéril sin nucleasa para la elución.
En un método, antes del proceso para aislar los
ácidos nucleicos que se han descrito anteriormente, las muestras
titulares se pesan y se ponen en tubos de cultivo de polipropileno
de 8 ó 14 ml y se pre-enfrían en hielo seco. Las
muestras tisulares congeladas se dividen después en trozos de
aproximadamente 50 mg o menos sin descongelarse. Todos los tampones
son los proporcionados por QIAGEN en el mini kit RNeasy. Se añade un
volumen de tampón de homogeneización (lisis) al tejido basándose en
la Tabla 3.
Después, la muestra tisular se homogeneiza, por
ejemplo, por el Omni GLH115 con un ajuste de potencia en grado 6,
Adaptor A1000 y sondas desechables. Después, el homogeneizado se
mezcla con un volumen igual de etanol al 70% y se mezcla
minuciosamente, por ejemplo, agitando vorticialmente en un VWR
Modelo G560 ajustado en velocidad 10 (máxima) aproximadamente 10
segundos o pipeteando 4-5 veces. La mezcla de
homogeneizado/etanol se aplica después a una minicolumna RNeasy
montada en un colector de vacío en un volumen de acuerdo con la
Tabla 4 de tal forma que se carga una cantidad uniforme del tejido
original (aproximadamente 5 mg/columna) produciendo, por tanto,
rendimientos de ARN comparables para cada muestra tisular.
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Después se aplica un vacío a la columna para
eliminar el líquido. El vacío se detiene y se aplican dos lavados
de 700 ml, en primer lugar con tampón RWI y en segundo lugar con
tampón RPE retirado cada uno por filtración. El vacío es a
800-1200 mBar en cada caso. Después, la columna se
pone en un tubo de recogida de 1,5 ml y se centrífuga en una
centrífuga Eppendorf 5415D a 13.200 rpm durante 30 segundos para el
secado. La columna se transfiere a un nuevo tubo de recogida de 1,5
ml. Se añaden directamente cincuenta \mul de agua sin RNasa a la
membrana y la columna se centrífuga en una centrífuga Eppendorf
5415D durante 30 segundos a 13.200 rpm para eluir el ARN. La
calidad de ARN se determina con un Bionalizador Agilent y el ARN se
almacena a -70ºC.
La melanina puede afectar negativamente a la
eficacia de las reacciones de transcripción inversa y amplificación.
En consecuencia, se realiza un proceso de retirada de melanina
cuando se sospecha que la muestra contiene una cantidad
significativa de melanina (como en el caso de muestras de un
melanoma primario o nevos de piel benignos) y es menos una
preocupación cuando se realiza el ensayo en un GLC, ya que el
contenido de melanocitos es bajo. Si es necesario, la melanina se
elimina para mejorar la transcripción inversa y/o la amplificación
de ácido nucleico.
Típicamente, la melanina se retira durante las
etapas de filtración que se han proporcionado anteriormente. En el
caso de tejido con alta concentración de melanina, se debe usar
menos tejido, aproximadamente 5 mg por mini columna RNeasy de
Qiagen.
Si se usa otro método que da con resultado
melanina residual en la muestra, la eliminación implica el uso de
una matriz que emplea un sistema de perlas poliméricas tal como
Bio-Gel P-60
(Bio-Rad Laboratories, Hercules, CA). Un método de
este tipo se describe por Satyamoorthy et al. (2002).
Esencialmente, este método implicar preparar una mezcla al 50%
(p/v) del material de Bio-Gel en acetato sódico 10
mM (pH 4,2). Aproximadamente 300 \mul de la mezcla se ponen en un
tubo de microcentrífuga y se centrifugan a 1000 rpm durante 1 min.
Se desecha el sobrenadante y las perlas se ponen en una
mini-columna o recipiente similar. Después, el
homogeneizado se pasa a través del recipiente que contiene las
perlas (después de incubar las mismas en el recipiente). Se recoge
el sobrenadante. El lavado adicional de las perlas con alícuotas de
100 \mul adicionales de acetato sódico 10 mM se puede usar para
capturar volúmenes adicionales de muestra sin melanina si fuera
necesario para el volumen adecuado de ensayo. La melanina oscura
será claramente visible sobre las perlas retenidas en el
recipiente. También se pueden usar otros filtros basados en sílice
para retirar el pigmento de melanina como se describe por Wang
et al. (2001).
Un aspecto importante de los métodos
intra-operativos es la detección rápida de Marcador.
Suponiendo que tales métodos se puedan realizar en el intervalo de
un periodo aceptable para un ensayo intra-operativo
(es decir, no más de aproximadamente 35 minutos), se puede usar
cualquier método fiable, sensible y específico.
En el caso de la medición de niveles de ARNm
para determinar la expresión génica, los ensayos pueden ser mediante
cualquier medio conocido en la técnica e incluyen métodos tales
como PCR, Amplificación por Círculo Rodante (RCA), Reacción en
Cadena de la Ligasa (LCR), Amplificación por Desplazamiento de
Cadena (SDA), Amplificación Basada en Secuencia de Ácido Nucleico
(NASBA) y otros. Los diagnósticos moleculares rápidos implicados son
muy preferiblemente métodos de PCR cuantitativa, incluyendo
QRT-PCR. La detección puede ser mediante cualquier
medio conocido en la técnica, incluyendo micromatrices, chips
génicos y fluorescencia.
Una PCR típica incluye múltiples etapas de
amplificación o ciclos que amplifican selectivamente especies de
ácido nucleico diana. Una PCR típica incluye tres etapas: una etapa
desnaturalizante en la que se desnaturaliza un ácido nucleico
diana; una etapa de hibridación en la que un conjunto de cebadores
de PCR (cebadores directo e inverso) hibridan con cadenas de ADN
complementarias; y una etapa de elongación en la que una ADN
polimerasa termoestable prolonga los cebadores. Repitiendo esta
etapa múltiples veces se amplifica un fragmento de ADN para
producir un amplicón, correspondiente a la secuencia de ADN diana.
La PCR típica incluye 20 o más ciclos de desnaturalización,
hibridación y elongación. A menudo, las etapas de hibridación y
elongación se pueden realizar de forma simultánea, en cuyo caso, el
ciclo contiene solamente dos etapas.
En el método preferido, que emplea
RT-PCR, la reacción de amplificación por
RT-PCR se realiza en un tiempo adecuado para
diagnóstico intra-operativo, las duraciones de cada
una de estas etapas pueden estar en el intervalo de segundos, en
vez de minutos. Específicamente, siendo ciertos termocicladores
nuevos capaces de generar una velocidad de incremento térmico de al
menos aproximadamente 5ºC por segundo, se usan amplificaciones por
RT-PCR en 30 minutos o menos. Más preferiblemente,
las amplificaciones se realizan en menos de 25 minutos. Con esto en
mente, los siguientes tiempos proporcionados para cada etapa de
ciclo de PCR no incluyen tiempos de incremento. La etapa de
desnaturalización se puede realizar durante tiempos de 10 segundos o
menos. De hecho, algunos termocicladores tienen ajustes para "0
segundos" que puede ser la duración óptima de la etapa de
desnaturalización. Es decir, es suficiente que el termociclador
alcance la temperatura de desnaturalización. Las etapas de
hibridación y elongación son muy preferiblemente inferiores a 10
segundos cada uno y, cuando se realizan a la misma temperatura, la
combinación de etapa de hibridación/elongación puede ser inferior a
10 segundos. Algunos métodos de detección de sonda homogénea pueden
requerir una etapa separada para la elongación para maximizar el
rendimiento de ensayo rápido. Para minimizar tanto el tiempo total
de amplificación como la formación de reacciones secundarias no
específicas, las temperaturas de hibridación están típicamente por
encima de 50ºC. Más preferiblemente, las temperaturas de hibridación
están por encima de 55ºC.
Una reacción combinada única para
RT-PCR, sin intervención del investigador, es
deseable por varios motivos: (1) riesgo disminuido de error de
investigador; (2) riesgo disminuido de contaminación de diana o
producto; y (3) velocidad de ensayo aumentada. La reacción puede
consistir en una o dos polimerasas. En el caso de dos polimerasas,
una de estas enzimas típicamente es una ADN polimerasa en basada en
ARN (transcriptasa inversa) y una es una ADN polimerasa basada en
ADN termoestable. Para maximizar el rendimiento del ensayo, es
preferible emplear una forma de tecnología de "inicio en
caliente" para estas dos funciones enzimáticas. Las Patentes de
Estados Unidos Nº 5.411.876 y 5.985.619 proporcionan ejemplos de
diferentes estrategias de "inicio en caliente". Los métodos
preferidos incluyen el uso de uno o más métodos de termoactivación
que secuestran uno o más de los componentes requeridos para la
polimerización eficaz de ADN. Las Patentes de Estados Unidos Nº
5.550.044 y 5.413.924 describen métodos para preparar reactivos
para el uso en tales métodos. La Patente de Estados Unidos Nº
6.403.341 describe una estrategia de secuestro que implica la
alteración química de uno o de los componentes de reactivo de PCR.
En la realización más preferida, ambas actividades de polimerasa
dependientes de ARN y ADN residen en una única enzima. Otros
componentes que se requieren para la amplificación eficaz incluyen
nucleósidos trifosfato, sales divalentes y componentes de tampón. En
algunos casos, pueden ser beneficiosos ácido nucleico no específico
y estabilizantes de enzima.
En la RT-PCR preferida, las
cantidades de cierta transcriptasa inversa y los componentes de PCR
son atípicas para beneficiarse de los tiempos de incremento más
rápidos de algunos termocicladores. Específicamente, las
concentraciones de cebador son muy altas.
Las concentraciones de cebador específico de gen
típicas para las reacciones de transcriptasa inversa son inferiores
a aproximadamente 20 nM. Para conseguir una reacción de
transcriptasa inversa rápida del orden de uno a dos minutos, la
concentración de cebador de transcriptasa inversa se aumenta hasta
más de 20 nM, preferiblemente al menos aproximadamente 50 nM y
típicamente aproximadamente 100 nM. Las concentraciones de cebador
de PCR convencionales varían de 100 nM a 300 nM. Se pueden usar
concentraciones mayores en PCR convencional para compensar
variaciones de Tm. Sin embargo, para los propósitos de este
documento, las concentraciones de cebador a las que se ha hecho
referencia son para circunstancias en las que no se necesita ninguna
compensación de Tm. Se pueden determinar empíricamente
concentraciones proporcionalmente superiores de cebadores y usar si
se necesita o desea la compensación de Tm. Para conseguir una PCR
rápida, las concentraciones de cebador de PCR son típicamente
superiores a 250 nM, preferiblemente superiores a aproximadamente
300 nM y típicamente aproximadamente 500 nM.
Los diagnósticos usados comercialmente también
emplean preferiblemente uno o más controles positivos internos que
confirman el funcionamiento de una reacción de amplificación
particular en el caso de un resultado negativo. Las causas
potenciales de resultados de falsos negativos que se tienen que
controlar en una RT-PCR incluyen: cantidad de ARN
inadecuada, degradación de ARN, inhibición de RT y/o PCR y error del
investigador.
En el caso de medir niveles de proteína para
determinar la expresión génica, cualquier método conocido en la
técnica es adecuado suponiendo que de como resultado especificidad y
sensibilidad adecuadas. Por ejemplo, los niveles de proteína se
pueden medir por unión a un anticuerpo o fragmento de anticuerpo
específico para la proteína y midiendo la cantidad de proteína
unida a anticuerpo. Los anticuerpos se pueden marcar con reactivos
radioactivos, fluorescentes u otros detectables para facilitar la
detección. Los métodos de detección incluyen, sin limitación,
ensayo inmunoabsorbente ligado a enzimas (ELISA) y técnicas de
inmunotransferencia.
La invención proporciona especificidad y
sensibilidad suficientes para identificar un melanocito maligno en
una muestra tisular. Los métodos determinan la expresión de genes
Marcadores particularmente midiendo el ARNm codificado por los
Marcadores. Los Marcadores preferidos de la invención muestran una
sobre-expresión de al menos dos veces en el tejido
que tiene melanocitos malignos con respecto a melanocito benigno o
tejido normal. Los resultados presentados en este documento
muestran que un Marcador primario es insuficiente para proporcionar
información clínicamente pertinente, pero que, cuando se combina con
uno o más Marcadores secundarios, la información obtenida se
compara con el "patrón de oro" de H&E e IHC del que
actualmente dependen los médicos. Los Marcadores terciarios y los
genes de control pueden aumentar los Marcadores primarios y
secundarios para aumentar adicionalmente la especificidad y/o
sensibilidad.
Como se describe en los siguientes Ejemplos, los
Marcadores se identificaron por el protocolo ilustrado en la Figura
1. Por tanto, la invención proporciona un método para identificar
Marcadores específicos de melanoma siguiendo el protocolo en la
Figura 1 y los Ejemplos proporcionados en este documento.
El Marcador primario puede ser PLAB y se define
en este documento como el gen que codifica cualquier variante,
alelo, etc., incluyendo la SEC ID Nº: 1. PLAB también se describe
por Paralkar et al. (1998) y se representa por el Nº de
Acceso AF003934. PLAB está ligado a la patogenia de cáncer de
próstata (Liu et al (2003); Karan et al. (2003); y
Nakamura et al. (2003); Patentes de Estados Unidos Nº
5.994.102; 6.107.476; 6.465.181; 6.500.638; 6.521.227; Publicaciones
de Patente de Estados Unidos Nº 2002/0048784; 2003/0013097; y
2003/0059431) y cáncer colorrectal (Brown et al. (2003);
Buckhaults et al. (2001); y Publicación de Patente de
Estados Unidos Nº 2002/0160382).
El Marcador secundario es L1CAM y se define en
este documento como el gen que codifica cualquier variante, alelo,
etc. incluyendo la SEC ID Nº: 2. L1CAM también se describe por
Haspel et al (2003); y las Patentes de Estados Unidos Nº
5.872.225; y 5.969.124 y se representa por el Nº de Acceso
NM_000425.
La invención proporciona adicionalmente
marcadores terciarios que se incluyen en varias categorías
funcionales. Por tanto, se pueden usar Marcadores adicionales que
se encuentran en estas categorías funcionales. Como se describe con
más detalle en los Ejemplos, los genes regulados positivamente
específicos de melanoma entran dentro de las categorías funcionales
de desarrollo de tejido nervioso y control de ciclo celular y los
genes regulados negativamente específicos de melanoma entran dentro
de las categorías funcionales de desarrollo tisular y
diferenciación celular.
Los Marcadores terciarios incluyen las SEC ID
Nº: 3, 29-978 y 999. Varios marcadores terciarios se
describen en la Tabla 5 y se resumen todos en la Tabla 15.
El NTRK3 se describe por Strausberg et
al. (2002); Marchetti et al. (2003); Hisaoka et
al. (2002); McGregor et al. (1999); Ryden et al.
(1996); Patentes de Estados Unidos Nº 5.348.856; 5.844.092;
5.910.574; y las Publicaciones de Patente de Estados Unidos Nº
2002/0155480; y 2003/014283 y se representa por el Nº de Acceso
BC013693 o S76476.1. NTRK3 también se define como el gen que
codifica ARNm reconocido por los conjuntos de cebador/sonda SEC ID
Nº: 16-18.
La tirosinasa se describe por
Mandelcorn-Monson et al. (2003); y la Patente
de Estados Unidos Nº 6.153.388 y se representa por el Nº de Acceso
NM_000372. La tirosinasa también se define como el gen que codifica
ARNm reconocido por los conjuntos de cebador/sonda SEC ID Nº:
19-21.
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Los Marcadores terciarios son capaces de
sustituir y/o suplementar los Marcadores primarios o secundarios
suponiendo que los ensayos resultantes tengan sensibilidad y
especificidad adecuadas.
La especificidad de cualquier diagnóstico
molecular basado en amplificación dado depende en gran medida, pero
no exclusivamente, de la identidad de los conjuntos de cebador. Los
conjuntos de cebador son pares de cebadores oligonucleotídicos
directos e inversos que hibridan con una secuencia de ADN diana para
permitir la amplificación de la secuencia diana, produciendo de
este modo un amplicón específico de secuencia diana. Los cebadores
tienen que ser capaces de amplificar Marcadores de la patología de
interés. En el caso de la presente invención, estos Marcadores se
dirigen a melanoma.
La reacción también tiene que contener algún
medio de detección de una señal específica. Esto se consigue
preferiblemente mediante el uso de un reactivo que detecta una
región de secuencia de ADN obtenida de la polimerización de la
secuencia diana de interés. Los reactivos preferidos para la
detección proporcionan una señal medible diferencial cuando se unen
a una secuencia de ácido nucleico específica de interés. A menudo,
estos métodos implican sondas de ácido nucleico que dan una
fluorescencia aumentada cuando se unen a la secuencia de interés.
Típicamente, el avance de las reacciones en los métodos inventivos
se controla analizando las velocidades relativas de producción de
amplicón para cada conjunto de cebador de PCR.
La solicitud incluye adicionalmente conjuntos de
cebador/sonda y su uso en los métodos reivindicados. Las secuencias
son:
- SEC ID Nº: 4
- (cebador directo de PLAB) ggcagaatcttcgtccgca
- SEC ID Nº: 5
- (cebador inverso de PLAB) ggacagtggtccccgttg
- SEC ID Nº: 6
- (sonda de PLAB) cccagctggagttgcacttgcggcc
- SEC ID Nº: 7
- (cebador superior de PLAB) gaacaccgacctcgtccc
- SEC ID Nº: 8
- (cebador inferior de PLAB) ggcggcccgagagata
- SEC ID Nº: 9
- (sonda de PLAB) cgccagaagtgcggctgggattt
- SEC ID Nº: 10
- (directo de L1CAM) gctgggactgggaacagaact
- SEC ID Nº: 11
- (Inverso de L1CAM) ggagcagagatggcaaagaaa
- SEC ID Nº: 12
- (sonda de L1CAM) ttccccaccatctgctgt
- SEC ID Nº: 13
- (superior de L1CAM) ccacagatgacatcagcctcaa
- SEC ID Nº: 14
- (inferior de L1CAM) ggtcacacccagctcttcctt
- SEC ID Nº: 15
- (sonda de L1CAM) tggcaagcccgaagtgcagttcctt
- SEC ID Nº: 16
- (cebador de NTRK3) gccccggcacccttta
- SEC ID Nº: 17
- (cebador de NTRK3) aaccctgccagtggtggat
- SEC ID Nº: 18
- (sonda de NTRK3) cagatgggtgttttc
- SEC ID Nº: 19
- (superior de Tyr) actcagcccagcatcattcttc
- SEC ID Nº: 20
- (inferior de Tyr) atggctgttgtactcctccaatc
- SEC ID Nº: 21
- (sonda de Tyr) cttctcctcttggcagattgtctgtagctt
- SEC ID Nº: 22
- (superior de PBGD) ccacacacagcctactttccaa
- SEC ID Nº: 23
- (inferior de PBGD) tacccacgcgaatcactctca
- SEC ID Nº: 24
- (sonda de PBGD) aacggcaatgcggctgcaacggcggaatt
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El control de la producción de amplicón se puede
conseguir mediante varios reactivos y métodos de detección, que
incluyen, sin limitación, cebadores fluorescentes y sondas
fluorógenas y colorantes fluorescentes que se unen a ADN
bicatenario. También se pueden usar sondas fluorescentes, Scorpions
y otros esquemas de detección. Un método común de controlar una PCR
emplea un ensayo de sonda de hidrólisis fluorescente. Este método
utiliza la actividad nucleasa 5' de ciertas ADN polimerasas
termoestables (tales como ADN polimerasas Taq o Tfl) para escindir
una sonda oligomérica durante el proceso de PCR.
A continuación se proporcionan amplicones
obtenidos mediante métodos de PCR utilizados en los métodos
inventivos. Estos amplicones incluyen lo siguiente:
El oligómero se selecciona para hibridar con la
secuencia diana amplificada en condiciones de elongación. La sonda
tiene típicamente un indicador fluorescente en su extremo 5' y un
extintor de fluorescencia del indiciador en el extremo 3'. Siempre
que el oligómero esté intacto, la señal fluorescente del indicador
se extingue. Sin embargo, cuando el oligómero se digiere durante el
proceso de elongación, el indicador fluorescente ya no está en
proximidad del extintor. La acumulación relativa de indicador
fluorescente libre para un amplicón dado se puede comparar con la
acumulación de los mismos amplicones para una muestra de control y/o
con la de un gen de control, tal como, sin limitación,
\beta-Actina o PBGD para determinar la abundancia
relativa de un producto de ADNc dado de un ARN dado en una
población de ARN. Los productos y reactivos para el ensayo con
sonda de hidrólisis fluorescente están fácilmente disponibles en el
mercado, por ejemplo, en Applied Biosystems.
Los reactivos de detección adecuados se
denominan comúnmente "Scorpions" y se describen en las Patentes
de Estados Unidos 6.326.145 y 5.525.494. Estos reactivos incluyen
una o más moléculas que comprenden un cebador con cola y un sistema
de señalización integrado. El cebador tiene una región de unión a
molde y una cola que comprende un enlazador y una región de unión a
diana. La región de unión a diana en la cola hibrida con la
secuencia complementaria en un producto de extensión del cebador.
Este acontecimiento de hibridación específica de diana está
acoplado a un sistema de señalización en el que la hibridación
conduce a un cambio detectable. En la PCR, la región de unión a
diana y la región de cola se disponen ventajosamente de tal forma
que la región de cola permanece monocatenaria, es decir, no
copiada. Por lo tanto, la región de cola no es amplificable en los
productos de amplificación por PCR. El enlazador comprende un resto
de bloqueo que evita la extensión de cadena mediada por polimerasa
en el molde de cebador.
Los reactivos de detección más preferidos son
sondas TaqMan® (Roche Diagnostics, Branchburg, NJ) y se describen
en las Patentes de Estados Unidos 5.210.015; 5.487.972; y 5.804.375.
Esencialmente, estas sondas implican la detección de ácido nucleico
mediante la separación de una combinación de
fluor-extintor en una sonda por la actividad
exonucleasa 5'-3' de la polimerasa usada en la PCR.
Se puede usar cualquier fluoróforo adecuado para cualquiera de los
Marcadores o controles. Tales fluoróforos incluyen, sin limitación,
Texas Red, Cal Red, Fam, Cy3 y Cy5. En una realización, los
siguientes fluoróforos se corresponden a los Marcadores indicados:
PLAB: Fam; L1CAM: Texas Red o Cal Red, tirosinasa: C1; PBGD:
Cy5.
El equipamiento y software también están
fácilmente disponibles para controlar y supervisar la acumulación
de amplicón en PCR y QRT-PCR incluyendo el
termociclador Smart Cycler disponible en el mercado en Cepheid de
Sunnyvale, California y el Sistema de Detección de Secuencia ABI
Prism 7700, disponible en el mercado en Applied Biosystems.
En el caso de ensayos de expresión génica, es
preferible usar un gen expresado constitutivamente en el tejido de
interés. El PBGD se usa comúnmente como un control interno debido a
varios factores: no contiene pseudogenes conocidos en seres
humanos, se expresa constitutivamente en tejidos humanos y se
expresa a un nivel relativamente bajo y, por lo tanto, es menos
probable que provoque inhibición de la amplificación de secuencias
diana de interés. El uso de PBGD como un control minimiza o elimina
el informe de resultados erróneos que surgen de todas las
potenciales fuentes de resultados de falsos negativos.
En la comercialización de los métodos descritos
para QRT-PCR, ciertos kits para la detección de
ácidos nucleicos específicos son particularmente útiles. En una
realización, el kit incluye reactivos para amplificar y detectar
Marcadores. Opcionalmente, el kit incluye reactivos de preparación
de muestra u otros artículos (por ejemplo, tubos) para extraer
ácidos nucleicos de tejido de ganglio linfático. Los kits también
pueden incluir artículos para minimizar el riesgo de contaminación
de la muestra (por ejemplo, bisturí desechable y superficie para
disección y preparación de ganglio linfático).
En un kit preferido, se incluyen reactivos
necesarios para el proceso de QRT-PCR de un tubo que
se ha descrito anteriormente tales como transcriptasa inversa, un
cebador de transcriptasa inversa, un conjunto de cebador de PCR
correspondiente (preferiblemente para Marcadores y controles), una
ADN polimerasa termoestable, tal como una polimerasa de Taq y un
reactivo o reactivos de detección adecuados, tales como, sin
limitación, una sonda scorpion, una sonda para un ensayo con sonda
de hidrólisis fluorescente, una sonda fluorescente, un cebador de
colorante único o un colorante fluorescente específico para ADN
bicatenario, tal como bromuro de etidio. Los cebadores están
preferiblemente en cantidades que proporcionan las altas
concentraciones que se han descrito anteriormente. Las ADN
polimerasas termoestables están disponibles comúnmente y en el
mercado en una diversidad de fabricantes. Los materiales
adicionales en el kit pueden incluir: tubos o viales de reacción
adecuados, una composición de barrera, típicamente una perla de
cera, que incluye opcionalmente magnesio, mezclas de reacción
(típicamente 10X) para las etapas de transcriptasa inversa y PCR,
incluyendo los tampones y reactivos necesarios tales como dNTP;
agua sin nucleasa o RNasa; inhibidor de RNasa; ácido o ácidos
nucleicos de control y/o cualquier tampón, compuesto,
co-factor, constituyente iónico, proteína y enzima,
polímero adicionales y similares que se pueda usar en etapas de
transcriptasa inversa y/o de PCR de QRT-PCR.
Opcionalmente, los kits incluyen reactivos y materiales para la
extracción de ácido nucleico. También se incluyen preferiblemente
instrucciones en los kits.
Los siguientes ejemplos se proporcionan para
ilustrar, pero no para limitar, la invención reivindicada.
Se obtuvieron muestras de melanoma maligno
congelado fresco, nevos de piel de benignos, piel normal, metástasis
de ganglio linfático de melanoma y ganglio linfático sin melanoma
en Genomics Collaborative, Inc. (Cambridge, MA), Asterand (Detroit,
Ml), Clinomics (Pittsfield, MA) y Proteogenex (Los Angeles, CA),
Ardais (Lexington, MA) e Impath (West-borough, MA).
Todos los vendedores de tejido declararon que las muestras tisulares
usadas en el estudio se recogieron de acuerdo con una protocolo
aprobado por la Comisión de Revisión Institucional de hospitales
correspondientes y principios de bioética. También se recogió la
información demográfica y anatomopatológica del paciente. Las
características histopatológicas de cada muestra se revisaron para
confirmar el diagnóstico y para estimar la conservación y el
contenido del tumor de la muestra.
Los tejidos primarios con melanoma y nevos
benignos elegidos para el análisis en micromatriz tenían un
contenido de melanocitos superior al 50% sin histología mixta. Los
ganglios linfáticos positivos a melanoma se recogieron de pacientes
con melanoma maligno; el diagnóstico de melanoma se confirmó por
H&E en combinación con IHC (S100 y HMB45). Los ganglios
linfáticos sin melanoma se obtuvieron de pacientes que no tenían
melanoma en su historial clínico y la ausencia de melanoma se
confirmó por H&E e IHC usando anticuerpos para S100 y HMB45.
Se usó el ARN de un total de 70 muestras de
tejido primarias para la formación del perfil de expresión génica y
la identificación de gen específico de melanoma. Las muestras
incluyeron 45 melanomas malignos primarios, 18 nevos de piel
benignos y 7 tejidos de piel normal. La mayoría de melanomas
primarios incluidos en el estudio representan un estadio temprano
de la enfermedad y tienen un grosor inferior a 4 mm, lo que
concuerda con la población de paciente con melanoma convencional.
Aitken et al. (2004). Las características demográficas,
clínicas y de anatomopatología del paciente se presentan en la Tabla
6 y se resumen en la Tabla 7.
Además, 77 metástasis de GL de melanoma maligno
y 18 muestras tisulares de GL sin melanoma se usaron para el ensayo
de PCR cuantitativa de una etapa. Los ganglios linfáticos positivos
a melanoma incluyeron los ganglios linfáticos axilar, cervical e
inguinal con metástasis producida por melanomas primarios de células
epitelioides y fusiformes. De los 18 GL sin melanoma, se recogieron
10 de otros pacientes con cáncer pero no se observaron células
cancerosas en estos ganglios por anatomopatólogos y 8 GL eran de
lesiones no malignas.
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Se usó el Mini kit de Qiagen RNeasy^{TM}
(QIAGEN Inc., Valencia, CA) con un protocolo modificado para
minimizar la melanina residual en la muestra de ARN. Para tejidos
que contenían melanocitos, se usaron y procesaron por separado
cuatro muestras tisulares replicadas obtenidas de un paciente
individual que pesaban cada una aproximadamente 5 mg. Las muestras
tisulares se homogeneizaron en 1,0 ml de tampón RLT (QIAGEN) que
contenía 10 \mul de \beta-mercaptoetanol (Sigma
Chemical Co., St. Louis, MO) con un homogeneizador mecánico
(UltraTurrex T8, IKA-Werke, Staufen, Alemania).
Después de la homogeneización, las muestras se cargaron en columnas
RNeasy^{TM} QIAGEN y siguió la centrifugación. Después de
desechar el flujo, se añadieron 700 ml de tampón RW1; la columna se
mantuvo durante 5 min a temperatura ambiente y después se
centrifugó. Esta etapa se repitió tres veces. Después se siguió el
protocolo de Mini Kit RNeasy^{TM} QIAGEN convencional. Para
retirar el ARN de la membrana de gel de sílice se realizó una
elución en dos etapas. El ARN total obtenido del tejido del mismo
paciente individual se combinó y se usó para análisis
posterior.
Se usó el protocolo convencional con Trizol para
el aislamiento de ARN de tejidos que no contienen ninguna
proporción significativa de melanocitos. El tejido se homogeneizó en
reactivo Trizol (Invitrogen, Carlsbad, CA). Después de la
centrifugación, la fase líquida superior se recogió y se precipitó
el ARN total con alcohol isopropílico a -20ºC. Los sedimentos de
ARN se lavaron con etanol al 75%, se separaron en agua y se
almacenaron a -80ºC hasta el uso. Se examinó la calidad del ARN con
un Nano Ensayo RNA 6000 y Bioanalizador Agilent 2100 (Agilent
Technologies, Palo Alto, CA).
Se preparó ARNc marcado y se hibridó con el
ensayo de oligonucleótidos de alta densidad Hu133A Gene Chip
(Affymetrix, Santa Clara, CA) que contenía un total de 22.000
conjuntos de sondas de acuerdo con el protocolo convencional del
fabricante. Las matrices se exploraron usando protocolos y escáneres
Affymetrix. Para análisis posterior, cada conjunto de sonda se
consideró como un gen separado. Los valores de expresión para cada
gen se calcularon usando el software de análisis de Gene Chip de
Affymetrix MAS 5.0. Todos los chips cumplieron tres patrones de
control de calidad: la lectura "presente" era superior al 35%,
el factor de escala era menor de 12 cuando se cambió de escala
hasta una intensidad de diana de 600 y el nivel de fondo era
inferior a 150. Se eligió un porcentaje inferior al habitual de
límites de lecturas "presentes" debido a que es difícil aislar
ARN de células de piel (Hipfel et al. (1998)) dando como
resultado niveles de expresión génica globales inferiores.
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Los datos de expresión génica se filtraron para
incluir solamente los genes denominados "presentes" en 2 o más
muestras. Este filtro se usó para retirar genes que no cambiaron la
expresión en las muestras. De los 22.000 genes presentados en la
matriz, 15.795 pasaron este filtro y se usaron para agrupamiento
jerárquico. Antes del agrupamiento, cada señal de expresión génica
se dividió por la expresión media en todas las muestras en el
conjunto de datos. Esta etapa de normalización minimizó el efecto de
la magnitud de la expresión génica y agrupó genes con patrones de
expresión similares en el análisis de agrupamiento. Se realizó el
agrupamiento jerárquico de ligamiento promedio usando la
correlación de Pearson tanto en los genes como en las muestras
usando GeneSpring 6.1.
Para identificar genes expresados
diferencialmente, se compararon las muestras de melanoma con los
nevos benignos y las muestras de piel normal por separado. El
primer análisis consistió en las 45 muestras de melanoma y las 7
muestras de piel normal; el segundo análisis consistió en 45
muestras de melanoma y 18 de nevos. Estos dos conjuntos de datos se
analizaron de forma separada en los siguientes procedimientos como
se muestra en la Figura 1. El análisis de significación de
micromatriz (SAM; Tusher et al. (2001)) y el ensayo T de
Student se usaron en la selección génica. Los parámetros para SAM se
ajustaron como \Delta = 2,5 y el factor de cambio = 2,0 con 1.000
permutaciones. La FDR era el 1%. No había datos omitidos y se usó el
número aleatorio por defecto. A continuación se realizó el análisis
de percentiles. Para genes regulados positivamente, el percentil
del 30% en las muestras de melanoma se comparó con el máximo de las
muestras normales o el de las muestras de nevos. También se realizó
el ensayo T de Student con corrección de Bonferroni con un límite p
< 0,05 para garantizar que los genes seleccionados tenían
expresión diferencial significativa entre los dos grupos de las
muestras. Como una etapa final, se identificaron genes comunes entre
las listas de genes de melanoma/benigno y melanoma/normal dando
como resultado la única lista de genes regulados positivamente en
melanoma mostrado en la Figura 1 donde los 439 genes comunes se
corresponden a las SEC ID Nº: 29-467 como se
describe en la Tabla 15 con los resultados mostrados en la Tabla
8.
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\vskip1.000000\baselineskip
Se seleccionó una lista corta de genes con una
sobre-expresión de al menos 10 veces en melanoma en
comparación con las muestras benignas. El conjunto de datos de
matriz completo se ha remitido a la base de datos NCBI/Genbank GEO
(entrada de serie pendiente).
El agrupamiento jerárquico mostró cuatro
agrupaciones distintas (Figura 2). Dos agrupaciones consistían en
la mayoría de las muestras de melanoma (43 de 45); la tercera
agrupación incluía la mayoría de las muestras de nevos benignos (15
de 18) y la cuarta contenía las 7 muestras de piel normal. Las
propias muestras de melanoma formaron dos agrupaciones con 35
muestras en una agrupación y 10 muestras en la otra. Las muestras
que formaron la agrupación pequeña representaban solamente el
melanoma epitelioide, que contenía visualmente menos melanina y que
demostró una mayor expresión de los genes de PRAME y MIA (p <
0,05). Los pocos tumores de estadio III y IV se agruparon todos en
la agrupación pequeña. La agrupación grande mostró una mayor
expresión de NTRK3 y nestina (NES) (p < 0,05). Todas las
muestras de melanoma y nevos benignos demostraron una expresión
igualmente elevada de marcadores de melanocitos conocidos tales
como tirosinasa y MART-1, confirmando que hay un
contenido de melanocitos comparable en estas muestras. Nuestros
datos indican que las muestras de melanoma, nevos benignos y piel
normal tienen distintos perfiles de expresión génica y se pueden
separar en una base molecular. Los genes seleccionados que estaban
altamente expresados en melanoma y sus categorías funcionales
asociadas se resumen en la
Tabla 9.
Tabla 9.
Se usó un total de 70 perfiles de expresión
génica para el análisis. Los porcentajes medios de "lecturas
presentes" para grupos de muestra de melanoma, benigno y normal
fueron del 43,8%, del 46,9% y del 41,7%. Sesenta micromatrices
(86%) tenían factores de cambio de escala con un intervalo de 3
veces del valor mínimo. Diez chips con los factores de cambio de
escala superiores a 3 se distribuyeron equitativamente entre las
categorías de muestra melanoma, benigno y normal.
El agrupamiento jerárquico no supervisado mostró
una separación distinta de las muestras de melanoma, nevos benignos
y piel normal (Figura 2). Se observaron cuatro agrupaciones,
incluyendo dos agrupaciones que consistían en la mayoría de las
muestras de melanoma (43 de 45), la tercera agrupación contenía las
7 muestras de piel normal, 3 de nevos benignos y 2 de melanoma y la
cuarta agrupación, que incluía 14 de las 18 muestras de nevos
benignos. La fuente de las muestras no afectó al agrupamiento. Los
espécimenes que se originaron de diferentes fuentes se agruparon
entre sí de acuerdo con el tipo de muestra (melanoma, benigno o
normal). Para ensayar adicionalmente la estabilidad de los patrones
de agrupamiento, se usó un límite alternativo en el filtrado de los
genes antes del análisis de agrupación. Específicamente, se
conservaron genes que tenían al menos el 10% de lecturas
"presentes" en cada una de las muestras de melanoma, nevos
benignos y de piel. Con este límite, se obtuvieron 15.306 genes y
se repitió la agrupación jerárquica. El patrón de agrupación de las
muestras del paciente era igual que las que 15.795 de las 2
lecturas "presentes", confirmando la estabilidad del
agrupamiento.
La muestra de nevos única que se agrupó con las
muestras de melanoma es una muestra de nevos atípicos (grado
moderado) sin melanoma presente in-situ. Las
tres muestras de nevos que se agruparon con piel normal son
muestras de nevos compuestos y una de las mismas tiene un contenido
de melanocitos inferior que los otros espécimenes de nevos. Las
propias muestras de melanoma formaron dos agrupaciones con 34
muestras en la agrupación grande y 9 muestras en la pequeña. Las
muestras que formaron la agrupación pequeña representaban solamente
melanoma epitelioide y contenían visualmente menos melanina. Los
pocos tumores de estadio III y IV usados en el estudio se
combinaron todos en la agrupación pequeña. La agrupación grande
estaba compuesta por muestras de histología mixta de célula
epitelioide, fusiforme y melanoma sin más presencia significativa de
melanina. La agrupación grande incluía solamente muestras de
Estadio I y Estadio II.
Se observaron distintas agrupaciones génicas en
asociación con melanoma. Esto se puede caracterizar por genes
regulados positivamente (Figura 2, A, B, C) y regulados
negativamente (Figura 2, E) en las muestras de melanoma. Al mismo
tiempo, las muestras de melanoma y nevos benignos demostró una alta
expresión de marcadores de melanocitos conocidos, tales como
MART-1 (Figura 3, D) confirmando un contenido
comparable de melanocitos en estas muestras y la incapacidad de los
marcadores específicos de melanocitos de diferenciar los mismos. Los
datos indican que las muestras de melanoma, nevos benignos y piel
normal tienen distintos perfiles de expresión génica y se pueden
separar en su base molecular.
Para identificar genes regulados positivamente
en melanoma maligno, se aplicó SAM en combinación con ensayo t con
corrección de Bonferroni y análisis de percentiles (Figura 1). El
ensayo t ajustado por Bonferroni y los análisis de percentiles se
usaron para abordar el aspecto de ensayo múltiple y la
heterogeneidad de las muestras de tumor, respectivamente. Como
resultado de estos análisis se seleccionaron 439 genes y se resumen
en la Tabla 15 como las SEC ID Nº: 29-467. De los
439 genes regulados positivamente en melanoma, se seleccionó una
lista corta de 33 genes que tenía una
sobre-expresión de más de 10 veces en las muestras
de melanoma que en la de las muestras benignas. Estas incluyen
muchos genes con asociación conocida con melanoma maligno tal como
NTRK3 (Xu et al. (2003)), L1CAM (Fogel et al. (2003);
y Thies et al. (2002)), me20m (Adema et al. (1994)),
así como genes novedosos. En la Tabla 10 se presentan genes con una
sobre-expresión de más de 10 veces en melanoma.
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Se seleccionaron adicionalmente tres genes
sobre-expresados en melanoma, que incluían NTRK3,
PLAB, L1CAM, para validación por RT-PCR en tiempo
real cuantitativa de los resultados de micromatriz (Figura 3). PLAB
es un gen novedoso, cuya expresión diferencial en melanoma no se ha
descrito anteriormente hasta lo que se conoce. Para L1CAM y NTRK3,
la expresión diferencial en melanoma se demostró solamente a nivel
proteico. Xu et al. (2003); Fogel et al. (2003); y
Thies et al. (2002). Además, se identificó PLAB y L1CAM como
la mejor combinación, en una base de complementariedad, para
separar melanoma de tejidos benignos/normales en este estudio.
GP100 se conoce como un marcador específico de melanoma y se
seleccionó como control positivo. Para el ensayo de
RT-PCR se usó un panel de 14 muestras de melanoma
primario, 7 de nevos benignos y 5 de piel normal, aisladas de los
mismos tejidos que los usados para el estudio de micromatriz. El
valor de expresión de cada gen se normalizó al gen de control
constitutivo PBGD. Los coeficientes de correlación entre los
resultados de la RT-PCR y micromatriz para L1CAM,
NTRK3, PLAB y gp100 son 0,79, 0,86, 0,87 y 0,88, respectivamente.
Este resultado indica que los resultados de la
RT-PCR son altamente coincidentes con los datos de
micromatriz.
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El análisis funcional de genes expresados
diferencialmente en melanoma se realizó usando la Aplicación de
Software de Análisis de Ruta Ingenuity^{TM} (Ingenuity, Mountain
View, CA). Se seleccionaron categorías funcionales o rutas
canónicas que tiene un valor p inferior a 0,05. Se ensayó la
especificidad de la identificación de rutas canónicas usando genes
seleccionados aleatoriamente.
Para obtener una mayor comprensión de un
potencial mecanismo que diferencia el melanoma de tejido benigno y
normal, se usó el software de análisis de ruta Ingenuity para
identificar rutas canónicas asociadas con melanoma. El análisis de
resultados mostró que muchos de los genes en el procesamiento de
amiloide estaban regulados positivamente en las muestras de
melanoma. Para verificar la especificidad de esta observación, se
seleccionaron tres listas aleatorias de genes de la micromatriz
Affymetrix Hu133A y se sometieron las mismas al análisis de ruta
Ingenuity. Ninguna de estas listas produjo una asociación
significativa con el procesamiento de amiloide o cualquier otra
ruta canónica. Para confirmar la activación de esta ruta canónica en
melanoma, se recuperaron los datos de expresión génica para todos
los genes en la ruta. Se calculó el factor de cambio y el valor p
de la expresión diferencial entre melanoma y tejidos
benignos/normales. De los 34 genes incluidos en la ruta de
procesamiento de amiloide (Esler et al. (2001); y Giancotti
et al. (1999)), 25 demostraron una tendencia a regulación
positiva y para 19 de las mismas (el 56%), la expresión diferencial
fue estadísticamente significativa (valor p < 0,05; Figura 4).
Como el control adicional, se seleccionaron aleatoriamente dos
rutas metabólicas con un número de genes similar. De los 63 genes en
la ruta de síntesis de alanina, 8 de los mismos (13%) mostró una
regulación positiva significativa con un valor p inferior a 0,05. De
los 47 genes en la ruta de síntesis de histidina, se encontraron
solamente 2 genes (4%) usando los mismos criterios. Por primera
vez, estos datos indicaron en gran medida que la activación de la
ruta de procesamiento de amiloide está implicada en el melanoma
maligno.
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Diez microgramos de ARN total de cada muestra se
trataron con ADNasa I y se realizó la transcripción inversa con
cebador oligo (dT) usando la transcriptasa inversa Superscript II de
acuerdo con las instrucciones del fabricante (Invitrogen, Carlsbad,
CA). Previamente se ensayó un gen de control de PBGD y se describió
como un gen constitutivo. Vandesompele et al. (2003).
Cebadores y sondas de MGB para me20m (gp100), L1CAM, NTRK3 y el gen
de control de PBGD se diseñaron usando el software Primer Express
(Applied Biosystems, Foster City, CA). La sonda del gen de PLAB
(MIC1) estaba basado en FAM-TAMRA ya que las
secuencias eran inadecuadas para diseñar sondas basadas en MGB. Las
secuencias de cebador/sonda eran las siguientes:
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Todos los cebadores y las sondas se ensayaron
para eficacia de amplificación óptima por encima del 90%. La curva
patrón estaba compuesta por seis diluciones de factor 10 del
producto de PCR del gen diana variando el número de copias de 10 a
10^{6}. La amplificación por RT-PCR se realizó en
una mezcla de reacción de 20 \mul que contenía 50 ng de ADNc
molde, mezcla maestra de PCR universal TaqMan® 2x (12,5 \mul)
(Applied Biosystems, Foster City, CA), cebadores directo e inverso
500 nM y sonda de 250 nM. Las reacciones se procesaron en un
Sistema de Detección de Secuencia ABI PRISM 7900HT (Applied
Biosystems, Foster City, CA). Las condiciones de ciclado fueron: 2
min de activación de AmpErase UNG a 50ºC, 10 min de activación de
polimerasa a 95ºC y 50 ciclos a 95ºC durante 15 s y temperatura de
hibridación (60ºC) durante 60 s. En cada ensayo, una curva patrón y
un control no molde junto con ADNc molde se incluyeron por duplicado
tanto para el gen de interés como el gen de control. La cantidad
relativa de cada gen diana se representó como \DeltaCt, que es
igual a Ct del gen diana al que se ha restado Ct del gen de
control.
control.
Para confirmar los genes específicos de melanoma
identificados por el análisis de micromatriz se seleccionaron
cuatro genes (L1CAM, NTRK3, PLAB y gp100) para validación por
RT-PCR en tiempo real cuantitativa (Figura 4). El
valor de expresión de cada gen se normalizó hasta el PBGD de control
constitutivo. El coeficiente de correlación entre los resultados de
RT-PCR y de micromatriz para L1CAM, NTRK3, PLAB y
gp100 son, respectivamente, 0,79, 0,86, 0,87 y 0.88, indicando que
los resultados de RT-PCR son altamente coherentes
con los datos de
micromatriz.
micromatriz.
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La evaluación de la expresión de genes
seleccionados se realizó con RT-PCR de una etapa con
ARN de melanoma primario, nevos benignos, piel normal, metástasis
en GL de melanoma y ganglios linfáticos sin melanoma. Se usó la
beta-actina como un gen constitutivo para controlar
la cantidad y calidad de aporte de ARN en las reacciones. No se usó
tratamiento con ADNasa. En su lugar, se diseñaron cebadores o sondas
para abarcar un intrón, de tal forma que no describirían en ADN
genómico. Se usaron ocho ng de ARN total para la
RT-PCR. El ARN total se sometió a transcripción
inversa usando Multiscribe 40X y mezcla de inhibidor de RNasa
contenida en el Kit de Reactivos de Mezcla Madre de PCR de una
Etapa TaqMan® (Applied Biosystems, Foster City, CA). Después, el
ADNc se sometió a la Mezcla Madre 2x sin UNG y se realizó la
amplificación por PCR en el Sistema de Detección de Secuencia ABI
7900HT (Applied Biosystems, Foster City, CA) en el formato de bloque
de 384 pocillos usando un tamaño de reacción de 10 \mul. Las
concentraciones de cebador y sonda fueron 4 \muM y 2,5 \muM,
respectivamente. La mezcla de reacción se incubó a 48ºC durante 30
min para la transcripción inversa, seguido de una etapa de
activación con Amplitaq de 95ºC durante 10 min y, finalmente, 40
ciclos de 95ºC durante 15 s de desnaturalización y 60ºC durante 1
min de hibridación y extensión. En cada placa se genera una curva
patrón de 8 pg a 80 ng y cuando el valor R2 era superior a 0,99, se
aceptaron los valores de Umbral de Ciclo (Ct).
Las secuencias usadas en las reacciones fueron
las siguientes, escrita cada una en la dirección de 5' a 3'.
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Para cada muestra se calculó \DeltaCt = Ct
(Gen Diana) -Ct \beta-actina. \DeltaCt se ha
usado ampliamente en ensayos clínicos de RT-PCR y
se seleccionó como un método directo. Cronin et al. (2004).
El ensayo T se realizó en \DeltaCt entre las muestras de melanoma
y de no melanoma que incluían muestras tanto primarias como de GL.
Después se usó \DeltaCt para construir dos puntuaciones para cada
paciente. Una puntuación se obtuvo de una combinación de 2 genes
específicos de melanoma, PLAB y L1CAM; y la otra puntuación se
obtuvo de una combinación de tres marcadores de melanoma
convencionales, tirosinasa, gp100 y MART1. La puntuación se definió
como la suma ponderada de los valores de \DeltaCt de los genes
ensayados con las estadísticas t correspondientes como el peso. Las
dos puntuaciones se normalizaron para tener la misma media para
comparar las mismas en la misma escala.
Se examinó una combinación de dos genes de
melanoma altamente sobre-expresados, PLAB y L1CAM,
en una diversidad de muestras tisulares clínicas que contenían
melanocitos malignos (melanoma primario y metástasis de GL de
melanoma), melanocitos benignos (nevos de piel benignos) y muestras
normales (piel normal y GL sin melanoma) por
RT-PCR. Los tejidos primarios eran iguales que los
usados para el estudio de micromatriz aunque todas las muestras de
GL se obtuvieron de pacientes independientes. También se ensayaron
marcadores de melanoma convencionales, tales como tirosinasa, gp100
y MART1, en las mismas muestras que los controles debido a que son
los marcadores usados más comúnmente para los ensayos moleculares de
melanoma en estudios clínicos actuales. Rimboldi et al.
(2003); Abrahamsen et al. (2005); y Kammula et al.
(2004). Las puntuaciones calculadas se presentaron en la Figura 4A
para PLAB y L1CAM y en la Figura 4B para tirosinasa, gp100 y MART1.
Los resultados demostraron una diferencia significativa en la
expresión de PLAB y L1CAM entre muestras de melanoma maligno
(primario y metástasis en GL) y nevos benignos y GL normal. Por el
contrario, tres marcadores convencionales mostraron niveles de
expresión similares en muestras benignas y de melanoma. Para
demostrar adicionalmente la capacidad de los marcadores de genes de
separar tejidos benignos y malignos, se ensayaron dos límites. El
primero se ajustó como la mayor puntuación en muestras normales
primarias y el segundo, como la mayor puntuación en muestras de
nevos benignos. Para cada límite se estimó la sensibilidad y del
ensayo en las muestras de GL. Determinándose el límite en las
muestras normales, los marcadores nuevos y los marcadores
convencionales dieron una sensibilidad del 90% y del 83%,
respectivamente. Usando los límites determinados en las muestras
benignas, la sensibilidad para los marcadores nuevos y
convencionales fue del 88% y el 42%. Los resultados indicaron que
los nuevos marcadores tienen potencialmente mejores capacidades para
diferenciar tejidos que contienen melanocitos benignos y
malignos.
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Cada reacción se ajustó en un volumen final de
25 \mul que contenía lo siguiente:
\newpage
Las secuencias de cebador y sonda se
proporcionan en la Tabla 13.
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\vskip1.000000\baselineskip
Las reacciones se procesan con PLAB en canales
de Fam, Tirosinasa en Cy3, L1CAM en Texas Red y PBGD in Cy5. El
protocolo de ciclado usado se describe más adelante y requiere 30
min para la finalización.
95ºC x 15 s
65ºC x 420 s
40º ciclos de:
95ºC durante 5 s
62ºC durante 15 s - lectura de fluor
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\vskip1.000000\baselineskip
\vskip1.000000\baselineskip
(Tabla pasa a página
siguiente)
\newpage
Los umbrales usados son 30 en canales de Fam, 20
en Cy3, 20 en Texas Red y 20 en Cy5. Los umbrales empleados en los
canales de Cy3 y Texas red se pueden disminuir. Los resultados
obtenidos se resumen en la Tabla 14.
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\vskip1.000000\baselineskip
Se realizó el análisis de formación de perfil de
expresión génica de muestras de melanoma primario, nevos benignos y
tejido de piel normal para encontrar marcadores génicos específicos
de melanoma para el uso potencial en el ensayo de estadificación
molecular de GL. Se identificaron genes novedosos que se expresan
altamente y diferencialmente en muestras de melanoma maligno. La
inclusión de nevos benignos en el diseño experimental fue clave
para el estudio. Por el contrario a piel normal, el contenido de
melanocitos en nevos benignos es próximo al de en melanoma. Esto se
confirmó, además de por evaluación histológica, por un nivel de
expresión igualmente elevado de marcadores de melanoma
convencionales tales como tirosinasa y MART1 en muestras tanto de
melanoma como de tejido de nevos. La composición celular similar
permitió controlar los cambios de expresión génica asociados
específicamente con transformación maligna de melanocitos, no
solamente con la diferenciación de linaje melanocítico. Como
resultado, se identificaron genes novedosos
sobre-expresados específicamente en melanoma. Uno
de los sobre-expresados altamente novedosos en genes
de melanoma, el factor de diferenciación de próstata (PLAB, MIC 1),
es un miembro de la superfamilia del factor de crecimiento
transformante beta y también se sabe que está asociado con otras
neoplasias. Bae et al. (2003); y Welsh et al. (2003).
El PLAB reduce la adhesión celular (Yamauchi et al. (2003)),
implicando su papel potencial en la progresión del melanoma. El
análisis de ruta de los genes sobre-expresados en
melanoma indicó que muchos de estos genes pertenecen al
funcionamiento y desarrollo del tejido neural, sugiriendo que la
desdiferenciación de melanocitos y la activación de los procesos
relacionados con una célula progenitora pluripotente pueden ser
importantes para el desarrollo y la progresión del melanoma.
Además, el análisis de rutas canónicas mostró que el procesamiento
de amiloide asociado a tejido neural está significativamente
modulado en melanoma. La propia ruta de procesamiento de amiloide
(APP) no se ha asociado anteriormente con el desarrollo y la
progresión de melanoma. Muchos genes en la ruta de APP, tales como
miembros de la familia de \beta y \Upsilon secretasa (BACE2,
PSEN2) también participan en la ruta Notch y desempeñan un papel de
escisión de las proteínas integrales de membrana tanto en Notch
como en APP. Esler et al. (2001). Notch suprime la
diferenciación y ayuda a mantener las células madre de cresta
neural en el estado indiferenciado (Gangemi et al. (2004)) y
la implicación de Notch en melanoma y, particularmente, el papel de
las \Upsilon-secretasas es el centro de muchos
estudios. Hoek et al. (2004); Baldi et al. (2003); y
Wilson et al. (2000).
Se compararon estos resultados con el estudio
reciente de Haqq et al (2005). En su trabajo, se usó una
micromatriz de ADNc que contenía 20.862 sondas para formar el perfil
de muestras de nevos benignos, melanoma primario y melanoma
metástasico. El conjunto de muestras incluyó melanoma metástasico y
primario y nevos benignos. En su estudio se observaron resultados
de agrupamiento similares que separaron los nevos benignos y los
tejidos de melanoma maligno primario. En ambos estudios se
describieron genes comunes que pueden diferenciar melanoma de nevos
benignos incluyendo similar a quinesina 5 (KNSL5), factor de
diferenciación de próstata (PLAB), CITED1, osteopontina (SPP1),
catepsina B (CSTB), caderina 3 (CDH3), presenilina 2 (PSEN2).
Estos resultados del ensayo de
RT-PCR de una etapa demostraron que el gen novedoso
específico de melanoma PLAB y L1CAM se expresó no solamente en
tejidos de melanoma primario sino también en metástasis de GL de
melanoma. Además, la capacidad de diferenciar el melanoma maligno
de nevos benignos hizo que fueran mejores candidatos que los
marcadores convencionales para el ensayo molecular del diagnóstico
de melanoma. Con validación adicional en estudios clínicos, estos
genes se podrían desarrollar como marcadores específicos para un
ensayo de estadificación molecular para detectar micrometastasis de
melanoma durante el procedimiento de biopsia del ganglio linfático
centinela (GLC). Otra aplicación potencial de los genes es para el
diagnóstico de lesiones melanocíticas con características
anatomopatológicos inciertas.
Aunque la anterior invención se ha descrito con
cierto detalle a modo de ilustración y ejemplo con propósitos de
claridad de comprensión, las descripciones y los ejemplos no se
deben considerar como limitantes del alcance de la invención.
\vskip1.000000\baselineskip
WO 96/29430
2003/0232356
2002/0160382
2002/0155480
2002/0110820
2002/0098535
2003/0059431
2003/0049701
2002/0048784
2003/014283
2003/0013097
6.500.919
4.715.545
5.210.015
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Xu et al. (2003) Expression
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Yamanaka et al. (1999)
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Yamauchi et al. (2003)
Neurotrophin 3 activation of TrkC induces Schwann cell migration
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14421-14426
Yang et al. (2003)
Macrophage inhibitory cytokine-1: a novel biomarker
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1023-1029
Yannoni et al. (2004)
P66ShcA interacts with MAPKAP kinase 2 and regulates its activity
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Zhang et al. (2003)
Negative regulation of T cell antigen
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<110> VERIDEX, LLC
\hskip1cmWang, Yixin
\hskip1cmTalantov, Dimitri
\hskip1cmMazumder, Abhij it
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<120> MÉTODOS Y REACTIVO PARA LA DETECCIÓN
DE MELANOMA
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<130> VDX5006WOPCT
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<140> US 60/582.906
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<141>
25-06-2004
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<150> US 60/582.906
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<151>
25-06-2004
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<160> 1001
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<170> PatentIn versión 3.2
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 1
\vskip0.400000\baselineskip
<211> 1204
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 1
\hskip1cm
\vskip0.400000\baselineskip
<210> 2
\vskip0.400000\baselineskip
<211> 4513
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 2
\vskip1.000000\baselineskip
\hskip1cm
\hskip1cm
\vskip0.400000\baselineskip
<210> 3
\vskip0.400000\baselineskip
<211> 2146
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 3
\hskip1cm
\hskip1cm
\vskip0.400000\baselineskip
<210> 4
\vskip0.400000\baselineskip
<211> 19
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 4
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 5
\vskip0.400000\baselineskip
<211> 18
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 5
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 6
\vskip0.400000\baselineskip
<211> 25
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 6
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 7
\vskip0.400000\baselineskip
<211> 18
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 7
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 8
\vskip0.400000\baselineskip
<211> 16
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 8
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 9
\vskip0.400000\baselineskip
<211> 23
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 9
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 10
\vskip0.400000\baselineskip
<211> 21
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 10
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 11
\vskip0.400000\baselineskip
<211> 21
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 11
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 12
\vskip0.400000\baselineskip
<211> 17
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 12
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 13
\vskip0.400000\baselineskip
<211> 22
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 13
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 14
\vskip0.400000\baselineskip
<211> 21
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 14
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 15
\vskip0.400000\baselineskip
<211> 25
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 15
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 16
\vskip0.400000\baselineskip
<211> 16
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 16
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 17
\vskip0.400000\baselineskip
<211> 19
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 17
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 18
\vskip0.400000\baselineskip
<211> 15
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 18
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 19
\vskip0.400000\baselineskip
<211> 22
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 19
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 20
\vskip0.400000\baselineskip
<211> 23
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 20
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 21
\vskip0.400000\baselineskip
<211> 30
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 21
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 22
\vskip0.400000\baselineskip
<211> 22
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 22
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 23
\vskip0.400000\baselineskip
<211> 21
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 23
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 24
\vskip0.400000\baselineskip
<211> 29
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 24
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 25
\vskip0.400000\baselineskip
<211> 100
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 25
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 26
\vskip0.400000\baselineskip
<211> 110
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 26
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 27
\vskip0.400000\baselineskip
<211> 70
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 27
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 28
\vskip0.400000\baselineskip
<211> 103
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 28
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 29
\vskip0.400000\baselineskip
<211> 512
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 29
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 30
\vskip0.400000\baselineskip
<211> 419
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 30
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 31
\vskip0.400000\baselineskip
<211> 505
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 31
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 32
\vskip0.400000\baselineskip
<211> 475
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 32
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 33
\vskip0.400000\baselineskip
<211> 441
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 33
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 34
\vskip0.400000\baselineskip
<211> 276
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 34
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 35
\vskip0.400000\baselineskip
<211> 567
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 35
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 36
\vskip0.400000\baselineskip
<211> 165
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 36
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 37
\vskip0.400000\baselineskip
<211> 481
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 37
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 38
\vskip0.400000\baselineskip
<211> 461
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 38
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 39
\vskip0.400000\baselineskip
<211> 479
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 39
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 40
\vskip0.400000\baselineskip
<211> 529
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 40
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 41
\vskip0.400000\baselineskip
<211> 195
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 41
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 42
\vskip0.400000\baselineskip
<211> 301
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 42
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 43
\vskip0.400000\baselineskip
<211> 562
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 43
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 44
\vskip0.400000\baselineskip
<211> 333
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 44
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 45
\vskip0.400000\baselineskip
<211> 411
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 45
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 46
\vskip0.400000\baselineskip
<211> 411
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 46
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 47
\vskip0.400000\baselineskip
<211> 555
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 47
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 48
\vskip0.400000\baselineskip
<211> 550
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 48
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 49
\vskip0.400000\baselineskip
<211> 198
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 49
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 50
\vskip0.400000\baselineskip
<211> 493
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 50
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 51
\vskip0.400000\baselineskip
<211> 509
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (210)..(210)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (212)..(213)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (226)..(226)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (228)..(231)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (233)..(234)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (236)..(240)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (243)..(243)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (245)..(246)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (248)..(249)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 51
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 52
\vskip0.400000\baselineskip
<211> 453
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 52
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 53
\vskip0.400000\baselineskip
<211> 398
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 53
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 54
\vskip0.400000\baselineskip
<211> 446
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 54
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 55
\vskip0.400000\baselineskip
<211> 456
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 55
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 56
\vskip0.400000\baselineskip
<211> 510
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 56
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 57
\vskip0.400000\baselineskip
<211> 522
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 57
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 58
\vskip0.400000\baselineskip
<211> 356
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 58
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 59
\vskip0.400000\baselineskip
<211> 381
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 59
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 60
\vskip0.400000\baselineskip
<211> 441
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 60
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 61
\vskip0.400000\baselineskip
<211> 442
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 61
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 62
\vskip0.400000\baselineskip
<211> 524
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 62
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 63
\vskip0.400000\baselineskip
<211> 416
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 63
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 64
\vskip0.400000\baselineskip
<211> 556
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 64
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 65
\vskip0.400000\baselineskip
<211> 453
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 65
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 66
\vskip0.400000\baselineskip
<211> 533
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (360)..(361)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 66
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 67
\vskip0.400000\baselineskip
<211> 408
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 67
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 68
\vskip0.400000\baselineskip
<211> 526
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 68
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 69
\vskip0.400000\baselineskip
<211> 432
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 69
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 70
\vskip0.400000\baselineskip
<211> 450
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 70
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 71
\vskip0.400000\baselineskip
<211> 477
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 71
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 72
\vskip0.400000\baselineskip
<211> 497
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (432)..(432)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 72
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 73
\vskip0.400000\baselineskip
<211> 481
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 73
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 74
\vskip0.400000\baselineskip
<211> 469
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (40)..(40)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 74
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 75
\vskip0.400000\baselineskip
<211> 455
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 75
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 76
\vskip0.400000\baselineskip
<211> 525
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 76
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 77
\vskip0.400000\baselineskip
<211> 397
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 77
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 78
\vskip0.400000\baselineskip
<211> 329
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 78
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 79
\vskip0.400000\baselineskip
<211> 535
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 79
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 80
\vskip0.400000\baselineskip
<211> 537
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 80
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 81
\vskip0.400000\baselineskip
<211> 483
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 81
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 82
\vskip0.400000\baselineskip
<211> 505
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 82
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 83
\vskip0.400000\baselineskip
<211> 299
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 83
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 84
\vskip0.400000\baselineskip
<211> 533
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (136)..(136)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 84
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 85
\vskip0.400000\baselineskip
<211> 403
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (117)..(117)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (119)..(119)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (339)..(339)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 85
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 86
\vskip0.400000\baselineskip
<211> 441
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 86
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 87
\vskip0.400000\baselineskip
<211> 467
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 87
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 88
\vskip0.400000\baselineskip
<211> 527
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 88
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 89
\vskip0.400000\baselineskip
<211> 546
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 89
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 90
\vskip0.400000\baselineskip
<211> 464
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 90
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 91
\vskip0.400000\baselineskip
<211>409
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 91
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 92
\vskip0.400000\baselineskip
<211> 481
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<214> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 92
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 93
\vskip0.400000\baselineskip
<211> 393
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 93
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 94
\vskip0.400000\baselineskip
<211> 564
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 94
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 95
\vskip0.400000\baselineskip
<211> 474
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 95
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 96
\vskip0.400000\baselineskip
<211> 448
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 96
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 97
\vskip0.400000\baselineskip
<211> 271
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 97
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 98
\vskip0.400000\baselineskip
<211> 344
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (106)..(106)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (108)..(113)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 98
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 99
\vskip0.400000\baselineskip
<211> 497
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 99
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 100
\vskip0.400000\baselineskip
<211> 540
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 100
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 101
\vskip0.400000\baselineskip
<211> 329
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 101
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 102
\vskip0.400000\baselineskip
<211> 540
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 102
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 103
\vskip0.400000\baselineskip
<211> 513
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 103
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 104
\vskip0.400000\baselineskip
<211> 529
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 104
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 105
\vskip0.400000\baselineskip
<211> 524
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 105
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 106
\vskip0.400000\baselineskip
<211> 532
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 106
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 107
\vskip0.400000\baselineskip
<211> 402
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 107
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 108
\vskip0.400000\baselineskip
<211> 504
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 108
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 109
\vskip0.400000\baselineskip
<211> 512
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 109
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 110
\vskip0.400000\baselineskip
<211> 212
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 110
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 111
\vskip0.400000\baselineskip
<211> 337
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 111
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 112
\vskip0.400000\baselineskip
<211> 330
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 112
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 113
\vskip0.400000\baselineskip
<211> 454
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 113
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 114
\vskip0.400000\baselineskip
<211> 459
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 114
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 115
\vskip0.400000\baselineskip
<211> 371
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 115
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 116
\vskip0.400000\baselineskip
<211> 319
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 116
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 117
\vskip0.400000\baselineskip
<211> 352
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 117
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 118
\vskip0.400000\baselineskip
<211> 487
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 118
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 119
\vskip0.400000\baselineskip
<211> 476
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 119
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 120
\vskip0.400000\baselineskip
<211> 419
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 120
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 121
\vskip0.400000\baselineskip
<211> 438
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 121
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 122
\vskip0.400000\baselineskip
<211> 471
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 122
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 123
\vskip0.400000\baselineskip
<211> 475
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 123
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 124
\vskip0.400000\baselineskip
<211> 482
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 124
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 125
\vskip0.400000\baselineskip
<211> 530
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 125
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 126
\vskip0.400000\baselineskip
<211> 504
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 126
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 127
\vskip0.400000\baselineskip
<211> 477
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 127
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 128
\vskip0.400000\baselineskip
<211> 460
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 128
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 129
\vskip0.400000\baselineskip
<211> 526
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 129
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 130
\vskip0.400000\baselineskip
<211> 463
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 130
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 131
\vskip0.400000\baselineskip
<211> 255
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 131
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 132
\vskip0.400000\baselineskip
<211> 560
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 132
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 133
\vskip0.400000\baselineskip
<211> 470
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 133
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 134
\vskip0.400000\baselineskip
<211> 541
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 134
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 135
\vskip0.400000\baselineskip
<211> 501
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 135
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 136
\vskip0.400000\baselineskip
<211> 533
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 136
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 137
\vskip0.400000\baselineskip
<211> 351
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 137
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 138
\vskip0.400000\baselineskip
<211> 542
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 138
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 139
\vskip0.400000\baselineskip
<211> 549
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 139
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 140
\vskip0.400000\baselineskip
<211> 558
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 140
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 141
\vskip0.400000\baselineskip
<211> 518
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 141
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 142
\vskip0.400000\baselineskip
<211> 433
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 142
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 143
\vskip0.400000\baselineskip
<211> 512
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 143
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 144
\vskip0.400000\baselineskip
<211> 500
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 144
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 145
\vskip0.400000\baselineskip
<211> 512
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 145
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 146
\vskip0.400000\baselineskip
<211> 562
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 146
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 147
\vskip0.400000\baselineskip
<211> 465
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 147
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 148
\vskip0.400000\baselineskip
<211> 493
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 148
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 149
\vskip0.400000\baselineskip
<211> 480
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 149
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 150
\vskip0.400000\baselineskip
<211> 483
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 150
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 151
\vskip0.400000\baselineskip
<211> 145
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 151
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 152
\vskip0.400000\baselineskip
<211> 539
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 152
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 153
\vskip0.400000\baselineskip
<211> 390
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 153
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 154
\vskip0.400000\baselineskip
<211> 398
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 154
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 155
\vskip0.400000\baselineskip
<211> 562
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 155
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 156
\vskip0.400000\baselineskip
<211> 268
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 156
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 157
\vskip0.400000\baselineskip
<211> 490
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 157
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 158
\vskip0.400000\baselineskip
<211> 496
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 158
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 159
\vskip0.400000\baselineskip
<211> 508
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 159
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 160
\vskip0.400000\baselineskip
<211> 370
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (251)..(251)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 160
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 161
\vskip0.400000\baselineskip
<211> 544
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 161
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 162
\vskip0.400000\baselineskip
<211> 412
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 162
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 163
\vskip0.400000\baselineskip
<211> 569
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 163
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 164
\vskip0.400000\baselineskip
<211> 375
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 164
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 165
\vskip0.400000\baselineskip
<211> 549
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 165
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 166
\vskip0.400000\baselineskip
<211> 230
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 166
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 167
\vskip0.400000\baselineskip
<211> 329
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 167
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 168
\vskip0.400000\baselineskip
<211> 437
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 168
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 169
\vskip0.400000\baselineskip
<211> 554
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (52)..(52)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (59)..(59)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (252)..(252)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (513)..(513)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 169
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 170
\vskip0.400000\baselineskip
<211> 309
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 170
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 171
\vskip0.400000\baselineskip
<211> 302
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 171
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 172
\vskip0.400000\baselineskip
<211> 491
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 172
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 173
\vskip0.400000\baselineskip
<211> 122
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 173
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 174
\vskip0.400000\baselineskip
<211> 536
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 174
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 175
\vskip0.400000\baselineskip
<211> 487
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 175
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 176
\vskip0.400000\baselineskip
<211> 504
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 176
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 177
\vskip0.400000\baselineskip
<211> 356
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 177
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 178
\vskip0.400000\baselineskip
<211> 225
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 178
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 179
\vskip0.400000\baselineskip
<211> 380
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 179
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 180
\vskip0.400000\baselineskip
<211> 440
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 180
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 181
\vskip0.400000\baselineskip
<211> 518
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (41)..(41)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 181
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 182
\vskip0.400000\baselineskip
<211> 538
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 182
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 183
\vskip0.400000\baselineskip
<211> 498
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 183
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 184
\vskip0.400000\baselineskip
<211> 421
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 184
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 185
\vskip0.400000\baselineskip
<211> 498
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 185
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 186
\vskip0.400000\baselineskip
<211> 426
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 186
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 187
\vskip0.400000\baselineskip
<211> 419
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 187
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 188
\vskip0.400000\baselineskip
<211> 481
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 188
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 189
\vskip0.400000\baselineskip
<211> 424
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 189
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 190
\vskip0.400000\baselineskip
<211> 515
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 190
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 191
\vskip0.400000\baselineskip
<211> 434
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 191
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 192
\vskip0.400000\baselineskip
<211> 403
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 192
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 193
\vskip0.400000\baselineskip
<211> 355
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 193
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 194
\vskip0.400000\baselineskip
<211> 527
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 194
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 195
\vskip0.400000\baselineskip
<211> 531
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 195
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 196
\vskip0.400000\baselineskip
<211> 441
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 196
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 197
\vskip0.400000\baselineskip
<211> 552
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 197
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 198
\vskip0.400000\baselineskip
<211> 467
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 198
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 199
\vskip0.400000\baselineskip
<211> 562
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 199
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 200
\vskip0.400000\baselineskip
<211> 432
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (34)..(34)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (46)..(46)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (104)..(104)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (108)..(108)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (274)..(274)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 200
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 201
\vskip0.400000\baselineskip
<211> 353
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 201
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 202
\vskip0.400000\baselineskip
<211> 546
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 202
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 203
\vskip0.400000\baselineskip
<211> 246
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 203
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 204
\vskip0.400000\baselineskip
<211> 470
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 204
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 205
\vskip0.400000\baselineskip
<211> 469
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 205
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 206
\vskip0.400000\baselineskip
<211> 512
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 206
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 207
\vskip0.400000\baselineskip
<211> 488
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 207
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 208
\vskip0.400000\baselineskip
<211> 459
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 208
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 209
\vskip0.400000\baselineskip
<211> 533
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 209
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 210
\vskip0.400000\baselineskip
<211> 438
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 210
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 211
\vskip0.400000\baselineskip
<211> 135
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 211
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 212
\vskip0.400000\baselineskip
<211> 440
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 212
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 213
\vskip0.400000\baselineskip
<211> 489
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 213
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 214
\vskip0.400000\baselineskip
<211> 514
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 214
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 215
\vskip0.400000\baselineskip
<211> 543
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 215
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 216
\vskip0.400000\baselineskip
<211> 518
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 216
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 217
\vskip0.400000\baselineskip
<211> 480
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 217
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 218
\vskip0.400000\baselineskip
<211> 472
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 218
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 219
\vskip0.400000\baselineskip
<211> 309
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 219
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 220
\vskip0.400000\baselineskip
<211> 560
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 220
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 221
\vskip0.400000\baselineskip
<211> 280
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 221
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 222
\vskip0.400000\baselineskip
<211> 524
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 222
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 223
\vskip0.400000\baselineskip
<211> 550
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 223
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 224
\vskip0.400000\baselineskip
<211> 233
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 224
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 225
\vskip0.400000\baselineskip
<211> 419
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 225
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 226
\vskip0.400000\baselineskip
<211> 265
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 226
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 227
\vskip0.400000\baselineskip
<211> 467
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 227
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 228
\vskip0.400000\baselineskip
<211> 277
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 228
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 229
\vskip0.400000\baselineskip
<211> 506
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (198)..(198)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (201)..(201)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (429)..(429)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (439)..(439)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 229
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 230
\vskip0.400000\baselineskip
<211> 536
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 230
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 231
\vskip0.400000\baselineskip
<211> 389
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 231
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 232
\vskip0.400000\baselineskip
<211> 525
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 232
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 233
\vskip0.400000\baselineskip
<211> 501
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 233
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 234
\vskip0.400000\baselineskip
<211> 432
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 234
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 235
\vskip0.400000\baselineskip
<211> 454
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 235
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 236
\vskip0.400000\baselineskip
<211> 475
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 236
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 237
\vskip0.400000\baselineskip
<211> 531
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 237
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 238
\vskip0.400000\baselineskip
<211> 543
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 238
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 239
\vskip0.400000\baselineskip
<211> 460
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (173)..(174)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 239
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 240
\vskip0.400000\baselineskip
<211> 498
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 240
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 241
\vskip0.400000\baselineskip
<211> 378
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 241
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 242
\vskip0.400000\baselineskip
<211> 428
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 242
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 243
\vskip0.400000\baselineskip
<211> 534
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 243
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 244
\vskip0.400000\baselineskip
<211> 532
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 244
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 245
\vskip0.400000\baselineskip
<211> 477
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (363)..(363)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (418)..(418)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\newpage
\vskip0.400000\baselineskip
<400> 245
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 246
\vskip0.400000\baselineskip
<211> 445
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 246
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 247
\vskip0.400000\baselineskip
<211> 182
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 247
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 248
\vskip0.400000\baselineskip
<211> 403
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 248
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 249
\vskip0.400000\baselineskip
<211> 487
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 249
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 250
\vskip0.400000\baselineskip
<211> 471
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 250
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 251
\vskip0.400000\baselineskip
<211> 529
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 251
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 252
\vskip0.400000\baselineskip
<211> 419
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (160)..(160)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 252
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 253
\vskip0.400000\baselineskip
<211> 358
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (134)..(135)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 253
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 254
\vskip0.400000\baselineskip
<211> 516
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 254
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 255
\vskip0.400000\baselineskip
<211> 514
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 255
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 256
\vskip0.400000\baselineskip
<211> 500
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (267)..(267)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (409)..(409)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\newpage
\vskip0.400000\baselineskip
<400> 256
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 257
\vskip0.400000\baselineskip
<211> 500
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 257
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 258
\vskip0.400000\baselineskip
<211> 516
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 258
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 259
\vskip0.400000\baselineskip
<211> 375
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 259
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 260
\vskip0.400000\baselineskip
<211> 427
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 260
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 261
\vskip0.400000\baselineskip
<211> 463
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (435)..(435)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 261
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 262
\vskip0.400000\baselineskip
<211> 531
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 262
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 263
\vskip0.400000\baselineskip
<211> 528
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 263
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 264
\vskip0.400000\baselineskip
<211> 529
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 264
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 265
\vskip0.400000\baselineskip
<211> 372
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 265
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 266
\vskip0.400000\baselineskip
<211> 409
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 266
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 267
\vskip0.400000\baselineskip
<211> 523
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 267
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 268
\vskip0.400000\baselineskip
<211> 161
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 268
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 269
\vskip0.400000\baselineskip
<211> 445
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 269
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 270
\vskip0.400000\baselineskip
<211> 503
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 270
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 271
\vskip0.400000\baselineskip
<211> 508
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 271
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 272
\vskip0.400000\baselineskip
<211> 502
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 272
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 273
\vskip0.400000\baselineskip
<211> 552
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 273
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 274
\vskip0.400000\baselineskip
<211> 417
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 274
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 275
\vskip0.400000\baselineskip
<211> 510
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 275
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 276
\vskip0.400000\baselineskip
<211> 551
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 276
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 277
\vskip0.400000\baselineskip
<211> 533
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 277
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 278
\vskip0.400000\baselineskip
<211> 238
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 278
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 279
\vskip0.400000\baselineskip
<211> 491
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 279
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 280
\vskip0.400000\baselineskip
<211> 268
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 280
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 281
\vskip0.400000\baselineskip
<211> 261
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 281
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 282
\vskip0.400000\baselineskip
<211> 372
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (43)..(43)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 282
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 283
\vskip0.400000\baselineskip
<211> 398
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (335)..(336)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (338)..(338)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 283
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 284
\vskip0.400000\baselineskip
<211> 478
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 284
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 285
\vskip0.400000\baselineskip
<211> 336
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (299)..(299)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 285
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 286
\vskip0.400000\baselineskip
<211> 262
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (47)..(47)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (81)..(81)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 286
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 287
\vskip0.400000\baselineskip
<211> 388
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (70)..(70)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (72)..(78)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (80)..(80)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (82)..(82)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\newpage
\vskip0.400000\baselineskip
<400> 287
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 288
\vskip0.400000\baselineskip
<211> 438
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (300)..(300)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (303)..(303)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 288
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 289
\vskip0.400000\baselineskip
<211> 509
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (440)..(440)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (448)..(448)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\newpage
\vskip0.400000\baselineskip
<400> 289
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 290
\vskip0.400000\baselineskip
<211> 442
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (286)..(286)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 290
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 291
\vskip0.400000\baselineskip
<211> 467
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 291
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 292
\vskip0.400000\baselineskip
<211> 356
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 292
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 293
\vskip0.400000\baselineskip
<211> 203
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 293
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 294
\vskip0.400000\baselineskip
<211> 487
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 294
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 295
\vskip0.400000\baselineskip
<211> 528
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (153)..(153)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (351)..(351)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 295
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 296
\vskip0.400000\baselineskip
<211> 438
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (121)..(121)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 296
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 297
\vskip0.400000\baselineskip
<211> 497
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 297
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 298
\vskip0.400000\baselineskip
<211> 557
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (73)..(73)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (244)..(244)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 298
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 299
\vskip0.400000\baselineskip
<211> 449
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (60)..(61)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 299
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 300
\vskip0.400000\baselineskip
<211> 311
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (125)..(126)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 300
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 301
\vskip0.400000\baselineskip
<211> 395
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 301
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 302
\vskip0.400000\baselineskip
<211> 517
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 302
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 303
\vskip0.400000\baselineskip
<211> 520
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (51)..(51)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (392)..(392)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 303
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 304
\vskip0.400000\baselineskip
<211> 329
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 304
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 305
\vskip0.400000\baselineskip
<211> 521
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (481)..(481)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 305
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 306
\vskip0.400000\baselineskip
<211> 496
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 306
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 307
\vskip0.400000\baselineskip
<211> 503
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (158)..(158)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (216)..(217)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (231)..(231)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (250)..(250)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (261)..(261)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (291)..(291)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (297)..(297)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (341)..(341)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (352)..(352)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_features
\vskip0.400000\baselineskip
<222> (365)..(365)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\newpage
\vskip0.400000\baselineskip
<400> 307
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 308
\vskip0.400000\baselineskip
<211> 434
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 308
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 309
\vskip0.400000\baselineskip
<211> 572
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (163)..(163)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (486)..(486)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (547)..(547)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\newpage
\vskip0.400000\baselineskip
<400> 309
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 310
\vskip0.400000\baselineskip
<211> 549
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (73)..(73)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 310
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 311
\vskip0.400000\baselineskip
<211> 463
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (37)..(37)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\newpage
\vskip0.400000\baselineskip
<400> 311
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 312
\vskip0.400000\baselineskip
<211> 238
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 312
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 313
\vskip0.400000\baselineskip
<211> 497
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (26)..(26)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (61)..(61)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (64)..(64)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (68)..(68)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (117)..(117)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (148)..(148)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (173)..(173)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (214)..(214)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (218)..(218)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (231)..(231)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (275)..(275)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (293)..(293)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (305)..(305)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (318)..(318)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (323)..(323)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (435)..(435)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\newpage
\vskip0.400000\baselineskip
<400> 313
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 314
\vskip0.400000\baselineskip
<211> 563
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (431)..(431)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 314
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 315
\vskip0.400000\baselineskip
<211> 524
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (29)..(29)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (39)..(39)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (41)..(41)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (45)..(45)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (47)..(47)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (55)..(55)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (187)..(187)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (373)..(373)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 315
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 316
\vskip0.400000\baselineskip
<211> 559
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 316
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 317
\vskip0.400000\baselineskip
<211> 504
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (44)..(44)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (63)..(63)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (94)..(94)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 317
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 318
\vskip0.400000\baselineskip
<211> 568
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 318
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 319
\vskip0.400000\baselineskip
<211> 543
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (36)..(36)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (62)..(66)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (402)..(402)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 319
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 320
\vskip0.400000\baselineskip
<211> 258
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 320
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 321
\vskip0.400000\baselineskip
<211> 263
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (92)..(92)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (190)..(190)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 321
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 322
\vskip0.400000\baselineskip
<211> 529
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 322
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 323
\vskip0.400000\baselineskip
<211> 467
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 323
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 324
\vskip0.400000\baselineskip
<211> 145
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 324
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 325
\vskip0.400000\baselineskip
<211> 208
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (85)..(85)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (100)..(100)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (102)..(102)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (119)..(123)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (125)..(126)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (128)..(128)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (148)..(148)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 325
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 326
\vskip0.400000\baselineskip
<211> 354
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 326
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 327
\vskip0.400000\baselineskip
<211> 518
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (61)..(65)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (71)..(71)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (73)..(73)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (112)..(112)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (163)..(163)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (295)..(295)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\newpage
\vskip0.400000\baselineskip
<400> 327
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 328
\vskip0.400000\baselineskip
<211> 509
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 328
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 329
\vskip0.400000\baselineskip
<211> 539
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (27)..(27)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (40)..(40)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (49)..(49)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (64)..(64)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (84)..(84)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (90)..(91)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 329
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 330
\vskip0.400000\baselineskip
<211> 471
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 330
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 331
\vskip0.400000\baselineskip
<211> 559
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (56)..(59)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (61)..(66)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (68)..(69)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (88)..(88)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (127)..(127)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 331
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 332
\vskip0.400000\baselineskip
<211> 115
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 332
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 333
\vskip0.400000\baselineskip
<211> 486
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (96)..(96)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (99)..(100)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (106)..(108)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (119)..(119)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (152)..(152)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (175)..(175)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (212)..(213)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (226)..(226)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (233)..(233)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (237)..(237)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (248)..(248)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (250)..(250)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (252)..(252)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (263)..(263)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (266)..(266)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (296)..(297)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (302)..(303)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (321)..(321)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (337)..(338)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (341)..(341)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (351)..(351)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (409)..(409)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (446)..(446)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (450)..(450)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (455)..(455)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (461)..(461)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 333
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 334
\vskip0.400000\baselineskip
<211> 473
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (191)..(192)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 334
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 335
\vskip0.400000\baselineskip
<211> 562
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (241)..(243)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (247)..(247)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (251)..(253)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (256)..(256)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (259)..(259)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (261)..(264)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (339)..(348)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (352)..(353)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (355)..(355)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (357)..(357)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (359)..(360)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (362)..(366)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (404)..(404)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (537)..(537)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\newpage
\vskip0.400000\baselineskip
<400> 335
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 336
\vskip0.400000\baselineskip
<211> 189
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (85)..(85)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 336
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 337
\vskip0.400000\baselineskip
<211> 523
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (38)..(38)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (47)..(47)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (74)..(74)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (86)..(86)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (109)..(109)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (434)..(434)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (456)..(456)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 337
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
210> 338
\vskip0.400000\baselineskip
<211> 493
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (161)..(161)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (163)..(163)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (165)..(176)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\newpage
\vskip0.400000\baselineskip
<400> 338
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 339
\vskip0.400000\baselineskip
<211> 463
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (61)..(61)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 339
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 340
\vskip0.400000\baselineskip
<211> 262
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 340
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 341
\vskip0.400000\baselineskip
<211> 459
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (181)..(181)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (287)..(287)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (316)..(319)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (324)..(325)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (328)..(330)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (362)..(362)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (375)..(375)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (381)..(381)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (386)..(386)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (397)..(397)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (403)..(403)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (408)..(408)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (411)..(411)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (418)..(418)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (420)..(420)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (430)..(430)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 341
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 342
\vskip0.400000\baselineskip
<211> 492
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (254)..(254)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (315)..(315)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (388)..(388)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\newpage
\vskip0.400000\baselineskip
<400> 342
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 343
\vskip0.400000\baselineskip
<211> 333
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (274)..(274)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (299)..(299)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 343
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 344
\vskip0.400000\baselineskip
<211> 514
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (41)..(41)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (43)..(43)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (68)..(68)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (91)..(91)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (97)..(97)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (103)..(103)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (109)..(109)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (133)..(133)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (138)..(138)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (150)..(150)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (158)..(158)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (170)..(170)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (316)..(316)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (411)..(411)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (481)..(481)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 344
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 345
\vskip0.400000\baselineskip
<211> 387
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (289)..(289)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (302)..(302)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (309)..(309)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (318)..(318)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (324)..(324)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (357)..(357)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (359)..(359)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\newpage
\vskip0.400000\baselineskip
<400> 345
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 346
\vskip0.400000\baselineskip
<211> 550
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 346
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 347
\vskip0.400000\baselineskip
<211> 535
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (256)..(256)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (502)..(502)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\newpage
\vskip0.400000\baselineskip
<400> 347
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 348
\vskip0.400000\baselineskip
<211> 517
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (210)..(210)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (481)..(481)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 348
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 349
\vskip0.400000\baselineskip
<211> 459
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (83)..(83)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (298)..(298)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 349
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 350
\vskip0.400000\baselineskip
<211> 485
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (33)..(34)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (88)..(88)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (288)..(288)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (349)..(349)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (380)..(380)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 350
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 351
\vskip0.400000\baselineskip
<211> 553
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 351
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 352
\vskip0.400000\baselineskip
<211> 447
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (186)..(186)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (193)..(193)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (297)..(297)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (319)..(319)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 352
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 353
\vskip0.400000\baselineskip
<211> 538
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 353
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 354
\vskip0.400000\baselineskip
<211> 556
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (27)..(27)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (74)..(74)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (91)..(91)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (100)..(100)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (109)..(109)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (112)..(112)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (121)..(121)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (138)..(138)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (155)..(155)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (162)..(162)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (169)..(169)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (181)..(182)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (184)..(184)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (186)..(186)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 354
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 355
\vskip0.400000\baselineskip
<211> 497
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 355
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 356
\vskip0.400000\baselineskip
<211> 533
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 356
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 357
\vskip0.400000\baselineskip
<211> 534
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 357
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 358
\vskip0.400000\baselineskip
<211> 260
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 358
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 359
\vskip0.400000\baselineskip
<211> 399
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 359
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 360
\vskip0.400000\baselineskip
<211> 458
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 360
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 361
\vskip0.400000\baselineskip
<211> 518
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 361
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 362
\vskip0.400000\baselineskip
<211> 560
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (76)..(76)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (153)..(153)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (236)..(236)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (238)..(238)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (245)..(245)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (249)..(249)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (426)..(426)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (446)..(446)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (451)..(451)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (487)..(487)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (490)..(490)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (502)..(502)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (525)..(525)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (528)..(528)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 362
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 363
\vskip0.400000\baselineskip
<211> 390
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 363
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 364
\vskip0.400000\baselineskip
<211> 532
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 364
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 365
\vskip0.400000\baselineskip
<211> 471
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 365
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 366
\vskip0.400000\baselineskip
<211> 505
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 366
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 367
\vskip0.400000\baselineskip
<211> 312
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 367
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 368
\vskip0.400000\baselineskip
<211> 501
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 368
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 369
\vskip0.400000\baselineskip
<211> 569
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 369
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 370
\vskip0.400000\baselineskip
<211> 459
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 370
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 371
\vskip0.400000\baselineskip
<211> 333
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 371
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 372
\vskip0.400000\baselineskip
<211> 422
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 372
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 373
\vskip0.400000\baselineskip
<211> 439
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 373
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 374
\vskip0.400000\baselineskip
<211> 453
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 374
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 375
\vskip0.400000\baselineskip
<211> 488
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 375
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 376
\vskip0.400000\baselineskip
<211> 485
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 376
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 377
\vskip0.400000\baselineskip
<211> 569
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 377
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 378
\vskip0.400000\baselineskip
<211> 336
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 378
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 379
\vskip0.400000\baselineskip
<211> 525
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 379
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 380
\vskip0.400000\baselineskip
<211> 525
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 380
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 381
\vskip0.400000\baselineskip
<211> 520
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 381
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 382
\vskip0.400000\baselineskip
<211> 261
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 382
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 383
\vskip0.400000\baselineskip
<211> 424
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 383
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 384
\vskip0.400000\baselineskip
<211> 460
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 384
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 385
\vskip0.400000\baselineskip
<211> 434
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 385
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 386
\vskip0.400000\baselineskip
<211> 416
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 386
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 387
\vskip0.400000\baselineskip
<211> 477
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 387
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 388
\vskip0.400000\baselineskip
<211> 548
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 388
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 389
\vskip0.400000\baselineskip
<211> 492
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 389
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 390
\vskip0.400000\baselineskip
<211> 354
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 390
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 391
\vskip0.400000\baselineskip
<211> 537
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 391
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 392
\vskip0.400000\baselineskip
<211> 258
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 392
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 393
\vskip0.400000\baselineskip
<211> 513
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 393
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 394
\vskip0.400000\baselineskip
<211> 402
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 394
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 395
\vskip0.400000\baselineskip
<211> 518
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 395
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 396
\vskip0.400000\baselineskip
<211> 444
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 396
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 397
\vskip0.400000\baselineskip
<211> 414
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 397
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 398
\vskip0.400000\baselineskip
<211> 480
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 398
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 399
\vskip0.400000\baselineskip
<211> 533
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 399
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 400
\vskip0.400000\baselineskip
<211> 509
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 400
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 401
\vskip0.400000\baselineskip
<211> 481
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 401
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 402
\vskip0.400000\baselineskip
<211> 481
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 402
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 403
\vskip0.400000\baselineskip
<211> 534
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 403
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 404
\vskip0.400000\baselineskip
<211> 213
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 404
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 405
\vskip0.400000\baselineskip
<211> 406
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 405
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 406
\vskip0.400000\baselineskip
<211> 432
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 406
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 407
\vskip0.400000\baselineskip
<211> 472
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 407
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 408
\vskip0.400000\baselineskip
<211> 519
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 408
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 409
\vskip0.400000\baselineskip
<211> 469
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 409
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 410
\vskip0.400000\baselineskip
<211> 495
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 410
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 411
\vskip0.400000\baselineskip
<211> 349
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 411
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 412
\vskip0.400000\baselineskip
<211> 562
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 412
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 413
\vskip0.400000\baselineskip
<211> 458
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 413
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 414
\vskip0.400000\baselineskip
<211> 560
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 414
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 415
\vskip0.400000\baselineskip
<211> 443
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 415
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 416
\vskip0.400000\baselineskip
<211> 357
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 416
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 417
\vskip0.400000\baselineskip
<211> 487
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 417
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 418
\vskip0.400000\baselineskip
<211> 523
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 418
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 419
\vskip0.400000\baselineskip
<211> 506
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 419
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 420
\vskip0.400000\baselineskip
<211> 504
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 420
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 421
\vskip0.400000\baselineskip
<211> 472
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 421
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 422
\vskip0.400000\baselineskip
<211> 475
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 422
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 423
\vskip0.400000\baselineskip
<211> 485
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 423
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 424
\vskip0.400000\baselineskip
<211> 538
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 424
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 425
\vskip0.400000\baselineskip
<211> 381
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 425
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 426
\vskip0.400000\baselineskip
<211> 457
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 426
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 427
\vskip0.400000\baselineskip
<211> 478
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 427
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 428
\vskip0.400000\baselineskip
<211> 501
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 428
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 429
\vskip0.400000\baselineskip
<211> 474
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 429
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 430
\vskip0.400000\baselineskip
<211> 316
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 430
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 431
\vskip0.400000\baselineskip
<211> 482
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 431
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 432
\vskip0.400000\baselineskip
<211> 511
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (32)..(32)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (34)..(34)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (37)..(37)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (73)..(73)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (284)..(285)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 432
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 433
\vskip0.400000\baselineskip
<211> 445
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 433
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 434
\vskip0.400000\baselineskip
<211> 443
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 434
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 435
\vskip0.400000\baselineskip
<211> 536
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 435
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 436
\vskip0.400000\baselineskip
<211> 464
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 436
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 437
\vskip0.400000\baselineskip
<211> 533
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 437
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 438
\vskip0.400000\baselineskip
<211> 502
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 438
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 439
\vskip0.400000\baselineskip
<211> 485
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 439
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 440
\vskip0.400000\baselineskip
<211> 525
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 440
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 441
\vskip0.400000\baselineskip
<211> 403
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 441
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 442
\vskip0.400000\baselineskip
<211> 346
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 442
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 443
\vskip0.400000\baselineskip
<211> 378
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (146)..(146)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (220)..(220)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 443
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 444
\vskip0.400000\baselineskip
<211> 556
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 444
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 445
\vskip0.400000\baselineskip
<211> 499
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (338)..(338)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 445
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 446
\vskip0.400000\baselineskip
<211> 462
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (352)..(352)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 446
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 447
\vskip0.400000\baselineskip
<211> 361
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 447
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 448
\vskip0.400000\baselineskip
<211> 527
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 448
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 449
\vskip0.400000\baselineskip
<211> 390
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (35)..(35)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (93)..(93)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (108)..(108)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (187)..(189)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 449
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 450
\vskip0.400000\baselineskip
<211> 515
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (214)..(214)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (224)..(224)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 450
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 451
\vskip0.400000\baselineskip
<211> 387
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 451
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 452
\vskip0.400000\baselineskip
<211> 449
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 452
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 453
\vskip0.400000\baselineskip
<211> 548
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 453
\hskip1cm
\vskip0.400000\baselineskip
<210> 454
\vskip0.400000\baselineskip
<211> 569
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (268)..(268)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (290)..(290)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (295)..(295)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (324)..(325)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 454
\hskip1cm
\vskip0.400000\baselineskip
<210> 455
\vskip0.400000\baselineskip
<211> 516
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 455
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 456
\vskip0.400000\baselineskip
<211> 334
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 456
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 457
\vskip0.400000\baselineskip
<211> 569
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 457
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 458
\vskip0.400000\baselineskip
<211> 467
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 458
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 459
\vskip0.400000\baselineskip
<211> 254
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 459
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 460
\vskip0.400000\baselineskip
<211> 338
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (95)..(95)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (99)..(99)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 460
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 461
\vskip0.400000\baselineskip
<211> 544
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (158)..(172)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (182)..(185)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (220)..(220)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (257)..(257)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (305)..(320)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (401)..(401)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (504)..(504)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 461
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 462
\vskip0.400000\baselineskip
<211> 238
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 462
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 463
\vskip0.400000\baselineskip
<211> 388
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (26)..(26)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (36)..(36)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (53)..(53)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (215)..(215)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (254)..(275)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (298)..(298)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 463
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 464
\vskip0.400000\baselineskip
<211> 345
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (67)..(83)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (137)..(137)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (143)..(146)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (148)..(155)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (157)..(157)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (160)..(160)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (162)..(162)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (164)..(164)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (166)..(168)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (170)..(188)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (247)..(248)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 464
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 465
\vskip0.400000\baselineskip
<211> 244
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (92)..(128)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 465
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 466
\vskip0.400000\baselineskip
<211> 578
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (138)..(138)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (141)..(141)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (145)..(145)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (148)..(148)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (165)..(165)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (168)..(170)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (377)..(377)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (424)..(451)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (453)..(453)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (485)..(485)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (487)..(487)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (489)..(489)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (495)..(495)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (497)..(497)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (517)..(517)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (522)..(522)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (528)..(528)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (531)..(531)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 466
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 467
\vskip0.400000\baselineskip
<211> 481
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 467
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 468
\vskip0.400000\baselineskip
<211> 452
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 468
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 469
\vskip0.400000\baselineskip
<211> 515
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 469
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 470
\vskip0.400000\baselineskip
<211> 378
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 470
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 471
\vskip0.400000\baselineskip
<211> 511
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 471
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 472
\vskip0.400000\baselineskip
<211> 215
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 472
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 473
\vskip0.400000\baselineskip
<211> 381
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 473
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 474
\vskip0.400000\baselineskip
<211> 484
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 474
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 475
\vskip0.400000\baselineskip
<211> 563
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 475
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 476
\vskip0.400000\baselineskip
<211> 295
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 476
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 477
\vskip0.400000\baselineskip
<211> 360
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 477
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 478
\vskip0.400000\baselineskip
<211> 461
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 478
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 479
\vskip0.400000\baselineskip
<211> 541
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 479
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 480
\vskip0.400000\baselineskip
<211> 488
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 480
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 481
\vskip0.400000\baselineskip
<211> 547
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (97)..(99)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (135)..(135)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (258)..(258)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 481
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 482
\vskip0.400000\baselineskip
<211> 451
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 482
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 483
\vskip0.400000\baselineskip
<211> 364
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 483
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 484
\vskip0.400000\baselineskip
<211> 468
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 484
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 485
\vskip0.400000\baselineskip
<211> 357
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 485
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 486
\vskip0.400000\baselineskip
<211> 436
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 486
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 487
\vskip0.400000\baselineskip
<211> 470
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (63)..(63)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (83)..(83)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 487
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 488
\vskip0.400000\baselineskip
<211> 446
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 488
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 489
\vskip0.400000\baselineskip
<211> 549
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 489
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 490
\vskip0.400000\baselineskip
<211> 474
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 490
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 491
\vskip0.400000\baselineskip
<211> 378
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 491
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 492
\vskip0.400000\baselineskip
<211> 542
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 492
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 493
\vskip0.400000\baselineskip
<211> 456
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 493
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 494
\vskip0.400000\baselineskip
<211> 513
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 494
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 495
\vskip0.400000\baselineskip
<211> 492
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 495
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 496
\vskip0.400000\baselineskip
<211> 536
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 496
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 497
\vskip0.400000\baselineskip
<211> 555
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 497
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 498
\vskip0.400000\baselineskip
<211> 507
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 498
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 499
\vskip0.400000\baselineskip
<211> 213
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 499
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 500
\vskip0.400000\baselineskip
<211> 173
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 500
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 501
\vskip0.400000\baselineskip
<211> 531
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 501
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 502
\vskip0.400000\baselineskip
<211> 511
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 502
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 503
\vskip0.400000\baselineskip
<211> 324
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 503
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 504
\vskip0.400000\baselineskip
<211> 122
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 504
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 505
\vskip0.400000\baselineskip
<211> 444
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 505
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 506
\vskip0.400000\baselineskip
<211> 212
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 506
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 507
\vskip0.400000\baselineskip
<211> 433
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 507
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 508
\vskip0.400000\baselineskip
<211> 442
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 508
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 509
\vskip0.400000\baselineskip
<211> 536
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 509
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 510
\vskip0.400000\baselineskip
<211> 325
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 510
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 511
\vskip0.400000\baselineskip
<211> 555
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 511
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 512
\vskip0.400000\baselineskip
<211> 513
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 512
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 513
\vskip0.400000\baselineskip
<211> 519
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (46)..(46)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (117)..(118)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 513
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 514
\vskip0.400000\baselineskip
<211> 563
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 514
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 515
\vskip0.400000\baselineskip
<211> 549
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (76)..(76)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 515
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 516
\vskip0.400000\baselineskip
<211> 443
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 516
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 517
\vskip0.400000\baselineskip
<211> 516
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 517
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 518
\vskip0.400000\baselineskip
<211> 516
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 518
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 519
\vskip0.400000\baselineskip
<211> 379
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (170)..(170)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 519
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 520
\vskip0.400000\baselineskip
<211> 466
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 520
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 521
\vskip0.400000\baselineskip
<211> 547
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 521
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 522
\vskip0.400000\baselineskip
<211> 502
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 522
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 523
\vskip0.400000\baselineskip
<211> 387
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 523
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 524
\vskip0.400000\baselineskip
<211> 320
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 524
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 525
\vskip0.400000\baselineskip
<211> 543
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 525
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 526
\vskip0.400000\baselineskip
<211> 541
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 526
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 527
\vskip0.400000\baselineskip
<211> 543
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 527
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 528
\vskip0.400000\baselineskip
<211> 520
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 528
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 529
\vskip0.400000\baselineskip
<211> 358
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 529
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 530
\vskip0.400000\baselineskip
<211> 451
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 530
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 531
\vskip0.400000\baselineskip
<211> 440
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 531
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 532
\vskip0.400000\baselineskip
<211> 225
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 532
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 533
\vskip0.400000\baselineskip
<211> 436
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 533
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 534
\vskip0.400000\baselineskip
<211> 127
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 534
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 535
\vskip0.400000\baselineskip
<211> 517
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 535
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 536
\vskip0.400000\baselineskip
<211> 512
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (30)..(30)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (34)..(34)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (473)..(473)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 536
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 537
\vskip0.400000\baselineskip
<211> 245
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 537
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 538
\vskip0.400000\baselineskip
<211> 435
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 538
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 539
\vskip0.400000\baselineskip
<211> 498
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 539
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 540
\vskip0.400000\baselineskip
<211> 474
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 540
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 541
\vskip0.400000\baselineskip
<211> 437
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 541
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 542
\vskip0.400000\baselineskip
<211> 428
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 542
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 543
\vskip0.400000\baselineskip
<211> 259
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 543
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 544
\vskip0.400000\baselineskip
<211> 446
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 544
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 545
\vskip0.400000\baselineskip
<211> 563
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 545
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 546
\vskip0.400000\baselineskip
<211> 484
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 546
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 547
\vskip0.400000\baselineskip
<211> 402
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 547
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 548
\vskip0.400000\baselineskip
<211> 503
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 548
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 549
\vskip0.400000\baselineskip
<211> 440
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (331)..(331)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 549
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 550
\vskip0.400000\baselineskip
<211> 505
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 550
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 551
\vskip0.400000\baselineskip
<211> 476
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 551
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 552
\vskip0.400000\baselineskip
<211> 493
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 552
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 553
\vskip0.400000\baselineskip
<211> 481
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 553
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 554
\vskip0.400000\baselineskip
<211> 377
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 554
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 555
\vskip0.400000\baselineskip
<211> 482
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 555
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 556
\vskip0.400000\baselineskip
<211> 515
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (89)..(89)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (110)..(110)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (227)..(227)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (250)..(250)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (276)..(276)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 556
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 557
\vskip0.400000\baselineskip
<211> 430
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (43)..(44)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (46)..(46)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (120)..(120)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (358)..(358)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\newpage
\vskip0.400000\baselineskip
<400> 557
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 558
\vskip0.400000\baselineskip
<211> 437
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (137)..(137)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 558
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 559
\vskip0.400000\baselineskip
<211> 519
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (49)..(49)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (61)..(61)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\newpage
\vskip0.400000\baselineskip
<400> 559
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 560
\vskip0.400000\baselineskip
<211> 412
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 560
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 561
\vskip0.400000\baselineskip
<211> 433
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 561
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 562
\vskip0.400000\baselineskip
<211> 490
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 562
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 563
\vskip0.400000\baselineskip
<211> 475
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 563
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 564
\vskip0.400000\baselineskip
<211> 306
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 564
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 565
\vskip0.400000\baselineskip
<211> 490
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 565
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 566
\vskip0.400000\baselineskip
<211> 491
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 566
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 567
\vskip0.400000\baselineskip
<211> 501
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 567
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 568
\vskip0.400000\baselineskip
<211> 474
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 568
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 569
\vskip0.400000\baselineskip
<211> 444
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 569
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 570
\vskip0.400000\baselineskip
<211> 464
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 570
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 571
\vskip0.400000\baselineskip
<211> 499
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 571
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 572
\vskip0.400000\baselineskip
<211> 468
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 572
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 573
\vskip0.400000\baselineskip
<211> 406
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 573
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 574
\vskip0.400000\baselineskip
<211> 535
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 574
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 575
\vskip0.400000\baselineskip
<211> 401
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 575
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 576
\vskip0.400000\baselineskip
<211> 396
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 576
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 577
\vskip0.400000\baselineskip
<211> 318
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 577
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 578
\vskip0.400000\baselineskip
<211> 411
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 578
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 579
\vskip0.400000\baselineskip
<211> 201
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 579
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 580
\vskip0.400000\baselineskip
<211> 336
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 580
\vskip1.000000\baselineskip
\hskip1cm
\hskip1cm
\vskip0.400000\baselineskip
<210> 581
\vskip0.400000\baselineskip
<211> 521
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 581
\hskip1cm
\vskip0.400000\baselineskip
<210> 582
\vskip0.400000\baselineskip
<211> 484
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 582
\hskip1cm
\vskip0.400000\baselineskip
<210> 583
\vskip0.400000\baselineskip
<211> 503
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 583
\hskip1cm
\vskip0.400000\baselineskip
<210> 584
\vskip0.400000\baselineskip
<211> 465
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 584
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 585
\vskip0.400000\baselineskip
<211> 360
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (271)..(271)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 585
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 586
\vskip0.400000\baselineskip
<211> 520
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 586
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 587
\vskip0.400000\baselineskip
<211> 468
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 587
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 588
\vskip0.400000\baselineskip
<211> 523
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 588
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 589
\vskip0.400000\baselineskip
<211> 465
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 589
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 590
\vskip0.400000\baselineskip
<211> 532
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 590
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 591
\vskip0.400000\baselineskip
<211> 129
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 591
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 592
\vskip0.400000\baselineskip
<211> 476
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 592
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 593
\vskip0.400000\baselineskip
<211> 537
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 593
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 594
\vskip0.400000\baselineskip
<211> 543
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 594
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 595
\vskip0.400000\baselineskip
<211> 568
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 595
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 596
\vskip0.400000\baselineskip
<211> 360
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (250)..(250)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 596
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 597
\vskip0.400000\baselineskip
<211> 538
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (314)..(319)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 597
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 598
\vskip0.400000\baselineskip
<211> 521
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 598
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 599
\vskip0.400000\baselineskip
<211> 532
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 599
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 600
\vskip0.400000\baselineskip
<211> 447
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 600
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 601
\vskip0.400000\baselineskip
<211> 447
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 601
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 602
\vskip0.400000\baselineskip
<211> 547
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 602
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 603
\vskip0.400000\baselineskip
<211> 543
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 603
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 604
\vskip0.400000\baselineskip
<211> 473
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 604
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 605
\vskip0.400000\baselineskip
<211> 465
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 605
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 606
\vskip0.400000\baselineskip
<211> 373
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 606
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 607
\vskip0.400000\baselineskip
<211> 364
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 607
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 608
\vskip0.400000\baselineskip
<211> 477
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 608
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 609
\vskip0.400000\baselineskip
<211> 480
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 609
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 610
\vskip0.400000\baselineskip
<211> 523
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 610
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 611
\vskip0.400000\baselineskip
<211> 556
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 611
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 612
\vskip0.400000\baselineskip
<211> 193
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 612
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 613
\vskip0.400000\baselineskip
<211> 402
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 613
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 614
\vskip0.400000\baselineskip
<211> 536
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 614
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 615
\vskip0.400000\baselineskip
<211> 548
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 615
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 616
\vskip0.400000\baselineskip
<211> 371
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 616
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 617
\vskip0.400000\baselineskip
<211> 545
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 617
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 618
\vskip0.400000\baselineskip
<211> 423
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 618
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 619
\vskip0.400000\baselineskip
<211> 543
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 619
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 620
\vskip0.400000\baselineskip
<211> 406
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 620
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 621
\vskip0.400000\baselineskip
<211> 530
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 621
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 622
\vskip0.400000\baselineskip
<211> 434
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 622
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 623
\vskip0.400000\baselineskip
<211> 417
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 623
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 624
\vskip0.400000\baselineskip
<211> 317
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 624
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 625
\vskip0.400000\baselineskip
<211> 383
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 625
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 626
\vskip0.400000\baselineskip
<211> 317
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 626
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 627
\vskip0.400000\baselineskip
<211> 397
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 627
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 628
\vskip0.400000\baselineskip
<211> 561
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 628
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 629
\vskip0.400000\baselineskip
<211> 514
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 629
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 630
\vskip0.400000\baselineskip
<211> 527
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 630
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 631
\vskip0.400000\baselineskip
<211> 489
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 631
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 632
\vskip0.400000\baselineskip
<211> 546
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 632
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 633
\vskip0.400000\baselineskip
<211> 493
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (87)..(87)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\newpage
\vskip0.400000\baselineskip
<400> 633
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 634
\vskip0.400000\baselineskip
<211> 489
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 634
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 635
\vskip0.400000\baselineskip
<211> 155
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 635
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 636
\vskip0.400000\baselineskip
<211> 355
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 636
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 637
\vskip0.400000\baselineskip
<211> 469
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 637
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 638
\vskip0.400000\baselineskip
<211> 455
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 638
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 639
\vskip0.400000\baselineskip
<211> 418
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 639
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 640
\vskip0.400000\baselineskip
<211> 505
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 640
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 641
\vskip0.400000\baselineskip
<211> 533
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 641
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 642
\vskip0.400000\baselineskip
<211> 493
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 642
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 643
\vskip0.400000\baselineskip
<211> 555
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 643
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 644
\vskip0.400000\baselineskip
<211> 300
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 644
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 645
\vskip0.400000\baselineskip
<211> 551
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (114)..(114)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (119)..(120)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (127)..(127)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (129)..(129)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (149)..(149)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (152)..(152)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (163)..(163)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (167)..(168)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (189)..(189)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (243)..(243)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\newpage
\vskip0.400000\baselineskip
<400> 645
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 646
\vskip0.400000\baselineskip
<211> 468
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 646
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 647
\vskip0.400000\baselineskip
<211> 416
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 647
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 648
\vskip0.400000\baselineskip
<211> 555
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 648
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 649
\vskip0.400000\baselineskip
<211> 343
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 649
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 650
\vskip0.400000\baselineskip
<211> 438
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (195)..(195)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 650
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 651
\vskip0.400000\baselineskip
<211> 389
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 651
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 652
\vskip0.400000\baselineskip
<211> 385
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 652
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 653
\vskip0.400000\baselineskip
<211> 464
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 653
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 654
\vskip0.400000\baselineskip
<211> 479
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 654
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 655
\vskip0.400000\baselineskip
<211> 469
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 655
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 656
\vskip0.400000\baselineskip
<211> 445
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 656
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 657
\vskip0.400000\baselineskip
<211> 535
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 657
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 658
\vskip0.400000\baselineskip
<211> 522
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 658
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 659
\vskip0.400000\baselineskip
<211> 567
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 659
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 660
\vskip0.400000\baselineskip
<211> 392
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 660
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 661
\vskip0.400000\baselineskip
<211> 196
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 661
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 662
\vskip0.400000\baselineskip
<211> 489
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 662
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 663
\vskip0.400000\baselineskip
<211> 386
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 663
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 664
\vskip0.400000\baselineskip
<211> 523
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 664
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 665
\vskip0.400000\baselineskip
<211> 446
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 665
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 666
\vskip0.400000\baselineskip
<211> 554
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 666
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 667
\vskip0.400000\baselineskip
<211> 504
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 667
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 668
\vskip0.400000\baselineskip
<211> 342
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 668
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 669
\vskip0.400000\baselineskip
<211> 463
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 669
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 670
\vskip0.400000\baselineskip
<211> 459
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 670
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 671
\vskip0.400000\baselineskip
<211> 265
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 671
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 672
\vskip0.400000\baselineskip
<211> 478
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 672
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 673
\vskip0.400000\baselineskip
<211> 513
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (215)..(215)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 673
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 674
\vskip0.400000\baselineskip
<211> 514
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 674
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 675
\vskip0.400000\baselineskip
<211> 387
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 675
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 676
\vskip0.400000\baselineskip
<211> 520
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 676
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 677
\vskip0.400000\baselineskip
<211> 465
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 677
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 678
\vskip0.400000\baselineskip
<211> 548
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 678
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 679
\vskip0.400000\baselineskip
<211> 345
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 679
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 680
\vskip0.400000\baselineskip
<211> 474
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 680
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 681
\vskip0.400000\baselineskip
<211> 479
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 681
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 682
\vskip0.400000\baselineskip
<211> 460
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 682
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 683
\vskip0.400000\baselineskip
<211> 493
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 683
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 684
\vskip0.400000\baselineskip
<211> 343
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 684
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 685
\vskip0.400000\baselineskip
<211> 522
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 685
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 686
\vskip0.400000\baselineskip
<211> 555
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 686
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 687
\vskip0.400000\baselineskip
<211> 455
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 687
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 688
\vskip0.400000\baselineskip
<211> 382
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 688
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 689
\vskip0.400000\baselineskip
<211> 451
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 689
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 690
\vskip0.400000\baselineskip
<211> 358
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 690
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 691
\vskip0.400000\baselineskip
<211> 473
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 691
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 692
\vskip0.400000\baselineskip
<211> 521
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 692
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 693
\vskip0.400000\baselineskip
<211> 388
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 693
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 694
\vskip0.400000\baselineskip
<211> 565
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 694
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 695
\vskip0.400000\baselineskip
<211> 564
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 695
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 696
\vskip0.400000\baselineskip
<211> 480
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (431)..(431)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 696
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 697
\vskip0.400000\baselineskip
<211> 525
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 697
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 698
\vskip0.400000\baselineskip
<211> 552
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 698
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 699
\vskip0.400000\baselineskip
<211> 503
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 699
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 700
\vskip0.400000\baselineskip
<211> 497
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 700
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 701
\vskip0.400000\baselineskip
<211> 505
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 701
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 702
\vskip0.400000\baselineskip
<211> 450
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 702
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 703
\vskip0.400000\baselineskip
<211> 542
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 703
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 704
\vskip0.400000\baselineskip
<211> 503
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 704
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 705
\vskip0.400000\baselineskip
<211> 396
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (148)..(149)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (151)..(154)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (156)..(156)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 705
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 706
\vskip0.400000\baselineskip
<211> 49
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 706
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 707
\vskip0.400000\baselineskip
<211> 262
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 707
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 708
\vskip0.400000\baselineskip
<211> 396
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 708
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 709
\vskip0.400000\baselineskip
<211> 455
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 709
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 710
\vskip0.400000\baselineskip
<211> 501
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 710
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 711
\vskip0.400000\baselineskip
<211> 379
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 711
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 712
\vskip0.400000\baselineskip
<211> 256
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 712
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 713
\vskip0.400000\baselineskip
<211> 423
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (369)..(370)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 713
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 714
\vskip0.400000\baselineskip
<211> 398
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (42)..(42)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (103)..(103)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (164)..(164)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (225)..(225)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (286)..(286)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (347)..(347)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 714
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 715
\vskip0.400000\baselineskip
<211> 480
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (207)..(208)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\newpage
\vskip0.400000\baselineskip
<400> 715
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 716
\vskip0.400000\baselineskip
<211> 559
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 716
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 717
\vskip0.400000\baselineskip
<211> 382
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 717
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 718
\vskip0.400000\baselineskip
<211> 486
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (77)..(77)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (351)..(351)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (457)..(457)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 718
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 719
\vskip0.400000\baselineskip
<211> 181
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 719
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 720
\vskip0.400000\baselineskip
<211> 464
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 720
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 721
\vskip0.400000\baselineskip
<211> 426
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 721
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 722
\vskip0.400000\baselineskip
<211> 445
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 722
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 723
\vskip0.400000\baselineskip
<211> 501
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 723
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 724
\vskip0.400000\baselineskip
<211> 477
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 724
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 725
\vskip0.400000\baselineskip
<211> 444
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 725
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 726
\vskip0.400000\baselineskip
<211> 475
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 726
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 727
\vskip0.400000\baselineskip
<211> 317
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 727
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 728
\vskip0.400000\baselineskip
<211> 496
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 728
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 729
\vskip0.400000\baselineskip
<211> 425
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 729
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 730
\vskip0.400000\baselineskip
<211> 400
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 730
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 731
\vskip0.400000\baselineskip
<211> 459
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (32)..(32)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (78)..(78)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (82)..(82)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (242)..(242)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 731
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 732
\vskip0.400000\baselineskip
<211> 528
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 732
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 733
\vskip0.400000\baselineskip
<211> 570
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (233)..(233)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (252)..(252)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (259)..(259)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (347)..(347)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 733
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 734
\vskip0.400000\baselineskip
<211> 246
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 734
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 735
\vskip0.400000\baselineskip
<211> 358
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 735
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 736
\vskip0.400000\baselineskip
<211> 454
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 736
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 737
\vskip0.400000\baselineskip
<211> 226
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 737
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 738
\vskip0.400000\baselineskip
<211> 560
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 738
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 739
\vskip0.400000\baselineskip
<211> 440
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 739
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 740
\vskip0.400000\baselineskip
<211> 473
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 740
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 741
\vskip0.400000\baselineskip
<211> 255
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 741
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 742
\vskip0.400000\baselineskip
<211> 566
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 742
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 743
\vskip0.400000\baselineskip
<211> 555
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 743
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 744
\vskip0.400000\baselineskip
<211> 436
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 744
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 745
\vskip0.400000\baselineskip
<211> 505
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 745
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 746
\vskip0.400000\baselineskip
<211> 471
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 746
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 747
\vskip0.400000\baselineskip
<211> 256
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 747
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 748
\vskip0.400000\baselineskip
<211> 528
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 748
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 749
\vskip0.400000\baselineskip
<211> 518
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 749
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 750
\vskip0.400000\baselineskip
<211> 545
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 750
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 751
\vskip0.400000\baselineskip
<211> 421
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 751
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 752
\vskip0.400000\baselineskip
<211> 375
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 752
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 753
\vskip0.400000\baselineskip
<211> 532
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 753
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 754
\vskip0.400000\baselineskip
<211> 159
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 754
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 755
\vskip0.400000\baselineskip
<211> 378
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 755
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 756
\vskip0.400000\baselineskip
<211> 436
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 756
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 757
\vskip0.400000\baselineskip
<211> 441
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 757
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 758
\vskip0.400000\baselineskip
<211> 437
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 758
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 759
\vskip0.400000\baselineskip
<211> 402
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 759
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 760
\vskip0.400000\baselineskip
<211> 501
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 760
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 761
\vskip0.400000\baselineskip
<211> 441
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (35)..(35)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 761
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 762
\vskip0.400000\baselineskip
<211> 521
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (82)..(82)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (89)..(89)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 762
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 763
\vskip0.400000\baselineskip
<211> 462
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (64)..(65)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (115)..(115)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (121)..(121)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (422)..(422)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (432)..(432)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 763
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 764
\vskip0.400000\baselineskip
<211> 495
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 764
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 765
\vskip0.400000\baselineskip
<211> 458
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (82)..(82)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 765
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 766
\vskip0.400000\baselineskip
<211> 414
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 766
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 767
\vskip0.400000\baselineskip
<211> 441
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 767
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 768
\vskip0.400000\baselineskip
<211> 529
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 768
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 769
\vskip0.400000\baselineskip
<211> 474
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 769
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 770
\vskip0.400000\baselineskip
<211> 536
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 770
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 771
\vskip0.400000\baselineskip
<211> 549
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (225)..(225)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 771
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 772
\vskip0.400000\baselineskip
<211> 443
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 772
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 773
\vskip0.400000\baselineskip
<211> 475
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (192)..(192)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (195)..(195)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (222)..(222)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (351)..(351)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 773
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 774
\vskip0.400000\baselineskip
<211> 504
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 774
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 775
\vskip0.400000\baselineskip
<211> 417
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 775
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 776
\vskip0.400000\baselineskip
<211> 304
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (238)..(238)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 776
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 777
\vskip0.400000\baselineskip
<211> 554
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (163)..(163)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 777
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 778
\vskip0.400000\baselineskip
<211> 147
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 778
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 779
\vskip0.400000\baselineskip
<211> 560
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (175)..(177)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (179)..(181)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (190)..(190)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (422)..(422)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (426)..(426)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (429)..(430)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\newpage
\vskip0.400000\baselineskip
<400> 779
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 780
\vskip0.400000\baselineskip
<211> 559
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (36)..(36)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (51)..(51)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (56)..(56)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 780
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 781
\vskip0.400000\baselineskip
<211> 507
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 781
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 782
\vskip0.400000\baselineskip
<211> 480
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 782
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 783
\vskip0.400000\baselineskip
<211> 341
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 783
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 784
\vskip0.400000\baselineskip
<211> 490
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 784
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 785
\vskip0.400000\baselineskip
<211> 398
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 785
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 786
\vskip0.400000\baselineskip
<211> 528
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (106)..(106)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (185)..(185)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (189)..(190)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (196)..(196)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (245)..(245)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (284)..(284)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 786
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 787
\vskip0.400000\baselineskip
<211> 543
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 787
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 788
\vskip0.400000\baselineskip
<211> 444
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (33)..(34)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (36)..(47)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (49)..(49)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (51)..(53)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (55)..(56)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (58)..(58)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (60)..(61)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (63)..(63)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (66)..(74)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (76)..(80)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (85)..(85)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (208)..(208)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\newpage
\vskip0.400000\baselineskip
<400> 788
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 789
\vskip0.400000\baselineskip
<211> 548
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 789
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 790
\vskip0.400000\baselineskip
<211> 196
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 790
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 791
\vskip0.400000\baselineskip
<211> 542
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (208)..(208)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (461)..(461)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 791
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 792
\vskip0.400000\baselineskip
<211> 522
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 792
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 793
\vskip0.400000\baselineskip
<211> 450
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (34)..(34)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\newpage
\vskip0.400000\baselineskip
<400> 793
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 794
\vskip0.400000\baselineskip
<211> 544
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 794
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 795
\vskip0.400000\baselineskip
<211> 558
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (158)..(158)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 795
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 796
\vskip0.400000\baselineskip
<211> 431
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (178)..(178)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 796
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 797
\vskip0.400000\baselineskip
<211> 358
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 797
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 798
\vskip0.400000\baselineskip
<211> 475
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (61)..(62)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (64)..(76)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (78)..(81)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 798
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 799
\vskip0.400000\baselineskip
<211> 519
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 799
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 800
\vskip0.400000\baselineskip
<211> 466
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (411)..(411)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 800
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 801
\vskip0.400000\baselineskip
<211> 549
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (148)..(149)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (189)..(189)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (191)..(194)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (339)..(339)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (399)..(399)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 801
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 802
\vskip0.400000\baselineskip
<211> 515
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (101)..(101)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (106)..(108)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (125)..(126)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (222)..(222)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (225)..(228)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 802
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 803
\vskip0.400000\baselineskip
<211> 197
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 803
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 804
\vskip0.400000\baselineskip
<211> 483
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (48)..(48)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (212)..(212)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 804
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 805
\vskip0.400000\baselineskip
<211> 508
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (224)..(224)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (260)..(261)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 805
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 806
\vskip0.400000\baselineskip
<211> 494
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 806
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 807
\vskip0.400000\baselineskip
<211> 533
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (26)..(26)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (42)..(42)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (48)..(48)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (75)..(75)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (83)..(83)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (121)..(121)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\newpage
\vskip0.400000\baselineskip
<400> 807
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 808
\vskip0.400000\baselineskip
<211> 358
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (146)..(146)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (180)..(181)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 808
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 809
\vskip0.400000\baselineskip
<211> 424
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (263)..(263)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\newpage
\vskip0.400000\baselineskip
<400> 809
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 810
\vskip0.400000\baselineskip
<211> 478
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (333)..(333)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (360)..(360)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 810
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 811
\vskip0.400000\baselineskip
<211> 529
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 811
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 812
\vskip0.400000\baselineskip
<211> 554
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 812
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 813
\vskip0.400000\baselineskip
<211> 533
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 813
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 814
\vskip0.400000\baselineskip
<211> 493
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (76)..(76)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 814
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 815
\vskip0.400000\baselineskip
<211> 295
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 815
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 816
\vskip0.400000\baselineskip
<211> 422
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 816
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 817
\vskip0.400000\baselineskip
<211> 352
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 817
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 818
\vskip0.400000\baselineskip
<211> 335
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 818
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 819
\vskip0.400000\baselineskip
<211> 261
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 819
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 820
\vskip0.400000\baselineskip
<211> 245
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 820
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 821
\vskip0.400000\baselineskip
<211> 273
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 821
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 822
\vskip0.400000\baselineskip
<211> 492
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 822
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 823
\vskip0.400000\baselineskip
<211> 519
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (118)..(118)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (125)..(125)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (133)..(133)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (136)..(136)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 823
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 824
\vskip0.400000\baselineskip
<211> 375
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (310)..(310)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (312)..(312)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 824
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 825
\vskip0.400000\baselineskip
<211> 387
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (74)..(74)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (99)..(99)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (112)..(112)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (128)..(128)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 825
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 826
\vskip0.400000\baselineskip
<211> 178
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (119)..(119)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (124)..(124)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 826
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 827
\vskip0.400000\baselineskip
<211> 426
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 827
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 828
\vskip0.400000\baselineskip
<211> 400
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 828
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 829
\vskip0.400000\baselineskip
<211> 520
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 829
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 830
\vskip0.400000\baselineskip
<211> 347
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (223)..(223)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 830
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 831
\vskip0.400000\baselineskip
<211> 519
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (326)..(326)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (374)..(376)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (398)..(401)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 831
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 832
\vskip0.400000\baselineskip
<211> 416
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 832
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 833
\vskip0.400000\baselineskip
<211> 482
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 833
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 834
\vskip0.400000\baselineskip
<211> 212
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 834
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 835
\vskip0.400000\baselineskip
<211> 264
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 835
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 836
\vskip0.400000\baselineskip
<211> 484
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (190)..(190)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (420)..(420)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (424)..(424)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 836
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 837
\vskip0.400000\baselineskip
<211> 383
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (319)..(319)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 837
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 838
\vskip0.400000\baselineskip
<211> 507
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 838
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 839
\vskip0.400000\baselineskip
<211> 502
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 839
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 840
\vskip0.400000\baselineskip
<211> 328
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 840
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 841
\vskip0.400000\baselineskip
<211> 546
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 841
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 842
\vskip0.400000\baselineskip
<211> 399
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 842
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 843
\vskip0.400000\baselineskip
<211> 543
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 843
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 844
\vskip0.400000\baselineskip
<211> 496
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 844
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 845
\vskip0.400000\baselineskip
<211> 330
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 845
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 846
\vskip0.400000\baselineskip
<211> 453
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 846
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 847
\vskip0.400000\baselineskip
<211> 152
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (53)..(53)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (87)..(87)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (100)..(100)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (110)..(110)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 847
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 848
\vskip0.400000\baselineskip
<211> 383
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (112)..(113)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (267)..(267)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 848
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 849
\vskip0.400000\baselineskip
<211> 506
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 849
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 850
\vskip0.400000\baselineskip
<211> 244
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 850
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 851
\vskip0.400000\baselineskip
<211> 538
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 851
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 852
\vskip0.400000\baselineskip
<211> 554
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 852
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 853
\vskip0.400000\baselineskip
<211> 549
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 853
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 854
\vskip0.400000\baselineskip
<211> 554
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 854
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 855
\vskip0.400000\baselineskip
<211> 542
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 855
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 856
\vskip0.400000\baselineskip
<211> 320
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 856
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 857
\vskip0.400000\baselineskip
<211> 501
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 857
\vskip1.000000\baselineskip
\hskip1cm
\vskip0.400000\baselineskip
<210> 858
\vskip0.400000\baselineskip
<211> 531
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 858
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 859
\vskip0.400000\baselineskip
<211> 493
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 859
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 860
\vskip0.400000\baselineskip
<211> 527
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 860
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 861
\vskip0.400000\baselineskip
<211> 464
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 861
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 862
\vskip0.400000\baselineskip
<211> 548
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 862
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 863
\vskip0.400000\baselineskip
<211> 505
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 863
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 864
\vskip0.400000\baselineskip
<211> 554
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 864
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 865
\vskip0.400000\baselineskip
<211> 498
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 865
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 866
\vskip0.400000\baselineskip
<211> 461
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 866
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 867
\vskip0.400000\baselineskip
<211> 398
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 867
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 868
\vskip0.400000\baselineskip
<211> 489
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 868
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 869
\vskip0.400000\baselineskip
<211> 495
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 869
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 870
\vskip0.400000\baselineskip
<211> 517
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 870
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 871
\vskip0.400000\baselineskip
<211> 519
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 871
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 872
\vskip0.400000\baselineskip
<211> 372
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 872
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 873
\vskip0.400000\baselineskip
<211> 486
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 873
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 874
\vskip0.400000\baselineskip
<211> 532
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 874
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 875
\vskip0.400000\baselineskip
<211> 498
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 875
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 876
\vskip0.400000\baselineskip
<211> 547
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 876
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 877
\vskip0.400000\baselineskip
<211> 342
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (163)..(163)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 877
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 878
\vskip0.400000\baselineskip
<211> 400
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 878
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 879
\vskip0.400000\baselineskip
<211> 509
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 879
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 880
\vskip0.400000\baselineskip
<211> 371
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 880
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 881
\vskip0.400000\baselineskip
<211> 317
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 881
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 882
\vskip0.400000\baselineskip
<211> 534
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 882
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 883
\vskip0.400000\baselineskip
<211> 500
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 883
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 884
\vskip0.400000\baselineskip
<211> 491
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 884
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 885
\vskip0.400000\baselineskip
<211> 493
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 885
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 886
\vskip0.400000\baselineskip
<211> 518
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 886
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 887
\vskip0.400000\baselineskip
<211> 533
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 887
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 888
\vskip0.400000\baselineskip
<211> 516
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 888
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 889
\vskip0.400000\baselineskip
<211> 529
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 889
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 890
\vskip0.400000\baselineskip
<211> 490
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 890
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 891
\vskip0.400000\baselineskip
<211> 433
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (289)..(289)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 891
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 892
\vskip0.400000\baselineskip
<211> 399
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 892
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 893
\vskip0.400000\baselineskip
<211> 356
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 893
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 894
\vskip0.400000\baselineskip
<211> 498
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 894
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 895
\vskip0.400000\baselineskip
<211> 453
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 895
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 896
\vskip0.400000\baselineskip
<211> 465
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 896
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 897
\vskip0.400000\baselineskip
<211> 447
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 897
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 898
\vskip0.400000\baselineskip
<211> 468
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 898
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 899
\vskip0.400000\baselineskip
<211> 528
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 899
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 900
\vskip0.400000\baselineskip
<211> 483
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 900
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 901
\vskip0.400000\baselineskip
<211> 393
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 901
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 902
\vskip0.400000\baselineskip
<211> 563
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 902
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 903
\vskip0.400000\baselineskip
<211> 471
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 903
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 904
\vskip0.400000\baselineskip
<211> 495
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 904
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 905
\vskip0.400000\baselineskip
<211> 437
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 905
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 906
\vskip0.400000\baselineskip
<211> 434
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 906
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 907
\vskip0.400000\baselineskip
<211> 551
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 907
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 908
\vskip0.400000\baselineskip
<211> 413
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 908
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 909
\vskip0.400000\baselineskip
<211> 535
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 909
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 910
\vskip0.400000\baselineskip
<211> 366
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 910
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 911
\vskip0.400000\baselineskip
<211> 532
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 911
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 912
\vskip0.400000\baselineskip
<211> 404
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 912
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 913
\vskip0.400000\baselineskip
<211> 503
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 913
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 914
\vskip0.400000\baselineskip
<211> 331
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 914
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 915
\vskip0.400000\baselineskip
<211> 434
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 915
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 916
\vskip0.400000\baselineskip
<211> 488
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 916
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 917
\vskip0.400000\baselineskip
<211> 381
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 917
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 918
\vskip0.400000\baselineskip
<211> 569
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 918
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 919
\vskip0.400000\baselineskip
<211> 460
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 919
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 920
\vskip0.400000\baselineskip
<211> 540
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 920
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 921
\vskip0.400000\baselineskip
<211> 232
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 921
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 922
\vskip0.400000\baselineskip
<211> 424
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 922
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 923
\vskip0.400000\baselineskip
<211> 571
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 923
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 924
\vskip0.400000\baselineskip
<211> 385
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 924
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 925
\vskip0.400000\baselineskip
<211> 386
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 925
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 926
\vskip0.400000\baselineskip
<211> 480
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 926
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 927
\vskip0.400000\baselineskip
<211> 514
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 927
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 928
\vskip0.400000\baselineskip
<211> 554
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 928
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 929
\vskip0.400000\baselineskip
<211> 547
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 929
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 930
\vskip0.400000\baselineskip
<211> 402
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 930
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 931
\vskip0.400000\baselineskip
<211> 452
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 931
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 932
\vskip0.400000\baselineskip
<211> 496
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 932
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 933
\vskip0.400000\baselineskip
<211> 487
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 933
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 934
\vskip0.400000\baselineskip
<211> 321
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 934
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 935
\vskip0.400000\baselineskip
<211> 194
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 935
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 936
\vskip0.400000\baselineskip
<211> 415
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 936
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 937
\vskip0.400000\baselineskip
<211> 523
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 937
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 938
\vskip0.400000\baselineskip
<211> 511
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 938
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 939
\vskip0.400000\baselineskip
<211> 389
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 939
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 940
\vskip0.400000\baselineskip
<211> 466
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 940
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 941
\vskip0.400000\baselineskip
<211> 505
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 941
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 942
\vskip0.400000\baselineskip
<211> 545
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 942
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 943
\vskip0.400000\baselineskip
<211> 414
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 943
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 944
\vskip0.400000\baselineskip
<211> 163
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 944
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 945
\vskip0.400000\baselineskip
<211> 553
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 945
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 946
\vskip0.400000\baselineskip
<211> 560
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 946
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 947
\vskip0.400000\baselineskip
<211> 288
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 947
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 948
\vskip0.400000\baselineskip
<211> 513
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 948
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 949
\vskip0.400000\baselineskip
<211> 284
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 949
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 950
\vskip0.400000\baselineskip
<211> 511
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 950
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 951
\vskip0.400000\baselineskip
<211> 316
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 951
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 952
\vskip0.400000\baselineskip
<211> 149
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (55)..(55)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 952
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 953
\vskip0.400000\baselineskip
<211> 475
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 953
\vskip1.000000\baselineskip
\hskip1cm
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 954
\vskip0.400000\baselineskip
<211> 402
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 954
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 955
\vskip0.400000\baselineskip
<211> 523
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (29)..(29)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 955
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 956
\vskip0.400000\baselineskip
<211> 491
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (332)..(332)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (365)..(365)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\newpage
\vskip0.400000\baselineskip
<400> 956
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 957
\vskip0.400000\baselineskip
<211> 253
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 957
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 958
\vskip0.400000\baselineskip
<211> 480
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (57)..(57)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (65)..(65)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 958
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 959
\vskip0.400000\baselineskip
<211> 323
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 959
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 960
\vskip0.400000\baselineskip
<211> 533
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 960
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 961
\vskip0.400000\baselineskip
<211> 472
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 961
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 962
\vskip0.400000\baselineskip
<211> 495
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 962
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 963
\vskip0.400000\baselineskip
<211> 120
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (43)..(43)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 963
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 964
\vskip0.400000\baselineskip
<211> 494
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (335)..(335)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 964
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 965
\vskip0.400000\baselineskip
<211> 324
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 965
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 966
\vskip0.400000\baselineskip
<211> 478
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 966
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 967
\vskip0.400000\baselineskip
<211> 44
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 967
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 968
\vskip0.400000\baselineskip
<211> 65
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 968
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 969
\vskip0.400000\baselineskip
<211> 494
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (33)..(33)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (35)..(35)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (45)..(54)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (168)..(168)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (203)..(257)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (304)..(304)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (306)..(306)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (348)..(362)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (427)..(427)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\newpage
\vskip0.400000\baselineskip
<400> 969
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 970
\vskip0.400000\baselineskip
<211> 332
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (229)..(252)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 970
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 971
\vskip0.400000\baselineskip
<211> 279
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 971
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 972
\vskip0.400000\baselineskip
<211> 145
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 972
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 973
\vskip0.400000\baselineskip
<211> 499
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (200)..(204)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (230)..(230)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (235)..(235)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (239)..(239)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (357)..(357)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 973
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 974
\vskip0.400000\baselineskip
<211> 419
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (26)..(29)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (44)..(58)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (63)..(139)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 974
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 975
\vskip0.400000\baselineskip
<211> 427
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (64)..(64)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (101)..(101)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (120)..(121)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (272)..(326)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\newpage
\vskip0.400000\baselineskip
<400> 975
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 976
\vskip0.400000\baselineskip
<211> 457
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (64)..(95)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (104)..(104)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (226)..(226)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (344)..(344)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (387)..(402)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 976
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 977
\vskip0.400000\baselineskip
<211> 493
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (28)..(28)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (44)..(44)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (53)..(53)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (73)..(74)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (88)..(88)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (95)..(96)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (98)..(98)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (108)..(123)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (351)..(351)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> misc_feature
\vskip0.400000\baselineskip
<222> (364)..(378)
\vskip0.400000\baselineskip
<223> n es a, c, g o t
\newpage
\vskip0.400000\baselineskip
<400> 977
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 978
\vskip0.400000\baselineskip
<211> 1536
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 978
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 979
\vskip0.400000\baselineskip
<211> 1524
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 979
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 980
\vskip0.400000\baselineskip
<211> 2026
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 980
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 981
\vskip0.400000\baselineskip
<211> 4204
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 981
\vskip1.000000\baselineskip
\hskip1cm
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 982
\vskip0.400000\baselineskip
<211> 23
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 982
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 983
\vskip0.400000\baselineskip
<211> 23
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 983
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 984
\vskip0.400000\baselineskip
<211> 15
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 984
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 985
\vskip0.400000\baselineskip
<211> 22
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 985
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 986
\vskip0.400000\baselineskip
<211> 22
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 986
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 987
\vskip0.400000\baselineskip
<211> 30
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 987
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 988
\vskip0.400000\baselineskip
<211> 2384
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 988
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 989
\vskip0.400000\baselineskip
<211> 1204
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 989
\vskip1.000000\baselineskip
\hskip1cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 990
\vskip0.400000\baselineskip
<211> 29
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Homo sapiens
Claims (1)
1. Un método para identificar un melanoma que
comprende las etapas de
- (a)
- obtener una muestra tisular; y
- (b)
- medir los niveles de expresión en la muestra de genes que codifican ARNm correspondiente a PLAB (SEC ID Nº: 1) y L1CAM (SEC ID Nº: 2); o PLAB, L1CAM y NTRK3 (SEC ID Nº: 3)
en el que los niveles de expresión génica por
encima de niveles límite predeterminados son indicativos de la
presencia de un melanoma en la muestra y en el que dichos niveles
límite predeterminados tienen la mayor puntuación en:
- muestras normales primarias; y/o
- muestras de nevos benignos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58290604P | 2004-06-25 | 2004-06-25 | |
| US582906P | 2004-06-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2323972T3 true ES2323972T3 (es) | 2009-07-28 |
Family
ID=35782385
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES05791715T Active ES2323972T3 (es) | 2004-06-25 | 2005-06-24 | Metodos y reactivos para la deteccion de melanoma. |
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| EP (1) | EP1812590B1 (es) |
| JP (1) | JP2008504034A (es) |
| KR (1) | KR20070048701A (es) |
| CN (1) | CN101258249A (es) |
| AT (1) | ATE428808T1 (es) |
| AU (1) | AU2005258331B2 (es) |
| BR (1) | BRPI0512587A (es) |
| CA (1) | CA2572338A1 (es) |
| DE (1) | DE602005013998D1 (es) |
| DK (1) | DK1812590T3 (es) |
| ES (1) | ES2323972T3 (es) |
| IL (1) | IL180208A0 (es) |
| MX (1) | MX2007000291A (es) |
| NZ (1) | NZ552324A (es) |
| PT (1) | PT1812590E (es) |
| WO (1) | WO2006002433A2 (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007002006A2 (en) | 2005-06-20 | 2007-01-04 | Panomics, Inc. | Multiplex detection of nucleic acids |
| ES2494843T3 (es) * | 2005-09-19 | 2014-09-16 | Janssen Diagnostics, Llc | Métodos y materiales para identificar el origen de un carcinoma de origen primario desconocido |
| FR2890859B1 (fr) | 2005-09-21 | 2012-12-21 | Oreal | Oligonucleotide d'arn double brin inhibant l'expression de la tyrosinase |
| US20100029504A1 (en) | 2007-01-16 | 2010-02-04 | Phigenix, Inc. | Detecting pax2 for the diagnosis of breast cancer |
| JP2007289063A (ja) * | 2006-04-25 | 2007-11-08 | Shiseido Co Ltd | しみ部位亢進遺伝子群を指標とした皮膚しみ形成予知方法、皮膚しみ形成抑制剤のスクリーニング方法 |
| US7851144B2 (en) | 2006-08-18 | 2010-12-14 | The University Of Washington | Compositions and methods for detecting cancer |
| BRPI0807227A2 (pt) * | 2007-02-01 | 2019-01-22 | Veridex Llc | métodos e materiais para identificação da origem de um carcinoma de origem primária desconhecida |
| WO2008141275A1 (en) * | 2007-05-11 | 2008-11-20 | The Johns Hopkins University | Biomarkers for melanoma |
| US20110160080A1 (en) | 2008-05-14 | 2011-06-30 | Chang Sherman H | Diagnosis of Melanoma and Solar Lentigo by Nucleic Acid Analysis |
| IL206810A (en) * | 2009-07-08 | 2015-07-30 | Janssen Diagnostics Llc | Methods for identifying melanoma and kits for using these methods |
| JP2013013327A (ja) * | 2009-10-29 | 2013-01-24 | Actgen Inc | Ｍａｎｓｃ１蛋白質に結合し、抗癌活性を有する抗体 |
| EP2619321B1 (en) * | 2010-09-20 | 2018-08-01 | Advanced Cell Diagnostics, Inc. | Biomarkers for differentiating melanoma from benign nevus in the skin |
| CN104849472A (zh) | 2010-10-21 | 2015-08-19 | 领先细胞医疗诊断有限公司 | 用于原位检测核酸的超灵敏方法 |
| US9758829B2 (en) | 2012-06-22 | 2017-09-12 | Htg Molecular Diagnostics, Inc. | Molecular malignancy in melanocytic lesions |
| EP3362462B1 (en) | 2015-10-12 | 2021-07-21 | Advanced Cell Diagnostics, Inc. | In situ detection of nucleotide variants in high noise samples, and compositions and methods related thereto |
| CN105331686B (zh) * | 2015-10-21 | 2018-09-21 | 中国科学院生物物理研究所 | Myosin9b蛋白特异性抗体的制备及Myosin9b基因家族变化在肿瘤诊断及预后中的应用 |
| WO2018071824A1 (en) * | 2016-10-13 | 2018-04-19 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for predicting response and resistance to ctla4 blockade in melanoma using a gene expression signature |
| CN106884018B (zh) * | 2017-01-19 | 2021-03-23 | 江苏大学 | 一种检测致癌蛋白表皮生长因子受体的试剂及试剂盒 |
| WO2019161126A1 (en) | 2018-02-14 | 2019-08-22 | Dermtech, Inc. | Novel gene classifiers and uses thereof in non-melanoma skin cancers |
| CN109371113A (zh) * | 2018-10-29 | 2019-02-22 | 湖南健基生物技术有限公司 | 一种检测人类apoe和slco1b1基因多态性的组合物、试剂盒、样品处理方法和应用 |
| AU2020247911A1 (en) | 2019-03-26 | 2021-11-11 | Dermtech, Inc. | Novel gene classifiers and uses thereof in skin cancers |
| CN112773730B (zh) * | 2021-01-28 | 2023-01-03 | 南昌大学 | 微小rna在美白护肤产品中的应用 |
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| US5310652A (en) * | 1986-08-22 | 1994-05-10 | Hoffman-La Roche Inc. | Reverse transcription with thermostable DNA polymerase-high temperature reverse transcription |
| DE19949594A1 (de) * | 1999-10-14 | 2001-04-26 | Deutsches Krebsforsch | Rekombinante attenuierte Listerien zur Immuntherapie |
| AU2001264559A1 (en) * | 2000-06-05 | 2001-12-17 | Avalon Pharmaceuticals | Cancer gene determination and therapeutic screening using signature gene sets |
| WO2002027028A1 (en) * | 2000-09-28 | 2002-04-04 | Atairgin Technologies, Inc. | A method of determining tumor characteristics by determining abnormal copy number or expression level of lipid-associated genes |
| WO2004019886A2 (en) * | 2002-08-29 | 2004-03-11 | Cytocure Llc | Methods for up-regulating antigen expression in tumors |
| US20060188889A1 (en) * | 2003-11-04 | 2006-08-24 | Christopher Burgess | Use of differentially expressed nucleic acid sequences as biomarkers for cancer |
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- 2005-06-24 NZ NZ552324A patent/NZ552324A/en not_active IP Right Cessation
- 2005-06-24 BR BRPI0512587-1A patent/BRPI0512587A/pt not_active Application Discontinuation
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- 2005-06-24 AU AU2005258331A patent/AU2005258331B2/en not_active Ceased
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- 2005-06-24 MX MX2007000291A patent/MX2007000291A/es active IP Right Grant
- 2005-06-24 JP JP2007518362A patent/JP2008504034A/ja active Pending
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Also Published As
| Publication number | Publication date |
|---|---|
| ATE428808T1 (de) | 2009-05-15 |
| DK1812590T3 (da) | 2009-07-13 |
| NZ552324A (en) | 2009-11-27 |
| CN101258249A (zh) | 2008-09-03 |
| AU2005258331B2 (en) | 2009-12-10 |
| CA2572338A1 (en) | 2006-01-05 |
| MX2007000291A (es) | 2007-08-07 |
| AU2005258331A1 (en) | 2006-01-05 |
| WO2006002433A3 (en) | 2006-08-24 |
| KR20070048701A (ko) | 2007-05-09 |
| WO2006002433A2 (en) | 2006-01-05 |
| EP1812590A2 (en) | 2007-08-01 |
| DE602005013998D1 (de) | 2009-05-28 |
| PT1812590E (pt) | 2009-07-06 |
| BRPI0512587A (pt) | 2007-09-18 |
| EP1812590B1 (en) | 2009-04-15 |
| JP2008504034A (ja) | 2008-02-14 |
| IL180208A0 (en) | 2007-07-04 |
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