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ES2173146T3 - Ensayo inmunologico para la cuantificacion del factor humano de estimulacion de las colonias de granulocitos humanos modificados por peg. - Google Patents

Ensayo inmunologico para la cuantificacion del factor humano de estimulacion de las colonias de granulocitos humanos modificados por peg.

Info

Publication number
ES2173146T3
ES2173146T3 ES95119829T ES95119829T ES2173146T3 ES 2173146 T3 ES2173146 T3 ES 2173146T3 ES 95119829 T ES95119829 T ES 95119829T ES 95119829 T ES95119829 T ES 95119829T ES 2173146 T3 ES2173146 T3 ES 2173146T3
Authority
ES
Spain
Prior art keywords
human
peg
modified
factor
granulocit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95119829T
Other languages
English (en)
Inventor
Nobuo Hanai
Akiko Furuya
Motoo Yamasaki
Satoshi Kobayashi
Takashi Kuwabara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Application granted granted Critical
Publication of ES2173146T3 publication Critical patent/ES2173146T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/243—Colony Stimulating Factors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

UN ENSAYO INMUNOLOGICO PARA CUANTIFICAR EL FACTOR ESTIMULADOR DE UNA COLONIA GRANULOCITICA HUMANA PEG MODIFICADA O DERIVADOS DEL MISMO EN UNA MUESTRA QUE COMPRENDE PONER EN CONTACTO CON DICHA MUESTRA UN ANTICUERPO QUE REACCIONA CON EL FACTOR ESTIMULADOR DE COLONIA GRANULOCITICA HUMANA O SU DERIVADO Y CON EL FACTOR ESTIMULADOR DE COLONIA GRANULOCITICA HUMANA PEG MODIFICADA O SU DERIVADO Y UN ANTICUERPO MONOCLONAL QUE REACCIONA ESPECIFICAMENTE CON EL FACTOR ESTIMULADOR DE COLONIA GRANULOCITICA HUMANA O SU DERIVADO PERO NO CON EL FACTOR ESTIMULADOR DE COLONIA GRANULOCITICA HUMANA PEG MODIFICADA O SU DERIVADO.
ES95119829T 1994-12-15 1995-12-15 Ensayo inmunologico para la cuantificacion del factor humano de estimulacion de las colonias de granulocitos humanos modificados por peg. Expired - Lifetime ES2173146T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP31176394A JP3708151B2 (ja) 1994-12-15 1994-12-15 Ｐｅｇ化したヒト顆粒球コロニー刺激因子の定量法

Publications (1)

Publication Number Publication Date
ES2173146T3 true ES2173146T3 (es) 2002-10-16

Family

ID=18021197

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95119829T Expired - Lifetime ES2173146T3 (es) 1994-12-15 1995-12-15 Ensayo inmunologico para la cuantificacion del factor humano de estimulacion de las colonias de granulocitos humanos modificados por peg.

Country Status (6)

Country Link
US (1) US5939280A (es)
EP (1) EP0721958B1 (es)
JP (1) JP3708151B2 (es)
AT (1) ATE215095T1 (es)
DE (1) DE69526056T2 (es)
ES (1) ES2173146T3 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030053982A1 (en) 1994-09-26 2003-03-20 Kinstler Olaf B. N-terminally chemically modified protein compositions and methods
US5824784A (en) 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
EP1369429A1 (en) * 1999-01-29 2003-12-10 F. Hoffmann-La Roche Ag GCSF conjugates
ATE246202T1 (de) * 1999-01-29 2003-08-15 Hoffmann La Roche Gcsf konjugate
KR100735784B1 (ko) 2005-07-20 2007-07-06 재단법인 목암생명공학연구소 인간 과립구콜로니자극인자 변이체 및 이의 화학적 접합물

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB331186A (en) * 1929-03-18 1930-06-18 Bataafsche Petroleum A process for the manufacture of valuable products from ethylene and/or its homologues
US4179337A (en) * 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US4778752A (en) * 1983-10-11 1988-10-18 Scripps Clinic And Research Foundation Receptors specific for hapten-modified self proteins
NZ218336A (en) * 1985-12-09 1991-08-27 Kirin Amgen Inc Monoclonal antibodies to human pluripotent granulocyte colony stimulating factor (hpg-csf)
US5214132A (en) * 1986-12-23 1993-05-25 Kyowa Hakko Kogyo Co., Ltd. Polypeptide derivatives of human granulocyte colony stimulating factor
JP2618618B2 (ja) * 1988-03-04 1997-06-11 協和醗酵工業株式会社 抗ｇ−ｃｓｆ誘導体、ｎｄ２８モノクローナル抗体
US5362853A (en) * 1986-12-23 1994-11-08 Kyowa Hakko Kogyo Co., Ltd. Polypeptide derivatives of human granulocyte colony stimulating factor
US5194592A (en) * 1986-12-23 1993-03-16 Kyowa Hakko Kogyo Co. Ltd. Monoclonal antibodies to novel polypeptide derivatives of human granulocyte colony stimulating factor
JPS63180860A (ja) * 1987-01-22 1988-07-25 Kyowa Hakko Kogyo Co Ltd 抗ｇ−ｃｓｆモノクロ−ナル抗体
JP2989002B2 (ja) * 1988-12-22 1999-12-13 キリン―アムジエン・インコーポレーテツド 化学修飾顆粒球コロニー刺激因子
JP3051145B2 (ja) * 1990-08-28 2000-06-12 住友製薬株式会社 新規なポリエチレングリコール誘導体修飾ペプチド
US6565841B1 (en) * 1991-03-15 2003-05-20 Amgen, Inc. Pulmonary administration of granulocyte colony stimulating factor
US5336782A (en) * 1991-04-24 1994-08-09 Kuraray Co., Ltd. Long chain carboxylic acid imide ester
JPH05115197A (ja) * 1991-10-21 1993-05-07 Fanuc Ltd リラクタンスモータ用ロータリエンコーダと駆動装置
JPH05115297A (ja) * 1991-10-29 1993-05-14 Otsuka Pharmaceut Co Ltd ヒトｇ−ｃｓｆ抗体及びヒトｇ−ｃｓｆの測定法
US5581476A (en) * 1993-01-28 1996-12-03 Amgen Inc. Computer-based methods and articles of manufacture for preparing G-CSF analogs
US5298410A (en) * 1993-02-25 1994-03-29 Sterling Winthrop Inc. Lyophilized formulation of polyethylene oxide modified proteins with increased shelf-life
US5605976A (en) * 1995-05-15 1997-02-25 Enzon, Inc. Method of preparing polyalkylene oxide carboxylic acids
US5536382A (en) * 1994-05-23 1996-07-16 Advanced Molecular Systems, Inc. Capillary electrophoresis assay method useful for the determination of constituents of a clinical sample
US5593666A (en) * 1994-08-16 1997-01-14 The University Of Tennessee Research Corp. Methods and compositions for treating thrombocytopenia

Also Published As

Publication number Publication date
EP0721958B1 (en) 2002-03-27
ATE215095T1 (de) 2002-04-15
US5939280A (en) 1999-08-17
EP0721958A3 (en) 1996-12-18
JPH08165300A (ja) 1996-06-25
JP3708151B2 (ja) 2005-10-19
DE69526056T2 (de) 2003-04-03
EP0721958A2 (en) 1996-07-17
DE69526056D1 (de) 2002-05-02

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