[go: up one dir, main page]

ES2131066T3 - Vacuna de conjugacion de oligosacarido con adhesina para hi(haemophilus influenzae). - Google Patents

Vacuna de conjugacion de oligosacarido con adhesina para hi(haemophilus influenzae).

Info

Publication number
ES2131066T3
ES2131066T3 ES92902826T ES92902826T ES2131066T3 ES 2131066 T3 ES2131066 T3 ES 2131066T3 ES 92902826 T ES92902826 T ES 92902826T ES 92902826 T ES92902826 T ES 92902826T ES 2131066 T3 ES2131066 T3 ES 2131066T3
Authority
ES
Spain
Prior art keywords
influenzae
prp
adhesine
oligosaccharid
proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92902826T
Other languages
English (en)
Inventor
Howard C Krivan
James E Samuel
Nils Thomas Norberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Emergent Product Development Gaithersburg Inc
Original Assignee
Antex Biologics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Antex Biologics Inc filed Critical Antex Biologics Inc
Application granted granted Critical
Publication of ES2131066T3 publication Critical patent/ES2131066T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/08—Polyoxyalkylene derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/285—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6068—Other bacterial proteins, e.g. OMP
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
    • A61K2039/627—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier characterised by the linker

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

LO QUE SE REVELA AQUI, SON ENLACES INMUNOGENICOS DE PROTEINA ADHESINA Y POLISACARIDO SINA H.INFLUENZAE PURIFICADA Y PROTEINAS RELACIONADAS, POLIPEPTIDOS, DNA UTIL PARA PRODUCIR PROTEINAS, OLIGOSACARIDOS SINTETICOS DE FOSFATO DE POLI RIOS UTILES PARA SU SINTESIS, Y METODOS DE HACER Y USAR ESTOS MATERIALES. LOS COMPUESTOS COMPRENDEN UN FRAGMENTO PRP, PREFERENTEMENTE UN OLIGOSACARIDO SINTETICO, ACOPLADO A UNA PROTEINA ADHESINA H. INFLUENZAE. EL INVENTO POSTERIOR COMPRENDE PROTEINA ADHESINA H. INFLUENZAE PURIFICADA Y NUEVOS OLIGOSACARIDOS PRP. EL INVENTO TAMBIEN COMPRENDE EL METODO DE PRODUCCION DE ESTOS MATERIALES Y EL EMPLEO DE ELLOS EN UNA VACUNA PARA PROTEGER AL HOMBRE Y OTROS MAMIFEROS CONTRA LA INFECCION DE H. INFLUENZAE.
ES92902826T 1990-12-21 1991-12-20 Vacuna de conjugacion de oligosacarido con adhesina para hi(haemophilus influenzae). Expired - Lifetime ES2131066T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63169890A 1990-12-21 1990-12-21
PCT/US1991/009693 WO1992010936A1 (en) 1990-12-21 1991-12-20 ADHESIN-OLIGOSACCHARIDE CONJUGATE VACCINE FOR $i(HAEMOPHILUS INFLUENZAE)

Publications (1)

Publication Number Publication Date
ES2131066T3 true ES2131066T3 (es) 1999-07-16

Family

ID=24532360

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92902826T Expired - Lifetime ES2131066T3 (es) 1990-12-21 1991-12-20 Vacuna de conjugacion de oligosacarido con adhesina para hi(haemophilus influenzae).

Country Status (8)

Country Link
EP (1) EP0565590B1 (es)
JP (1) JP3330935B2 (es)
AT (1) ATE176989T1 (es)
CA (1) CA2098598A1 (es)
DE (1) DE69130955T2 (es)
DK (1) DK0565590T3 (es)
ES (1) ES2131066T3 (es)
WO (1) WO1992010936A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2138765C (en) * 1992-06-22 1999-09-07 Howard C. Krivan Recombinant haemophilus influenzae protein and nucleotide sequence encoding same
US5981503A (en) * 1994-06-07 1999-11-09 Connaught Laboratories Limited Analog of Haemophilus Hin47 with reduced protease activity
US5939297A (en) * 1994-07-21 1999-08-17 Connaught Laboratories Limited Analog of haemophilus HIN47 with reduced protease activity
US5506139A (en) * 1994-07-21 1996-04-09 Connaught Laboratories Limited Analog of haemophilus Hin47 with reduced protease activity
US6153580A (en) * 1994-07-21 2000-11-28 Loosmore; Sheena M. Analog of haemophilus Hin47 with reduced protease activity
BR9506272B8 (pt) * 1994-07-21 2014-08-05 Connaught Lab PROTEÍNA MUTANTE ISOLADA E PURIFICADA Hin47 DE Haemophilus influenzae, MOLÉCULA QUIMÉRICA, MOLÉCULA DE ÁCIDO NUCLÉICO, PLASMÍDEO RECOMBINANTE, CÉLULA E. coli TRANSFORMADA, COMPOSIÇÃO IMUNOGÊNICA, PROCESSO PARA DETERMINAR A PRESENÇA DE ANTICORPOS, ESPECIFICAMENTE REATIVOS COM A PROTEÍNA Hin47 NUMA AMOSTRA, PROCESSO PARA DETERMINAR A PRESENÇA DE PROTEÍNA Hin47 NUMA AMOSTRA E KIT DE DIAGNÓSTICO PARA DETERMINAR A PRESENÇA DE ANTICORPOS NUMA AMOSTRA ESPECIFICAMENTE REATIVA COM A PROTEÍNA Hin47.
US5681570A (en) 1995-01-12 1997-10-28 Connaught Laboratories Limited Immunogenic conjugate molecules
US5646259A (en) 1995-03-24 1997-07-08 St. Louis University DNA encoding haemophilus adhesion proteins
US5780606A (en) * 1995-06-07 1998-07-14 Connaught Laboratories Limited Neisseria meningitidis capsular polysaccharide conjugates
US6824997B1 (en) 1998-09-18 2004-11-30 Binax, Inc. Process and materials for the rapid detection of streptococcus pneumoniae employing purified antigen-specific antibodies
US9134303B1 (en) 1998-08-25 2015-09-15 Alere Scarborough, Inc. ICT immunoassay for Legionella pneumophila serogroup 1 antigen employing affinity purified antibodies thereto
JP4856836B2 (ja) * 2000-03-01 2012-01-18 バイナックス インコーポレイティッド 標的細菌またはその標的糖質抗原成分の存在を検出する方法
US11014952B2 (en) 2016-07-28 2021-05-25 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Stable hydrolysis-resistant synthetic polyribosylribitolphosphate derivatives as vaccines against Haemophilus influenzae type b

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL78775A (en) * 1985-05-15 1992-06-21 Biotech Australia Pty Ltd Oral vaccines
US5173294A (en) * 1986-11-18 1992-12-22 Research Foundation Of State University Of New York Dna probe for the identification of haemophilus influenzae
NZ223009A (en) * 1986-12-31 1990-06-26 Nl Rivm Of Thoven Oligosaccharides containing d-ribose d-ribitol and phosphate units mimicing haemophilus influenzae type b antigens
EP0320942A3 (en) * 1987-12-18 1989-10-04 American Cyanamid Company Novel polysaccharides novel macromolecular conjugates of the polysaccharides
DE68915046T2 (de) * 1988-04-19 1994-12-08 American Cyanamid Co Haemophilus influenzae Typ B Polysaccharid-Aussermembranprotein-Konjugat als Impfstoff.
CA2006587C (en) * 1988-12-23 2000-01-18 Robert W. Tolan Membrane proteins and peptides of haemophilus influenzae type b
GB8924473D0 (en) * 1989-10-31 1989-12-20 Connaught Lab Outer membrane protein p1 and peptides of haemophilus influenzae b

Also Published As

Publication number Publication date
CA2098598A1 (en) 1992-06-22
ATE176989T1 (de) 1999-03-15
WO1992010936A1 (en) 1992-07-09
EP0565590A4 (en) 1995-07-05
JP3330935B2 (ja) 2002-10-07
EP0565590B1 (en) 1999-03-03
DK0565590T3 (da) 1999-09-27
EP0565590A1 (en) 1993-10-20
JPH06508346A (ja) 1994-09-22
DE69130955T2 (de) 1999-07-01
DE69130955D1 (de) 1999-04-08

Similar Documents

Publication Publication Date Title
AP2001002199A0 (en) Novel streptococcus antigens
ES2131066T3 (es) Vacuna de conjugacion de oligosacarido con adhesina para hi(haemophilus influenzae).
ES542919A0 (es) Un procedimiento para la preparacion de conjugados estables y covalentemente copulados de polisacarido-proteina.
PT99067A (pt) Processo para a producao de um conjugado de oligossacarido e de uma proteina veiculo
ATE236194T1 (de) Antigene polysaccharidfragmente mit einer terminalen 2,5-anhydro-d-mannosegruppevon gruppe b-streptococcus, typ ii und typ iii, und daraus hergestellte konjugatimpfstoffe
ATE479756T1 (de) Streptococcus pneumoniae-antigene und impfstoffe
AP2000001886A0 (en) Group B streptococcus antigens.
GR3035081T3 (en) Pneumococcal polysaccharide-recombinant pneumolysin conjugate vaccines for immunization against pneumococcal infections
ES2068907T3 (es) Secuencias de nucleotidos que codifican una proteina con actividad ureasica.
HK1043943A1 (zh) 肺炎鏈球菌蛋白質和疫苗
DE69930630D1 (de) B2microglobulin fusionsproteine und varianten mit hoher affinität
HUT50048A (en) Process for producing streptococcus protein antigen and pharmaceutical compositions comprising same
DE68915046D1 (de) Haemophilus influenzae Typ B Polysaccharid-Aussermembranprotein-Konjugat als Impfstoff.
DK160888A (da) Polypeptider til diagnose af mycoplasma-infektioner hos svin og rekombinante-dna-metoder til fremstilling deraf
EP0320942A3 (en) Novel polysaccharides novel macromolecular conjugates of the polysaccharides
CA2138765A1 (en) Recombinant haemophilus influenzae protein and nucleotide sequence encoding same
SE8403929L (sv) Rekombinant-dna-molekyl, transformerade mikroorganismer och forfarande for framstellning av penicillin v-amidas
EP1950302A3 (en) Streptococcus antigens
TH17361A (th) โปรตีนจากรีคอมบิแนนท์ มิวแทนท์ ของpasteurella multocida กรรมวิธีสำหรับเตรียมลำดับดีเอนเอที่มีประมวลรหัสของโปรตีนเรพลิคอนที่มีลำดับดีเอนเอและเซลล์ที่ทรานสฟอร์มด้วยเรพลิคอนดังกล่าวชนิดเดียวกัน

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 565590

Country of ref document: ES