ES2139744T3 - Sintesis estereoselectiva de analogos de nucleosidos empleando un intermediario biciclico. - Google Patents
Sintesis estereoselectiva de analogos de nucleosidos empleando un intermediario biciclico.Info
- Publication number
- ES2139744T3 ES2139744T3 ES94918252T ES94918252T ES2139744T3 ES 2139744 T3 ES2139744 T3 ES 2139744T3 ES 94918252 T ES94918252 T ES 94918252T ES 94918252 T ES94918252 T ES 94918252T ES 2139744 T3 ES2139744 T3 ES 2139744T3
- Authority
- ES
- Spain
- Prior art keywords
- bicycle
- intermediary
- stereoselective synthesis
- nucleosid
- analogs
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- VZQXUWKZDSEQRR-UHFFFAOYSA-N Nucleosid Natural products C12=NC(SC)=NC(NCC=C(C)C)=C2N=CN1C1OC(CO)C(O)C1O VZQXUWKZDSEQRR-UHFFFAOYSA-N 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 230000000707 stereoselective effect Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- DUAJIKVIRGATIW-UHFFFAOYSA-N trinitrogen(.) Chemical group [N]=[N+]=[N-] DUAJIKVIRGATIW-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D497/08—Bridged systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
LA INVENCION SE REFIERE A UN PROCESO PARA PRODUCIR ANALOGOS DE NUCLEOSIDOS CIS PREDOMINANTEMENTE PUROS UTILIZANDO UN NUEVO COMPUESTO INTERMEDIO BICICLICO DE LA FORMULA (III), EN LA X ES S, U O; Y ES S, CH2, O O CH(R); EN DONDE R ES AZIDO O HALOGENO, Y Z ES S U O.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939311709A GB9311709D0 (en) | 1993-06-07 | 1993-06-07 | Stereoselective synthesis of nucleoside analogues using bicycle intermediate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2139744T3 true ES2139744T3 (es) | 2000-02-16 |
Family
ID=10736757
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES94918252T Expired - Lifetime ES2139744T3 (es) | 1993-06-07 | 1994-06-07 | Sintesis estereoselectiva de analogos de nucleosidos empleando un intermediario biciclico. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5763606A (es) |
| EP (1) | EP0654031B1 (es) |
| JP (1) | JP3110461B2 (es) |
| KR (1) | KR100304072B1 (es) |
| CN (1) | CN1046720C (es) |
| AT (1) | ATE188215T1 (es) |
| AU (1) | AU668829B2 (es) |
| BR (1) | BR9405423A (es) |
| CA (1) | CA2141029C (es) |
| DE (1) | DE69422374T2 (es) |
| DK (1) | DK0654031T3 (es) |
| ES (1) | ES2139744T3 (es) |
| FI (1) | FI112078B (es) |
| GB (1) | GB9311709D0 (es) |
| HU (1) | HU219199B (es) |
| NO (1) | NO303449B1 (es) |
| NZ (1) | NZ267379A (es) |
| OA (1) | OA10349A (es) |
| PL (1) | PL180870B1 (es) |
| RU (1) | RU2139870C1 (es) |
| WO (1) | WO1994029301A1 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6175008B1 (en) * | 1988-04-11 | 2001-01-16 | Biochem Pharma Inc. | Processes for preparing substituted 1,3-oxathiolanes with antiviral properties |
| AU3710395A (en) * | 1994-10-22 | 1996-05-15 | Chong Kun Dang Corporation | Nucleoside derivatives and process for preparing thereof |
| ES2232169T3 (es) | 1998-08-12 | 2005-05-16 | Gilead Sciences, Inc. | Procedimiento de fabricacion de nucleosidos de 1,3-oxatiolano. |
| US6979561B1 (en) | 1998-10-09 | 2005-12-27 | Gilead Sciences, Inc. | Non-homogeneous systems for the resolution of enantiomeric mixtures |
| CA2308559C (en) | 2000-05-16 | 2005-07-26 | Brantford Chemicals Inc. | 1,3-oxathiolan-5-ones useful in the production of antiviral nucleoside analogues |
| ATE312097T1 (de) | 2001-03-01 | 2005-12-15 | Gilead Sciences Inc | Polymorphe und andere kristalline formen von cis- ftc |
| ATE398455T1 (de) | 2003-01-14 | 2008-07-15 | Gilead Sciences Inc | Zusammensetzungen und verfahren zur antiviralen kombinationstherapie |
| WO2005074654A2 (en) | 2004-02-03 | 2005-08-18 | Emory University | Methods to manufacture 1,3-dioxolane nucleosides |
| TWI375560B (en) | 2005-06-13 | 2012-11-01 | Gilead Sciences Inc | Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same |
| TWI471145B (zh) | 2005-06-13 | 2015-02-01 | Bristol Myers Squibb & Gilead Sciences Llc | 單一式藥學劑量型 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5047407A (en) * | 1989-02-08 | 1991-09-10 | Iaf Biochem International, Inc. | 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties |
| US5204466A (en) * | 1990-02-01 | 1993-04-20 | Emory University | Method and compositions for the synthesis of bch-189 and related compounds |
| GB9009861D0 (en) * | 1990-05-02 | 1990-06-27 | Glaxo Group Ltd | Chemical compounds |
| AU9125991A (en) * | 1990-12-05 | 1992-07-08 | University Of Georgia Research Foundation, Inc., The | Enantiomerically pure beta -l-(-)-1,3-oxathiolane nucleosides |
| ZA923640B (en) * | 1991-05-21 | 1993-02-24 | Iaf Biochem Int | Processes for the diastereoselective synthesis of nucleosides |
| GB9116601D0 (en) * | 1991-08-01 | 1991-09-18 | Iaf Biochem Int | 1,3-oxathiolane nucleoside analogues |
| US5332814A (en) * | 1991-11-12 | 1994-07-26 | Ciba-Geigy Corporation | Process for the preparation of carbacyclic nucleosides, and intermediates |
-
1993
- 1993-06-07 GB GB939311709A patent/GB9311709D0/en active Pending
- 1993-11-19 OA OA60438A patent/OA10349A/en unknown
-
1994
- 1994-06-07 KR KR1019950700453A patent/KR100304072B1/ko not_active Expired - Fee Related
- 1994-06-07 CA CA002141029A patent/CA2141029C/en not_active Expired - Fee Related
- 1994-06-07 JP JP07501139A patent/JP3110461B2/ja not_active Expired - Fee Related
- 1994-06-07 NZ NZ267379A patent/NZ267379A/en not_active IP Right Cessation
- 1994-06-07 DE DE69422374T patent/DE69422374T2/de not_active Expired - Fee Related
- 1994-06-07 RU RU95108553A patent/RU2139870C1/ru not_active IP Right Cessation
- 1994-06-07 WO PCT/CA1994/000311 patent/WO1994029301A1/en active IP Right Grant
- 1994-06-07 AT AT94918252T patent/ATE188215T1/de not_active IP Right Cessation
- 1994-06-07 AU AU69667/94A patent/AU668829B2/en not_active Ceased
- 1994-06-07 EP EP94918252A patent/EP0654031B1/en not_active Expired - Lifetime
- 1994-06-07 BR BR9405423A patent/BR9405423A/pt not_active Application Discontinuation
- 1994-06-07 CN CN94190356A patent/CN1046720C/zh not_active Expired - Fee Related
- 1994-06-07 US US08/379,644 patent/US5763606A/en not_active Expired - Fee Related
- 1994-06-07 ES ES94918252T patent/ES2139744T3/es not_active Expired - Lifetime
- 1994-06-07 PL PL94307350A patent/PL180870B1/pl not_active IP Right Cessation
- 1994-06-07 DK DK94918252T patent/DK0654031T3/da active
- 1994-06-07 HU HU9500364A patent/HU219199B/hu not_active IP Right Cessation
-
1995
- 1995-02-06 NO NO950432A patent/NO303449B1/no unknown
- 1995-02-07 FI FI950535A patent/FI112078B/fi active
Also Published As
| Publication number | Publication date |
|---|---|
| WO1994029301A1 (en) | 1994-12-22 |
| GB9311709D0 (en) | 1993-07-21 |
| EP0654031A1 (en) | 1995-05-24 |
| HU9500364D0 (en) | 1995-05-29 |
| DK0654031T3 (da) | 2000-06-13 |
| AU668829B2 (en) | 1996-05-16 |
| FI950535A0 (fi) | 1995-02-07 |
| AU6966794A (en) | 1995-01-03 |
| KR100304072B1 (ko) | 2001-11-22 |
| CN1110479A (zh) | 1995-10-18 |
| DE69422374D1 (de) | 2000-02-03 |
| CN1046720C (zh) | 1999-11-24 |
| RU95108553A (ru) | 1996-11-20 |
| NO950432L (no) | 1995-03-13 |
| PL307350A1 (en) | 1995-05-15 |
| OA10349A (en) | 2001-10-18 |
| BR9405423A (pt) | 1999-05-25 |
| FI112078B (fi) | 2003-10-31 |
| JP3110461B2 (ja) | 2000-11-20 |
| CA2141029C (en) | 2000-07-25 |
| US5763606A (en) | 1998-06-09 |
| NO950432D0 (no) | 1995-02-06 |
| RU2139870C1 (ru) | 1999-10-20 |
| DE69422374T2 (de) | 2000-06-29 |
| CA2141029A1 (en) | 1994-12-22 |
| PL180870B1 (pl) | 2001-04-30 |
| FI950535L (fi) | 1995-02-07 |
| ATE188215T1 (de) | 2000-01-15 |
| HU219199B (en) | 2001-03-28 |
| EP0654031B1 (en) | 1999-12-29 |
| NO303449B1 (no) | 1998-07-13 |
| HUT73630A (en) | 1996-08-28 |
| JPH08505643A (ja) | 1996-06-18 |
| HK1008673A1 (en) | 1999-05-14 |
| NZ267379A (en) | 1997-04-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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