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ES2165358T3 - Utilizaciones de la proteinquinasa de neurofilamento/tau pk40. - Google Patents

Utilizaciones de la proteinquinasa de neurofilamento/tau pk40.

Info

Publication number
ES2165358T3
ES2165358T3 ES92915162T ES92915162T ES2165358T3 ES 2165358 T3 ES2165358 T3 ES 2165358T3 ES 92915162 T ES92915162 T ES 92915162T ES 92915162 T ES92915162 T ES 92915162T ES 2165358 T3 ES2165358 T3 ES 2165358T3
Authority
ES
Spain
Prior art keywords
kinases
tau
neurofilament
proteinquinase
relating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92915162T
Other languages
English (en)
Inventor
Vernon M Ingram
Hanno M Roder
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
Original Assignee
Massachusetts Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Institute of Technology filed Critical Massachusetts Institute of Technology
Application granted granted Critical
Publication of ES2165358T3 publication Critical patent/ES2165358T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10345—Special targeting system for viral vectors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

NUEVAS QUINASAS DE PROTEINA TAU/NEUROFILAMENTO PK40 Y PK36, SON ESENCIALMENTE PURIFICADAS Y CARACTERIZADAS. TAMBIEN ESTAN PREVISTAS NUEVAS PRUEBAS DE INMUNIDAD RELACIONADAS CON LAS QUINASAS E INHIBIDORES PARA LAS QUINASAS. FINALMENTE, SE PRESENTAN SECUENCIAS DNA QUE CODIFICAN LAS QUINASAS Y LAS LINEAS DE CELULAS RELACIONADAS CON LAS QUINASAS.
ES92915162T 1991-08-09 1992-07-10 Utilizaciones de la proteinquinasa de neurofilamento/tau pk40. Expired - Lifetime ES2165358T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US74288091A 1991-08-09 1991-08-09

Publications (1)

Publication Number Publication Date
ES2165358T3 true ES2165358T3 (es) 2002-03-16

Family

ID=24986618

Family Applications (2)

Application Number Title Priority Date Filing Date
ES00104460T Expired - Lifetime ES2216745T3 (es) 1991-08-09 1992-07-10 Utilizacion de un inhibidor de la proteina quinasa de tau/neurofilamento pk40.
ES92915162T Expired - Lifetime ES2165358T3 (es) 1991-08-09 1992-07-10 Utilizaciones de la proteinquinasa de neurofilamento/tau pk40.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES00104460T Expired - Lifetime ES2216745T3 (es) 1991-08-09 1992-07-10 Utilizacion de un inhibidor de la proteina quinasa de tau/neurofilamento pk40.

Country Status (9)

Country Link
EP (2) EP0667898B1 (es)
JP (1) JPH06510427A (es)
AT (2) ATE206755T1 (es)
AU (1) AU675410B2 (es)
CA (1) CA2115151C (es)
DE (2) DE69232121T2 (es)
DK (2) DK1026237T3 (es)
ES (2) ES2216745T3 (es)
WO (1) WO1993003148A2 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2302343T3 (es) * 1991-12-06 2008-07-01 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Uso de proteina quinasas para el diagnostico y tratamiento de la enfermedad de alzheimer.
US7408027B1 (en) 1991-12-06 2008-08-05 Max-Planck-Gesellschaft Zur Forderung Der Wissenchaften Tools for the diagnosis and treatment of Alzheimer's disease
WO1993023429A1 (en) * 1992-05-11 1993-11-25 Ludwig Institute For Cancer Research Receptor-type tyrosine kinase-like molecules
US6013646A (en) * 1998-07-02 2000-01-11 Bayer Corporation Indolocarbazole derivatives useful for the treatment of neurodegenerative diseases and cancer
KR20030022265A (ko) * 2000-07-07 2003-03-15 밀리켄 앤드 캄파니 지속가능한 발수능 및 오염제거능이 개선된 텍스타일 기재및 이의 제조방법
US7790881B2 (en) 2004-09-23 2010-09-07 Wista Laboratories Ltd. Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (MTC)
CN108034005B (zh) * 2011-10-07 2021-06-25 Ac免疫有限公司 识别Tau的磷酸化特异抗体

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU643235B2 (en) * 1989-09-15 1993-11-11 Gensia Pharmaceuticals, Inc. Methods of treating neurodegenerative conditions
HUT61567A (en) * 1990-12-07 1993-01-28 Sandoz Ag Process for producing new pharmaceutical compositions comprising 2'-o-alkyladenosine derivatives and for producing 6-cyclohexyl-2'-o-methyladenosinehydrate
WO1993003177A1 (en) * 1991-08-09 1993-02-18 Massachusetts Institute Of Technology Novel tau/neurofilament protein kinases
EP0544942A1 (en) * 1991-12-06 1993-06-09 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Novel tools for the diagnosis and treatment of Alzheimer disease

Also Published As

Publication number Publication date
EP0667898B1 (en) 2001-10-10
AU675410B2 (en) 1997-02-06
ES2216745T3 (es) 2004-11-01
WO1993003148A3 (en) 1993-04-01
DE69233330D1 (de) 2004-04-29
EP0667898A1 (en) 1995-08-23
CA2115151A1 (en) 1993-02-18
DE69232121D1 (de) 2001-11-15
ATE262584T1 (de) 2004-04-15
DE69232121T2 (de) 2002-06-20
EP1026237A3 (en) 2001-03-28
DK0667898T3 (da) 2002-02-04
DE69233330T2 (de) 2005-03-10
EP1026237A2 (en) 2000-08-09
CA2115151C (en) 2005-05-17
DK1026237T3 (da) 2004-07-19
AU2324092A (en) 1993-03-02
EP1026237B1 (en) 2004-03-24
WO1993003148A2 (en) 1993-02-18
ATE206755T1 (de) 2001-10-15
JPH06510427A (ja) 1994-11-24

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