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ES2121554B1 - PROCEDURE FOR OBTAINING 14-HYDROXIMOFINONES BY PHOTOOXIDATION OF MORPHINE ALKALOIDS WITH ALCOXIDIENIC SYSTEM IN RING C. - Google Patents

PROCEDURE FOR OBTAINING 14-HYDROXIMOFINONES BY PHOTOOXIDATION OF MORPHINE ALKALOIDS WITH ALCOXIDIENIC SYSTEM IN RING C.

Info

Publication number
ES2121554B1
ES2121554B1 ES9602718A ES9602718A ES2121554B1 ES 2121554 B1 ES2121554 B1 ES 2121554B1 ES 9602718 A ES9602718 A ES 9602718A ES 9602718 A ES9602718 A ES 9602718A ES 2121554 B1 ES2121554 B1 ES 2121554B1
Authority
ES
Spain
Prior art keywords
ring
alcoxidienic
photooxidation
procedure
obtaining
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES9602718A
Other languages
Spanish (es)
Other versions
ES2121554A1 (en
Inventor
Vega Ricardo Riguera
Cabana Emilio Quinoa
Souto Ma Dolores Lopez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universidade de Santiago de Compostela
Original Assignee
Universidade de Santiago de Compostela
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidade de Santiago de Compostela filed Critical Universidade de Santiago de Compostela
Priority to ES9602718A priority Critical patent/ES2121554B1/en
Publication of ES2121554A1 publication Critical patent/ES2121554A1/en
Application granted granted Critical
Publication of ES2121554B1 publication Critical patent/ES2121554B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE 14-HIDROXIMORFINONAS MEDIANTE FOTOOXIDACION DE ALCALOIDES MORFINICOS CON SISTEMA ALCOXIDIENICO EN EL ANILLO C. LA FOTOOXIDACION EN MEDIO ACIDO DE ALCALOIDES MORFINICOS CON SISTEMA ALCOXIDIENICO EN EL ANILLO C (ESTRUCTURA GENERAL II), TALES COMO TEBAINA Y ORIPAVINA, PRODUCE ALCALOIDES OXIGENADOS EN LAS POSICIONES C-6 Y C-14 CON ESTRUCTURA GENERAL I, TALES COMO SALES DE 14-HIDROXICODEINONA Y 14-HIDROXIMORFINONA. LOS COMPUESTOS CON ESTRUCTURA GENERAL I SE PREPARAN TAMBIEN POR TRATAMIENTO ACIDO DE LOS CORRESPONDIENTES ENDOPEROXIDOS III, OBTENIDOS POR FOTOOXIDACION DE SALES DE LOS ALCALOIDES TEBAINA, OVIPARINA Y ANALOGOS CON SISTEMA ALCOXIDIENICO EN EL ANILLO C.PROCEDURE FOR OBTAINING 14-HYDROXYMORPHINONS BY PHOTOXIDATION OF MORPHINE ALKALOIDS WITH ALCOXIDIENIC RING IN THE RING C. ACIDAL ACIDAL, YELLOW EYE, YELLOW-EYE (ALCOID), IN POSITIONS C-6 AND C-14 WITH GENERAL STRUCTURE I, SUCH AS SALTS OF 14-HYDROXYCODEINONE AND 14-HYDROXYMORPHINONE. THE COMPOUNDS WITH GENERAL STRUCTURE I ARE ALSO PREPARED BY ACID TREATMENT OF THE CORRESPONDING ENDOPEROXIDES III, OBTAINED BY PHOTOOXIDATION OF SALTS FROM THE THEBAINE, OVIPARINE AND ANALOGS WITH ALCOXIDIENIC SYSTEM IN THE RING C.

ES9602718A 1996-12-23 1996-12-23 PROCEDURE FOR OBTAINING 14-HYDROXIMOFINONES BY PHOTOOXIDATION OF MORPHINE ALKALOIDS WITH ALCOXIDIENIC SYSTEM IN RING C. Expired - Lifetime ES2121554B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9602718A ES2121554B1 (en) 1996-12-23 1996-12-23 PROCEDURE FOR OBTAINING 14-HYDROXIMOFINONES BY PHOTOOXIDATION OF MORPHINE ALKALOIDS WITH ALCOXIDIENIC SYSTEM IN RING C.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9602718A ES2121554B1 (en) 1996-12-23 1996-12-23 PROCEDURE FOR OBTAINING 14-HYDROXIMOFINONES BY PHOTOOXIDATION OF MORPHINE ALKALOIDS WITH ALCOXIDIENIC SYSTEM IN RING C.

Publications (2)

Publication Number Publication Date
ES2121554A1 ES2121554A1 (en) 1998-11-16
ES2121554B1 true ES2121554B1 (en) 1999-06-16

Family

ID=8297120

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9602718A Expired - Lifetime ES2121554B1 (en) 1996-12-23 1996-12-23 PROCEDURE FOR OBTAINING 14-HYDROXIMOFINONES BY PHOTOOXIDATION OF MORPHINE ALKALOIDS WITH ALCOXIDIENIC SYSTEM IN RING C.

Country Status (1)

Country Link
ES (1) ES2121554B1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201509943A (en) 2004-03-30 2015-03-16 Euro Celtique Sa Oxycodone hydrochloride composition, pharmaceutical dosage form, sustained release oral dosage form and pharmaceutically acceptable package having less than 25 PPM 14-hydroxycodeinone
NZ575620A (en) 2006-09-20 2010-11-26 Mallinckrodt Inc Preparation of substituted morphinan-6-ones and salts and intermediates thereof
AU2008223328B2 (en) 2007-03-06 2012-10-11 SpecGx LLC Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
US9040726B2 (en) 2007-03-06 2015-05-26 Mallinckrodt Llc Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
EP2285780B1 (en) 2008-05-27 2015-08-26 Mallinckrodt LLC Processes and compounds for the preparation of normorphinans
US9458109B2 (en) 2008-09-03 2016-10-04 Mallinckrodt Llc Substituted berbines and processes for their synthesis
WO2012003468A1 (en) 2010-07-02 2012-01-05 Johnson Matthey Public Limited Company Process for the synthesis and purification of oxycodone
US8846923B1 (en) 2013-12-18 2014-09-30 Cody Laboratories, Inc. Preparation of 14-hydroxycodeinone sulfate
US10227354B2 (en) 2013-12-18 2019-03-12 Cody Laboratories, Inc. Conversion of oxycodone base to oxycodone hydrochloride
US9062062B1 (en) 2013-12-18 2015-06-23 Cody Laboratories, Inc. Synthesis of oxycodone hydrochloride

Also Published As

Publication number Publication date
ES2121554A1 (en) 1998-11-16

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