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ES2135441T3 - Procedimiento para la preparacion de derivados de indolo-pirrolocarbazol. - Google Patents

Procedimiento para la preparacion de derivados de indolo-pirrolocarbazol.

Info

Publication number
ES2135441T3
ES2135441T3 ES93120137T ES93120137T ES2135441T3 ES 2135441 T3 ES2135441 T3 ES 2135441T3 ES 93120137 T ES93120137 T ES 93120137T ES 93120137 T ES93120137 T ES 93120137T ES 2135441 T3 ES2135441 T3 ES 2135441T3
Authority
ES
Spain
Prior art keywords
group
formula
compound
preparation
chem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93120137T
Other languages
English (en)
Inventor
Katsuhisa Kojiri
Hajime Suzuki
Hisao Kondo
Hiroyuki Suda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MSD KK
Original Assignee
Banyu Phamaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Phamaceutical Co Ltd filed Critical Banyu Phamaceutical Co Ltd
Application granted granted Critical
Publication of ES2135441T3 publication Critical patent/ES2135441T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

LOS COMPUESTOS RESULTANTES DE LOS COMPUESTOS (I) TIENEN UNA EXCELENTE ACTIVIDAD ANTITUMORAL. SE PRESENTA UN PROCESO PARA LA PREPARACION DE UN COMPUESTO REPRESENTADO POR LA FORMULA (I) EN LA QUE X1 Y X2 REPRESENTAN CADA UNO INDEPENDIENTEMENTE UN ATOMO DE HIDROGENO, UN ATOMO DE HALOGENO, UN GRUPO DE AMINO, UN GRUPO DE ALQUILAMINO MONOILO, UN GRUPO DE ALCOXIDO INFERIOR, UN GRUPO DE ARALCOXIDO, UN GRUPO CARBOXILO, UN GRUPO ALCOXICARBONILO INFERIOR, UN GRUPO DE ALCANOILOXIDO INFERIOR O UN GRUPO DE ALQUILO INFERIOR Y R ES UN ATOMO DE HIDROGENO, UN GRUPO AMINO, UN GRUPO FORMILAMINO, UN GRUPO ALCANOILAMINO INFERIOR, UN GRUPO ALQUILAMINO MONO INFERIOR, UN GRUPO HIDROXILO, UN GRUPO ALCOXIDO INFERIOR, UN GRUPO DE ARALCOXIDO, UN GRUPO ARALQUILO O UN GRUPO DE ALQUILO INFERIOR; QUE COMPRENDE EL CULTIVO DE MICROORGANISMOS QUE TENGA LA HABILIDAD DE GLICOSILAR UN COMPUESTO REPRESENTADO POR LA FORMULA (II) EN LA X1 , X2 Y R TIENEN LOS MISMOS SIGNIFICADOS QUE SE DEFINIERON ANTERIORMENTE, EN UN MEDIO NUTRIENTEQUE CONTIENE EL COMPUESTO DE LA MENCIONADA FORMULA (II) Y LA RECUPERACION DEL COMPUESTO FORMADO DE LA FORMULA (I) A PARTIR DEL MEDIO DE CULTIVO.
ES93120137T 1992-12-14 1993-12-14 Procedimiento para la preparacion de derivados de indolo-pirrolocarbazol. Expired - Lifetime ES2135441T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP35362392 1992-12-14
JP5303593 1993-02-18

Publications (1)

Publication Number Publication Date
ES2135441T3 true ES2135441T3 (es) 1999-11-01

Family

ID=26393744

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93120137T Expired - Lifetime ES2135441T3 (es) 1992-12-14 1993-12-14 Procedimiento para la preparacion de derivados de indolo-pirrolocarbazol.

Country Status (10)

Country Link
EP (1) EP0602597B1 (es)
JP (1) JP3603322B2 (es)
KR (1) KR100293578B1 (es)
AT (1) ATE184053T1 (es)
AU (1) AU669584B2 (es)
CA (1) CA2111283C (es)
DE (1) DE69326222T2 (es)
DK (1) DK0602597T3 (es)
ES (1) ES2135441T3 (es)
GR (1) GR3031359T3 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5437992A (en) * 1994-04-28 1995-08-01 Genencor International, Inc. Five thermostable xylanases from microtetraspora flexuosa for use in delignification and/or bleaching of pulp
US5922860A (en) * 1994-05-09 1999-07-13 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazole derivatives
EP0760375B1 (en) * 1994-05-09 2003-11-26 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyprolocarbazole derivative
EP0769555B1 (en) * 1994-06-13 2003-09-03 Banyu Pharmaceutical Co., Ltd. Gene coding for glycosyltransferase and use thereof
AU3086495A (en) * 1994-08-02 1996-03-04 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazoles
AU4485400A (en) * 1999-04-26 2000-11-10 Advanced Life Sciences Inc. Synthetic indolocarbazole regioisomers and uses thereof
US6653290B2 (en) 2000-10-06 2003-11-25 Bristol-Myers Squibb Company Tumor proliferation inhibitors
US6610727B2 (en) 2000-10-06 2003-08-26 Bristol-Myers Squibb Company Anhydro sugar derivatives of indolocarbazoles
US6677450B2 (en) 2000-10-06 2004-01-13 Bristol-Myers Squibb Company Topoisomerase inhibitors
KR20030085035A (ko) 2001-03-22 2003-11-01 브리스톨-마이어스스퀴브컴파니 토포아이소머라아제 ｉ 선택성 세포독성인돌로피롤로카바졸 당 유도체
US6559299B2 (en) * 2001-03-29 2003-05-06 Merck & Co., Inc. Preparation and isolation of indolocarbazole glycosides
CA2398828A1 (en) 2002-08-09 2004-02-09 Merck & Co., Inc. A pharmaceutical composition containing an indolopyrrolocarbazole derivative
EP1666485A1 (en) * 2003-09-16 2006-06-07 Banyu Pharmaceutical Co., Ltd. Novel indolopyrrolocarbazole derivative with antitumor activity
ES2326459B1 (es) 2008-04-08 2010-05-28 Universidad De Oviedo Indolocarbazoles glicosilados, su procedimiento de obtencion y sus usos.
CN106478643B (zh) * 2016-09-07 2018-07-10 河南师范大学 吲哚[2,3-a]吡咯[3,4-c]咔唑-5,7-二酮-6-芳腙类化合物及其制备方法和在抗癌药物中的应用
CN106432250B (zh) * 2016-09-07 2018-07-10 河南师范大学 具有抗癌活性的吲哚[2,3-a]吡咯[3,4-c]咔唑-5,7-二酮-6-缩氨基硫脲类化合物及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4524145A (en) * 1984-09-04 1985-06-18 Bristol-Myers Company 4'-Deschlororebeccamycin pharmaceutical composition and method of use
US4785085A (en) * 1986-11-21 1988-11-15 Bristol-Myers Company Rebeccamycin analogs
IL97233A (en) * 1990-03-06 1995-03-30 Bristol Myers Squibb Co Rebeccamycin analogs, their production and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
EP0602597A2 (en) 1994-06-22
GR3031359T3 (en) 2000-01-31
KR940014800A (ko) 1994-07-19
DE69326222D1 (de) 1999-10-07
JP3603322B2 (ja) 2004-12-22
KR100293578B1 (ko) 2001-09-17
CA2111283C (en) 2004-10-26
JPH06296494A (ja) 1994-10-25
AU669584B2 (en) 1996-06-13
DK0602597T3 (da) 2000-02-28
CA2111283A1 (en) 1994-06-15
EP0602597A3 (en) 1995-04-19
DE69326222T2 (de) 1999-12-30
EP0602597B1 (en) 1999-09-01
AU5235493A (en) 1994-06-23
ATE184053T1 (de) 1999-09-15

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