[go: up one dir, main page]

ES2173087T3 - AZETIDINONE COMPOUND AND PROCEDURE FOR PREPARATION. - Google Patents

AZETIDINONE COMPOUND AND PROCEDURE FOR PREPARATION.

Info

Publication number
ES2173087T3
ES2173087T3 ES93118085T ES93118085T ES2173087T3 ES 2173087 T3 ES2173087 T3 ES 2173087T3 ES 93118085 T ES93118085 T ES 93118085T ES 93118085 T ES93118085 T ES 93118085T ES 2173087 T3 ES2173087 T3 ES 2173087T3
Authority
ES
Spain
Prior art keywords
substituent
procedure
preparation
azetidinone compound
oxygen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93118085T
Other languages
Spanish (es)
Inventor
Tameo Iwasaki
Kazuhiko Kondo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Seiyaku Co Ltd
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Application granted granted Critical
Publication of ES2173087T3 publication Critical patent/ES2173087T3/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/20—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 4
    • C07D265/22—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
    • C07D279/08—1,3-Thiazines; Hydrogenated 1,3-thiazines condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C07D477/04—Preparation by forming the ring or condensed ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

There is disclosed an azetidinone compound of the formula [I]: <CHEM> wherein Ring B is a benzene ring which may have substituent(s), R<1> is a hydroxy-substituted lower alkyl group which may have substituent(s), X is oxygen atom and the like, Y is oxygen atom and the like, and Z is a methylene group which may have substituent(s), which is useful as a synthetic intermediate of the 1 beta -methylcarbapenem-type antibacterial agent.
ES93118085T 1992-11-13 1993-11-08 AZETIDINONE COMPOUND AND PROCEDURE FOR PREPARATION. Expired - Lifetime ES2173087T3 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP30366292 1992-11-13
JP11146093 1993-05-13
JP16918293 1993-07-08
JP23815593 1993-09-24

Publications (1)

Publication Number Publication Date
ES2173087T3 true ES2173087T3 (en) 2002-10-16

Family

ID=27469913

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93118085T Expired - Lifetime ES2173087T3 (en) 1992-11-13 1993-11-08 AZETIDINONE COMPOUND AND PROCEDURE FOR PREPARATION.

Country Status (12)

Country Link
US (1) US5442055A (en)
EP (1) EP0597423B1 (en)
JP (1) JP2897153B2 (en)
KR (3) KR100231223B1 (en)
AT (1) ATE214061T1 (en)
CA (1) CA2102772C (en)
DE (1) DE69331652T2 (en)
DK (1) DK0597423T3 (en)
ES (1) ES2173087T3 (en)
IL (2) IL107532A (en)
PT (1) PT597423E (en)
SG (1) SG50416A1 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5731431A (en) * 1991-12-26 1998-03-24 Nippon Soda Co., Ltd. Process for preparing 4-substituted azetidinone derivatives
US6011150A (en) * 1992-11-13 2000-01-04 Tanabe Seiyaku Co., Ltd. Azetidinone compound and process for preparation thereof
US5550229A (en) * 1993-06-23 1996-08-27 Tanabe Seiyaku Co., Ltd. Alkylation process for preparing azetidinone compound and starting compound therefor
EP0632037B1 (en) * 1993-06-30 1997-10-01 Tanabe Seiyaku Co., Ltd. Process for the production of 4-substituted azetidinone derivatives
JPH09143156A (en) * 1995-11-17 1997-06-03 Tanabe Seiyaku Co Ltd Production of acetoxyazetidinone derivative and its synthetic intermediate
JP3450193B2 (en) * 1998-07-24 2003-09-22 高砂香料工業株式会社 Method for producing 4-substituted azetidinone derivatives
KR100377448B1 (en) * 2000-08-10 2003-03-26 동화약품공업주식회사 Intermediate of Carbapenem Antibiotics and Process for the Preparation thereof
JP2008056564A (en) * 2004-11-12 2008-03-13 Shionogi & Co Ltd Method for producing azetidinone derivative
DK2326648T3 (en) 2008-07-30 2012-10-15 Ranbaxy Lab Ltd Process for the preparation of carbapenem compounds
AU2010276537B2 (en) 2009-07-27 2015-04-16 Gilead Sciences, Inc. Fused heterocyclic compounds as ion channel modulators
KR101911560B1 (en) 2010-07-02 2018-10-24 길리애드 사이언시즈, 인코포레이티드 Fused heterocyclic compounds as ion channel modulators
CA2834164A1 (en) 2011-05-10 2012-11-15 Gilead Sciences, Inc. Fused benzoxazinones as ion channel modulators
TWI549944B (en) 2011-07-01 2016-09-21 吉李德科學股份有限公司 Fused heterocyclic compound as ion channel regulator
NO3175985T3 (en) 2011-07-01 2018-04-28
CN108774188A (en) * 2018-07-23 2018-11-09 湖北宇阳药业有限公司 A kind of preparation method of meropenem intermediate
CN110025619B (en) * 2019-04-29 2022-03-22 江苏汉阔生物有限公司 Application of meropenem intermediate in preparation of antioxidant drugs

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4194047A (en) * 1975-11-21 1980-03-18 Merck & Co., Inc. Substituted N-methylene derivatives of thienamycin
EP0010348A1 (en) * 1978-09-12 1980-04-30 Imperial Chemical Industries Plc Heterocyclic trichloromethyl derivatives, process for their preparation and their use
US4350631A (en) * 1980-12-18 1982-09-21 Merck & Co., Inc. 6- and 4-Substituted-1-azabicyclo[3.2.0]heptan-3,7-dione-2-carboxylates
JPS5910570A (en) * 1982-07-08 1984-01-20 Wakamoto Pharmaceut Co Ltd New isocarbostyryl derivatives and their production method
JPS60202886A (en) * 1984-03-27 1985-10-14 Sankyo Co Ltd 1-substituted carbapenem-3-carboxylic acid derivative and its preparation
JPS615081A (en) * 1984-06-18 1986-01-10 Sankyo Co Ltd Preparation of 1-substituted carbapenem-3-carboxylic acid derivative
DK270685A (en) * 1984-06-29 1985-12-30 Hoffmann La Roche carbapenem derivatives
JPS6225286A (en) * 1985-07-26 1987-02-03 株式会社東芝 Power unit for nuclear fusion device
EP0213610A1 (en) * 1985-08-31 1987-03-11 Lederle (Japan) Ltd. Azetidin-2-one derivatives and process for production thereof
JPS6277384A (en) * 1985-10-01 1987-04-09 Nippon Redarii Kk Azetidin-2-one derivative and production thereof
JPS62252785A (en) * 1986-01-08 1987-11-04 Sankyo Co Ltd 4-substituted beta-lactam compound
JPS62169781A (en) * 1986-01-21 1987-07-25 Sankyo Co Ltd Beta-lactam compound
JP2789190B2 (en) * 1986-01-27 1998-08-20 住友製薬株式会社 Novel β-lactam derivative and method for producing the same
GB8607921D0 (en) * 1986-04-01 1986-05-08 Fujisawa Pharmaceutical Co 3,4-disubstituted-2-azetidinone derivatives
JP2510860B2 (en) * 1987-02-02 1996-06-26 住友製薬株式会社 Process for producing new β-lactam derivative
JPS63284176A (en) * 1987-05-15 1988-11-21 Nippon Redarii Kk Highly stereoselective production of (1r,5r,6s)-6-((1r)-1-hydroxyethyl)-1-methylcarbapenem-3-carboxylic acid derivative
NO168304C (en) * 1988-04-01 1992-02-05 Sankyo Co ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE 2- (HETEROCYCYLYLTIO) CARBAPENE SUBSTANCES
JPH02178262A (en) * 1988-12-28 1990-07-11 Sumitomo Pharmaceut Co Ltd 1-(2'-halopropionyl)pyrrolidin-2-one derivative
JPH0662547B2 (en) * 1989-01-10 1994-08-17 田辺製薬株式会社 Glycine derivative
JPH02292269A (en) * 1989-05-06 1990-12-03 Lederle Japan Ltd Active amide compound
CA2050255C (en) * 1990-09-07 1997-02-04 Tameo Iwasaki 1-methylcarbapenem derivatives and process for preparation thereof
WO1993013064A1 (en) * 1991-12-26 1993-07-08 Nippon Soda Co., Ltd. Process for producing 4-substituted azetidinone derivative

Also Published As

Publication number Publication date
IL107532A0 (en) 1994-02-27
EP0597423A2 (en) 1994-05-18
DE69331652D1 (en) 2002-04-11
US5442055A (en) 1995-08-15
EP0597423B1 (en) 2002-03-06
CA2102772A1 (en) 1994-05-14
CA2102772C (en) 2001-04-03
IL121842A0 (en) 1998-02-22
DK0597423T3 (en) 2002-05-21
JPH07165760A (en) 1995-06-27
KR100231223B1 (en) 1999-11-15
SG50416A1 (en) 1998-07-20
ATE214061T1 (en) 2002-03-15
KR940011460A (en) 1994-06-21
EP0597423A3 (en) 1995-04-12
PT597423E (en) 2002-06-28
KR100256863B1 (en) 2000-05-15
IL107532A (en) 1999-06-20
DE69331652T2 (en) 2002-10-17
KR100252404B1 (en) 2000-04-15
JP2897153B2 (en) 1999-05-31

Similar Documents

Publication Publication Date Title
ES2173087T3 (en) AZETIDINONE COMPOUND AND PROCEDURE FOR PREPARATION.
ATE124699T1 (en) TRICYCLIC CARBAPENEM COMPOUNDS.
PT705833E (en) DERIVED FROM DC-89
AU1282495A (en) Anthranilic acid derivative
PT918776E (en) TOTAL SYNTHESIS OF ANTITUMAL ACILFULVENOS
EP0632031A4 (en)
AU648338B2 (en) Benzene, pyridine and pyrimidine derivatives
AU2623192A (en) Antifungal agent
IL118367A0 (en) Heteroaroyl derivatives
ATE141272T1 (en) BETA-LACTAM COMPOUNDS AND THEIR PRODUCTION
ES2087247T3 (en) ALDOSA REDUCTASA INHIBITOR.
ES2146661T3 (en) NEW DERIVATIVES OF CEFEM.
AU4983790A (en) Aralkylamine compounds
AU623500B2 (en) Carboxylimino benzothiazole derivatives
GB9015485D0 (en) Heterocyclic derivatives
DE69711506D1 (en) Methylsulfomycin 1, process for its preparation and use
ES2077697T3 (en) DERIVATIVES OF 1-PHENOXICARBONYL-2-PYRROLIDINONE AND NOOTROPIC AGENTS.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 597423

Country of ref document: ES