[go: up one dir, main page]

ES2145067T3 - Composiciones farmaceuticas a base de analogos de argatroban. - Google Patents

Composiciones farmaceuticas a base de analogos de argatroban.

Info

Publication number
ES2145067T3
ES2145067T3 ES94101051T ES94101051T ES2145067T3 ES 2145067 T3 ES2145067 T3 ES 2145067T3 ES 94101051 T ES94101051 T ES 94101051T ES 94101051 T ES94101051 T ES 94101051T ES 2145067 T3 ES2145067 T3 ES 2145067T3
Authority
ES
Spain
Prior art keywords
group
polycyclic compound
compound residue
benzene ring
condensed polycyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94101051T
Other languages
English (en)
Inventor
Matsuo Igaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Chemical Corp
Original Assignee
Mitsubishi Chemical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Chemical Corp filed Critical Mitsubishi Chemical Corp
Application granted granted Critical
Publication of ES2145067T3 publication Critical patent/ES2145067T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

UNA COMPOSICION DE ANTITROMBINA EN FORMA DE UNA EMULSION LIPIDA QUE COMPRENDE, JUNTAMENTE CON ACIDO GRASO NO SATURADO Y UN EMULSOR, N2 ARILSULFONIL GENERAL SIGUIENTE (I): EN LA QUE R1 REPRESENTA GRUPO (2R, 4R) DEFINIDO ANTERIORMENTE, TENIENDO OPCIONALMENTE R2 UNO O MAS SUSTITUYENTES SELECCIONADOS DEL GRUPO ALQUILO INFERIOR, GRUPO ALCOXI INFERIOR, O GRUPO AMINO SUSTITUIDO POR GRUPO ALQUILO INFERIOR, SIENDO EL CITADO RESIDUO COMPUESTO POLICICLICO CONDENSADO UN RESIDUO COMPUESTO POLICILICO CONDENSADO INCLUYENDO UN ANILLO BENCENICO, ESTANDO EL CITADO ANILLO BENCENICO UNIDO AL ATOMO DE AZUFRE DEL GRUPO SULFONILO EN LA FORMULA GENERAL (I), Y ESTANDO EL CITADO ANILLO BENCENICO CONDENSADO CON OTRO ANILLO QUE PUEDE SER UN ANILLO HETEROCICLICO, Y TENIENDO EL CITADO RESIDUO COMPUESTO POLICICLICO DE 7 A 14 ATOMOS DE CARBONO EN TOTAL; SE PROPORCIONAN SU HIDRATO Y/O SU SAL.
ES94101051T 1993-01-25 1994-01-25 Composiciones farmaceuticas a base de analogos de argatroban. Expired - Lifetime ES2145067T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5010060A JPH06219948A (ja) 1993-01-25 1993-01-25 抗トロンビン剤及びその製造方法

Publications (1)

Publication Number Publication Date
ES2145067T3 true ES2145067T3 (es) 2000-07-01

Family

ID=11739847

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94101051T Expired - Lifetime ES2145067T3 (es) 1993-01-25 1994-01-25 Composiciones farmaceuticas a base de analogos de argatroban.

Country Status (6)

Country Link
EP (1) EP0608828B1 (es)
JP (1) JPH06219948A (es)
AT (1) ATE190841T1 (es)
CA (1) CA2114153A1 (es)
DE (1) DE69423528T2 (es)
ES (1) ES2145067T3 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9426038D0 (en) 1994-12-22 1995-02-22 Iaf Biochem Int Low molecular weight bicyclic thrombin inhibitors
US6057314A (en) * 1995-12-21 2000-05-02 Biochem Pharma Inc. Low molecular weight bicyclic thrombin inhibitors
US5840733A (en) 1996-07-01 1998-11-24 Redcell, Canada, Inc. Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes
FR2795960B1 (fr) * 1999-07-05 2001-10-19 Sanofi Elf Microemulsions stables pour l'administration d'acides gras a l'homme ou a l'animal, et utilisation de ces microemulsions
AUPR510001A0 (en) * 2001-05-18 2001-06-14 Jupitar Pty Ltd Formulation and method
JP2007008857A (ja) * 2005-06-30 2007-01-18 Nisshin Pharma Inc 大豆油不けん化物含有組成物
WO2007027565A2 (en) 2005-09-01 2007-03-08 Baxter International Inc. Argatroban formulation comprising an acid as solubilizer
US7687516B2 (en) 2006-09-27 2010-03-30 Eagle Pharmaceuticals, Inc. Alcohol free formulation of argatroban
US7589106B2 (en) 2006-09-27 2009-09-15 Eagle Pharmaceuticals, Inc. Alcohol free formulation of argatroban
US7915290B2 (en) 2008-02-29 2011-03-29 Baxter International Inc. Argatroban formulations and methods for making and using same
JP5673525B2 (ja) * 2009-12-24 2015-02-18 東レ株式会社 抗血液凝固作用を有する親水性高分子化合物
DE102014108210A1 (de) 2014-06-11 2015-12-17 Dietrich Gulba Rodentizid
CN107773533A (zh) * 2016-08-26 2018-03-09 四川科瑞德制药股份有限公司 一种新型凝血酶抑制剂及其制备方法
EP4070658A1 (de) 2021-04-06 2022-10-12 BIORoxx GmbH Verwendung von blutgerinnungshemmenden verbindungen als rodentizide

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE48623B1 (en) * 1978-08-31 1985-03-20 Mitsubishi Chem Ind Alpha-(n-arylsulfonyl-l-argininamides,processes for their preparation and pharmaceutical compositions containing these substances
JPS61112018A (ja) * 1984-11-06 1986-05-30 Mitsubishi Chem Ind Ltd 線溶増強剤
JPS6431727A (en) * 1987-07-28 1989-02-02 Mitsubishi Chem Ind Dissolution of argininamide and drug composition containing argininamides
JPH02129123A (ja) * 1988-11-07 1990-05-17 Mitsubishi Kasei Corp 抗血液凝固剤

Also Published As

Publication number Publication date
ATE190841T1 (de) 2000-04-15
CA2114153A1 (en) 1994-07-26
JPH06219948A (ja) 1994-08-09
DE69423528T2 (de) 2000-09-14
EP0608828B1 (en) 2000-03-22
DE69423528D1 (de) 2000-04-27
EP0608828A1 (en) 1994-08-03

Similar Documents

Publication Publication Date Title
ES2145067T3 (es) Composiciones farmaceuticas a base de analogos de argatroban.
KR910003078A (ko) 윤활제 조성물
ATE318881T1 (de) Schmierölzusammensetzung enthaltend ein gemisch aus carboxylsäuren und aminen als rostschutzmittel
EP0193148A3 (en) 8-Chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-(alkoxy-containing acyl)hydrazides
KR910002800A (ko) 4-아실록시퀴놀린 유도체와 이를 함유하는 살충 또는 살비조성물
DE69423529D1 (de) Arzneizusammensetzungen enthaltend Argatrobananaloge
DE69921151D1 (de) Fluorszierende marker
SE8604950L (sv) Demensforbettrande och terapeutiska medel
KR910006309A (ko) 인지질 및 인지질 유도체를 유효 성분으로 하는 항비루스성 약제
MX20597A (es) 1-arilimidazoles plaguicidas y procedimiento para su preparacion.
KR920701120A (ko) 치환된 비시클로헵탄디온 유도체
PT90986A (pt) Processo para a preparacao de esteres de estramustina e de composicoes farmaceuticas que os contem
KR900016178A (ko) 2-치환 n,n'-디트리메톡시벤조일 피페라진, 그의 제조 방법 및 그를 함유하는 치료 조성물
KR840006481A (ko) 테트라졸화합물의 제조방법 및 이들화합물을 유효성분으로 하는 항균 및 항미 조성물
DE3866292D1 (de) Piperazinylalkylpiperazindion-derivate, ihre verfahren zur herstellung und diese enthaltende pharmazeutische zusammenstellungen.
KR910015537A (ko) 신규 1-아릴술포닐-2-피페리디논 유도체, 이의 제조방법, 제조용 중간체, 의약품으로서의 용도 및 이 화합물을 함유하는 조성물
KR930702339A (ko) 에폭시숙시남산 유도체
HRP20000027B1 (en) Process for the preparation of alkoxyfuranoneamine derivatives, compounds obtained by this process, and the use of these compounds
DK0485204T3 (da) Fremgangsmåde til fremstilling af 3-alkoxymethyl-cephalosporin-derivater
KR890701584A (ko) 20, 21-디노르에비나메닌의 신규 치환 유도체, 그의 제조 방법 및 이 방법으로 얻는 신규 중간체, 약제로서의 그의 용도 및 그를 함유하는 제약 조성물
ES8602712A1 (es) Un procedimiento para preparar un derivado de rodanina
ATE101390T1 (de) Formalverbindungen, kraftstoffzusaetze und kraftstoffmischungen.
KR970006283A (ko) 신규 아민고리 화합물
ES8207137A1 (es) Procedimiento de preparacion de nuevos derivados biciclo (2.2.1)heptanos.
BR8700908A (pt) Composicao fungicida,processo para produzir uma composicao fungicida,composto de naftimidazolona,processo para a preparacao de um composto e processo para combater fungos num local

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 608828

Country of ref document: ES