ES2211276B1 - METHOD OF OBTAINING THE LEUCOPLAQUETAR LAYER, ITS GEL AND APPLICATIONS. - Google Patents
METHOD OF OBTAINING THE LEUCOPLAQUETAR LAYER, ITS GEL AND APPLICATIONS.Info
- Publication number
- ES2211276B1 ES2211276B1 ES200200816A ES200200816A ES2211276B1 ES 2211276 B1 ES2211276 B1 ES 2211276B1 ES 200200816 A ES200200816 A ES 200200816A ES 200200816 A ES200200816 A ES 200200816A ES 2211276 B1 ES2211276 B1 ES 2211276B1
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- layer
- leucoplaquetar
- gel
- obtaining
- minutes
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- Expired - Fee Related
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- 238000000034 method Methods 0.000 title claims abstract description 15
- 102000004127 Cytokines Human genes 0.000 claims abstract description 12
- 108090000695 Cytokines Proteins 0.000 claims abstract description 12
- 210000004623 platelet-rich plasma Anatomy 0.000 claims abstract description 8
- 238000000605 extraction Methods 0.000 claims abstract description 7
- 210000004369 blood Anatomy 0.000 claims abstract description 5
- 239000008280 blood Substances 0.000 claims abstract description 5
- 210000005259 peripheral blood Anatomy 0.000 claims abstract description 5
- 239000011886 peripheral blood Substances 0.000 claims abstract description 5
- 210000002381 plasma Anatomy 0.000 claims abstract description 5
- 210000003743 erythrocyte Anatomy 0.000 claims abstract description 4
- 239000001963 growth medium Substances 0.000 claims abstract description 3
- 238000001085 differential centrifugation Methods 0.000 claims abstract 2
- 238000001356 surgical procedure Methods 0.000 claims description 12
- 239000002609 medium Substances 0.000 claims description 8
- 229930182816 L-glutamine Natural products 0.000 claims description 3
- 238000007654 immersion Methods 0.000 claims description 3
- 125000003338 L-glutaminyl group Chemical group O=C([*])[C@](N([H])[H])([H])C([H])([H])C([H])([H])C(=O)N([H])[H] 0.000 claims description 2
- 210000000988 bone and bone Anatomy 0.000 description 16
- 239000007943 implant Substances 0.000 description 16
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 4
- 239000000945 filler Substances 0.000 description 4
- 210000003456 pulmonary alveoli Anatomy 0.000 description 4
- 229910052719 titanium Inorganic materials 0.000 description 4
- 239000010936 titanium Substances 0.000 description 4
- 239000004053 dental implant Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 241000283690 Bos taurus Species 0.000 description 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 2
- 108090000190 Thrombin Proteins 0.000 description 2
- 229910001628 calcium chloride Inorganic materials 0.000 description 2
- 239000001110 calcium chloride Substances 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 238000002513 implantation Methods 0.000 description 2
- 210000000265 leukocyte Anatomy 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 229960004072 thrombin Drugs 0.000 description 2
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
Landscapes
- Health & Medical Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dentistry (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
Abstract
Método de obtención de la capa leucoplaquetar, su gel y aplicaciones, partiendo de una extracción de sangre periférica, preferentemente, de la flexura del codo, en principio, se obtiene la capa leucoplaquetar, partir de la cual se obtendrá su gel, comprendiendo el método de obtención una centrifugación diferencial de la sangre a unas revoluciones de 150 a 400 g. durante 10 a 30 minutos, extrayendo, posteriormente, la capa relativa al plasma pobre en plaquetas y al plasma rico en plaquetas (P. R. P.), correspondientes a la capa leucoplaquetar, pudiendo coger una parte de glóbulos rojos, aproximadamente, 0,5 ml., añadiendo a la misma un medio de cultivo de McCOYS con citoquinas.Method of obtaining the leucoplaquetar layer, its gel and applications, starting from a peripheral blood extraction, preferably, from the flexure of the elbow, in principle, the leucoplaquetar layer is obtained, from which its gel will be obtained, comprising the method to obtain a differential centrifugation of the blood at revolutions of 150 to 400 g. for 10 to 30 minutes, subsequently removing the layer relative to platelet-poor plasma and platelet-rich plasma (PRP), corresponding to the leukoplate layer, being able to take a portion of red blood cells, approximately, 0.5 ml., adding to it a culture medium of McCOYS with cytokines.
Description
Método de obtención de la capa leucoplaquetar, su gel y aplicaciones.Method of obtaining the leucoplaquetar layer, its gel and applications.
La siguiente invención, según se expresa en el enunciado de la presente memoria descriptiva, se refiere a método de obtención de la capa leucoplaquetar, su gel y aplicaciones, de forma que la capa leucoplaquetar es obtenida a partir de una extracción de sangre periférica, preferentemente, de una vena de la flexura del codo.The following invention, as expressed in the set forth herein, refers to method of obtaining the leucoplaquetar layer, its gel and applications, of way that the leucoplaquetar layer is obtained from a peripheral blood collection, preferably, from a vein in the elbow flexion.
Así, la capa leucoplaquetar obtenida tiene por objeto su utilización, principalmente, en traumatología, en cirugía ortognática y en implantología, de forma que en implantología al estar en contacto con el elemento a implantar se produce un crecimiento celular, consiguiendo una mejor calidad de hueso y acortar el tiempo de recuperación.Thus, the leucoplaquetar layer obtained has for object its use, mainly in traumatology, surgery orthognathic and in implantology, so that in implantology at being in contact with the element to be implanted there is a cell growth, getting better bone quality and Shorten recovery time.
Por otra parte, el gel obtenido a partir de la capa leucoplaquetar, es de utilidad en cirugía reparadora, en traumatología, en cirugía ortognática, en implantología, y en odontología, pudiendo ser empleado, bien como único elemento o en combinación con otros.On the other hand, the gel obtained from the leucoplaquetar layer, is useful in restorative surgery, in traumatology, in orthognathic surgery, in implantology, and in dentistry, being able to be employed, either as the sole element or in combination with others.
La capa leucoplaquetar, es de especial aplicación en implantología, al actuar de baño para la inmersión del correspondiente elemento a implantar, incubándose durante un tiempo determinado a un temperatura constante, para su adhesión al elemento a implantar.The leucoplaquetar layer is of special application in implantology, when acting as a bath for the immersion of corresponding element to be implanted, incubating for a while determined at a constant temperature, for adhesion to element to implant.
El gel de la capa leucoplaquetar, es de especial aplicación como elemento de relleno, bien como único elemento a colocar o en combinación con otros.The gel of the leucoplaquetar layer is special application as a filler element, either as a single element to place or in combination with others.
Convencionalmente, para la obtención de plasma rico en plaquetas, en primer lugar, la sangre obtenida por una extracción de sangre periférica, preferentemente, de la flexura del codo es centrifugada a 5.600 rev/min., separándose sus tres componentes, de forma que se desecha la capa pobre en plaquetas, y el resto se vuelve a centrifugar a 2.400 rev/min. para conseguir la separación precisa de la capa de plasma rico en plaquetas (P. R. P.) y los glóbulos rojos, siendo a partir de ella de la que se obtendrá el gel, como más adelante veremos.Conventionally, to obtain plasma rich in platelets, first of all, the blood obtained by a peripheral blood collection, preferably from the flexure of the elbow is centrifuged at 5,600 rev / min., separating its three components, so that the platelet-poor layer is discarded, and the rest is centrifuged again at 2,400 rev / min. to obtain it precise separation of the platelet-rich plasma layer (P. R. P.) and the red blood cells, being from it from which You will get the gel, as we will see later.
En cuanto al gel, en primer lugar, podemos indicar que el mismo se trata de un compuesto derivado del plasma rico en plaquetas, en un estado semisólido o de consistencia semisólida, a modo de coágulo, siendo utilizado como elemento de relleno en traumatología y en odontología.As for the gel, first of all, we can indicate that it is a plasma-derived compound rich in platelets, in a semi-solid state or consistency semi-solid, as a clot, being used as an element of filling in traumatology and dentistry.
Así, dicho gel, en odontología, se utilizará como elemento de relleno tras extracciones dentales, rellenando el alvéolo o alvéolos de las raíces, dejando un campo mejor preparado, bien para recibir implantes o bien para eliminar la cirugía preprotésica.Thus, said gel, in dentistry, will be used as filling element after dental extractions, filling the alveolus or root alveoli, leaving a better prepared field, either to receive implants or to eliminate surgery preprosthetic
Ello es como consecuencia de que tras las extracciones dentales se produce una reabsorción provocando unos cráteres o irregularidades, y con ello que la dentadura postiza quede mal asentada, precisando en ocasiones cirugía preprotésica.This is as a consequence of the fact that after tooth extractions a resorption occurs causing some craters or irregularities, and with it that the dentures is poorly seated, sometimes requiring surgery preprosthetic
Convencionalmente, para la obtención del gel de plasma rico en plaquetas, a partir de la obtención de la misma, se requiere iniciar el proceso de coagulación con una mezcla de 10 ml. de cloruro cálcico al 10% con trombina bovina tópica de 10.000 unidades, requiriendo utilizar jeringas individuales para cada mezcla que contiene del orden de 6 ml. de plasma rico en plaquetas (P. R. P.), 1 ml. de la mezcla de cloruro cálcico y trombina y 1 ml. de aire para completar el proceso.Conventionally, to obtain the gel platelet rich plasma, from obtaining it, it It requires starting the coagulation process with a 10 ml mixture. 10% calcium chloride with 10,000 bovine thrombin topical units, requiring the use of individual syringes for each mixture containing the order of 6 ml. of platelet rich plasma (P. R. P.), 1 ml. of the mixture of calcium chloride and thrombin and 1 ml. of air to complete the process.
Finalmente, la jeringa se agita durante 6-10 segundos para homogeneizar el producto, que, ya en forma de gel, se puede utilizar del modo deseado.Finally, the syringe is shaken for 6-10 seconds to homogenize the product, which, already in gel form, it can be used as desired.
Por otra parte, para complementar la descripción que seguidamente se va a realizar, y con objeto de ayudar a una mejor comprensión de las características de la invención, se acompaña a la presente memoria descriptiva, de un juego de planos, en cuyas figuras de forma ilustrativa y no limitativa, se representan, a modo de ejemplo, la aplicación de gel de células mononucleares en odontología.Moreover, to complement the description which will then be done, and in order to help a better understanding of the features of the invention, it accompanies the present specification, of a set of drawings, whose figures are illustrative and not limiting, represent, by way of example, the application of cell gel mononuclear in dentistry.
Figura 1. Muestra un implante contenido en un vial a cuyo implante se ha adherido gel de células mononucleares.Figure 1. Shows an implant contained in a vial to which implant cell gel has adhered mononuclear
Figura 2. Muestra una vista en alzado lateral del posicionamiento del implante de la figura anterior en un alvéolo, pudiendo observar como el gel se distribuye por la superficie exterior de dicho implante.Figure 2. Shows a side elevation view of the positioning of the implant of the previous figure in an alveolus, being able to observe how the gel is distributed over the surface exterior of said implant.
En la presente memoria se describe un método de obtención de la capa leucoplaquetar, su gel y aplicaciones, de manera que partiendo de una extracción de sangre periférica, preferentemente, de la flexura del codo, en principio se obtiene la capa leucoplaquetar, a partir de la cual se obtendrá su gel, de forma que el método de obtención comprende una centrifugación diferencial de la sangre a unas revoluciones de 150 a 400 g. durante 10 a 30 minutos, extrayendo, posteriormente, la capa relativa al plasma pobre en plaquetas y al plasma rico en plaquetas (P. R. P.), correspondientes a la capa leucoplaquetar, pudiendo coger una parte de glóbulos rojos, aproximadamente, 0,5 ml., añadiendo a la misma un medio de cultivo de McCOYS con citoquinas.This method describes a method of obtaining the leucoplaquetar layer, its gel and applications, of so that starting from a peripheral blood collection, preferably, from the flexure of the elbow, in principle the leucoplaquetar layer, from which your gel will be obtained, from so that the method of obtaining comprises a centrifugation blood differential at revolutions of 150 to 400 g. for 10 to 30 minutes, subsequently removing the layer relative to platelet poor plasma and platelet rich plasma (P. R. P.), corresponding to the leucoplaquetar layer, being able to take a part of red blood cells, approximately, 0.5 ml., adding to it a culture medium of McCOYS with cytokines
Por otra parte, para la obtención del gel de la capa leucoplaquetar, la citada capa leucoplaquetar, tratada con un medio de McCOYS con citoquinas, contenida en el correspondiente vial abierto o cerrado, es introducida en una estufa a 37°C durante un tiempo de 30 a 60 minutos.On the other hand, to obtain the gel of the leucoplaquetar layer, said leucoplaquetar layer, treated with a McCOYS medium with cytokines, contained in the corresponding open or closed vial, is introduced in an oven at 37 ° C for A time of 30 to 60 minutes.
Preferentemente, la capa leucoplaquetar, tratada con un medio de McCOYS con citoquinas, será mantenida en la estufa durante, aproximadamente, 30 minutos.Preferably, the leukoplate layer, treated with a McCOYS medium with cytokines, it will be kept on the stove for about 30 minutes.
La capa leucoplaquetar, tratada con un medio de McCOYS con citoquinas, es de uso en implantología como baño de inmersión para elementos a implantar, incubándose durante un tiempo, de 30 a 60 minutos, a una temperatura constante de 37°C., quedando el elemento a implantar preparado para su implantación.The leucoplaquetar layer, treated with a medium of McCOYS with cytokines, is used in implantology as a bath of immersion for elements to be implanted, incubating during a time, from 30 to 60 minutes, at a constant temperature of 37 ° C., leaving the element to be implanted ready for implantation.
Así, el elemento a implantar puede ser de titanio u otro material metálico, como puede ser acero inoxidable, de forma que en contacto con la capa leucoplaquetar se produce una adherencia de células al elemento a implantar.Thus, the element to be implanted can be titanium or other metallic material, such as stainless steel, so that in contact with the leucoplaquetar layer there is a adhesion of cells to the element to be implanted.
De esta forma, es de aplicación en todo tipo de intervenciones en las cuales sea preciso la implantación de algún elemento, como puede ser tornillos, vástagos, placas, prótesis (cadera, rodilla, etc.), dado que se obtiene un crecimiento celular, consiguiendo una mejor calidad del hueso y un acortamiento en el tiempo de recuperación.In this way, it is applicable in all types of interventions in which it is necessary to implement some element, such as screws, stems, plates, prostheses (hip, knee, etc.), since growth is obtained cell, getting better bone quality and a shortening in recovery time.
Por otra parte, el gel obtenido a partir de la capa leucoplaquetar, tratada con un medio de McCOYS con citoquinas, es de uso en cirugía reparadora, en traumatología, en cirugía ortognática y otras especialidades, como elemento independiente o en combinación con otros elementos.On the other hand, the gel obtained from the leucoplaquetar layer, treated with a McCOYS medium with cytokines, It is used in restorative surgery, in traumatology, in surgery orthognathic and other specialties, as an independent element or in combination with other elements.
Así, puede ser utilizado en combinación de malla de titanio para la reconstrucción de zonas tales como los maxilares.Thus, it can be used in mesh combination Titanium for the reconstruction of areas such as jaws
Igualmente, el gel obtenido a partir de la capa leucoplaquetar es de uso en odontología como elemento de relleno de forma independiente o en combinación con otros elementos.Likewise, the gel obtained from the layer leucoplaquetar is used in dentistry as a filler element of independently or in combination with other elements.
De esta forma, puede ser utilizado como elemento de relleno independiente en extracciones dentales, rellenando el alvéolo o alvéolos de las raíces, dejando un campo mejor preparado, bien para recibir implantes o bien para eliminar la cirugía preprotésica como consecuencia de los ``cráteres'' irregulares que se forman por las extracciones, y que como consecuencia de los mismos la dentadura queda mal asentada.In this way, it can be used as an element of independent filling in dental extractions, filling the alveolus or root alveoli, leaving a better prepared field, either to receive implants or to eliminate surgery preprotésica as a result of irregular `` craters '' that they are formed by extractions, and that as a consequence of The dentures themselves are poorly seated.
Asimismo, puede utilizarse en combinación con otros materiales de relleno, como puede ser hueso demineralizado, hueso natural, injerto de hueso del propio paciente extraído de las zonas convencionales, hueso de banco, es decir, banco de hueso utilizado en traumatología.It can also be used in combination with other fillers, such as demineralized bone, natural bone, bone graft of the patient himself extracted from the conventional areas, bone of bank, that is, bone bank Used in traumatology.
Preferentemente, la citoquina es L-Glutamina.Preferably, the cytokine is L-Glutamine
Una vez realizada una extracción de sangre periférica se obtiene la capa leucoplaquetar por centrifugación diferencial, en un tiempo aproximado de 10 a 30 minutos, siendo tratada con un medio de McCOYS con citoquinas, procediéndose a su introducción en un vial que contiene un implante dental, para ser introducido en una estufa a una temperatura de 37°C., obteniendo de esta forma un implante dental recubierto de una capa leucoplaquetar en forma de gel, mediante el cual podremos remodelar un alvéolo de una reciente extracción por fractura radicular.Once a blood draw is done Peripheral leukoplate layer is obtained by centrifugation differential, in an approximate time of 10 to 30 minutes, being treated with a McCOYS medium with cytokines, proceeding to its introduction into a vial containing a dental implant, to be introduced in an oven at a temperature of 37 ° C., obtaining from this way a dental implant coated with a white blood cell layer in the form of a gel, through which we can reshape an alveolus of a recent root fracture extraction.
Así, debido a la forma general tronco-cónica de los alvéolos uniradiculares conseguiremos, a la vez que se va roscando el implante que la capa leucoplaquetar rellene aquellas zonas alveolares alejadas de la geometría del propio implante, consiguiendo una mejor adaptación del hueso al implante.Thus, due to the general form conical trunk of the uniradicular alveoli we will achieve, at the same time that the implant is threading the layer leucoplaquetar fill those alveolar areas away from the geometry of the implant itself, getting a better adaptation from bone to implant.
En los diseños adjuntos se observa como el implante dental 1 esta colocado en el vial 2, quedando unido a su tapa 3 a través de un cuerpo intermedio 4, de forma que al implante 1 se ha fijado gel 5 de la capa leucoplaquetar tratada con un medio de McCOYS y L-Glutamina, estando dicho implante 1 preparado para su implantación.In the attached designs it looks like the dental implant 1 is placed in vial 2, being attached to its cap 3 through an intermediate body 4, so that the implant 1 gel 5 of the leukoplaque layer treated with a medium has been fixed of McCOYS and L-Glutamine, said implant being 1 Prepared for implantation.
Así, el implante 1 se dispone en el correspondiente alvéolo, roscándose al hueso 6 en relación a su extremo, en tanto que el gel 5 adherido a él se distribuye por su superficie rellenando la oquedad alveolar.Thus, implant 1 is arranged in the corresponding socket, threading to bone 6 in relation to its extreme, while the gel 5 attached to it is distributed by its surface filling the alveolar cavity.
De esta forma, el gel se dispersa hasta la mucosa 8 quedando libre la pieza 7 portadora de la prótesis dental, de manera que aunque el implante 1 sólo quede roscado en el hueso la distancia ``d'' el gel favorece su fijación.In this way, the gel disperses to the mucosa 8 leaving the piece 7 carrying the dental prosthesis free of so that although implant 1 is only threaded into the bone the distance `` d '' the gel favors its fixation.
Para la reconstrucción ósea de la cara en los casos que se haya tenido que eliminar hueso como consecuencia de un tumor, hemimandibulectomía, (cirugía maxilo-facial), para poder realizar una reconstrucción (plastia reparadora), una vez accedido al hueso, separación planos musculares, se fija una o más mallas de titanio flexible, mediante unos tornillos, rellenando el hueco con un material de relleno compuesto por hueso autólogo, hueso demineralizado bovino, hueso de banco de trauma o combinación de ellos con gel.For bone reconstruction of the face in the cases that had to remove bone as a result of a tumor, hemimandibulectomy, (surgery maxilo-facial), in order to perform a reconstruction (repair plasty), once the bone is accessed, muscle plane separation, one or more titanium meshes are fixed flexible, using screws, filling the hole with a filler material composed of autologous bone, bone demineralized bovine, trauma bank bone or combination of They with gel.
Así, sobre la malla se podrá colocar posteriormente uno o varios implantes incubados, asimismo, los implantes incubados podrán ser colocados directamente en la malla de titanio con el relleno quedando preparado para la colocación de la correspondiente prótesis.Thus, on the mesh it can be placed subsequently one or more implants incubated, likewise, the incubated implants may be placed directly on the mesh of titanium with the filling being prepared for the placement of the corresponding prosthesis.
Claims (7)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| ES200200816A ES2211276B1 (en) | 2002-04-09 | 2002-04-09 | METHOD OF OBTAINING THE LEUCOPLAQUETAR LAYER, ITS GEL AND APPLICATIONS. |
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| ES200200816A ES2211276B1 (en) | 2002-04-09 | 2002-04-09 | METHOD OF OBTAINING THE LEUCOPLAQUETAR LAYER, ITS GEL AND APPLICATIONS. |
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| ES2211276A1 ES2211276A1 (en) | 2004-07-01 |
| ES2211276B1 true ES2211276B1 (en) | 2005-10-01 |
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| DE19630034A1 (en) * | 1996-07-25 | 1998-04-23 | Huels Chemische Werke Ag | Biohybrid dental implant |
| AU7180398A (en) * | 1996-11-13 | 1998-06-03 | Morphogenesis, Inc. | Antibody MG1 recognizing a small subset of human hematopoietic cells |
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