[go: up one dir, main page]

ES2145479T3 - Procedimiento mejorado de obtencion de lovastatina, compactina o pravastatina. - Google Patents

Procedimiento mejorado de obtencion de lovastatina, compactina o pravastatina.

Info

Publication number
ES2145479T3
ES2145479T3 ES96928423T ES96928423T ES2145479T3 ES 2145479 T3 ES2145479 T3 ES 2145479T3 ES 96928423 T ES96928423 T ES 96928423T ES 96928423 T ES96928423 T ES 96928423T ES 2145479 T3 ES2145479 T3 ES 2145479T3
Authority
ES
Spain
Prior art keywords
compactine
pravastatin
improved procedure
lovastatin
obtaining
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96928423T
Other languages
English (en)
Inventor
Pater Robertus Mattheus De
Mieke Sibeyn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke DSM NV
Original Assignee
DSM NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM NV filed Critical DSM NV
Application granted granted Critical
Publication of ES2145479T3 publication Critical patent/ES2145479T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LA INVENCION PROPORCIONA UN METODO SENCILLO Y SELECTIVO PARA LA DESACILACION DE ESTATINAS 4-ACILADAS DURANTE LA PREPARACION DE ESTATINAS A PARTIR DE UN CALDO DE FERMENTACION, EN CONCRETO, UNA REDUCCION DE IMPUREZAS A PARTIR DEL PROCEDIMIENTO, MEDIANTE EL INCREMENTO DEL PH DEL CALDO DE FERMENTACION.
ES96928423T 1995-08-03 1996-08-05 Procedimiento mejorado de obtencion de lovastatina, compactina o pravastatina. Expired - Lifetime ES2145479T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US186095P 1995-08-03 1995-08-03
EP95202125 1995-08-03

Publications (1)

Publication Number Publication Date
ES2145479T3 true ES2145479T3 (es) 2000-07-01

Family

ID=26139544

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96928423T Expired - Lifetime ES2145479T3 (es) 1995-08-03 1996-08-05 Procedimiento mejorado de obtencion de lovastatina, compactina o pravastatina.

Country Status (15)

Country Link
EP (1) EP0784605B1 (es)
JP (1) JPH11501218A (es)
CN (1) CN1078583C (es)
AT (1) ATE189804T1 (es)
AU (1) AU6820096A (es)
CA (1) CA2201729C (es)
DE (1) DE69606696T2 (es)
DK (1) DK0784605T3 (es)
ES (1) ES2145479T3 (es)
GR (1) GR3033402T3 (es)
HU (1) HU221636B1 (es)
MX (1) MX9702403A (es)
PT (1) PT784605E (es)
SI (1) SI0784605T1 (es)
WO (1) WO1997006128A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0251582A (ja) * 1988-08-12 1990-02-21 Kyokado Eng Co Ltd 地盤注入用薬液
US6165757A (en) * 1997-02-20 2000-12-26 Dsm N.V. Nitrogen feed in statin fermentation
EP0877089A1 (en) * 1997-05-07 1998-11-11 Gist-Brocades B.V. HMG-CoA reductase inhibitor preparation process
SI9800046A (sl) * 1998-02-18 1999-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze visoke čistosti
CZ20031166A3 (cs) * 2000-10-05 2004-04-14 Biogal Gyogyszergyar Rt Sodná sůl pravastatinu, která v podstatě neobsahuje pravastatin lakton a epi-pravastatin a kompozice na její bázi
JP3236282B1 (ja) * 2000-10-16 2001-12-10 三共株式会社 プラバスタチンを精製する方法
EP1477471A1 (en) * 2003-05-14 2004-11-17 Chunghwa Chemical Synthesis & Biotech Co., Ltd. Process for purifying pravastin sodium from a fermentation broth
PL1641447T3 (pl) 2003-11-24 2009-04-30 Teva Gyogyszergyar Zartkoerueen Muekoedoe Reszvenytarsasag Sposób oczyszczania prawastatyny
TWI307360B (en) 2004-12-03 2009-03-11 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Process for constructing strain having compactin hydroxylation ability
CN104311517B (zh) * 2014-10-17 2017-06-06 上海应用技术学院 他汀内酯脱水化合物及其用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5159104A (en) * 1991-05-01 1992-10-27 Merck & Co., Inc. Process to simvastatin ester
GB2255974A (en) * 1991-05-24 1992-11-25 Merck & Co Inc Enzymatic deacylation of simvastatin

Also Published As

Publication number Publication date
CN1164851A (zh) 1997-11-12
HU221636B1 (hu) 2002-12-28
SI0784605T1 (en) 2000-08-31
EP0784605A1 (en) 1997-07-23
AU6820096A (en) 1997-03-05
ATE189804T1 (de) 2000-03-15
CA2201729A1 (en) 1997-02-20
CA2201729C (en) 2002-03-12
DE69606696T2 (de) 2000-08-17
JPH11501218A (ja) 1999-02-02
DK0784605T3 (da) 2000-07-31
GR3033402T3 (en) 2000-09-29
HUP9702444A1 (hu) 1998-04-28
DE69606696D1 (de) 2000-03-23
CN1078583C (zh) 2002-01-30
WO1997006128A1 (en) 1997-02-20
HUP9702444A3 (en) 1999-10-28
PT784605E (pt) 2000-08-31
MX9702403A (es) 1997-06-28
EP0784605B1 (en) 2000-02-16

Similar Documents

Publication Publication Date Title
BR9710994A (pt) Derivados anticonvulsivos úteis no tratamento de obesidade.
ES2149514T3 (es) Procedimiento para la obtencion simultanea de capro-lactama y hexametilendiamina.
BR9612258B1 (pt) inibidores de enzima conversora de interleucina-1beta, bem como composição farmacêutica.
CO4950529A1 (es) Dihidropirimidinas y productos que las contienen
ATE184613T1 (de) Varianten des grünen fluoreszenzproteins, gfp
ES2105999T1 (es) Procedimiento para la preparacion industrial de fosfatidilserina.
ES2145479T3 (es) Procedimiento mejorado de obtencion de lovastatina, compactina o pravastatina.
ZA986087B (en) Induction of male sterility in plants by expression of high levels of avidin.
IT1311590B1 (it) Metodo per la realizzazione di una calzatura e calzatura da essoottenibile.
NO981019L (no) Deodoriserende preparater inneholdende kationiske biopolymerer, aluminiumklorhydrat og esteraseinhibitorer
AU1681095A (en) Hydrophilic signal oligopeptides and methods of therapeutic use
ES2139332T3 (es) Procedimiento para la preparacion del trihidrato del (2r,3s)-3-benzoilamino-2-hidroxi-3-fenilpropionato de 4,10-diacetoxi-2alfa-benzoiloxi-5beta,20-epoxi-1,7beta-dihidroxi-9-oxo-tax-11-en-13alfa-ilo.
ATE261724T1 (de) Antikonvulsive derivate zur behandlung von posttraumatischen stresserkrankungen
IT1281240B1 (it) Pastorizzatore.
MXPA03008837A (es) Una composicion farmaceutica estable de pravastatina.
ES2137756T3 (es) Sistema para el tratamiento de flejes de acero afinado.
BG106918A (en) Perocess for the preparation of sodium salts of statins
EP0663210A3 (en) Inhibitor of tumor necrosis factor production.
ZA966970B (en) Water treatment method.
BR0008791A (pt) Derivados anticonvulsivos, úteis no tratamento de tremor essencial
FR2717185B1 (fr) Microfiltration de la bière.
NL1000591C2 (nl) Weefsel.
BR9710992A (pt) Derivados anticovulsivos úteis no tratamento de psorìase
PT938589E (pt) Metodo para identificar agentes farmaceuticos a partir de extractos vegetais
KR970016336U (ko) 오,폐수처리장의 탈취장치

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 784605

Country of ref document: ES