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ES2196195T3 - Procedimiento para la reduccion estereoselectiva de cetonas alfa, beta-insaturadas. - Google Patents

Procedimiento para la reduccion estereoselectiva de cetonas alfa, beta-insaturadas.

Info

Publication number
ES2196195T3
ES2196195T3 ES96943265T ES96943265T ES2196195T3 ES 2196195 T3 ES2196195 T3 ES 2196195T3 ES 96943265 T ES96943265 T ES 96943265T ES 96943265 T ES96943265 T ES 96943265T ES 2196195 T3 ES2196195 T3 ES 2196195T3
Authority
ES
Spain
Prior art keywords
group
carbon atoms
procedure
renting
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96943265T
Other languages
English (en)
Inventor
Geza Galambos
Kardos Zsuzsanna Baloghne
Nandor Benno
Povarny Magdolna Beresne
Gyula Dalmadi
Katalin Ebinger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chinoin Private Co Ltd
Original Assignee
Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt filed Critical Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Application granted granted Critical
Publication of ES2196195T3 publication Critical patent/ES2196195T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Catalysts (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Furan Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A UN PROCEDIMIENTO DE PREPARACION DE ALCOHOLES AL , BE - INSATURADOS DE FORMULA GENERAL (I), DONDE R REPRESENTA UN GRUPO ALQUILO DE 1-4 ATOMOS DE CARBONO, O UN GRUPO BENZOILOXI OPCIONALMENTE SUSTITUIDO POR UN GRUPO FENILO; R 1 REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ALQ UILO DE 1-4 ATOMOS DE CARBONO; R 2 REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO DE 1-4 ATOMOS DE CARBONO; R 3 REPRESENTA UN GRUPO ALQUILO DE 1-6 ATOMOS DE CARBONO, OPCIONALMENTE SUSTITUIDO POR UN GRUPO FENILO O CICLOALQUILO DE 5-7 ATOMOS DE CARBONO; O UN GRUPO FENOXI OPCIONALMENTE SUSTITUIDO POR UN ATOMO DE HALOGENO O POR UN GRUPO CICLOALQUILO DE 5-7 ATOMOS DE CARBONO; R 4 REPRESENTA UN ATOMO DE HIDROGENO O UN ATOMO DE HALOGENO. DICHO PROCEDIMIENTO SE CARACTERIZA PORQUE UNA CETONA AL , BE -INSATURADA DE FORMULA GENERAL (II), DONDE LOS SIGNIFICADOS DE R, R 1 , R 2 , R 3 Y R 4 SON TAL Y COMO SE DESCRIBIERON ANTERIORMENTE, SE REDUCE DIASTEREOSELECTIVAMENTE CON UN COMPUESTO DE TIPO BOROHIDRUROEN UN DISOLVENTE APROTICO, EN PRESENCIA DE UNA SUSTANCIA INORGANICA SOLUBLE EN LA MEZCLA DE REACCION, Y CON UN TAMAÑO DE PARTICULA COMPRENDIDO ENTRE 0,01 Y 10000 MICROMETROS Y, OPCIONALMENTE, SE SEPARA EL ALCOHOL AL , BE - INSATURADO DE FORMULA GENERAL (I) A PARTIR DE LA MEZCLA RESULTANTE DE ALCOHOLES EPIMERICOS AL , BE - INSATURADOS DE FORMULA GENERAL (I) Y (III), DONDE LOS SIGNIFICADOS DE R, R 1 , R 2 , R 3 Y R 4 SON TAL Y COMO SE DEFINIERON ANTERIORMENTE, MEDIANTE PROCEDIMIENTOS CONOCIDOS PER SE.
ES96943265T 1995-12-20 1996-12-18 Procedimiento para la reduccion estereoselectiva de cetonas alfa, beta-insaturadas. Expired - Lifetime ES2196195T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9503665A HU223345B1 (hu) 1995-12-20 1995-12-20 Eljárás alfa, béta-telítetlen ketonok sztereoszelektív redukciójára

Publications (1)

Publication Number Publication Date
ES2196195T3 true ES2196195T3 (es) 2003-12-16

Family

ID=10987490

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96943265T Expired - Lifetime ES2196195T3 (es) 1995-12-20 1996-12-18 Procedimiento para la reduccion estereoselectiva de cetonas alfa, beta-insaturadas.

Country Status (9)

Country Link
US (1) US6482959B1 (es)
EP (1) EP0939756B1 (es)
JP (1) JP2000502099A (es)
AT (1) ATE240309T1 (es)
DE (1) DE69628207T2 (es)
ES (1) ES2196195T3 (es)
HU (1) HU223345B1 (es)
PT (1) PT939756E (es)
WO (1) WO1997022602A2 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6310227B1 (en) 1997-01-31 2001-10-30 The Procter & Gamble Co. Reduced calorie cooking and frying oils having improved hydrolytic stability, and process for preparing
WO2001087816A1 (en) * 2000-05-15 2001-11-22 Pharmacia & Upjohn Company Process and intermediates to prepare latanoprost
GB0112699D0 (en) 2001-05-24 2001-07-18 Resolution Chemicals Ltd Process for the preparation of prostglandins and analogues thereof
MXPA04000473A (es) * 2001-07-17 2004-12-06 Pharmacia & Up John Company Procedimiento e intermediarios en la preparacion del latanoprost.
CN1870899B (zh) * 2003-09-25 2010-09-29 三得利控股株式会社 咖啡果实的处理方法
TW200719833A (en) * 2005-03-24 2007-06-01 Suntory Ltd Novel microorganism and method of processing fresh coffee beans by using the same
CN101040653B (zh) * 2005-03-24 2011-11-23 三得利控股株式会社 使用表面加工咖啡果实的生咖啡豆的处理方法
WO2006126588A1 (ja) * 2005-05-25 2006-11-30 Suntory Limited 熱水を用いるコーヒー果実の処理方法
WO2006126587A1 (ja) * 2005-05-25 2006-11-30 Suntory Limited ｐＨ制御によるコーヒー生豆の処理方法
US8871779B2 (en) 2006-03-02 2014-10-28 Mallinckrodt Llc Process for preparing morphinan-6-one products with low levels of α,β-unsaturated ketone compounds
CN101588725A (zh) * 2006-11-20 2009-11-25 三得利控股株式会社 处理咖啡果实的方法、生咖啡豆、烘焙咖啡豆以及咖啡饮料
HU231350B1 (hu) 2019-12-18 2023-01-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt Eljárás királis prosztaglandin-enol intermedier előállítására, és az eljárásban hasznos köztitermék vegyületek

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3974183A (en) * 1973-01-17 1976-08-10 Corey Elias J Reduction of trans-1-(2-carboxymethyl-3-hydroxy-5-p-phenylbenzoyloxycyclopentyl)-1-octen-3-one-γ-lactone
US3970684A (en) 1973-07-06 1976-07-20 Syntex (U.S.A.) Inc. Polyunsaturated prostaglandin derivatives
ES8705382A1 (es) 1983-07-26 1987-05-01 Sankyo Co Un procedimiento para la preparacion de nuevos derivados de carbaciclina.
US4739078A (en) 1984-02-17 1988-04-19 The Upjohn Company Use of borohydride-salt lanthanide salt reagents for stereo selective reduction of C-15-keto prostaglandin precursors
DE3574470D1 (en) * 1985-09-18 1990-01-04 Upjohn Co Stereoselective reduktion.
CA1324129C (en) 1987-04-30 1993-11-09 Ryuzo Ueno Prostaglandins of the f series
CA2030345C (en) 1989-11-22 1998-12-08 Ryuji Ueno Use of 15-keto-prostaglandin compound for improvement of encephalic function
CA2041417C (en) 1990-05-01 2002-05-21 Ryuji Ueno Treatment of pancreatic disease with 15-keto-prostaglandin compounds
CA2046069C (en) 1990-07-10 2002-04-09 Ryuji Ueno Treatment of inflammatory diseases with 15-keto-prostaglandin compounds

Also Published As

Publication number Publication date
EP0939756A2 (en) 1999-09-08
DE69628207D1 (de) 2003-06-18
WO1997022602A3 (en) 1997-07-24
EP0939756B1 (en) 2003-05-14
WO1997022602A2 (en) 1997-06-26
HU223345B1 (hu) 2004-08-30
ATE240309T1 (de) 2003-05-15
HU9503665D0 (en) 1996-02-28
US6482959B1 (en) 2002-11-19
JP2000502099A (ja) 2000-02-22
PT939756E (pt) 2003-09-30
DE69628207T2 (de) 2004-02-19

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