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ES2193285T3 - Inhibidor de oxido nitrico (no)-sintasa para prevenir la diabetes de tipo ii. - Google Patents

Inhibidor de oxido nitrico (no)-sintasa para prevenir la diabetes de tipo ii.

Info

Publication number
ES2193285T3
ES2193285T3 ES96944077T ES96944077T ES2193285T3 ES 2193285 T3 ES2193285 T3 ES 2193285T3 ES 96944077 T ES96944077 T ES 96944077T ES 96944077 T ES96944077 T ES 96944077T ES 2193285 T3 ES2193285 T3 ES 2193285T3
Authority
ES
Spain
Prior art keywords
diabetes
synthease
nitric oxide
oxide inhibitor
prevent type
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96944077T
Other languages
English (en)
Inventor
Nicholas Charles Mithk Turner
Valerie Piercy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Application granted granted Critical
Publication of ES2193285T3 publication Critical patent/ES2193285T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

UN METODO PARA EL TRATAMIENTO Y/O PROFILAXIS DE LA DIABETES DE TIPO II, EL CUAL METODO COMPRENDE LA ADMINISTRACION, A UN MAMIFERO HUMANO O NO HUMANO, DE UNA CANTIDAD EFECTIVA ACEPTABLE FARMACEUTICAMENTE Y NO TOXICA DE UN INHIBIDOR DE SINTASA DE NO, TAL COMO LA AMINOGUANIDINA, O UN DERIVADO FARMACEUTICAMENTE ACEPTABLE DE LA MISMA.
ES96944077T 1995-12-22 1996-12-18 Inhibidor de oxido nitrico (no)-sintasa para prevenir la diabetes de tipo ii. Expired - Lifetime ES2193285T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9526331.5A GB9526331D0 (en) 1995-12-22 1995-12-22 Novel method

Publications (1)

Publication Number Publication Date
ES2193285T3 true ES2193285T3 (es) 2003-11-01

Family

ID=10785930

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96944077T Expired - Lifetime ES2193285T3 (es) 1995-12-22 1996-12-18 Inhibidor de oxido nitrico (no)-sintasa para prevenir la diabetes de tipo ii.

Country Status (20)

Country Link
EP (1) EP0868175B1 (es)
JP (1) JP2000502668A (es)
KR (1) KR19990076595A (es)
CN (1) CN1209057A (es)
AT (1) ATE232724T1 (es)
AU (1) AU1379497A (es)
BR (1) BR9612245A (es)
CA (1) CA2240396A1 (es)
CZ (1) CZ198698A3 (es)
DE (1) DE69626307T2 (es)
ES (1) ES2193285T3 (es)
GB (1) GB9526331D0 (es)
HU (1) HUP9903979A3 (es)
IL (1) IL124870A0 (es)
MX (1) MX9805098A (es)
NO (1) NO982854D0 (es)
NZ (1) NZ325307A (es)
PL (1) PL327472A1 (es)
TR (1) TR199801133T2 (es)
WO (1) WO1997023204A1 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012104467A1 (es) * 2011-02-04 2012-08-09 Servicio Andaluz De Salud Uso de inhibidores de la actividad de las no sintasas (nos) y sus composiciones, en la elaboración de un medicamento para el tratamiento y la prevención de la prediabetes y la diabetes mellitus tipo 1 (dm1)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999044598A2 (en) * 1998-03-03 1999-09-10 Board Of Regents, The University Of Texas System Methods for inhibiting βcell apoptosis
CN1660428B (zh) * 2005-01-10 2011-09-07 王振军 一氧化氮合酶（nos）抑制剂用于治疗痔的新用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT793646E (pt) * 1994-11-23 2002-03-28 Biovitrum Ab Carboxilatos de aminoguanidina destinados ao tratamento de diabetes mellitus nao-insulinodependente

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012104467A1 (es) * 2011-02-04 2012-08-09 Servicio Andaluz De Salud Uso de inhibidores de la actividad de las no sintasas (nos) y sus composiciones, en la elaboración de un medicamento para el tratamiento y la prevención de la prediabetes y la diabetes mellitus tipo 1 (dm1)
ES2386831A1 (es) * 2011-02-04 2012-08-31 Servicio Andaluz De Salud Uso de inhibidores de la actividad de las NO sintasas (NOS) y sus composiciones, en la elaboración de un medicamento para el tratamiento y la prevención de la prediabetes y la diabetes mellitus tipo 1 (DM1)

Also Published As

Publication number Publication date
CZ198698A3 (cs) 1999-06-16
DE69626307T2 (de) 2003-10-16
TR199801133T2 (xx) 1998-09-21
EP0868175B1 (en) 2003-02-19
CA2240396A1 (en) 1997-07-03
NZ325307A (en) 1999-11-29
CN1209057A (zh) 1999-02-24
ATE232724T1 (de) 2003-03-15
HUP9903979A3 (en) 2000-05-29
MX9805098A (es) 1998-10-31
BR9612245A (pt) 1999-07-13
WO1997023204A1 (en) 1997-07-03
PL327472A1 (en) 1998-12-07
IL124870A0 (en) 1999-01-26
DE69626307D1 (de) 2003-03-27
AU1379497A (en) 1997-07-17
NO982854L (no) 1998-06-19
NO982854D0 (no) 1998-06-19
JP2000502668A (ja) 2000-03-07
HUP9903979A2 (hu) 2000-03-28
EP0868175A1 (en) 1998-10-07
GB9526331D0 (en) 1996-02-21
KR19990076595A (ko) 1999-10-15

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