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ES2139824T3 - Uso de 1,4-dihidropiridinas con puente 1,2 como moduladores selectivos de canales de potasio. - Google Patents

Uso de 1,4-dihidropiridinas con puente 1,2 como moduladores selectivos de canales de potasio.

Info

Publication number
ES2139824T3
ES2139824T3 ES95119052T ES95119052T ES2139824T3 ES 2139824 T3 ES2139824 T3 ES 2139824T3 ES 95119052 T ES95119052 T ES 95119052T ES 95119052 T ES95119052 T ES 95119052T ES 2139824 T3 ES2139824 T3 ES 2139824T3
Authority
ES
Spain
Prior art keywords
potassium channel
dihydropyridines
bridge
channel modulators
selective potassium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95119052T
Other languages
English (en)
Inventor
Klaus Dr Urbahns
Hans-Georg Dr Heine
Bodo Dr Junge
Thomas Dr Glaser
Reilinde Wittka
Vry Jean-Marie-Viktor Dr De
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Application granted granted Critical
Publication of ES2139824T3 publication Critical patent/ES2139824T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Manufacture Of Tobacco Products (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

LA PRESENTE INVENCION TRATA FE LA NUEVA UTILIZACION DE LAS CONOCIDAS EN PARTE 1,4-DIHIDROPIRIDINAS 1,2-PUENTEADAS DE FORMULA GENERAL (I), DONDE R{SUP,1} A R{SUP,4} Y A TIENEN EL SIGNIFICADO DADO EN LA DESCRIPCION, EL PROCEDIMIENTO PARA SU OBTENCION Y SU USO COMO MEDICAMENTOS, DADO QUE SON MODULADORES SELECTIVOS DEL CANAL DE POTASIO, EN EL TRATAMIENTO DEL SISTEMA NERVIOSO CENTRAL.
ES95119052T 1994-12-16 1995-12-04 Uso de 1,4-dihidropiridinas con puente 1,2 como moduladores selectivos de canales de potasio. Expired - Lifetime ES2139824T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4444860A DE4444860A1 (de) 1994-12-16 1994-12-16 Verwendung von 1,2-überbrückten 1,4-Dihydropyridinen als Arzneimittel

Publications (1)

Publication Number Publication Date
ES2139824T3 true ES2139824T3 (es) 2000-02-16

Family

ID=6535985

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95119052T Expired - Lifetime ES2139824T3 (es) 1994-12-16 1995-12-04 Uso de 1,4-dihidropiridinas con puente 1,2 como moduladores selectivos de canales de potasio.

Country Status (25)

Country Link
US (2) US5990121A (es)
EP (2) EP0924211A3 (es)
JP (1) JPH08239384A (es)
KR (1) KR960022517A (es)
CN (1) CN1059442C (es)
AT (1) ATE186536T1 (es)
AU (1) AU709760B2 (es)
CA (1) CA2165131A1 (es)
CZ (1) CZ332895A3 (es)
DE (2) DE4444860A1 (es)
DK (1) DK0717043T3 (es)
EE (1) EE9500076A (es)
ES (1) ES2139824T3 (es)
FI (1) FI956016L (es)
GR (1) GR3032394T3 (es)
HU (1) HUT74166A (es)
IL (1) IL116386A (es)
MX (1) MX9505097A (es)
NO (1) NO955103L (es)
NZ (1) NZ280661A (es)
PL (1) PL180439B1 (es)
RU (1) RU2155765C2 (es)
SI (1) SI0717043T1 (es)
SK (1) SK158095A3 (es)
ZA (1) ZA9510695B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050075359A1 (en) * 2003-03-14 2005-04-07 Rikako Kono Large conductance calcium-activated K channel opener
US7394475B2 (en) * 2004-02-13 2008-07-01 Infoprint Solutions Company, Llc Apparatus, system, and method for image registration
EP1782815B1 (en) * 2004-06-23 2010-09-08 Neurotec Pharma, S.L. Compound for use in the diagnosis of cns acute damage
EP1782812A1 (en) * 2004-06-23 2007-05-09 Neurotec Pharma, S.L. Compounds for the treatment of inflammation of the central nervous system
CA2603676A1 (en) * 2005-01-07 2006-07-13 Roskamp Research Llc Compounds for inhibiting beta-amyloid production and methods of identifying the compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE220633C (es) *
DE2210674C3 (de) * 1972-03-06 1981-09-24 Bayer Ag, 5090 Leverkusen 2-Amino-6-methyl-1,4-dihydropyridine, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel
US4053614A (en) * 1972-03-06 1977-10-11 Bayer Aktiengesellschaft 1,2-pentamethylene-1,4-dihydropyridine derivatives
US3935220A (en) * 1972-03-06 1976-01-27 Bayer Aktiengesellschaft Tetrahydroimidazolo[1,2-a]pyridine derivatives
US3951988A (en) * 1972-03-06 1976-04-20 Bayer Aktiengesellschaft 1,2-Pentamethylene-1,4-dihydropyridine derivatives
DE2210633C2 (de) * 1972-03-06 1983-09-22 Bayer Ag, 5090 Leverkusen Kondensierte Pyridinderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US5225566A (en) * 1992-05-08 1993-07-06 American Home Products Corporation Indazolanonyl derivative of benzopyran

Also Published As

Publication number Publication date
US6147087A (en) 2000-11-14
FI956016L (fi) 1996-06-17
SI0717043T1 (en) 2000-02-29
FI956016A0 (fi) 1995-12-14
SK158095A3 (en) 1996-09-04
NO955103D0 (no) 1995-12-15
AU709760B2 (en) 1999-09-09
HUT74166A (en) 1996-11-28
GR3032394T3 (en) 2000-05-31
CN1133841A (zh) 1996-10-23
IL116386A (en) 1999-06-20
DK0717043T3 (da) 2000-05-08
AU4029495A (en) 1996-06-27
CN1059442C (zh) 2000-12-13
ATE186536T1 (de) 1999-11-15
EP0717043A1 (de) 1996-06-19
MX9505097A (es) 1997-01-31
PL180439B1 (pl) 2001-02-28
EP0924211A2 (de) 1999-06-23
RU2155765C2 (ru) 2000-09-10
HU9503597D0 (en) 1996-02-28
DE4444860A1 (de) 1996-06-20
EP0717043B1 (de) 1999-11-10
CZ332895A3 (en) 1997-12-17
NZ280661A (en) 1997-06-24
IL116386A0 (en) 1996-03-31
JPH08239384A (ja) 1996-09-17
ZA9510695B (en) 1996-07-03
PL311843A1 (en) 1996-06-24
US5990121A (en) 1999-11-23
KR960022517A (ko) 1996-07-18
EE9500076A (et) 1996-06-17
EP0924211A3 (de) 1999-07-07
DE59507220D1 (de) 1999-12-16
NO955103L (no) 1996-06-17
CA2165131A1 (en) 1996-06-17

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