[go: up one dir, main page]

ES2194033T3 - Amino-alquiloximas, un procedimiento para su preparacion, su uso como medicamentos y compuestos intermedios. - Google Patents

Amino-alquiloximas, un procedimiento para su preparacion, su uso como medicamentos y compuestos intermedios.

Info

Publication number
ES2194033T3
ES2194033T3 ES95111895T ES95111895T ES2194033T3 ES 2194033 T3 ES2194033 T3 ES 2194033T3 ES 95111895 T ES95111895 T ES 95111895T ES 95111895 T ES95111895 T ES 95111895T ES 2194033 T3 ES2194033 T3 ES 2194033T3
Authority
ES
Spain
Prior art keywords
preparation
alquiloximas
medications
amino
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95111895T
Other languages
English (en)
Inventor
Gregory Shutske
Brian S Freed
John Dick Tomer
R Richard L Hamer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Aventis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharmaceuticals Inc filed Critical Aventis Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2194033T3 publication Critical patent/ES2194033T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A AMINOALQUILOXIMAS DE LA FORMULA 1 EN LA QUE X, A, R{SUP,1}, R{SUP,2}, M, N Y P SON COMO SE DEFINEN, UN PROCESO PARA SU PREPARACION Y PRECURSORES. LAS AMINOALQUILOXIMAS SON UTILES PARA EL TRATAMIENTO DE LA DEPRESION Y DE TRASTORNOS COMPULSIVOS OBSESIVOS.
ES95111895T 1994-08-03 1995-07-28 Amino-alquiloximas, un procedimiento para su preparacion, su uso como medicamentos y compuestos intermedios. Expired - Lifetime ES2194033T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/285,668 US5665756A (en) 1994-08-03 1994-08-03 Aminoalkyloximes useful in the treatment of depression and obsessive compulsive disorders

Publications (1)

Publication Number Publication Date
ES2194033T3 true ES2194033T3 (es) 2003-11-16

Family

ID=23095223

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95111895T Expired - Lifetime ES2194033T3 (es) 1994-08-03 1995-07-28 Amino-alquiloximas, un procedimiento para su preparacion, su uso como medicamentos y compuestos intermedios.

Country Status (9)

Country Link
US (8) US5665756A (es)
EP (1) EP0709378B1 (es)
JP (1) JP3947238B2 (es)
AT (1) ATE234820T1 (es)
CA (1) CA2155275C (es)
DE (1) DE69529958T2 (es)
DK (1) DK0709378T3 (es)
ES (1) ES2194033T3 (es)
PT (1) PT709378E (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001023405A2 (en) * 1999-09-30 2001-04-05 Hollis-Eden Pharmaceuticals, Inc. Therapeutic treatment of androgen receptor driven conditions
DE19952146A1 (de) * 1999-10-29 2001-06-07 Boehringer Ingelheim Pharma Arylalkane, Arylalkene und Aryl-azaalkane, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
AU5565401A (en) 2000-04-24 2001-11-07 Aryx Therapeutics Materials and methods for the treatment of depression
US7256191B2 (en) * 2000-04-24 2007-08-14 Aryx Therapeutics Materials and methods for the treatment of depression
US8193768B2 (en) * 2008-02-28 2012-06-05 Jason S. Hallett Contactless charging system for musical instruments
WO2019036024A1 (en) 2017-08-17 2019-02-21 Bristol-Myers Squibb Company 2- (1,1'-BIPHENYL) -1H-BENZO [D] IMIDAZOLE DERIVATIVES AND RELATED COMPOUNDS AS AGONISTS OF APELIN AND APJ FOR THE TREATMENT OF CARDIOVASCULAR DISEASES

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3692835A (en) * 1967-04-05 1972-09-19 Jan Van Dijk Pharmacologically active amino-ethyl oximes
BE759128R (fr) * 1969-11-18 1971-05-18 Usv Pharma Corp Carbamoyl oximes et leur methode de
FR2162312B1 (es) * 1971-12-10 1975-02-07 Buzas Andre
FR2215953B2 (es) * 1973-02-05 1976-05-14 Buzas Andre
NL7503310A (nl) * 1975-03-20 1976-09-22 Philips Nv Verbindingen met antidepressieve werking.
NL7503313A (en) * 1975-03-20 1976-09-22 Philips Nv Antiaggressive oxime ethers - viz 4-nitro-2-butyl(oxy)-acetophenone O-aminoalkyl-oximes
US4192893A (en) * 1975-03-20 1980-03-11 U.S. Philips Corporation Anti-depressive compounds
NL7610399A (en) * 1976-09-20 1978-03-22 Philips Nv O-Aminoethyl oxime derivs. of halophenyl ketone cpds. - are selective nor-adrenalin potentiators useful as antidepressants
AT364354B (de) * 1976-10-14 1981-10-12 Byk Gulden Lomberg Chem Fab Verfahren zur herstellung von neuen pyrazol-1yl-phenylessigsaeuren, deren salzen und optischen isomeren
DE2658938A1 (de) * 1976-12-24 1978-07-06 Hoechst Ag Neue basisch substituierte 0-propyloxime, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE2658762A1 (de) * 1976-12-24 1978-06-29 Hoechst Ag Neue o-alkylierte oxime, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4297359A (en) * 1978-07-25 1981-10-27 Acf Chemiefarma Nv Anti-ulcer compositions containing certain pyridyl oxime ethers
US4352804A (en) * 1978-07-25 1982-10-05 Acf Chemiefarma Nv Oxime ethers, their preparation and pharmaceutical compositions containing them
AU532700B2 (en) * 1979-04-02 1983-10-13 Sumitomo Chemical Company, Limited Diphenylalkanoether
DE3019497A1 (de) * 1980-05-22 1981-11-26 Bayer Ag, 5090 Leverkusen Aminopropiophenon-derivate, verfahren zu ihrer herstellung und ihre verwendung als fungizide
EP0053107B1 (de) * 1980-06-07 1985-01-23 DR.-ING. RUDOLF HELL GmbH Verfahren zur steuerung eines elektronenstrahlerzeugers hoher konstanz für materialbearbeitung
DE3169110D1 (en) * 1980-11-24 1985-03-28 Ici Plc Amide derivatives
US4851423A (en) * 1986-12-10 1989-07-25 Schering Corporation Pharmaceutically active compounds
JPS6463574A (en) * 1987-09-03 1989-03-09 Mitsubishi Chem Ind Ethanone oximes
GB8811056D0 (en) * 1988-05-10 1988-06-15 Ici Plc Antibiotic compounds
HU207988B (en) * 1988-10-20 1993-07-28 Biorex Kutato Fejlesztoe Kft Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components
DE3927483A1 (de) * 1989-08-19 1991-02-21 Boehringer Ingelheim Kg Neue substituierte heterocyclische fuenfringe, ihre herstellung und verwendung
IL97144A (en) * 1990-02-27 1994-11-28 Erba Carlo Spa History of 1-) Alkoxy-Iminoalkyl (Imidazole Transformed Preparation and Pharmaceutical Preparations Containing Them

Also Published As

Publication number Publication date
US5696142A (en) 1997-12-09
US5648367A (en) 1997-07-15
US5684021A (en) 1997-11-04
US5686446A (en) 1997-11-11
PT709378E (pt) 2003-06-30
JP3947238B2 (ja) 2007-07-18
ATE234820T1 (de) 2003-04-15
JPH0859617A (ja) 1996-03-05
CA2155275A1 (en) 1996-02-04
DE69529958T2 (de) 2004-01-08
EP0709378A3 (en) 1996-10-02
CA2155275C (en) 2007-05-15
EP0709378B1 (en) 2003-03-19
DK0709378T3 (da) 2003-07-14
US5665756A (en) 1997-09-09
US5686447A (en) 1997-11-11
US5686483A (en) 1997-11-11
US5770740A (en) 1998-06-23
EP0709378A2 (en) 1996-05-01
DE69529958D1 (de) 2003-04-24

Similar Documents

Publication Publication Date Title
MXPA04005456A (es) Derivados de acetileno que tienen actividad antagonistica de mglur5.
NO932870L (no) Ny fremgangsmaate for fremstilling av 9-amino-6-demetyl-6-deoksyetracykliner
IL160440A (en) Dihydropteridinones, method for producing the same and the use thereof as medicaments
MX9205573A (es) Nuevas 9-amino-7-(amino substituido)-6-desmetil-6-desoxitetraciclinas, metodo para su produccion y composicion farmaceutica que las contiene
CA2150123A1 (en) Aminomethylene substituted non-aromatic heterocycles
MX9205532A (es) Nuevas 7-sustituidas-9-amino sustituidas 6-desmetil-6-desoxitetraciclinas, metodo para su producciony composicion farmaceutica que las contiene.
ATE218576T1 (de) Phosphohalohydrine, verfahren zu deren herstellung und verwendungen
BR9510012A (pt) Processo para a purificação de uma composição de 1,3-propanodiol contendo carbonila
FI920023A0 (fi) Heteroarylpiperazinfoereningar som antipsykotiska aemnen.
EP0604354A3 (en) Antidepressant and anti-Parkinson's disease compounds.
MX9304353A (es) Aminotienopiridinas sustituidas, procedimiento para su preparacion y su uso como medicamento.
DE60004671D1 (de) Neue piperazinylalkylthiopyrimidine derivate, diese enthaltende pharmazeutische zusammenstellungen und verfahren zu deren herstellung
ES2194033T3 (es) Amino-alquiloximas, un procedimiento para su preparacion, su uso como medicamentos y compuestos intermedios.
DE60235365D1 (de) Verfahren zur herstellung von 7-amino-syn-3,5-dihydroxyheptansäurederivaten und zwischenverbindungen diesesverfahrens und deren herestellung
ATE312094T1 (de) Neue heteroarylderivate, deren herstellung und verwendung
ES2101373T3 (es) Tetrahidrociclopent(b)indol-metaminas y compuestos relacionados, un procedimiento para su preparacion y su uso como medicamentos.
DE60224884D1 (de) Verfahren zur herstellung von 3, 3', 6, 6'-tetraalkylen-2, 2'-biphenolen und 3, 3', 6, 6'-tetraalkylen-5, 5'-dihalo-2, 2' biphenolen
ATE226585T1 (de) Thiazolobenzoheterocyclen, ihre herstellung und diese enthaltende phatrmazeutische zubereitungen
DE69917668D1 (de) Substanz gm-95, verfahren zu ihrer herstellung und ihre verwendung
EP0703232A3 (en) 2,3-dihydro-1H-isoindole derivatives, process for their preparation and their use as serotonin re-assimilation inhibitors
ES2160893T3 (es) Procedimiento y compuestos intermedios para la preparacion de compuestos de fluoroolefinas plaguicidas.
BR9909151A (pt) processos para preparação de intermediários
PT1250335E (pt) Processo e intermediarios para a preparacao de imidazopiridinas
ATE243683T1 (de) Polyhydroxybutylpyrazinen, deren herstellung und diese enthaltende arzneimitteln
BR0211480A (pt) Derivados de tetraidropiridazina e seu uso como pesticidas