[go: up one dir, main page]

ES2143938B1 - BIOCOMPATIBLE COATINGS PRODUCED BY LASER. - Google Patents

BIOCOMPATIBLE COATINGS PRODUCED BY LASER.

Info

Publication number
ES2143938B1
ES2143938B1 ES009800392A ES9800392A ES2143938B1 ES 2143938 B1 ES2143938 B1 ES 2143938B1 ES 009800392 A ES009800392 A ES 009800392A ES 9800392 A ES9800392 A ES 9800392A ES 2143938 B1 ES2143938 B1 ES 2143938B1
Authority
ES
Spain
Prior art keywords
biocompatible
laser
coatings produced
biocompatible coatings
coatings
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES009800392A
Other languages
Spanish (es)
Other versions
ES2143938A1 (en
Inventor
Rodriguez Fernando Lusquinos
Saracho Juan Maria Pou
Otero Jorge Luis Arias
Leiros Mercedes Belen Mayor
Costas R F Soto
Kenneth Gordon Watkins
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universidade de Vigo
Original Assignee
Universidade de Vigo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidade de Vigo filed Critical Universidade de Vigo
Priority to ES009800392A priority Critical patent/ES2143938B1/en
Priority to AU29351/99A priority patent/AU2935199A/en
Priority to PCT/ES1999/000043 priority patent/WO1999042631A1/en
Publication of ES2143938A1 publication Critical patent/ES2143938A1/en
Application granted granted Critical
Publication of ES2143938B1 publication Critical patent/ES2143938B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C23COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
    • C23CCOATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
    • C23C26/00Coating not provided for in groups C23C2/00 - C23C24/00
    • C23C26/02Coating not provided for in groups C23C2/00 - C23C24/00 applying molten material to the substrate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/30767Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28Materials for coating prostheses
    • A61L27/30Inorganic materials
    • A61L27/306Other specific inorganic materials not covered by A61L27/303 - A61L27/32
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28Materials for coating prostheses
    • A61L27/30Inorganic materials
    • A61L27/32Phosphorus-containing materials, e.g. apatite
    • CCHEMISTRY; METALLURGY
    • C23COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
    • C23CCOATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
    • C23C4/00Coating by spraying the coating material in the molten state, e.g. by flame, plasma or electric discharge
    • C23C4/12Coating by spraying the coating material in the molten state, e.g. by flame, plasma or electric discharge characterised by the method of spraying
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/3094Designing or manufacturing processes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/3094Designing or manufacturing processes
    • A61F2002/3097Designing or manufacturing processes using laser
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005The prosthesis being constructed from a particular material
    • A61F2310/00011Metals or alloys
    • A61F2310/00017Iron- or Fe-based alloys, e.g. stainless steel
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005The prosthesis being constructed from a particular material
    • A61F2310/00011Metals or alloys
    • A61F2310/00023Titanium or titanium-based alloys, e.g. Ti-Ni alloys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005The prosthesis being constructed from a particular material
    • A61F2310/00011Metals or alloys
    • A61F2310/00029Cobalt-based alloys, e.g. Co-Cr alloys or Vitallium
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389The prosthesis being coated or covered with a particular material
    • A61F2310/00592Coating or prosthesis-covering structure made of ceramics or of ceramic-like compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389The prosthesis being coated or covered with a particular material
    • A61F2310/00592Coating or prosthesis-covering structure made of ceramics or of ceramic-like compounds
    • A61F2310/00796Coating or prosthesis-covering structure made of a phosphorus-containing compound, e.g. hydroxy(l)apatite
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389The prosthesis being coated or covered with a particular material
    • A61F2310/00928Coating or prosthesis-covering structure made of glass or of glass-containing compounds, e.g. of bioglass
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C41/00Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor
    • B29C41/02Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor for making articles of definite length, i.e. discrete articles
    • B29C41/20Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor for making articles of definite length, i.e. discrete articles incorporating preformed parts or layers, e.g. moulding inserts or for coating articles
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29KINDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2995/00Properties of moulding materials, reinforcements, fillers, preformed parts or moulds
    • B29K2995/0037Other properties
    • B29K2995/0056Biocompatible, e.g. biopolymers or bioelastomers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29LINDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00Other particular articles
    • B29L2031/753Medical equipment; Accessories therefor
    • B29L2031/7532Artificial members, protheses

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Metallurgy (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Organic Chemistry (AREA)
  • Transplantation (AREA)
  • Materials Engineering (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Plasma & Fusion (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
  • Chemically Coating (AREA)

Abstract

Recubrimientos de materiales biocompatibles pueden ser aplicados sobre diferentes elementos y componentes por medio de un método basado en el plaqueado superficial por láser. Este método permite aplicar el recubrimiento biocompatible directamente sobre la superficie del componente produciéndose un verdadero enlace químico entre recubrimiento y sustrato. Estos recubrimientos biocompatibles son de especial aplicación para la mejora de la osteointegración de implantes de fijación ósea.Coatings of biocompatible materials can be applied to different elements and components by means of a method based on laser surface plating. This method allows the biocompatible coating to be applied directly on the surface of the component, producing a true chemical bond between the coating and the substrate. These biocompatible coatings are of special application to improve osseointegration of bone fixation implants.

ES009800392A 1998-02-19 1998-02-19 BIOCOMPATIBLE COATINGS PRODUCED BY LASER. Expired - Fee Related ES2143938B1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
ES009800392A ES2143938B1 (en) 1998-02-19 1998-02-19 BIOCOMPATIBLE COATINGS PRODUCED BY LASER.
AU29351/99A AU2935199A (en) 1998-02-19 1999-02-18 Biocompatible coatings produced by means of laser
PCT/ES1999/000043 WO1999042631A1 (en) 1998-02-19 1999-02-18 Biocompatible coatings produced by means of laser

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009800392A ES2143938B1 (en) 1998-02-19 1998-02-19 BIOCOMPATIBLE COATINGS PRODUCED BY LASER.

Publications (2)

Publication Number Publication Date
ES2143938A1 ES2143938A1 (en) 2000-05-16
ES2143938B1 true ES2143938B1 (en) 2000-12-16

Family

ID=8302891

Family Applications (1)

Application Number Title Priority Date Filing Date
ES009800392A Expired - Fee Related ES2143938B1 (en) 1998-02-19 1998-02-19 BIOCOMPATIBLE COATINGS PRODUCED BY LASER.

Country Status (3)

Country Link
AU (1) AU2935199A (en)
ES (1) ES2143938B1 (en)
WO (1) WO1999042631A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0028557D0 (en) * 2000-11-23 2001-01-10 Innovative Materials Proc Tech Fabrication method and apparatus
US9284409B2 (en) 2007-07-19 2016-03-15 Boston Scientific Scimed, Inc. Endoprosthesis having a non-fouling surface
US7931683B2 (en) 2007-07-27 2011-04-26 Boston Scientific Scimed, Inc. Articles having ceramic coated surfaces
WO2009018340A2 (en) * 2007-07-31 2009-02-05 Boston Scientific Scimed, Inc. Medical device coating by laser cladding
JP2010535541A (en) 2007-08-03 2010-11-25 ボストン サイエンティフィック リミテッド Coating for medical devices with large surface area
US8216632B2 (en) 2007-11-02 2012-07-10 Boston Scientific Scimed, Inc. Endoprosthesis coating
JP5581311B2 (en) 2008-04-22 2014-08-27 ボストン サイエンティフィック サイムド,インコーポレイテッド MEDICAL DEVICE HAVING INORGANIC MATERIAL COATING AND MANUFACTURING METHOD THEREOF
WO2009132176A2 (en) 2008-04-24 2009-10-29 Boston Scientific Scimed, Inc. Medical devices having inorganic particle layers
ES2393517B1 (en) 2010-07-28 2013-11-21 Universidad Del Pais Vasco-Euskal Herriko Unibersitatea PROCEDURE FOR THE CONTRIBUTION OF METAL MATERIALS.
CN110777375A (en) * 2019-10-12 2020-02-11 保定市立中车轮制造有限公司 Laser cladding welding device and process for aluminum alloy wheel mold
CN113249716B (en) * 2020-02-12 2023-03-31 上海飞机制造有限公司 Laser ultrasonic powder feeding device and processing method

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2052566B (en) * 1979-03-30 1982-12-15 Rolls Royce Laser aplication of hard surface alloy
JPS6254588A (en) * 1985-08-30 1987-03-10 Toyota Motor Corp Formation of composite aluminum alloy layer dispersed with ceramic particles
JPS62289388A (en) * 1986-06-06 1987-12-16 Mitsubishi Electric Corp Overlaying device
FR2605310B1 (en) * 1986-10-16 1992-04-30 Comp Generale Electricite METHOD FOR REINFORCING CERAMIC WORKPIECES BY LASER TREATMENT
US5242706A (en) * 1991-07-31 1993-09-07 The United States Of America As Represented By The Secretary Of The Navy Laser-deposited biocompatible films and methods and apparatuses for producing same
ES2088767B1 (en) * 1994-05-31 1997-03-16 Consejo Superior Investigacion PROCEDURE FOR SURFACE COATING WITH HYDROXIAPATITE OF METALLIC IMPLANTS.
GB9423277D0 (en) * 1994-11-18 1995-01-11 Univ Nottingham Pulsed laser deposition of coatings
AU3020697A (en) * 1996-06-06 1998-01-05 1179568 Ontario Inc. Apparatus and procedure for depositing materials
ES2113834B1 (en) * 1996-11-12 1999-01-01 Univ Vigo METHOD FOR IMPROVING OSTEOINTEGRATION OF BONE FIXING IMPLANTS.

Also Published As

Publication number Publication date
ES2143938A1 (en) 2000-05-16
AU2935199A (en) 1999-09-06
WO1999042631A1 (en) 1999-08-26

Similar Documents

Publication Publication Date Title
ES2143938B1 (en) BIOCOMPATIBLE COATINGS PRODUCED BY LASER.
DE602004019938D1 (en) COATED IMPLANTS AND COATING PROCESS
ES2173817A1 (en) METHOD FOR THE MANUFACTURE OF ENDO-OSEOS IMPLANTS OR MEDICAL PROTESIS THROUGH THE IONIC IMPLEMENTATION TECHNIQUE.
DE50310328D1 (en) Implant with a ceramic coating
DK1381402T3 (en) Method for improving soft tissue reception and implants using this method
BR0113184A (en) Artificial implant and process to produce the same
ATE304328T1 (en) CERAMIC DENTAL IMPLANT
DE60033660D1 (en) IMPLANT FOR USE IN THE BONE AND METHOD FOR THE PRODUCTION OF SUCH IMPLANT
ATE462451T1 (en) INTERFACE BIOMATERIALS TO PROMOTE ADHESION OF TARGET ANALYTES
ATE448812T1 (en) COATING OF STENTS WITH DELAYED RELEASE
PT1196111E (en) DENTAL IMPLANT COMPOSED BY TWO BIOCOMPATIBLE MATERIALS
ATE505216T1 (en) IN-SITU OXYDED STRUCTURED SURFACES OF PROSTHESIS AND METHOD FOR THEIR PRODUCTION
EP3238665A3 (en) Diffusion-hardened medical implant
ATE299719T1 (en) BIOACTIVE PROSTHESIS MADE OF CONDUCTIVE MATERIAL COATED WITH A POLYMER AND A SUBSTANCE WITH IMMUNOSUPRESSIVE, ANTISTENOSIS AND ANTITHROMBOSIS PROPERTIES
DE60030777D1 (en) BIOACTIVE SILICA FIBERS PRODUCED BY A SOL-GEL PROCESS, AND RELATED METHODS AND APPLICATIONS
BR0212464A (en) Self-depositing composition, metal substrate, and methods for coating a metal substrate, and for producing self-depositing composition
ES2098278T3 (en) PROCEDURE FOR OBTAINING OSTEOINTEGRANT SURFACES ON SKELETON GRAFT, AS WELL AS SKELETON GRAFT.
ITTO20040854A1 (en) WORKING PROCEDURE FOR GLASS, CERAMIC AND GLASS SURFACES FOR THE IMPLEMENTATION OF IMPLANTABLE DEVICES WITH ANTIBACTERIAL ACTION
SE0102391L (en) Implants, for example dental implants, coated with bone growth stimulants
ATE435668T1 (en) OSTEOGENIC MATRIX COMPOSITE, METHOD FOR THE PRODUCTION THEREOF AND IMPLANT AND SCAFFOLD FOR TISSUE ENGINEERING WITH A COATING MADE OF AN OSTEOGENIC MATRIX COMPOSITE
ES2174603T3 (en) OSEO IMPLANT.
ATE464074T1 (en) BONE IMPLANTS
ATE481942T1 (en) IMPLANT
MX2020007814A (en) Zirconium and titanium phosphate coatings for implants and other substrates.
DK1539261T3 (en) Metal implant coated under reduced oxygen concentration with osteoinductive protein

Legal Events

Date Code Title Description
EC2A Search report published

Date of ref document: 20000516

Kind code of ref document: A1

Effective date: 20000516

FD2A Announcement of lapse in spain

Effective date: 20180525