ES2196001T3 - Derivado de pirroloazepina. - Google Patents
Derivado de pirroloazepina.Info
- Publication number
- ES2196001T3 ES2196001T3 ES92916818T ES92916818T ES2196001T3 ES 2196001 T3 ES2196001 T3 ES 2196001T3 ES 92916818 T ES92916818 T ES 92916818T ES 92916818 T ES92916818 T ES 92916818T ES 2196001 T3 ES2196001 T3 ES 2196001T3
- Authority
- ES
- Spain
- Prior art keywords
- rent
- represent
- link
- pirroloazepina
- derived
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Abstract
UN DERIVADO DE LA PIRROLAZEPINA REPRESENTADO POR UNA FORMULA GENERAL (1), Y UNA SAL DEL MISMO, UN PROCEDIMIENTO PARA SU PRODUCCION Y UN REMEDIO PARA LAS ENFERMEDADES DE LOS ORGANOS CIRCULATORIOS CONTENIENDOLO COMO INGREDIENTE ACTIVO. EN LA FORMULA (1) Z1 REPRESENTA H CUANDO EXISTE UN ENLACE REPRESENTADO POR UNA LINEA DE PUNTOS, MIENTRAS QUE CUANDO NO EXISTE DICHO ENLACE, Z1 REPRESENTA H Y Z2 REPRESENTA OH, O ALTERNATIVAMENTE Z1 Y Z2 SE COMBINAN JUNTOS PARA REPRESENTAR O O NOR1 (DONDE R1 REPRESENTA H, ALQUILO, ETC.); R REPRESENTA H, ALQUILO, ETC.; A REPRESENTA AL ALQUILENO, ALQUENILENO O ALQUINILENO, CADA UNO DE LOS CUALES PUEDE SER SUBSTITUIDO POR UN GRUPO OH; E Y REPRESENTA (ALFA) O (BETA) DONDE R2 Y R3 REPRESENTA CADA UNO H, ALQUILO, ETC.; R4 Y R5 REPRESENTAN, CADA UNO, H O ALQUILO; B REPRESENTA CARBONILO, SULFONILO, ETC.; M REPRESENTA 1 O 2; N REPRESENTA 0 O 1; Y D REPRESENTA ALCOXI, Y HETEROCICLOS AROMATICOS, ETC.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP22119191 | 1991-08-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2196001T3 true ES2196001T3 (es) | 2003-12-16 |
Family
ID=16762903
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES92916818T Expired - Lifetime ES2196001T3 (es) | 1991-08-07 | 1992-08-06 | Derivado de pirroloazepina. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5397780A (es) |
| EP (1) | EP0551527B8 (es) |
| JP (1) | JP3242652B2 (es) |
| KR (1) | KR100243514B1 (es) |
| AT (1) | ATE236162T1 (es) |
| AU (1) | AU655841B2 (es) |
| CA (1) | CA2093631C (es) |
| DE (1) | DE69232980T2 (es) |
| ES (1) | ES2196001T3 (es) |
| WO (1) | WO1993003031A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL121432A (en) | 1995-12-01 | 2000-09-28 | Suntory Ltd | Pyrrolo [3,2-C]azepine-4-one derivatives and pyrrolo [3,4-C]azepine-4-one derivatives their preparation and pharmaceutical compositions containing them |
| JPH10251258A (ja) | 1997-03-14 | 1998-09-22 | Suntory Ltd | ピロロアゼピン系化合物 |
| JPH11193290A (ja) | 1997-12-26 | 1999-07-21 | Suntory Ltd | ピロールスルホンアミド系化合物 |
| JPH11193289A (ja) | 1997-12-26 | 1999-07-21 | Suntory Ltd | ピロールスルホンアミド誘導体 |
| IL283725B2 (en) | 2017-06-20 | 2024-04-01 | Imbria Pharmaceuticals Inc | Compositions and methods for increasing efficiency of cardiac metabolism |
| US11780811B2 (en) | 2020-06-30 | 2023-10-10 | Imbria Pharmaceuticals, Inc. | Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate |
| US11530184B2 (en) | 2020-06-30 | 2022-12-20 | Imbria Pharmaceuticals, Inc. | Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate |
| US11883396B2 (en) | 2021-05-03 | 2024-01-30 | Imbria Pharmaceuticals, Inc. | Methods of treating kidney conditions using modified forms of trimetazidine |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3563979A (en) * | 1966-10-21 | 1971-02-16 | Upjohn Co | 1,2,3,4,5,6 - hexahydroazepino(4,3 - b)indoles and 1,2,3,4,5,6-hexahydroazepino(3,2-b)indoles |
| US3573323A (en) * | 1969-02-28 | 1971-03-30 | Upjohn Co | 1,2,3,4,5,10-hexahydroazepino(2,3-b)indoles |
| US3573324A (en) * | 1969-02-28 | 1971-03-30 | Upjohn Co | 2,3,4,5,10,10a-hexahydroazepino(2,3-b)indoles |
| JPS62161786A (ja) * | 1986-01-08 | 1987-07-17 | Mitsubishi Chem Ind Ltd | ピロ−ル化合物 |
| US4729996A (en) * | 1986-05-29 | 1988-03-08 | Harbor Branch Oceanographic Institution, Inc. | Antitumor compositions and their methods of use |
| DE3903368A1 (de) * | 1989-02-04 | 1990-08-09 | Basf Ag | Verfahren zur herstellung von kondensierten cyclischen amidinen |
| JP3198117B2 (ja) * | 1990-02-07 | 2001-08-13 | サントリー株式会社 | ピロロアゼピン誘導体 |
-
1992
- 1992-08-06 DE DE69232980T patent/DE69232980T2/de not_active Expired - Fee Related
- 1992-08-06 US US08/030,268 patent/US5397780A/en not_active Expired - Fee Related
- 1992-08-06 JP JP50348093A patent/JP3242652B2/ja not_active Expired - Fee Related
- 1992-08-06 EP EP92916818A patent/EP0551527B8/en not_active Expired - Lifetime
- 1992-08-06 ES ES92916818T patent/ES2196001T3/es not_active Expired - Lifetime
- 1992-08-06 KR KR1019930701044A patent/KR100243514B1/ko not_active IP Right Cessation
- 1992-08-06 AU AU24031/92A patent/AU655841B2/en not_active Ceased
- 1992-08-06 CA CA002093631A patent/CA2093631C/en not_active Expired - Fee Related
- 1992-08-06 AT AT92916818T patent/ATE236162T1/de not_active IP Right Cessation
- 1992-08-06 WO PCT/JP1992/001008 patent/WO1993003031A1/ja active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| EP0551527A4 (es) | 1994-08-31 |
| US5397780A (en) | 1995-03-14 |
| AU655841B2 (en) | 1995-01-12 |
| KR100243514B1 (ko) | 2000-03-02 |
| EP0551527A1 (en) | 1993-07-21 |
| DE69232980T2 (de) | 2004-02-05 |
| ATE236162T1 (de) | 2003-04-15 |
| WO1993003031A1 (en) | 1993-02-18 |
| EP0551527B1 (en) | 2003-04-02 |
| CA2093631C (en) | 2003-09-23 |
| AU2403192A (en) | 1993-03-02 |
| JP3242652B2 (ja) | 2001-12-25 |
| KR930702354A (ko) | 1993-09-08 |
| CA2093631A1 (en) | 1993-02-08 |
| EP0551527B8 (en) | 2003-08-13 |
| DE69232980D1 (de) | 2003-05-08 |
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