[go: up one dir, main page]

ES2130162T3 - Formas topicas de alta dosificacion de colagenasa. - Google Patents

Formas topicas de alta dosificacion de colagenasa.

Info

Publication number
ES2130162T3
ES2130162T3 ES92310008T ES92310008T ES2130162T3 ES 2130162 T3 ES2130162 T3 ES 2130162T3 ES 92310008 T ES92310008 T ES 92310008T ES 92310008 T ES92310008 T ES 92310008T ES 2130162 T3 ES2130162 T3 ES 2130162T3
Authority
ES
Spain
Prior art keywords
colagenase
high dosage
topical forms
collagenase
provides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92310008T
Other languages
English (en)
Inventor
Harold Dr Stern
David Dr Yee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Advance Biofactures of Curacao NV
Original Assignee
Advance Biofactures of Curacao NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advance Biofactures of Curacao NV filed Critical Advance Biofactures of Curacao NV
Application granted granted Critical
Publication of ES2130162T3 publication Critical patent/ES2130162T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

LA INVENCION SUMINISTRA COMPOSICIONES FARMACEUTICAS PARA APLICACION TOPICA QUE CONTIENEN ALTAS CONCENTRACIONES DE COLAGENASA DE ENZIMAS EN EXCIPIENTES NO ACUOSOS. LA INVENCION TAMBIEN SUMINISTRA UN EXCIPIENTE PARTICUAR, DEXTRANO, QUE ES ESPECIALMENTE UTIL PARA MEZCLAR CON LA COLAGENASA Y QUE TAMBIEN PUEDE USARSE DE FORMA VENTAJOSA CON OTROS MATERIALES FARMACEUTICAMENTE ACTIVOS.
ES92310008T 1991-11-20 1992-11-02 Formas topicas de alta dosificacion de colagenasa. Expired - Lifetime ES2130162T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79591591A 1991-11-20 1991-11-20
US07/963,995 US5393792A (en) 1991-11-20 1992-10-29 High dosage topical forms of collagenase

Publications (1)

Publication Number Publication Date
ES2130162T3 true ES2130162T3 (es) 1999-07-01

Family

ID=27121667

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92310008T Expired - Lifetime ES2130162T3 (es) 1991-11-20 1992-11-02 Formas topicas de alta dosificacion de colagenasa.

Country Status (12)

Country Link
US (3) US5393792A (es)
EP (1) EP0543521B1 (es)
JP (1) JPH0789871A (es)
AT (1) ATE179612T1 (es)
AU (1) AU654881B2 (es)
CA (1) CA2083333C (es)
DE (1) DE69229098T2 (es)
ES (1) ES2130162T3 (es)
HU (1) HUT62802A (es)
RU (1) RU2129862C1 (es)
SI (1) SI9200334A (es)
YU (1) YU98792A (es)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE213955T1 (de) * 1994-12-15 2002-03-15 Advance Biofactures Curacao Verminderung des fettgewebes durch verwendung von kollagenase
US6958150B2 (en) 1994-12-15 2005-10-25 Advance Biofactures Of Curacao, N.V. Reduction of adipose tissue
DE19503338C2 (de) * 1995-02-02 1998-07-30 Lohmann Therapie Syst Lts Arzneiform zur Abgabe von Kollagenase an Wunden und Verfahren zu ihrer Herstellung und ihre Verwendung
US5851522A (en) * 1995-06-07 1998-12-22 Trustees Of Tufts College Enhancing keratinocyte migration
US5718897A (en) * 1995-06-07 1998-02-17 Trustees Of Tufts College Enhancing keratinocyte migration and proliferation
DE19521829A1 (de) * 1995-06-16 1996-12-19 Knoll Ag Neue Verwendung von Collagenase
US6086872A (en) * 1997-03-27 2000-07-11 Advance Biofactures Of Curacao, Nv Amelioration of dupuytren's disease
WO1999062552A1 (fr) * 1998-06-03 1999-12-09 Hwa Seong Kim Medicaments a effet d'adhesion / fixation / refroidissement pour brulure et methode therapeutique permettant de soulager une cicatrice de brulure
DE19825794A1 (de) * 1998-06-10 1999-12-16 Knoll Ag Collagenase-Applikationsform
IL127209A0 (en) * 1998-11-23 1999-09-22 Bio Silk Ltd Composition and method for treatment of hypertrophic skin accumulations and their prevention
US20030198631A1 (en) * 2002-04-18 2003-10-23 Healthpoint, Ltd. Thermolysin enzymatic wound debrider
US7169405B2 (en) * 2003-08-06 2007-01-30 Warsaw Orthopedic, Inc. Methods and devices for the treatment of intervertebral discs
US20050220821A1 (en) * 2004-03-31 2005-10-06 Allergan, Inc. Pressure sore treatment
CA2572895A1 (en) * 2004-07-13 2006-01-19 Mediwound, Ltd. Compositions and methods for dermatological wound healing
US20070224184A1 (en) * 2006-02-22 2007-09-27 The Research Foundation Of The State University Of New York Method for treating cellulite
ITPD20050207A1 (it) * 2005-07-07 2007-01-08 Fidia Farmaceutici Nuove composizioni farmaceutiche contenenti acido ialuronico e collagenas nel trattamento topico di ferite, ustioni ed ulcere
CN1935262B (zh) * 2005-09-23 2010-12-29 沈阳胜宝康生物制药有限公司 红色诺卡氏菌细胞壁骨架在制备抗人乳头瘤病毒药物的用途
US20070141106A1 (en) * 2005-10-19 2007-06-21 Bonutti Peter M Drug eluting implant
US7811560B2 (en) * 2006-01-30 2010-10-12 Auxilium Us Holdings, Llc Compositions and methods for treating collagen-mediated diseases
US7879027B2 (en) * 2006-04-24 2011-02-01 Warsaw Orthopedic, Inc. Controlled release devices for fusion of osteal structures
US7771414B2 (en) * 2006-04-24 2010-08-10 Warsaw Orthopedic, Inc. Controlled release devices for therapeutic treatments of spinal discs
US8642059B2 (en) * 2006-04-24 2014-02-04 Warsaw Orthopedic, Inc. Controlled release systems and methods for intervertebral discs
US8642060B2 (en) * 2006-04-24 2014-02-04 Warsaw Orthopedic, Inc. Controlled release systems and methods for osteal growth
US8323642B2 (en) * 2006-12-13 2012-12-04 Depuy Mitek, Inc. Tissue fusion method using collagenase for repair of soft tissue
US10071143B1 (en) 2007-05-03 2018-09-11 The Research Foundation For The State University Of New York Methods for non-surgical treatment of carpal tunnel syndrome
US20100159564A1 (en) * 2007-11-30 2010-06-24 Dwulet Francis E Protease resistant recombinant bacterial collagenases
WO2010050980A1 (en) * 2008-10-31 2010-05-06 Laboratory Skin Care, Inc. Topical formulations comprising hydroxyapatite particles for stimulation and maintenance of collagen fibers
US9694100B2 (en) 2009-12-08 2017-07-04 Smith & Nephew, Inc. Enzymatic wound debriding compositions with enhanced enzymatic activity
WO2012125948A1 (en) 2011-03-16 2012-09-20 Biospecifics Technologies Corp. Compositions and methods for producing clostridial collagenases
NZ750379A (en) 2012-01-12 2022-10-28 Auxilium Int Holdings Inc Clostridium histolyticum enzymes and methods for the use thereof
CN103764038A (zh) * 2012-02-21 2014-04-30 株式会社东芝 X射线ct装置、图像显示装置、图像显示方法
US9636385B2 (en) 2012-10-24 2017-05-02 The Research Foundation For The State University Of New York Use of collagenase to treat glaucoma
US11382958B2 (en) 2016-01-31 2022-07-12 Mediwound Ltd. Debriding composition for treating wounds
KR102376363B1 (ko) 2016-04-18 2022-03-21 메디운드 리미티드 만성 상처의 괴사조직제거 방법
JP7558654B2 (ja) 2017-03-01 2024-10-01 エンド ベンチャーズ アンリミテッド カンパニー セルライトを評価及び処置するための装置及び方法
EP3601556A2 (en) 2017-03-28 2020-02-05 Endo Ventures Limited Improved method of producing collagenase
US20220362327A1 (en) * 2021-05-13 2022-11-17 Nasser Diab Compositions and methods for wound healing
WO2025114817A1 (en) 2023-11-30 2025-06-05 Osiris Therapeutics, Inc. Methods and compositions for enzymatic wound debridement

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH437641A (de) * 1961-05-30 1967-06-15 Bernburg Serum Werk Veb Verfahren zur Herstellung von fettfreien Salbengrundlagen
US3392161A (en) * 1964-10-15 1968-07-09 Gen Tire & Rubber Co Gel-free halogenated polybutadiene rubber-resins
US3705083A (en) * 1966-07-08 1972-12-05 Agricultural Biolog Corp Process for producing collagenase
US3792161A (en) * 1970-05-18 1974-02-12 Research Corp Burn ointment comprising silver sulfadiazine and collagenase
US3678158A (en) * 1971-05-11 1972-07-18 Worthington Bio Chem Corp Treatment of herniated intervertebral discs of mammals
US4089333A (en) * 1972-10-28 1978-05-16 Nippi, Incorporated Method of treating a wound or burn
US3876501A (en) * 1973-05-17 1975-04-08 Baxter Laboratories Inc Binding enzymes to activated water-soluble carbohydrates
US4174389A (en) * 1977-05-13 1979-11-13 Cope Louise A Ophthalmic use of collagenase
US4338300A (en) * 1981-02-05 1982-07-06 The Regents Of The University Of California Use of purified clostridial collangenase in the treatment of Peyronie's disease
US4485088A (en) * 1982-03-26 1984-11-27 Bio-Products, Inc. Method of treatment of fibrotic lesions by topical administration of lathyrogenic drugs
US4524065A (en) * 1983-08-04 1985-06-18 Bio-Specifics N.V. Method for the prevention and treatment of scars with enzymes
GB2150833B (en) * 1983-12-08 1987-04-15 Ceskoslovenska Akademie Ved Proteolytic wounds dressing
NZ226171A (en) * 1987-09-18 1990-06-26 Ethicon Inc Gel formulation containing polypeptide growth factor
US5173295A (en) * 1990-10-05 1992-12-22 Advance Biofactures Of Curacao, N.V. Method of enhancing the regeneration of injured nerves and adhesive pharamaceutical formulation therefor

Also Published As

Publication number Publication date
CA2083333C (en) 2000-05-30
AU2853592A (en) 1993-05-27
US5514370A (en) 1996-05-07
RU2129862C1 (ru) 1999-05-10
AU654881B2 (en) 1994-11-24
YU98792A (sh) 1995-12-04
US5422103A (en) 1995-06-06
JPH0789871A (ja) 1995-04-04
CA2083333A1 (en) 1993-05-21
HU9203623D0 (en) 1993-01-28
EP0543521A3 (en) 1993-07-28
EP0543521A2 (en) 1993-05-26
DE69229098D1 (de) 1999-06-10
ATE179612T1 (de) 1999-05-15
US5393792A (en) 1995-02-28
HUT62802A (en) 1993-06-28
SI9200334A (en) 1993-06-30
EP0543521B1 (en) 1999-05-06
DE69229098T2 (de) 1999-09-09

Similar Documents

Publication Publication Date Title
ES2130162T3 (es) Formas topicas de alta dosificacion de colagenasa.
RU92004549A (ru) Высокодозированные формы коллагеназы для наружного применения
BR9303469A (pt) Conjugado de interferon,composto,processo de preparacao de um conjugado de interferon,use e composicoes farmaceuticas
DK0999853T3 (da) Stabiliseret antostofformulering
ATE113650T1 (de) Ausgewählte stämme von lactobacillus enthaltende pharmazeutische zusammensetzungen.
AR092919A2 (es) Composicion farmaceutica liquida
ATE101517T1 (de) Pharmazeutische zusammensetzung, enthaltend loratadin, ibuprofen und pseudoephedrin.
FI875272L (fi) Baerarloesningsmedelssystem i tvao fas.
MX9304710A (es) Composicion farmaceutica y/o cosmetica y su uso.
DK0722313T3 (da) Viskoelastiske sammensætninger af fluorerede organiske forbindelser
AU618443B2 (en) The use of the active substance azelastine in combatting psoriasis disorders and inflammatory disorders
IT1281188B1 (it) Composizione per prevenire e trattare infiammazioni con immunoglobulina a.
ES2011232A4 (es) Compuestos farmaceuticos en piroxicam en soluciones acuosas y proceso para su preparacion
DE69034226D1 (de) Herstellungsverfahren von Huperzine A und deren Analogen und Verbindungen nützlich dazu
IT1252692B (it) Composizione farmaceutica per uso oftalmico contenente un antiinfiammatorio non steroideo ed un decongestionante come principi attivi
IT8423263A1 (it) Formulazioni farmaceutiche acquose di piroxicam monoidrato
IT1264856B1 (it) Composizione farmaceutica ad attivita' analgesica
NO884123L (no) Stabilisering av terapeutisk virksomme proteiner i farmasoeytiske preparater.
DE69434199D1 (de) Absorptionsförderer für topische pharmazeutische formulierungen
ES2193007T1 (es) Formulacion farmaceutica estable que comprende la modificacion ii de torsemida.
NO932843D0 (no) Farmasoeytiske preparater
ES2189886T3 (es) Composicion farmaceutica para aplicacion topica.
IT1216233B (it) Utilizzazione della forma farmaceutica 'gel'contenente acido n (2,6 dicloro m tolil) antranilico (acido meclofenamico) impiegabile in terapia per uso topico.
IT8819447A0 (it) Composizione di composti che migliorano l'attivita' analgesica, antipiretica e antinfiammatoria.
GB950065A (en) Pharmaceutical preparations comprising 1:3-benzoxazine-2:4-dione

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 543521

Country of ref document: ES