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ES2115060T3 - Microparticulas, procedimiento para su produccion, asi como la utilizacion de estas para finalidades de diagnostico. - Google Patents

Microparticulas, procedimiento para su produccion, asi como la utilizacion de estas para finalidades de diagnostico.

Info

Publication number
ES2115060T3
ES2115060T3 ES93912897T ES93912897T ES2115060T3 ES 2115060 T3 ES2115060 T3 ES 2115060T3 ES 93912897 T ES93912897 T ES 93912897T ES 93912897 T ES93912897 T ES 93912897T ES 2115060 T3 ES2115060 T3 ES 2115060T3
Authority
ES
Spain
Prior art keywords
beta
procedure
microparticles
production
well
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93912897T
Other languages
English (en)
Other versions
ES2115060T5 (es
Inventor
Michael Dr Stein
Werner Dr Weitschies
Thomas Dr Fritzsch
Dieter Dr Heldmann
Joachim Dr Siegert
Volkmar Dr Uhlendorf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6461144&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2115060(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering AG filed Critical Schering AG
Application granted granted Critical
Publication of ES2115060T3 publication Critical patent/ES2115060T3/es
Publication of ES2115060T5 publication Critical patent/ES2115060T5/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Acoustics & Sound (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Saccharide Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A MEDIOS DE CONTRASTE PARA SU UTILIZACION EN DIAGNOSTICO ULTRASONICO, CONSISTIENDO LOS MEDIOS DE CONTRASTE EN MICROPARTICULAS QUE CONTIENEN GAS CON UNA ENVUELTA ELABORADA A BASE DE ACRILATOS POLICIANO O POLIESTERES DE ALFA-, BETA-, O GAMMA SE REFIERE TAMBIEN A UN PROCEDIMIENTO PARA LA ELABORACION DE TALES MEDIOS DE CONTRASTE.
ES93912897T 1992-06-13 1993-06-05 Microparticulas, procedimiento para su produccion, asi como la utilizacion de estas para finalidades de diagnostico. Expired - Lifetime ES2115060T5 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4219723 1992-06-13
DE4219723A DE4219723A1 (de) 1992-06-13 1992-06-13 Mikropartikel, Verfahren zu deren Herstellung, sowie die Verwendung dieser in der Diagnostik

Publications (2)

Publication Number Publication Date
ES2115060T3 true ES2115060T3 (es) 1998-06-16
ES2115060T5 ES2115060T5 (es) 2004-06-16

Family

ID=6461144

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93912897T Expired - Lifetime ES2115060T5 (es) 1992-06-13 1993-06-05 Microparticulas, procedimiento para su produccion, asi como la utilizacion de estas para finalidades de diagnostico.

Country Status (18)

Country Link
EP (1) EP0644777B2 (es)
JP (1) JPH07507780A (es)
KR (1) KR100254746B1 (es)
CN (1) CN1064851C (es)
AT (1) ATE163134T1 (es)
AU (1) AU686103B2 (es)
CA (1) CA2138010A1 (es)
DE (2) DE4219723A1 (es)
DK (1) DK0644777T4 (es)
ES (1) ES2115060T5 (es)
FI (1) FI945837L (es)
GR (1) GR3026498T3 (es)
HU (1) HU217121B (es)
IL (1) IL105891A (es)
NO (1) NO307646B1 (es)
NZ (1) NZ253115A (es)
TW (1) TW239079B (es)
WO (1) WO1993025242A1 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7083778B2 (en) 1991-05-03 2006-08-01 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US5578292A (en) 1991-11-20 1996-11-26 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US6613306B1 (en) 1990-04-02 2003-09-02 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
USRE39146E1 (en) 1990-04-02 2006-06-27 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
IN172208B (es) 1990-04-02 1993-05-01 Sint Sa
US6989141B2 (en) 1990-05-18 2006-01-24 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
NZ244147A (en) † 1991-09-03 1994-09-27 Hoechst Ag Echogenic particles which comprise a gas and at least one shaping substance, and their use as diagnostic agents
IL104084A (en) 1992-01-24 1996-09-12 Bracco Int Bv Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them
EP0711179B2 (en) * 1993-07-30 2010-09-01 IMCOR Pharmaceutical Co. Stabilized microbubble compositions for ultrasound
US5798091A (en) 1993-07-30 1998-08-25 Alliance Pharmaceutical Corp. Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement
GB9318288D0 (en) * 1993-09-03 1993-10-20 Nycomed Imaging As Improvements in or relating to contrast agents
GB9417941D0 (en) * 1994-09-06 1994-10-26 Nycomed Imaging As Improvements in or relating to contrast agents
US5540909A (en) * 1994-09-28 1996-07-30 Alliance Pharmaceutical Corp. Harmonic ultrasound imaging with microbubbles
DE19508049C2 (de) * 1995-02-23 1997-02-06 Schering Ag Verwendung von Methylenmalondiesterderivaten zur Herstellung von gasenthaltenden Mikropartikeln
DE19510690A1 (de) 1995-03-14 1996-09-19 Schering Ag Polymere Nano- und/oder Mikropartikel, Verfahren zu deren Herstellung, sowie Verwendung in medizinischen Diagnostik und Therapie
US5804162A (en) * 1995-06-07 1998-09-08 Alliance Pharmaceutical Corp. Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients
US5611344A (en) * 1996-03-05 1997-03-18 Acusphere, Inc. Microencapsulated fluorinated gases for use as imaging agents
DK0904113T3 (da) * 1996-03-05 2004-08-30 Acusphere Inc Mikroindkapslede fluorerede gasser til anvendelse som billeddannende midler
US6017310A (en) * 1996-09-07 2000-01-25 Andaris Limited Use of hollow microcapsules
US6068600A (en) * 1996-12-06 2000-05-30 Quadrant Healthcare (Uk) Limited Use of hollow microcapsules
US6045777A (en) * 1997-06-30 2000-04-04 Acusphere, Inc. Method for enhancing the echogenicity and decreasing the attenuation of microencapsulated gases
GB9800813D0 (en) 1998-01-16 1998-03-11 Andaris Ltd Improved ultrasound contrast imaging method and apparatus
DE19925311B4 (de) * 1999-05-27 2004-06-09 Schering Ag Mehrstufen-Verfahren zur Herstellung von gasgefüllten Mikrokapseln
DE10013850A1 (de) * 2000-03-15 2001-09-20 Schering Ag Gasgefüllte Mikrokapseln enthaltend funktionalisiertes Polyalkylcyanacrylat, sowie Verfahren zu deren Herstellung
US8012457B2 (en) 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4265251A (en) * 1979-06-28 1981-05-05 Rasor Associates, Inc. Method of determining pressure within liquid containing vessel
IE66912B1 (en) * 1988-02-05 1996-02-07 Schering Ag Ultrasonic contrast agents process for their preparation and their use as diagnostic and therapeutic agents
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
NZ244147A (en) * 1991-09-03 1994-09-27 Hoechst Ag Echogenic particles which comprise a gas and at least one shaping substance, and their use as diagnostic agents

Also Published As

Publication number Publication date
GR3026498T3 (en) 1998-07-31
CN1082924A (zh) 1994-03-02
TW239079B (es) 1995-01-21
IL105891A (en) 1998-10-30
DK0644777T4 (da) 2004-02-23
KR100254746B1 (ko) 2000-08-01
NO307646B1 (no) 2000-05-08
DE59308146D1 (de) 1998-03-19
CA2138010A1 (en) 1993-12-23
KR950701823A (ko) 1995-05-17
AU4323293A (en) 1994-01-04
FI945837A0 (fi) 1994-12-12
IL105891A0 (en) 1993-10-20
WO1993025242A1 (de) 1993-12-23
HU217121B (hu) 1999-11-29
NO944805D0 (no) 1994-12-12
EP0644777B1 (de) 1998-02-11
JPH07507780A (ja) 1995-08-31
NO944805L (no) 1994-12-12
NZ253115A (en) 1996-01-26
ES2115060T5 (es) 2004-06-16
DE4219723A1 (de) 1993-12-16
HU9403566D0 (en) 1995-02-28
AU686103B2 (en) 1998-02-05
HUT69380A (en) 1995-09-28
EP0644777B2 (de) 2003-10-15
FI945837L (fi) 1994-12-12
DK0644777T3 (da) 1998-09-23
EP0644777A1 (de) 1995-03-29
CN1064851C (zh) 2001-04-25
ATE163134T1 (de) 1998-02-15

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