ES2184650B1 - USE OF CHOLESTEROL AND PHOSPHOLIPIDS IN MEDICINES FOR THE TREATMENT OF LEISHMANIASIS IN LOS CANIDOS. - Google Patents
USE OF CHOLESTEROL AND PHOSPHOLIPIDS IN MEDICINES FOR THE TREATMENT OF LEISHMANIASIS IN LOS CANIDOS.Info
- Publication number
- ES2184650B1 ES2184650B1 ES200102260A ES200102260A ES2184650B1 ES 2184650 B1 ES2184650 B1 ES 2184650B1 ES 200102260 A ES200102260 A ES 200102260A ES 200102260 A ES200102260 A ES 200102260A ES 2184650 B1 ES2184650 B1 ES 2184650B1
- Authority
- ES
- Spain
- Prior art keywords
- treatment
- cholesterol
- leishmaniasis
- phospholipids
- canidos
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 title abstract 6
- 238000011282 treatment Methods 0.000 title abstract 5
- 208000004554 Leishmaniasis Diseases 0.000 title abstract 3
- 235000012000 cholesterol Nutrition 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title abstract 3
- 150000003904 phospholipids Chemical class 0.000 title abstract 2
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 abstract 1
- 241000282465 Canis Species 0.000 abstract 1
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- OFCNXPDARWKPPY-UHFFFAOYSA-N allopurinol Chemical compound OC1=NC=NC2=C1C=NN2 OFCNXPDARWKPPY-UHFFFAOYSA-N 0.000 abstract 1
- 229960003459 allopurinol Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000002483 medication Methods 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Utilización de colesterol y fosfolípidos en medicamentos para el tratamiento de la leishmaniasis en los cánidos. Se describe la utilización combinada del colesterol y la fosfatidilserina en la fabricación de medicamentos para el tratamiento de la leishmaniasis canina. Dicha combinación resulta eficaz por sí sola en el tratamiento de los animales afectados por la mencionada enfermedad y además, cuando se utiliza de forma combinada con otros tratamientos convencionales, especialmente con compuestos antimoniales y alopurinol, resulta ser altamente efectiva.Use of cholesterol and phospholipids in medications for the treatment of leishmaniasis in canids. The combined use of cholesterol and phosphatidylserine in the manufacture of medicaments for the treatment of canine leishmaniasis is described. This combination is effective in itself in the treatment of animals affected by the aforementioned disease and also, when used in combination with other conventional treatments, especially with antimonial compounds and allopurinol, it is highly effective.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200102260A ES2184650B1 (en) | 2001-10-10 | 2001-10-10 | USE OF CHOLESTEROL AND PHOSPHOLIPIDS IN MEDICINES FOR THE TREATMENT OF LEISHMANIASIS IN LOS CANIDOS. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200102260A ES2184650B1 (en) | 2001-10-10 | 2001-10-10 | USE OF CHOLESTEROL AND PHOSPHOLIPIDS IN MEDICINES FOR THE TREATMENT OF LEISHMANIASIS IN LOS CANIDOS. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2184650A1 ES2184650A1 (en) | 2003-04-01 |
| ES2184650B1 true ES2184650B1 (en) | 2004-09-16 |
Family
ID=8499152
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES200102260A Expired - Fee Related ES2184650B1 (en) | 2001-10-10 | 2001-10-10 | USE OF CHOLESTEROL AND PHOSPHOLIPIDS IN MEDICINES FOR THE TREATMENT OF LEISHMANIASIS IN LOS CANIDOS. |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2184650B1 (en) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4302459A (en) * | 1980-03-19 | 1981-11-24 | The United States Of America As Represented By The Secretary Of The Army | Liposome carriers in leishmaniasis chemotherapy with 8-aminoquinoline derivatives |
| ATE226210T1 (en) * | 1997-08-18 | 2002-11-15 | Max Planck Gesellschaft | PHOSPHOLIPIDE ANALOGOUS COMPOUNDS |
| DE10015814A1 (en) * | 2000-03-30 | 2001-10-11 | Max Planck Gesellschaft | Medicines to stimulate leukopoiesis, treat tumors and protozoan diseases and process for its manufacture |
-
2001
- 2001-10-10 ES ES200102260A patent/ES2184650B1/en not_active Expired - Fee Related
Non-Patent Citations (1)
| Title |
|---|
| ALVING, C.R. et al.: "Therapy of leishmaniasis: superior efficacies of liposome-encapsulated drugs", P.N.A.S. U.S.A. (1978), 75 (6), páginas 2959-63, ISSN: 0027-8424, todo el documento. * |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2184650A1 (en) | 2003-04-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EC2A | Search report published |
Date of ref document: 20030401 Kind code of ref document: A1 |
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| FG2A | Definitive protection |
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| FD2A | Announcement of lapse in spain |
Effective date: 20180807 |