[go: up one dir, main page]

ES2191200T3 - Procedimiento simplificado para producir captopril de calidad superior. - Google Patents

Procedimiento simplificado para producir captopril de calidad superior.

Info

Publication number
ES2191200T3
ES2191200T3 ES97943179T ES97943179T ES2191200T3 ES 2191200 T3 ES2191200 T3 ES 2191200T3 ES 97943179 T ES97943179 T ES 97943179T ES 97943179 T ES97943179 T ES 97943179T ES 2191200 T3 ES2191200 T3 ES 2191200T3
Authority
ES
Spain
Prior art keywords
superior quality
simplified procedure
produce superior
captopril
quality captopril
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97943179T
Other languages
English (en)
Inventor
Koichi Kinoshita
Fumihiko Kanou
Takahiro Okubo
Yasuyoshi Ueda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kaneka Corp
Original Assignee
Kaneka Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaneka Corp filed Critical Kaneka Corp
Application granted granted Critical
Publication of ES2191200T3 publication Critical patent/ES2191200T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

UN PROCESO PARA PRODUCIR CAPTOPRIL CON LA FORMULA (1) SIGUIENTE QUE INCLUYE SOMETER UN COMPUESTO SUSTRATO DE LA SIGUIENTE FORMULA GENERAL (2) A REACCION DE HIDROLISIS EN MEDIO ACUOSO PARA ELIMINAR EL GRUPO RCO Y AISLARLO, LLEVANDOSE A CABO DICHA HIDROLISIS EN MEDIO ACUOSO EN PRESENCIA DE UN ACIDO FUERTE A PH NO SUPERIOR A 1 Y CON UNA TEMPERATURA DE REACCION NO INFERIOR A 40 (GRADOS) C.
ES97943179T 1996-10-11 1997-10-13 Procedimiento simplificado para producir captopril de calidad superior. Expired - Lifetime ES2191200T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP28934096A JP3980684B2 (ja) 1996-10-11 1996-10-11 高品質カプトプリルの簡便な製造方法

Publications (1)

Publication Number Publication Date
ES2191200T3 true ES2191200T3 (es) 2003-09-01

Family

ID=17741941

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97943179T Expired - Lifetime ES2191200T3 (es) 1996-10-11 1997-10-13 Procedimiento simplificado para producir captopril de calidad superior.

Country Status (14)

Country Link
US (1) US6187932B1 (es)
EP (1) EP0889031B1 (es)
JP (1) JP3980684B2 (es)
KR (1) KR19990072045A (es)
AT (1) ATE231125T1 (es)
CA (1) CA2249543A1 (es)
DE (1) DE69718450T2 (es)
ES (1) ES2191200T3 (es)
HR (1) HRP970536A2 (es)
HU (1) HUP0000199A3 (es)
IL (1) IL124747A (es)
IN (1) IN183229B (es)
SI (1) SI9720012A (es)
WO (1) WO1998016509A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107652215A (zh) * 2017-09-19 2018-02-02 重庆西南制药二厂有限责任公司 一种卡托普利的制备方法
CN110950792A (zh) * 2019-12-11 2020-04-03 华中药业股份有限公司 一种卡托普利的改进制备方法
CN116655512A (zh) * 2023-05-31 2023-08-29 江苏阿尔法药业股份有限公司 一种卡托普利的制备工艺

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5538363A (en) * 1978-09-13 1980-03-17 Yoshitomi Pharmaceut Ind Ltd Preparation of optically active n-mercaptoacyl-imino acid
US4297282A (en) * 1979-03-02 1981-10-27 Sumitomo Chemical Company, Limited Resolution of mercaptopropionic acids
US5026873A (en) * 1989-11-06 1991-06-25 E. R. Squibb & Sons, Inc. Process for direct isolation of captopril
JP2896818B2 (ja) * 1991-04-02 1999-05-31 三菱レイヨン株式会社 Ｌ−プロリン誘導体の製造法
JPH05221966A (ja) * 1992-02-18 1993-08-31 Mitsubishi Rayon Co Ltd Ｌ−プロリン誘導体の製造方法
HU211101B (en) * 1992-03-13 1995-10-30 Egyt Gyogyszervegyeszeti Gyar Process for preparing 1-[/2s/-methyl-3-mercapto-propionyl]-pyrrolidine-/2s/-carboxylic acid
US5387697A (en) * 1994-06-13 1995-02-07 Merck & Co., Inc. Process for the preparation of 1-[3-acetylthio-2(s)-methylpropanoyl]-l-proline
JPH09157251A (ja) 1995-10-06 1997-06-17 Kanegafuchi Chem Ind Co Ltd Ｎ−（Ｄ−α−メチル−β−メルカプトプロピオニル）−Ｌ−プロリン及び該中間体の製造方法

Also Published As

Publication number Publication date
JP3980684B2 (ja) 2007-09-26
ATE231125T1 (de) 2003-02-15
HRP970536A2 (en) 1998-08-31
JPH10114740A (ja) 1998-05-06
IN183229B (es) 1999-10-09
IL124747A (en) 2003-05-29
WO1998016509A1 (fr) 1998-04-23
DE69718450T2 (de) 2003-11-20
EP0889031A4 (en) 2000-03-22
KR19990072045A (ko) 1999-09-27
US6187932B1 (en) 2001-02-13
HUP0000199A2 (hu) 2000-06-28
EP0889031A1 (en) 1999-01-07
IL124747A0 (en) 1999-01-26
HUP0000199A3 (en) 2001-12-28
EP0889031B1 (en) 2003-01-15
CA2249543A1 (en) 1998-04-23
SI9720012A (sl) 1998-12-31
DE69718450D1 (de) 2003-02-20

Similar Documents

Publication Publication Date Title
DE69914073D1 (de) Verfahren zur umsetzung von sauerstoffverbindungen zu olefinen mit abschreckung des produktes zur wärmegewinnung
ATE470727T1 (de) Verfahren zur herstellung von l-arabinose durch saure hydrolyse
ATE207964T1 (de) Produktion von ammonium-acrylat
DE69632199T2 (de) Verfahren zur herstellung von d-pantoinsäure und d-pantothensäure oder deren salze
EP0666320A3 (en) Process for the production of alpha-hydroxy acids or alpha-hydroxyamides by microorganisms.
MY117543A (en) Removal of ammonia and cyanide from synthesis gas with water production
ATE196458T1 (de) Verfahren zur herstellung von xylitol
DE69722195D1 (de) Verfahren zur herstellung von methylmercatopropanal
PH31685A (en) Method of producing l-glutamic acid by fermentation.
ES2191200T3 (es) Procedimiento simplificado para producir captopril de calidad superior.
ATE135047T1 (de) Verfahren zur herstellung optisch aktiver cyanhydrine durch enzyme
DE69403087D1 (de) Verfahren zur herstellung von 9-(2-hydroxy)-ethoxy-guanin
ZA992250B (en) Improved processes for synthesis and purification of nondigestible fats.
GB9325757D0 (en) Fluorination process
DE59705175D1 (de) Verfahren zur herstellung von dialkylcarbonaten
ATE171930T1 (de) Verfahren zur herstellung von 1,4-butandiol
DE69714858D1 (de) Verfahren zur herstellung von cyanozimtsäure-amiden
GB9523924D0 (en) Production of optically active 2-substituted tetrahydropyran-4-ones
DE69613101D1 (de) Verfahren zur herstellung von palatinitol
ES2141258T3 (es) Enzima y su uso en la preparacion de acido (s)-pipecolico.
BR9508432A (pt) Processo para a preparação de 2,5-dimetil-2,5-dihidroperóxi-hexano
ATE211460T1 (de) Verfahren zur herstellung von substituierten anthrachinonen und deren verwendung zur herstellung von rheinen
DE59801881D1 (de) Verfahren zur herstellung von cellulose-derivaten
DE3884922D1 (de) Verfahren zur Herstellung von thermostabilen alpha-Amylasen durch Kultivierung von überproduzierenden Mikroorganismen.
EP0725146A4 (en) METHOD FOR PRODUCING OPTICALLY ACTIVE TRIAZOLE COMPOUNDS AND METHOD FOR RAZEMIZING OPTICALLY ACTIVE TRIAZOLE COMPOUNDS