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ES2117178T3 - Procedimiento para preparar derivados de acidos gamma-mercaptocarboxilicos. - Google Patents

Procedimiento para preparar derivados de acidos gamma-mercaptocarboxilicos.

Info

Publication number
ES2117178T3
ES2117178T3 ES94113811T ES94113811T ES2117178T3 ES 2117178 T3 ES2117178 T3 ES 2117178T3 ES 94113811 T ES94113811 T ES 94113811T ES 94113811 T ES94113811 T ES 94113811T ES 2117178 T3 ES2117178 T3 ES 2117178T3
Authority
ES
Spain
Prior art keywords
gamma
acid derivatives
procedure
mercaptocarboxylic acid
prepare gamma
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94113811T
Other languages
English (en)
Inventor
Wilhelm Dr Quittmann
John Dr Mcgarrity
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lonza AG
Original Assignee
Lonza AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza AG filed Critical Lonza AG
Application granted granted Critical
Publication of ES2117178T3 publication Critical patent/ES2117178T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

LOS GAMMA ESPECIALMENTE ESTER Y AMIDA, SON ELABORADOS A PARTIR DE GAMMA BUTIROLACTONAS A TRAVES DE TIOLACTONAS CORRESPONDIENTES. LAS TIOLACTONAS SE OBTIENEN MEDIANTE TRANSFORMACION DE LA LACTONA CON TIOCARBOXILATOS EN DISOLVENTES POLARES Y A TRAVES DE FORMACIONES DE ANILLO CON REACTIVOS NUCLEOFILOS COMO POR EJEMPLO ALCOHOLATOS ALCALINOS EN TRANSFORMACION DE LOS DERIVADOS GAMMA MERCAPTO ACIDO CARBOXILICO. ESTOS COMPUESTOS SON PRODUCTOS INTERMEDIOS, POR EJEMPLO PARA LA SINTESIS DE ANTAGONISTAS LEUCOTRIENO.
ES94113811T 1993-09-03 1994-09-02 Procedimiento para preparar derivados de acidos gamma-mercaptocarboxilicos. Expired - Lifetime ES2117178T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH262693 1993-09-03

Publications (1)

Publication Number Publication Date
ES2117178T3 true ES2117178T3 (es) 1998-08-01

Family

ID=4237994

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94113811T Expired - Lifetime ES2117178T3 (es) 1993-09-03 1994-09-02 Procedimiento para preparar derivados de acidos gamma-mercaptocarboxilicos.

Country Status (21)

Country Link
US (1) US5534651A (es)
EP (1) EP0641775B1 (es)
JP (1) JP3843464B2 (es)
KR (1) KR100318102B1 (es)
CN (1) CN1059677C (es)
AT (1) ATE165086T1 (es)
AU (1) AU685477B2 (es)
BR (1) BR9403427A (es)
CA (1) CA2130723C (es)
CZ (1) CZ288652B6 (es)
DE (1) DE59405698D1 (es)
DK (1) DK0641775T3 (es)
ES (1) ES2117178T3 (es)
HU (2) HU214204B (es)
IL (1) IL110841A (es)
PL (1) PL176613B1 (es)
RU (1) RU94031752A (es)
SI (1) SI0641775T1 (es)
SK (1) SK103494A3 (es)
TR (1) TR27849A (es)
ZA (1) ZA946755B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2371048C (en) 2002-02-06 2011-01-04 Delmar Chemicals Inc. Process for the preparation of 1-(mercaptomethyl)-cyclopropaneacetic acid
CN1318400C (zh) * 2002-02-06 2007-05-30 戴尔玛化学品股份有限公司 制备1－(巯基甲基)－环丙烷乙酸的方法
US7271268B1 (en) 2006-12-22 2007-09-18 Formosa Laboratories Inc. Process for preparation of [1-(mercaptomethyl)cyclopropyl]acetic acid and related derivatives
KR101095706B1 (ko) * 2009-06-16 2011-12-20 화일약품주식회사 몬테루카스트산 또는 그 나트륨염의 신규한 제조 방법
EP2648510B1 (en) 2010-12-09 2016-08-31 ImmunoGen, Inc. Methods for the preparation of charged crosslinkers
KR101431678B1 (ko) 2012-01-10 2014-08-22 (주)위즈켐 1-(1'-(카복시메틸)시클로프로판메틸디설파닐메틸)시클로프로판아세트산과 그 유도체의 제조방법
CN103467276B (zh) * 2013-09-13 2015-05-06 天津速研医药科技有限公司 一种孟鲁司特钠侧链关键中间体的合成方法
CN105461671B (zh) * 2015-11-17 2017-11-07 苏州大学 酮酸与炔制备α,β‑不饱和丁内酯的方法
KR102384780B1 (ko) * 2020-02-27 2022-04-11 (주) 파마젠 호모시스테인 티오락톤 또는 셀레노락톤의 제조방법
CN114181121B (zh) * 2021-12-08 2024-04-26 江苏阿尔法药业股份有限公司 一种1-巯甲基环丙基乙酸的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1199276B (de) * 1962-09-20 1965-08-26 Degussa Verfahren zur Herstellung von D, L-Homo-cysteinderivaten
US4219562A (en) * 1979-03-08 1980-08-26 Shell Oil Company 3-(Hydrocarbylthiomethyl)-2,2-dimethylcyclopropanecarboxylate pesticides
DK304185A (da) * 1984-07-27 1986-01-28 Hoffmann La Roche Fremgangsmaade til fremstilling af furanon
US5028725A (en) * 1985-12-16 1991-07-02 Polaroid Corporation Thiolactone metal complexes
US4707491A (en) * 1985-12-20 1987-11-17 Washington University Anticonvulsant γ-thiobutyrolactone derivatives
DE3801479A1 (de) * 1987-01-31 1988-08-11 Sandoz Ag Pilocarpinderivate
CA2053209C (en) * 1990-10-12 1998-12-08 Michel L. Belley Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists
US5270324A (en) * 1992-04-10 1993-12-14 Merck Frosst Canada, Inc. Fluorinated hydroxyalkylquinoline acids as leukotriene antagonists

Also Published As

Publication number Publication date
HUT68782A (en) 1995-07-28
DK0641775T3 (da) 1998-05-25
CZ211594A3 (en) 1995-03-15
HU214204B (hu) 1998-01-28
DE59405698D1 (de) 1998-05-20
BR9403427A (pt) 1995-05-09
US5534651A (en) 1996-07-09
CN1108256A (zh) 1995-09-13
IL110841A0 (en) 1994-11-28
AU685477B2 (en) 1998-01-22
PL176613B1 (pl) 1999-06-30
IL110841A (en) 2000-07-26
PL304884A1 (en) 1995-03-06
HU9701400D0 (en) 1997-10-28
CA2130723A1 (en) 1995-03-04
KR100318102B1 (ko) 2002-11-27
SK103494A3 (en) 1995-03-08
CN1059677C (zh) 2000-12-20
RU94031752A (ru) 1996-07-20
CZ288652B6 (cs) 2001-08-15
HU216808B (hu) 1999-08-30
JP3843464B2 (ja) 2006-11-08
ATE165086T1 (de) 1998-05-15
JPH0782241A (ja) 1995-03-28
TR27849A (tr) 1995-09-01
CA2130723C (en) 2006-01-31
AU7164694A (en) 1995-03-16
KR950008480A (ko) 1995-04-17
ZA946755B (en) 1995-04-21
SI0641775T1 (en) 1998-08-31
HU9402537D0 (en) 1994-11-28
EP0641775A1 (de) 1995-03-08
EP0641775B1 (de) 1998-04-15

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