ES2111891T3 - Empleo de l-carnitina o acil l-carnitinas y valproato para tratar trastornos epilepticos. - Google Patents
Empleo de l-carnitina o acil l-carnitinas y valproato para tratar trastornos epilepticos.Info
- Publication number
- ES2111891T3 ES2111891T3 ES94830306T ES94830306T ES2111891T3 ES 2111891 T3 ES2111891 T3 ES 2111891T3 ES 94830306 T ES94830306 T ES 94830306T ES 94830306 T ES94830306 T ES 94830306T ES 2111891 T3 ES2111891 T3 ES 2111891T3
- Authority
- ES
- Spain
- Prior art keywords
- acil
- carnitines
- valproate
- carnitine
- epileptic disorders
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 title abstract 2
- 230000001037 epileptic effect Effects 0.000 title abstract 2
- AEQFSUDEHCCHBT-UHFFFAOYSA-M sodium valproate Chemical compound [Na+].CCCC(C([O-])=O)CCC AEQFSUDEHCCHBT-UHFFFAOYSA-M 0.000 title abstract 2
- 229940102566 valproate Drugs 0.000 title abstract 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
EL USO COORDINADO DE L-CARNITINA O ACILO L-CARNITINAS Y VALPROATO PERMITE UNA DISMINUCION CONSIDERABLE EN LA FRECUENCIA DEL AGARROTAMIENTO, SEGUN SE HA OBSERVADO EN PACIENTES EPILEPTICOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITRM930441A IT1261808B (it) | 1993-07-06 | 1993-07-06 | Impiego di l-carnitina o acido l-carnitine e valproato nel trattamentodei disosrdini convulsivi |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2111891T3 true ES2111891T3 (es) | 1998-03-16 |
Family
ID=11401844
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94830306T Expired - Lifetime ES2111891T3 (es) | 1993-07-06 | 1994-06-22 | Empleo de l-carnitina o acil l-carnitinas y valproato para tratar trastornos epilepticos. |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0637449B1 (es) |
AT (1) | ATE161718T1 (es) |
DE (1) | DE69407684T2 (es) |
DK (1) | DK0637449T3 (es) |
ES (1) | ES2111891T3 (es) |
GR (1) | GR3025845T3 (es) |
HK (1) | HK1005771A1 (es) |
IT (1) | IT1261808B (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR9709627A (pt) * | 1996-05-31 | 1999-08-10 | Sigma Tau Ind Farmaceuti | Sais n o-higroscópicos estáveis de L(-)carnitina e alcanoílal(-)carnitinas um processo para sua preparação e composições sólidas oralmente administráveis contendo tais sais |
EP0972516A1 (en) * | 1998-06-25 | 2000-01-19 | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. | Gastro-intestinal adverse effect-free composition comprising an L-carnitine replacement. |
ITRM20010030A1 (it) * | 2001-01-23 | 2002-07-23 | Aldo Fassi | Sali di carnitine utili come integratori dietetici/nutrizionali o come farmaci, composizioni che li contengono e procedimenti per la loro pr |
GB0307860D0 (en) * | 2003-04-04 | 2003-05-14 | Novartis Ag | Organic compounds |
US20060252745A1 (en) | 2005-05-06 | 2006-11-09 | Almeida Jose L D | Methods of preparing pharmaceutical compositions comprising eslicarbazepine acetate and methods of use |
GB0700773D0 (en) | 2007-01-15 | 2007-02-21 | Portela & Ca Sa | Drug therapies |
US7456216B2 (en) * | 2007-03-19 | 2008-11-25 | Biolink Life Sciences, Inc. | Methods for the preparation and formulation of l-carnitine valproate salts |
US20110015267A1 (en) * | 2009-07-20 | 2011-01-20 | Deanna Jean Nelson | Methods for the preparation and use of aqueous solutions of magnesium valproate hydrate and l-carnitine |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3726945A1 (de) * | 1987-08-13 | 1989-02-23 | Dietl Hans | L-carnitinderivate der valproinsaeure und diese enthaltende arzneimittel |
-
1993
- 1993-07-06 IT ITRM930441A patent/IT1261808B/it active IP Right Grant
-
1994
- 1994-06-22 AT AT94830306T patent/ATE161718T1/de not_active IP Right Cessation
- 1994-06-22 DK DK94830306.0T patent/DK0637449T3/da active
- 1994-06-22 ES ES94830306T patent/ES2111891T3/es not_active Expired - Lifetime
- 1994-06-22 DE DE69407684T patent/DE69407684T2/de not_active Expired - Fee Related
- 1994-06-22 EP EP94830306A patent/EP0637449B1/en not_active Expired - Lifetime
-
1998
- 1998-01-08 GR GR970402218T patent/GR3025845T3/el unknown
- 1998-06-05 HK HK98104925A patent/HK1005771A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE69407684T2 (de) | 1998-04-30 |
DK0637449T3 (da) | 1998-05-25 |
GR3025845T3 (en) | 1998-04-30 |
DE69407684D1 (de) | 1998-02-12 |
EP0637449A1 (en) | 1995-02-08 |
EP0637449B1 (en) | 1998-01-07 |
HK1005771A1 (en) | 1999-01-22 |
IT1261808B (it) | 1996-06-03 |
ITRM930441A1 (it) | 1995-01-06 |
ATE161718T1 (de) | 1998-01-15 |
ITRM930441A0 (it) | 1993-07-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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