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ES2127695B1 - PROCEDURE FOR THE REDUCTION OF THE CONTENT OF PLATELET FACTOR 4 IN PLASMA PROTEINS THAT HAVE AFFINITY TO HEPARIN. - Google Patents

PROCEDURE FOR THE REDUCTION OF THE CONTENT OF PLATELET FACTOR 4 IN PLASMA PROTEINS THAT HAVE AFFINITY TO HEPARIN.

Info

Publication number
ES2127695B1
ES2127695B1 ES9700301A ES9700301A ES2127695B1 ES 2127695 B1 ES2127695 B1 ES 2127695B1 ES 9700301 A ES9700301 A ES 9700301A ES 9700301 A ES9700301 A ES 9700301A ES 2127695 B1 ES2127695 B1 ES 2127695B1
Authority
ES
Spain
Prior art keywords
heparin
affinity
procedure
content
platelet
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES9700301A
Other languages
Spanish (es)
Other versions
ES2127695A1 (en
Inventor
Debart Pere Ristol
Rodriguez Jesus Fernandez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Grifols SA
Original Assignee
Grifols SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grifols SA filed Critical Grifols SA
Priority to ES9700301A priority Critical patent/ES2127695B1/en
Publication of ES2127695A1 publication Critical patent/ES2127695A1/en
Application granted granted Critical
Publication of ES2127695B1 publication Critical patent/ES2127695B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Procedimiento para la reducción del contenido de factor plaquetar 4 en proteínas plasmáticas que poseen afinidad a heparina. El procedimiento para la reducción del contenido de factor plaquetar 4 en proteínas plasmáticas que poseen afinidad a heparina, comprende la separación de un material de origen plaquetar de alta afinidad por heparina, con respecto a proteínas de interés terapéutico derivadas del plasma humano, que contienen dicho contaminante, por adsorción selectiva mediante un adsorbente de muy baja capacidad para la adsorción proteica inespecífica, siendo el adsorbente preferentemente una resina de polisulfona o derivados del tipo aril o fenilsulfonas y preferentemente el material de origen plaquetar de alta afinidad por heparina es el factor 4 plaquetar (FP4).Procedure for the reduction of platelet factor 4 content in plasma proteins that have an affinity for heparin. The procedure for reducing the content of platelet factor 4 in plasma proteins that have an affinity for heparin, comprises the separation of a platelet material of high affinity for heparin, with respect to proteins of therapeutic interest derived from human plasma, which contain said contaminant, by selective adsorption by a very low capacity adsorbent for nonspecific protein adsorption, the adsorbent preferably being a polysulfone resin or derivatives of the aryl or phenylsulfone type and preferably the platelet material of high affinity for heparin is the factor 4 platelet (FP4).

ES9700301A 1997-02-14 1997-02-14 PROCEDURE FOR THE REDUCTION OF THE CONTENT OF PLATELET FACTOR 4 IN PLASMA PROTEINS THAT HAVE AFFINITY TO HEPARIN. Expired - Fee Related ES2127695B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9700301A ES2127695B1 (en) 1997-02-14 1997-02-14 PROCEDURE FOR THE REDUCTION OF THE CONTENT OF PLATELET FACTOR 4 IN PLASMA PROTEINS THAT HAVE AFFINITY TO HEPARIN.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9700301A ES2127695B1 (en) 1997-02-14 1997-02-14 PROCEDURE FOR THE REDUCTION OF THE CONTENT OF PLATELET FACTOR 4 IN PLASMA PROTEINS THAT HAVE AFFINITY TO HEPARIN.

Publications (2)

Publication Number Publication Date
ES2127695A1 ES2127695A1 (en) 1999-04-16
ES2127695B1 true ES2127695B1 (en) 2000-03-16

Family

ID=8298242

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9700301A Expired - Fee Related ES2127695B1 (en) 1997-02-14 1997-02-14 PROCEDURE FOR THE REDUCTION OF THE CONTENT OF PLATELET FACTOR 4 IN PLASMA PROTEINS THAT HAVE AFFINITY TO HEPARIN.

Country Status (1)

Country Link
ES (1) ES2127695B1 (en)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3877529T2 (en) * 1987-10-23 1996-11-07 Centre Regional De Transfusion Production of highly purified human factor IX and other plasma protein concentrate and its therapeutic use.
DE68928907T2 (en) * 1988-10-17 1999-09-16 Hemasure,Inc. METHOD FOR THE COVALENT SURFACE MODIFICATION OF HYDROPHOBIC POLYMERS AND PRODUCTS THEREOF
US5391580A (en) * 1992-03-20 1995-02-21 Anatrace Inc. Poly(sulfone-alpha-olefin) composite permselective membrane article for use in blood oxygenation
WO1997034687A1 (en) * 1996-03-21 1997-09-25 Kaneka Corporation Hollow yarn membrane used for blood purification and blood purifier

Also Published As

Publication number Publication date
ES2127695A1 (en) 1999-04-16

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