ES2244831T5 - Uso de pantenol y/o ácido pantoténico y ácido hialurónico y/o hialuronato para la producción de una composición farmacéutica para aplicación oftalmológica - Google Patents
Uso de pantenol y/o ácido pantoténico y ácido hialurónico y/o hialuronato para la producción de una composición farmacéutica para aplicación oftalmológica Download PDFInfo
- Publication number
- ES2244831T5 ES2244831T5 ES02794984.1T ES02794984T ES2244831T5 ES 2244831 T5 ES2244831 T5 ES 2244831T5 ES 02794984 T ES02794984 T ES 02794984T ES 2244831 T5 ES2244831 T5 ES 2244831T5
- Authority
- ES
- Spain
- Prior art keywords
- pharmaceutical composition
- panthenol
- hyaluronate
- production
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title abstract description 3
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 title abstract description 3
- 229920002674 hyaluronan Polymers 0.000 title abstract description 3
- 229960003160 hyaluronic acid Drugs 0.000 title abstract description 3
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 title abstract 2
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 title abstract 2
- 229940014041 hyaluronate Drugs 0.000 title abstract 2
- 229940101267 panthenol Drugs 0.000 title abstract 2
- 235000019161 pantothenic acid Nutrition 0.000 title abstract 2
- 239000011713 pantothenic acid Substances 0.000 title abstract 2
- 229940055726 pantothenic acid Drugs 0.000 title abstract 2
- 235000020957 pantothenol Nutrition 0.000 title abstract 2
- 239000011619 pantothenol Substances 0.000 title abstract 2
- 239000012752 auxiliary agent Substances 0.000 abstract 1
- 230000007257 malfunction Effects 0.000 abstract 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 235000004866 D-panthenol Nutrition 0.000 description 1
- 239000011703 D-panthenol Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 229960003949 dexpanthenol Drugs 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
50 mg/ml de dexpantenol 1,55 mg/ml de ácido hialurónico, peso molecular: 1,5 x 106 - 3,5 x 106 Dalton 2 mg/ml de citrato de sodio Adición de disolución acuosa de ácido cítrico al 1% hasta que se alcanza pH 7,0 - pH 7,4 Adición de agua con fines de inyección hasta 1 ml
7
Claims (1)
-
imagen1
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10161110 | 2001-12-12 | ||
DE10161110A DE10161110A1 (de) | 2001-12-12 | 2001-12-12 | Pharmazeutische Zusammensetzung zur ophthalmologischen und rhinologischen Anwendung |
PCT/DE2002/004527 WO2003049747A1 (de) | 2001-12-12 | 2002-12-11 | Pharmazeutische zusammensetzung zur ophtalmologischen und rhinologischen anwendung |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2244831T3 ES2244831T3 (es) | 2005-12-16 |
ES2244831T5 true ES2244831T5 (es) | 2016-05-10 |
Family
ID=7708986
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES02794984.1T Expired - Lifetime ES2244831T5 (es) | 2001-12-12 | 2002-12-11 | Uso de pantenol y/o ácido pantoténico y ácido hialurónico y/o hialuronato para la producción de una composición farmacéutica para aplicación oftalmológica |
Country Status (11)
Country | Link |
---|---|
US (1) | US20050164979A1 (es) |
EP (1) | EP1455803B2 (es) |
JP (1) | JP3994089B2 (es) |
CN (1) | CN1310651C (es) |
AT (1) | ATE300306T1 (es) |
AU (1) | AU2002360895A1 (es) |
CA (1) | CA2468771C (es) |
DE (2) | DE10161110A1 (es) |
ES (1) | ES2244831T5 (es) |
MX (1) | MXPA04005387A (es) |
WO (1) | WO2003049747A1 (es) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10356248A1 (de) | 2003-11-13 | 2005-06-23 | Maria Clementine Martin Klosterfrau Vertriebsgesellschaft Mbh | Pharmazeutische Zusammensetzung zur Behandlung von Rhinitiden |
DE102004002001A1 (de) * | 2004-01-14 | 2005-08-11 | Reinmüller, Johannes, Dr.med. | Mittel zur Behandlung von entzündlichen Erkrankungen |
CN1285382C (zh) * | 2004-12-20 | 2006-11-22 | 凌沛学 | 含海藻糖和玻璃酸的鼻腔用药传递系统及其制备方法 |
DE102005055275A1 (de) * | 2005-11-17 | 2007-05-24 | Ursapharm Arzneimittel Gmbh & Co. Kg | Phosphatfreie pharmazeutische Zusammensetzung sowie deren Verwendung |
KR20090053892A (ko) | 2006-07-25 | 2009-05-28 | 오스모티카 코프. | 점안액 |
WO2008068866A1 (en) * | 2006-11-30 | 2008-06-12 | Menicon Co., Ltd. | Ophthalmic composition |
KR100927579B1 (ko) * | 2006-12-13 | 2009-11-23 | 주식회사 엘지생명과학 | 히아루론산 및/또는 그것의 염을 함유하는 아토피성피부염의 개선 및 치료를 위한 조성물 |
FR2919185B1 (fr) * | 2007-07-23 | 2010-09-10 | Ard Sa | Utilisation d'acide hyaluronique pour la preparation de compositions destinees a l'amelioration notamment de l'etat des muqueuses |
DE202008016517U1 (de) * | 2008-12-12 | 2009-03-05 | Ratiopharm Gmbh | Wässrige Zusammensetzung enthaltend Dexpanthenol und Natriumchlorid |
US9473792B2 (en) * | 2009-11-06 | 2016-10-18 | Texas Instruments Incorporated | Method and system to improve the performance of a video encoder |
FR2962044B1 (fr) * | 2010-04-21 | 2013-02-22 | Horus Pharma | Emulsion lacrymimetique |
JP2013534527A (ja) * | 2010-07-02 | 2013-09-05 | ブライエン ホールデン ビジョン インスティテュート | コンタクトレンズ乳頭結膜炎及びアレルギー性眼疾患の予防及び処置のための組成物 |
DE202010012255U1 (de) * | 2010-09-07 | 2010-11-18 | Krewel Meuselbach Gmbh | Nasenspray |
WO2012119261A1 (en) * | 2011-03-10 | 2012-09-13 | Biocia Inc. | Enhanced artificial mucus composition comprising hyaluronan for the treatment of rhinitis |
CN102579478A (zh) * | 2012-03-30 | 2012-07-18 | 济南康众医药科技开发有限公司 | 玻璃酸钠在制备药物中的应用 |
DE202012005650U1 (de) * | 2012-05-14 | 2013-05-15 | Maria Clementine Martin Klosterfrau Vertriebsgesellschaft Mbh | Kombinationstherapeutikum für die Behandlung von Rhinitis |
EP2664330A1 (de) * | 2012-05-15 | 2013-11-20 | F. Holzer GmbH | Zusammensetzung und Arzneimittel enthaltend Omega-3-Fettsäuren sowie einen Glucosaminoglucan |
CN102989045B (zh) * | 2012-11-12 | 2015-02-25 | 广州共禾医药科技有限公司 | 生物相容的水性组合物及其用途 |
KR20230019268A (ko) * | 2014-08-08 | 2023-02-08 | 센젠 하이타이드 바이오파마슈티컬 리미티드 | 액체 제형 조성물, 약제 전달 장치, 및 이들의 제조 및 사용 방법 |
EP2985027B1 (en) | 2014-08-16 | 2021-03-31 | Church & Dwight Co., Inc. | Nasal composition comprising mixture of hyaluronic acids and saline solution |
EP2985019B1 (en) | 2014-08-16 | 2021-10-20 | Church & Dwight Co., Inc. | Nasal composition having anti-viral properties |
EP3072503B1 (en) | 2015-03-26 | 2020-09-23 | D.M.G. Italia Srl | Ophthalmic composition for the corneal protection |
DE102016203696A1 (de) * | 2016-03-07 | 2017-09-07 | Ursapharm Arzneimittel Gmbh | Ophthalmologische Zusammensetzung |
DE102016204472A1 (de) * | 2016-03-17 | 2017-09-21 | Ursapharm Arzneimittel Gmbh | Kit zur kosmetischen Behandlung des Auges und der Haut und Kosmetikum zur Anwendung am Auge und auf der Haut |
TWI609957B (zh) * | 2016-06-27 | 2018-01-01 | 晶碩光學股份有限公司 | 用以處理隱形眼鏡之溶液及隱形眼鏡的包裝系統 |
JP7044467B2 (ja) * | 2017-01-16 | 2022-03-30 | ロート製薬株式会社 | 眼科組成物 |
DE202017104738U1 (de) * | 2017-07-31 | 2018-08-01 | Maria Clementine Martin Klosterfrau Vertriebsgesellschaft Mbh | Neue Zusammensetzung für die nasale Applikation |
CN107260657B (zh) * | 2017-08-03 | 2019-02-05 | 广东莱恩医药研究院有限公司 | 一种缓释型连翘苷滴眼液及其制备方法 |
ES2972897T3 (es) * | 2017-08-10 | 2024-06-17 | Elixir Ilac Arastirma Ve Gelistirme A S | Composiciones descongestionantes nasales que comprenden mentol, dexpantenol e hialuronato de sodio |
CA3097470A1 (en) * | 2018-04-18 | 2019-10-24 | i.com medical GmbH | High molecular weight hyaluronic acid for enhancing epithelial survival and reconstitution of body surfaces |
CN112292135A (zh) * | 2018-04-18 | 2021-01-29 | I.Com医疗有限责任公司 | 用于治疗和预防严重眼表疾病的高分子量透明质酸 |
US11576926B2 (en) * | 2018-09-12 | 2023-02-14 | Neilos S.r.l. | Composition for use in the prevention and/or treatment of epistaxis |
EP3827818A1 (en) * | 2019-11-26 | 2021-06-02 | Warszawskie Zaklady Farmaceutyczne Polfa S.A. | Ophthalmic composition |
CN112870216A (zh) * | 2021-01-29 | 2021-06-01 | 张宽才 | 一种药物组合物及制剂和用途 |
EP4039248A1 (en) * | 2021-02-04 | 2022-08-10 | Warszawskie Zaklady Farmaceutyczne Polfa S.A. | Ophthalmic composition |
FR3151481A1 (fr) * | 2023-07-28 | 2025-01-31 | Horus Pharma | Emulsion de type huile dans eau comprenant de l’acide hyaluronique et du dexpanthenol |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4851521A (en) * | 1985-07-08 | 1989-07-25 | Fidia, S.P.A. | Esters of hyaluronic acid |
JPS6479103A (en) * | 1987-06-09 | 1989-03-24 | Lion Corp | External preparation |
DE3832401A1 (de) † | 1988-09-23 | 1990-03-29 | Cassella Ag | Pharmazeutische zubereitung zur behandlung entzuendeter nasenschleimhaeute |
US5141741A (en) * | 1988-12-09 | 1992-08-25 | Lion Corporation | Anti-sunburn skin-care preparation |
IL101056A (en) † | 1992-02-24 | 1997-03-18 | Res & Dev Co Ltd | Composition for nasal treatment |
IT1273011B (it) * | 1994-07-25 | 1997-07-01 | Trhecnopharma S A | Preparato oftalmico per l'uso come lacrima artificiale |
DE19517251A1 (de) * | 1995-05-11 | 1996-11-14 | Klosterfrau Mcm Vetrieb Gmbh | Verwendung von Dexpanthenol zur Behandlung trockener Nasenschleimhäute |
DE19541919C2 (de) † | 1995-11-10 | 1997-11-20 | Klosterfrau Mcm Vetrieb Gmbh | Pharmazeutische Zubereitung zur Behandlung akuter Rhinitiden |
DE19549421C2 (de) † | 1995-11-10 | 1999-11-18 | Klosterfrau Mcm Vetrieb Gmbh | Pharmazeutische Zubereitung zur Behandlung akuter Rhinitiden |
AU740404B2 (en) * | 1997-07-11 | 2001-11-01 | Toray Industries, Inc. | Stable pharmaceutical composition including 4,5-epoxymorphinane derivative |
DE19923829A1 (de) * | 1999-05-17 | 2000-11-23 | Ulrich Kluegel | Hyaluronat-Wirkstoff-Wasser-Komplex, dessen Herstellung und Verwendung |
CA2434242A1 (en) * | 2001-01-09 | 2002-08-08 | Louis Johan Wagenaar | Procedure and composition of treatment and/or care of the eye |
-
2001
- 2001-12-12 DE DE10161110A patent/DE10161110A1/de not_active Ceased
-
2002
- 2002-12-11 CA CA002468771A patent/CA2468771C/en not_active Expired - Lifetime
- 2002-12-11 CN CNB028248309A patent/CN1310651C/zh not_active Expired - Lifetime
- 2002-12-11 ES ES02794984.1T patent/ES2244831T5/es not_active Expired - Lifetime
- 2002-12-11 US US10/496,456 patent/US20050164979A1/en not_active Abandoned
- 2002-12-11 EP EP02794984.1A patent/EP1455803B2/de not_active Expired - Lifetime
- 2002-12-11 JP JP2003550796A patent/JP3994089B2/ja not_active Expired - Lifetime
- 2002-12-11 WO PCT/DE2002/004527 patent/WO2003049747A1/de active IP Right Grant
- 2002-12-11 AU AU2002360895A patent/AU2002360895A1/en not_active Abandoned
- 2002-12-11 MX MXPA04005387A patent/MXPA04005387A/es active IP Right Grant
- 2002-12-11 AT AT02794984T patent/ATE300306T1/de active
- 2002-12-11 DE DE50203788T patent/DE50203788D1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ES2244831T3 (es) | 2005-12-16 |
JP2006501133A (ja) | 2006-01-12 |
EP1455803A1 (de) | 2004-09-15 |
CN1602198A (zh) | 2005-03-30 |
EP1455803B2 (de) | 2016-03-23 |
ATE300306T1 (de) | 2005-08-15 |
DE50203788D1 (de) | 2005-09-01 |
EP1455803B1 (de) | 2005-07-27 |
CA2468771A1 (en) | 2003-06-19 |
JP3994089B2 (ja) | 2007-10-17 |
AU2002360895A1 (en) | 2003-06-23 |
CA2468771C (en) | 2007-01-30 |
US20050164979A1 (en) | 2005-07-28 |
WO2003049747A1 (de) | 2003-06-19 |
DE10161110A1 (de) | 2003-06-26 |
WO2003049747A8 (de) | 2003-10-02 |
CN1310651C (zh) | 2007-04-18 |
MXPA04005387A (es) | 2005-03-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2244831T5 (es) | Uso de pantenol y/o ácido pantoténico y ácido hialurónico y/o hialuronato para la producción de una composición farmacéutica para aplicación oftalmológica | |
TNSN98090A1 (fr) | Formulations pharmaceutiques contenant du voriconazole, et procede pour leur preparation. | |
EA200200106A1 (ru) | Фармацевтическая композиция леводопа/карбидопа/энтакапон | |
BRPI0411678A (pt) | nanopartìculas de ácido hialurÈnico | |
CO5190689A1 (es) | Sales de tramadol formadas por tramadol y un edulcorante y formas farmaceuticas que contienen dichas sales | |
ATE332138T1 (de) | Flibanserin zur behandlung extrapyramidaler bewegungsstörungen | |
BR0214757A (pt) | Formulações farmacêuticas de derivados de platina | |
RS50876B (sr) | Upotreba flibanserina u lečenju seksualnih poremećaja | |
CY1110906T1 (el) | Φαρμακευτικη συνθεση για ρινικη χορηγηση φεντανυλης | |
BR0210293A (pt) | Uma preparação farmacêutica aquosa de cilostazol para utilização parenteral | |
EE05072B1 (et) | Farmatseutilised kompositsioonid limaskestale kandmiseks | |
ES2195344T3 (es) | Composicion farmaceutica que presenta una actividad antitumoral mejorada y/o efectos secundarios reducidos, que contiene un agente antitumoral y un derivado de acido hidroximico. | |
NO20034863L (no) | Deutererte 3-piperidinopropiofenon så vel som legemidler som inneholder disse forbindelser | |
ES2153906T3 (es) | Uso de incienso para el tratamiento de la enfermedad de alzheimer. | |
IT1314185B1 (it) | Composizione farmaceutica per somministrazione di sostanze attivescarsamente solubili in mezzi acquosi | |
EA200300406A1 (ru) | Фармацевтическая композиция дронедарона для парентерального введения | |
BR0312157A (pt) | Preparação lìquida que compreende oligopeptìdeos e ciclodextrina eterificada | |
UY27373A1 (es) | Formulaciones de interferón beta-humano | |
BR0011845A (pt) | Complexo farmacêutico | |
ATE233105T1 (de) | Pharmazeutische zubereitung für die intravenöse oder intramuskuläre verabreichung von octreotid | |
RU92004583A (ru) | Фармацевтическая композиция и способ ее получения | |
ATE299027T1 (de) | Verwendung von übersulfatierten polysacchariden als hiv-hemmer | |
MXPA04005033A (es) | Composicion farmaceutica que comprende una combinacion de metformina y acido 4-oxobutanoico y el uso de la misma para el tratamiento contra diabetes. | |
EA200400382A1 (ru) | Применение специфической дозы фондапаринукса натрия для лечения окс | |
GR1010769B (el) | Υδατικο διαλυμα ιβουπροφαινης για χρηση σε ενδοφλεβια χορηγηση |