ES2141776T3 - Utilizacion de enzima hidrolitica para reducir o impedir los efectos secundarios de la bleomicina. - Google Patents

Utilizacion de enzima hidrolitica para reducir o impedir los efectos secundarios de la bleomicina.

Info

Publication number: ES2141776T3
Authority: ES; Spain
Prior art keywords: bleomycin; side effects; prevent; reduce; hydrolytic enzyme
Prior art date: 1994-02-10
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

ES94102079T

Other languages

English (en)

Spanish (es)

Inventor

Karl Dr Ransberger

Michael W Dr Schedler

Gerhard Dr Stauder

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Mucos Emulsion GmbH

Original Assignee

Mucos Emulsion GmbH

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-02-10

Filing date

1994-02-10

Publication date

2000-04-01

1994-02-10 Application filed by Mucos Emulsion GmbH filed Critical Mucos Emulsion GmbH

2000-04-01 Application granted granted Critical

2000-04-01 Publication of ES2141776T3 publication Critical patent/ES2141776T3/es

2014-02-10 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

108010006654 Bleomycin Proteins 0.000 title abstract 2
102000004190 Enzymes Human genes 0.000 title abstract 2
108090000790 Enzymes Proteins 0.000 title abstract 2
229960001561 bleomycin Drugs 0.000 title abstract 2
OYVAGSVQBOHSSS-UAPAGMARSA-O bleomycin A2 Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C OYVAGSVQBOHSSS-UAPAGMARSA-O 0.000 title abstract 2
230000000694 effects Effects 0.000 title abstract 2
230000003301 hydrolyzing effect Effects 0.000 title abstract 2
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- A61K38/166—Streptokinase
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4826—Trypsin (3.4.21.4) Chymotrypsin (3.4.21.1)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4873—Cysteine endopeptidases (3.4.22), e.g. stem bromelain, papain, ficin, cathepsin H
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/49—Urokinase; Tissue plasminogen activator

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)

ES94102079T 1994-02-10 1994-02-10 Utilizacion de enzima hidrolitica para reducir o impedir los efectos secundarios de la bleomicina. Expired - Lifetime ES2141776T3 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP94102079A EP0667164B1 (de)	1994-02-10	1994-02-10	Verwendung hydrolytischer Enzyme zur Verringerung bzw. Vermeidung der Nebenwirkungen von Bleomycin

Publications (1)

Publication Number	Publication Date
ES2141776T3 true ES2141776T3 (es)	2000-04-01

Family

ID=8215675

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES94102079T Expired - Lifetime ES2141776T3 (es)	1994-02-10	1994-02-10	Utilizacion de enzima hidrolitica para reducir o impedir los efectos secundarios de la bleomicina.

Country Status (7)

Country	Link
EP (1)	EP0667164B1 (de)
AT (1)	ATE188121T1 (de)
DE (1)	DE59409038D1 (de)
DK (1)	DK0667164T3 (de)
ES (1)	ES2141776T3 (de)
GR (1)	GR3032850T3 (de)
PT (1)	PT667164E (de)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1951822C3 (de) *	1969-10-14	1980-12-11	Kowa Co., Ltd., Nagoya, Aichi (Japan)	Pharmazeutisches Präparat zur Krebsbehandlung
FR2665363B1 (fr) *	1990-07-31	1992-12-04	Cayla	Composition pharmaceutique comprenant une ou des bleomycines, et une ou des proteines inactivant les bleomycines.

1994
- 1994-02-10 DE DE59409038T patent/DE59409038D1/de not_active Expired - Lifetime
- 1994-02-10 ES ES94102079T patent/ES2141776T3/es not_active Expired - Lifetime
- 1994-02-10 EP EP94102079A patent/EP0667164B1/de not_active Expired - Lifetime
- 1994-02-10 AT AT94102079T patent/ATE188121T1/de not_active IP Right Cessation
- 1994-02-10 PT PT94102079T patent/PT667164E/pt unknown
- 1994-02-10 DK DK94102079T patent/DK0667164T3/da active
2000
- 2000-03-03 GR GR20000400542T patent/GR3032850T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE59409038D1 (de)	2000-02-03
PT667164E (pt)	2000-04-28
EP0667164B1 (de)	1999-12-29
ATE188121T1 (de)	2000-01-15
EP0667164A1 (de)	1995-08-16
GR3032850T3 (en)	2000-07-31
DK0667164T3 (da)	2000-05-29

Publication	Publication Date	Title
HN1995009160A (es)	2000-04-24	Derivados de cicloalcano indol y azaindol
GR3026222T3 (en)	1998-05-29	Novel mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
MC2313A1 (fr)	1993-09-27	Inhibiteurs d'enzymes
AU2534092A (en)	1993-05-20	2-substituted saccharin derivative proteolytic enzyme inhibitors
FI930632L (fi)	1994-08-13	Kytkentä lähetinvahvistimen tehon säätämiseksi
DE69528884D1 (de)	2003-01-02	Selbsteinstellende lager
FI943728A0 (fi)	1994-08-12	Enkefalinaasin ja ACE:n inhibiittoreina käyttökelpoisia uusia aminoasetyylimerkaptojohdannaisia
DK349586D0 (da)	1986-07-23	Enzyminhibitor
DK154492D0 (da)	1992-12-23	Enzym
FI971198L (fi)	1997-03-21	4-metyylitiobutyronitriilien entsymaattinen hydrolyysi
ES2141776T3 (es)	2000-04-01	Utilizacion de enzima hidrolitica para reducir o impedir los efectos secundarios de la bleomicina.
ES547913A0 (es)	1986-06-01	Procedimiento enzimatico de resolucion de n-fenilacetil-ami-nocompuestos y purificacion de sus isomeros opticamente ac- tivos
FI865019A0 (fi)	1986-12-10	Skaeranordning foer pappersbana.
FI940999L (fi)	1994-09-04	Piperidin-2-alkyylikarboksylaattien entsymaattinen toisiintuminen ja saatujen yhdisteiden käyttö synteesin välituotteina
UY24915A1 (es)	2000-12-29	Derivados de benzoxazindiona, aplicación de los mismos y medicamentos que los contienen
FI950454L (fi)	1995-08-04	3-hydroksimetyylikefalosporiinien entsymaattinen asylointi
FI963263L (fi)	1996-08-21	Bromelaiinin lääkinnällinen käyttö
ES1009892Y (es)	1990-04-01	Napa de fibras.
DK84986A (da)	1986-09-05	Stabilisering af ekstracellulaere enzymer
ES546542A0 (es)	1986-07-16	Procedimiento para la inmovilizacion de celulas de bacillus subtilis
NO158083C (no)	1988-07-13	Fremgangsmaate for fremstilling av eggalbumin og soyaprotein som er tilpasset enzymatisk hydrolyse.
FI972792L (fi)	1997-08-27	Entsyymistabilointi
ATE218809T1 (de)	2002-06-15	Kombination von enzymen
MX164331B (es)	1992-08-03	Concentrado enzimatico liquido estable y procedimiento para su produccion
IT8620599V0 (it)	1986-01-23	Giunto dinamico stretto.

Legal Events

Date	Code	Title	Description
2000-04-01	FG2A	Definitive protection	Ref document number: 667164 Country of ref document: ES

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